Ethical issues in the use of in-depth interviews: literature review and discussion

This paper reports a literature review on the topic of ethical issues in in-depth interviews. The review returned three types of article: general discussion, issues in particular studies, and studies of interview-based research ethics. Whilst many of the issues discussed in these articles are generic to research ethics, such as confidentiality, they often had particular manifestations in this type of research. For example, privacy was a significant problem as interviews sometimes probe unexpected areas. For similar reasons, it is difficult to give full information of the nature of a particular interview at the outset, hence informed consent is problematic. Where a pair is interviewed (such as carer and cared-for) there are major difficulties in maintaining confidentiality and protecting privacy. The potential for interviews to harm participants emotionally is noted in some papers, although this is often set against potential therapeutic benefit. As well as these generic issues, there are some ethical issues fairly specific to in-depth interviews. The problem of dual role is noted in many papers. It can take many forms: an interviewer might be nurse and researcher, scientist and counsellor, or reporter and evangelist. There are other specific issues such as taking sides in an interview, and protecting vulnerable groups. Little specific study of the ethics of in-depth interviews has taken place. However, that which has shows some important findings. For example, one study shows participants are not averse to discussing painful issues provided they feel the study is worthwhile. Some papers make recommendations for researchers. One such is that they should consider using a model of continuous (or process) consent rather than viewing consent as occurring once, at signature, prior to the interview. However, there is a need for further study of this area, both philosophical and empirical

A Spitzer/IRS Spectrum of the 2008 Luminous Transient in NGC 300: Connection to Proto-Planetary Nebulae

We present a Spitzer/IRS low-resolution mid-infrared spectrum (5-14 micron) of the luminous transient discovered in the nearby galaxy NGC 300 in May 2008. The spectrum, obtained three months after discovery, shows that the transient is very luminous in the mid-IR. Furthermore, the spectrum shows strong, broad emission features at 8 and 12 micron that are observed in Galactic carbon-rich proto-planetary nebulae. Combining these data with published optical and near-IR photometry obtained at the same epoch, we find that the mid-IR excess traced by the Spitzer spectrum accounts for ~20% of the total energy output. This component can be well explained by emission from ~3x10^-4 Msun of pre-existing progenitor dust at temperature ~400 K. The spectral energy distribution of the transient also shows a near-IR excess that can be explained by emission from newly-formed dust in the ejecta. Alternatively, both the near-IR and mid-IR excesses can together be explained by a single pre-existing geometrically thick dust shell. In light of the new observations obtained with Spitzer, we revisit the analysis of the optical spectra and kinematics, which were compared to the massive yellow-hypergiant IRC+10420 in previous studies. We show that proto-planetary nebulae share many properties with the NGC 300 transient and SN 2008S. We conclude that even though the explosion of a massive star (> 10 Msun) cannot be ruled out, an explosive event on a massive (6-10 Msun) carbon-rich AGB/super-AGB or post-AGB star is consistent with all observations of the transients and their progenitors presented thus far.Comment: 9 pages, 5 figures, 3 tables; references update

Sport and the local economy: the role of stadia in regenerating commercial property

The use of sports stadia for economic development and regeneration has gained increasingly credibility in recent years, both academically and in terms of UK urban policy. However, evidence to support the effectiveness of stadia for these purposes is highly variable. This paper uses a comparative case study of the Millennium Stadium and the City of Manchester Stadium to examine the effects of stadia development on the commercial property market, an area of research that has received little attention in the literature. It uses the expert opinion of professionals working in real estate, together with the experience of key stakeholders in Manchester and Cardiff to provide empirical evidence that stadia can create tangible and intangible impacts on the commercial property market, but that these are variable between different sectors. It concludes by arguing the need for further research on the role of stadia in the regeneration process if the impacts of these developments are to be maximised in the future.</p

