Kontrola akustičnom metodom raspadanja stijena pri rotacionom bušenju

The contribution describes the technical and algorithmic solution of the optimization of rotary drilling. The global optimization criteria express the minimum specific energy on drilling and the maximum speed of drilling. The article presents the first results of research on the utilization of acoustic methods in indirect measurement of criterion function by optimizing these processes.Rad opisuje tehničko i algoritmičko rješenje optimalizacije rotacionog bušenja. Globalna optimalizacija kriterija izražava minimalnu specifičnu energiju bušenja i maksimalnu brzinu bušenja. Članak predstavlja prve rezultate istraživanja primjene akustičkih metoda u neizravnom mjerenju funkcije kriterija optimaliziranjem tih procesa

The Virtual Monte Carlo

The concept of Virtual Monte Carlo (VMC) has been developed by the ALICE Software Project to allow different Monte Carlo simulation programs to run without changing the user code, such as the geometry definition, the detector response simulation or input and output formats. Recently, the VMC classes have been integrated into the ROOT framework, and the other relevant packages have been separated from the AliRoot framework and can be used individually by any other HEP project. The general concept of the VMC and its set of base classes provided in ROOT will be presented. Existing implementations for Geant3, Geant4 and FLUKA and simple examples of usage will be described.Comment: Talk from the 2003 Computing in High Energy and Nuclear Physics (CHEP03), La Jolla, Ca, USA, March 2003, 8 pages, LaTeX, 6 eps figures. PSN THJT006. See http://root.cern.ch/root/vmc/VirtualMC.htm

Quantitative analysis and detection of chaptalization and watering down of wine using isotope ratio mass spectrometry

In early 1990's European Union has established new isotopic approach for detection of wine authenticity. In this article we setup the possibility of using new approach using new EIM - Module - IRMS (Ethanol Isotope Measurement - Module - Isotope Ratio Mass Spectrometry) instrumental technique and new analytical parameter delta D-n(delta H-2(n)) wine ethanol value, which represents delta H-2 value of non-exchangeable hydrogen stable isotope ratio in ethanol, with other isotopic species (delta O-18 values in wine water) to improve detection of illegal wine production practices such as addition of sugar and/or dilution with water. Total of 42 wine samples were analyzed. 10 wine samples (out of 42) were prepared from grapes by alcoholic fermentation and analyzed for delta D-n values of ethanol. 19 wine samples (out of 42) were collected from wine producers in Serbia plus 1 wine samples designated from United States was taken from Serbian market and analyzed for delta D-n values of ethanol, delta O-18 values in wine water and also delta C-13 values in wine ethanol. Furthermore 9 wine samples (out of 42) were taken from Hungarian market and analyzed for delta D-n values of ethanol, and also 3 wine samples (out of 42) were taken from Austrian market and analyzed for delta D-n values of ethanol. All experiments were done in 4 isotope laboratories located in US, Austria, Hungary and People's Republic of China. delta D-n values of ethanol were measured by using EIM Module connected to FlashHT 2000 pyrolizer (one laboratory - Imprint Analytics GmbH, Austria), while in other 3 laboratories (US - COIL - Cornell University, Stable Isotope Laboratory, Hungary - Isotoptech Ltd, Debrecen, Hungary and China - C.N.R.I.F.F.I. - China National Institute of Food and Fermentation Industries Limited) EIM Module was connected to TC/EA (High Temperature Conversion Elemental Analyzer). Peripherals in all laboratories were further interfaced with isotope ratio mass spectrometer. Furthermore delta O-18 values in wine water were measured by using Gas Bench II interfaced also with isotope ratio mass spectrometer (one laboratory - US). Obtained results from all 4 laboratories have shown that this new approach which uses delta D-n in wine ethanol is more effective in improving detection of illegal wine production practices (sugar enrichment and water dilution) and origin of ethanol, and also detecting the addition of corn or beet sugar, sugar syrup to wine, or dilution of grape must with water prior to alcoholic fermentation