Wind modelling of very massive stars up to 300 solar masses

Some studies have claimed a universal stellar upper-mass limit of 150 Msun. A factor that is often overlooked is that there might be a difference between the current and initial masses of the most massive stars, as a result of mass loss. We present Monte Carlo mass-loss predictions for very massive stars in the range 40-300 Msun, with large luminosities and Eddington factors Gamma. Using our new dynamical approach, we find an upturn in the mass-loss vs. Gamma dependence, at the point where the winds become optically thick. This coincides with the location where wind efficiency numbers surpass the single-scattering limit of Eta = 1, reaching values up to Eta = 2.5. Our modelling suggests a transition from common O-type winds to Wolf-Rayet characteristics at the point where the winds become optically thick. This transitional behaviour is also revealed with respect to the wind acceleration parameter beta, which starts at values below 1 for the optically thin O-stars, and naturally reaches values as high as 1.5-2 for the optically thick Wolf-Rayet models. An additional finding concerns the transition in spectral morphology of the Of and WN characteristic He II line at 4686 Angstrom. When we express our mass-loss predictions as a function of the electron scattering Gamma_e (=L/M) only, we obtain a mass-loss Gamma dependence that is consistent with a previously reported power-law Mdot propto Gamma^5 (Vink 2006) that was based on our semi-empirical modelling approach. When we express Mdot in terms of both Gamma and stellar mass, we find Mdot propto M^0.8 Gamma^4.8 for our high Gamma models. Finally, we confirm that the Gamma-effect on the mass-loss predictions is much stronger than that of an increased helium abundance, calling for a fundamental revision in the way mass loss is incorporated in evolutionary models of the most massive stars.Comment: minor language changes (Astronomy & Astrophysics in press - 11 pages, 10 figures

Evidence-based planning and costing palliative care services for children : novel multi-method epidemiological and economic exemplar

Background: Children’s palliative care is a relatively new clinical specialty. Its nature is multi-dimensional and its delivery necessarily multi-professional. Numerous diverse public and not-for-profit organisations typically provide services and support. Because services are not centrally coordinated, they are provided in a manner that is inconsistent and incoherent. Since the first children’s hospice opened in 1982, the epidemiology of life-limiting conditions has changed with more children living longer, and many requiring transfer to adult services. Very little is known about the number of children living within any given geographical locality, costs of care, or experiences of children with ongoing palliative care needs and their families. We integrated evidence, and undertook and used novel methodological epidemiological work to develop the first evidence-based and costed commissioning exemplar. Methods: Multi-method epidemiological and economic exemplar from a health and not-for-profit organisation perspective, to estimate numbers of children under 19 years with life-limiting conditions, cost current services, determine child/parent care preferences, and cost choice of end-of-life care at home. Results: The exemplar locality (North Wales) had important gaps in service provision and the clinical network. The estimated annual total cost of current children’s palliative care was about £5.5 million; average annual care cost per child was £22,771 using 2007 prevalence estimates and £2,437- £11,045 using new 2012/13 population-based prevalence estimates. Using population-based prevalence, we estimate 2271 children with a life-limiting condition in the general exemplar population and around 501 children per year with ongoing palliative care needs in contact with hospital services. Around 24 children with a wide range of life-limiting conditions require end-of-life care per year. Choice of end-of-life care at home was requested, which is not currently universally available. We estimated a minimum (based on 1 week of end-of-life care) additional cost of £336,000 per year to provide end-of-life support at home. Were end-of-life care to span 4 weeks, the total annual additional costs increases to £536,500 (2010/11 prices). Conclusions: Findings make a significant contribution to population-based needs assessment and commissioning methodology in children’s palliative care. Further work is needed to determine with greater precision which children in the total population require access to services and when. Half of children who died 2002-7 did not have conditions that met the globally used children's palliative care condition categories, which need revision in light of findings

Mass-loss rates of Very Massive Stars

We discuss the basic physics of hot-star winds and we provide mass-loss rates for (very) massive stars. Whilst the emphasis is on theoretical concepts and line-force modelling, we also discuss the current state of observations and empirical modelling, and address the issue of wind clumping.Comment: 36 pages, 15 figures, Book Chapter in "Very Massive Stars in the Local Universe", Springer, Ed. Jorick S. Vin

The semi-classical expansion and resurgence in gauge theories: new perturbative, instanton, bion, and renormalon effects

We study the dynamics of four dimensional gauge theories with adjoint fermions for all gauge groups, both in perturbation theory and non-perturbatively, by using circle compactification with periodic boundary conditions for the fermions. There are new gauge phenomena. We show that, to all orders in perturbation theory, many gauge groups are Higgsed by the gauge holonomy around the circle to a product of both abelian and nonabelian gauge group factors. Non-perturbatively there are monopole-instantons with fermion zero modes and two types of monopole-anti-monopole molecules, called bions. One type are "magnetic bions" which carry net magnetic charge and induce a mass gap for gauge fluctuations. Another type are "neutral bions" which are magnetically neutral, and their understanding requires a generalization of multi-instanton techniques in quantum mechanics - which we refer to as the Bogomolny-Zinn-Justin (BZJ) prescription - to compactified field theory. The BZJ prescription applied to bion-anti-bion topological molecules predicts a singularity on the positive real axis of the Borel plane (i.e., a divergence from summing large orders in peturbation theory) which is of order N times closer to the origin than the leading 4-d BPST instanton-anti-instanton singularity, where N is the rank of the gauge group. The position of the bion--anti-bion singularity is thus qualitatively similar to that of the 4-d IR renormalon singularity, and we conjecture that they are continuously related as the compactification radius is changed. By making use of transseries and Ecalle's resurgence theory we argue that a non-perturbative continuum definition of a class of field theories which admit semi-classical expansions may be possible.Comment: 112 pages, 7 figures; v2: typos corrected, discussion of supersymmetric models added at the end of section 8.1, reference adde

Pharmacological Properties and Physiological Function of a P2X-Like Current in Single Proximal Tubule Cells Isolated from Frog Kidney

Although previous studies have provided evidence for the expression of P2X receptors in renal proximal tubule, only one cell line study has provided functional evidence. The current study investigated the pharmacological properties and physiological role of native P2X-like currents in single frog proximal tubule cells using the whole-cell patch-clamp technique. Extracellular ATP activated a cation conductance (P2Xf) that was also Ca2+-permeable. The agonist sequence for activation was ATP = αβ-MeATP > BzATP = 2-MeSATP, and P2Xf was inhibited by suramin, PPADS and TNP-ATP. Activation of P2Xf attenuated the rundown of a quinidine-sensitive K+ conductance, suggesting that P2Xf plays a role in K+ channel regulation. In addition, ATP/ADP apyrase and inhibitors of P2Xf inhibited regulatory volume decrease (RVD). These data are consistent with the presence of a P2X receptor that plays a role in the regulation of cell volume and K+ channels in frog renal proximal tubule cells

Cholangiocyte organoids can repair bile ducts after transplantation in the human liver.

Organoid technology holds great promise for regenerative medicine but has not yet been applied to humans. We address this challenge using cholangiocyte organoids in the context of cholangiopathies, which represent a key reason for liver transplantation. Using single-cell RNA sequencing, we show that primary human cholangiocytes display transcriptional diversity that is lost in organoid culture. However, cholangiocyte organoids remain plastic and resume their in vivo signatures when transplanted back in the biliary tree. We then utilize a model of cell engraftment in human livers undergoing ex vivo normothermic perfusion to demonstrate that this property allows extrahepatic organoids to repair human intrahepatic ducts after transplantation. Our results provide proof of principle that cholangiocyte organoids can be used to repair human biliary epithelium

Dynamics of stellar black holes in young star clusters with different metallicities - I. Implications for X-ray binaries

We present N-body simulations of intermediate-mass (3000-4000 M-circle dot) young star clusters (SCs) with three different metallicities (Z = 0.01, 0.1 and 1 Z(circle dot)), including metal-dependent stellar evolution recipes and binary evolution. Following recent theoretical models of wind mass-loss and core-collapse supernovae, we assume that the mass of the stellar remnants depends on the metallicity of the progenitor stars. In particular, massive metal-poor stars (Z = 0.3 Z(circle dot)) are enabled to form massive stellar black holes (MSBHs, with mass &gt;= 25 M-circle dot) through direct collapse. We find that three-body encounters, and especially dynamical exchanges, dominate the evolution of the MSBHs formed in our simulations. In SCs with Z = 0.01 and 0.1 Z(circle dot), about 75 per cent of simulated MSBHs form from single stars and become members of binaries through dynamical exchanges in the first 100 Myr of the SC life. This is a factor of greater than or similar to 3 more efficient than in the case of low-mass (&lt;25 M-circle dot) stellar black holes. A small but non-negligible fraction of MSBHs power wind-accreting (10-20 per cent) and Roche lobe overflow (RLO, 5-10 per cent) binary systems. The vast majority of MSBH binaries that undergo wind accretion and/or RLO were born from dynamical exchange. This result indicates that MSBHs can power X-ray binaries in low-metallicity young SCs, and is very promising to explain the association of many ultraluminous X-ray sources with low-metallicity and actively star-forming environments