Extended Thromboprophylaxis with Betrixaban in Acutely Ill Medical Patients

Background Patients with acute medical illnesses are at prolonged risk for venous thrombosis. However, the appropriate duration of thromboprophylaxis remains unknown. Methods Patients who were hospitalized for acute medical illnesses were randomly assigned to receive subcutaneous enoxaparin (at a dose of 40 mg once daily) for 10±4 days plus oral betrixaban placebo for 35 to 42 days or subcutaneous enoxaparin placebo for 10±4 days plus oral betrixaban (at a dose of 80 mg once daily) for 35 to 42 days. We performed sequential analyses in three prespecified, progressively inclusive cohorts: patients with an elevated d-dimer level (cohort 1), patients with an elevated d-dimer level or an age of at least 75 years (cohort 2), and all the enrolled patients (overall population cohort). The statistical analysis plan specified that if the between-group difference in any analysis in this sequence was not significant, the other analyses would be considered exploratory. The primary efficacy outcome was a composite of asymptomatic proximal deep-vein thrombosis and symptomatic venous thromboembolism. The principal safety outcome was major bleeding. Results A total of 7513 patients underwent randomization. In cohort 1, the primary efficacy outcome occurred in 6.9% of patients receiving betrixaban and 8.5% receiving enoxaparin (relative risk in the betrixaban group, 0.81; 95% confidence interval [CI], 0.65 to 1.00; P=0.054). The rates were 5.6% and 7.1%, respectively (relative risk, 0.80; 95% CI, 0.66 to 0.98; P=0.03) in cohort 2 and 5.3% and 7.0% (relative risk, 0.76; 95% CI, 0.63 to 0.92; P=0.006) in the overall population. (The last two analyses were considered to be exploratory owing to the result in cohort 1.) In the overall population, major bleeding occurred in 0.7% of the betrixaban group and 0.6% of the enoxaparin group (relative risk, 1.19; 95% CI, 0.67 to 2.12; P=0.55). Conclusions Among acutely ill medical patients with an elevated d-dimer level, there was no significant difference between extended-duration betrixaban and a standard regimen of enoxaparin in the prespecified primary efficacy outcome. However, prespecified exploratory analyses provided evidence suggesting a benefit for betrixaban in the two larger cohorts. (Funded by Portola Pharmaceuticals; APEX ClinicalTrials.gov number, NCT01583218. opens in new tab.

The parent?infant dyad and the construction of the subjective self

Developmental psychology and psychopathology has in the past been more concerned with the quality of self-representation than with the development of the subjective agency which underpins our experience of feeling, thought and action, a key function of mentalisation. This review begins by contrasting a Cartesian view of pre-wired introspective subjectivity with a constructionist model based on the assumption of an innate contingency detector which orients the infant towards aspects of the social world that react congruently and in a specifically cued informative manner that expresses and facilitates the assimilation of cultural knowledge. Research on the neural mechanisms associated with mentalisation and social influences on its development are reviewed. It is suggested that the infant focuses on the attachment figure as a source of reliable information about the world. The construction of the sense of a subjective self is then an aspect of acquiring knowledge about the world through the caregiver's pedagogical communicative displays which in this context focuses on the child's thoughts and feelings. We argue that a number of possible mechanisms, including complementary activation of attachment and mentalisation, the disruptive effect of maltreatment on parent-child communication, the biobehavioural overlap of cues for learning and cues for attachment, may have a role in ensuring that the quality of relationship with the caregiver influences the development of the child's experience of thoughts and feelings

pengaruh model pembelajaran inductive thinking - deductive thinking terhadap hasil belajar IPS ditinjau dari jenis kelamin siswa kelas VII SMP N 2 KARTASURA

ABSTRAK Ulfah Fajar Hayati (K5411064) PENGARUH MODEL PEMBELAJARAN DEDUCTIVE THINKING–INDUCTIVE THINKING DITINJAU DARI JENIS KELAMIN TERHADAP HASIL BELAJAR SISWA KELAS VII SMP NEGERI 2 KARTASURA TAHUN AJARAN 2014/2015 (Materi Pembelajaran Kondisi Geografis dan Penduduk). Proposal Skripsi, Surakarta: Fakultas Keguruan dan Ilmu Pendidikan. Universitas Sebelas Maret. Februari 2015. Tujuan penelitian ini adalah 1) Untuk mengetahui perbedaan hasil belajar IPS materi pembelajaran kondisi geografis dan penduduk antara model pembelajaran deductive thinking dan model pembelajaran induktive thinking pada siswa kelas VII SMP Negeri 2 Kartasura tahun ajaran 2014/2015. 2) Untuk mengetahui perbedaan hasil belajar IPS materi pembelajaran kondisi geografis dan penduduk pada siswa laki-laki yang disampaikan dengan model pembelajaran deductive thinking dan model pembelajaran inductive thinking pada siswa kelas VII SMP Negeri 2 Kartasura tahun ajaran 2014/2015. 3) Untuk mengetahui perbedaan hasil belajar IPS materi pembelajaran kondisi geografis dan penduduk pada siswa perempuan yang disampaikan dengan model pembelajaran deductive thinking dan model pembelajaran inductive thinking pada siswa kelas VII SMP Negeri 2 Kartasura tahun ajaran 2014/2015. 4) Untuk mengetahui pengaruh interaksi antara model pembelajaran dan jenis kelamin terhadap hasil belajar IPS materi pembelajaran kondisi geografis dan penduduk pada siswa kelas VII SMP Negeri 2 Kartasura tahun ajaran 2014/2015. Jenis penelitian ini merupakan penelitian Quasi Eksperimental dengan rencana design grup factorial 2x2. Populasi penelitian adalah kelas VII SMP Negeri 2 Kartasura, Sukoharjo dan sampel penelitian adalah siswa kelas VIID dan VIIA Sampel tersebut diambil dengan menggunakan teknik simple random sampling. Teknik pengumpulan data menggunakan tes dalam bentuk tes obyektif pilihan ganda. Teknik analisis data yang digunakan dengan pengujian hipotesis analisis Anova Dua Arah (Two Way Anova) pada taraf signifikasi 5%

Effects of Once-Weekly Exenatide on Cardiovascular Outcomes in Type 2 Diabetes.

Abstract BACKGROUND: The cardiovascular effects of adding once-weekly treatment with exenatide to usual care in patients with type 2 diabetes are unknown. METHODS: We randomly assigned patients with type 2 diabetes, with or without previous cardiovascular disease, to receive subcutaneous injections of extended-release exenatide at a dose of 2 mg or matching placebo once weekly. The primary composite outcome was the first occurrence of death from cardiovascular causes, nonfatal myocardial infarction, or nonfatal stroke. The coprimary hypotheses were that exenatide, administered once weekly, would be noninferior to placebo with respect to safety and superior to placebo with respect to efficacy. RESULTS: In all, 14,752 patients (of whom 10,782 [73.1%] had previous cardiovascular disease) were followed for a median of 3.2 years (interquartile range, 2.2 to 4.4). A primary composite outcome event occurred in 839 of 7356 patients (11.4%; 3.7 events per 100 person-years) in the exenatide group and in 905 of 7396 patients (12.2%; 4.0 events per 100 person-years) in the placebo group (hazard ratio, 0.91; 95% confidence interval [CI], 0.83 to 1.00), with the intention-to-treat analysis indicating that exenatide, administered once weekly, was noninferior to placebo with respect to safety (P<0.001 for noninferiority) but was not superior to placebo with respect to efficacy (P=0.06 for superiority). The rates of death from cardiovascular causes, fatal or nonfatal myocardial infarction, fatal or nonfatal stroke, hospitalization for heart failure, and hospitalization for acute coronary syndrome, and the incidence of acute pancreatitis, pancreatic cancer, medullary thyroid carcinoma, and serious adverse events did not differ significantly between the two groups. CONCLUSIONS: Among patients with type 2 diabetes with or without previous cardiovascular disease, the incidence of major adverse cardiovascular events did not differ significantly between patients who received exenatide and those who received placebo. (Funded by Amylin Pharmaceuticals; EXSCEL ClinicalTrials.gov number, NCT01144338 .)