62 research outputs found

    Natural solution to antibiotic resistance: bacteriophages ‘The Living Drugs’

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    Assessing Theoretical Conclusions With Blinded Inference to Investigate a Potential Inference Crisis

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    Scientific advances across a range of disciplines hinge on the ability to make inferences about unobservable theoretical entities on the basis of empirical data patterns. Accurate inferences rely on both discovering valid, replicable data patterns and accurately interpreting those patterns in terms of their implications for theoretical constructs. The replication crisis in science has led to widespread efforts to improve the reliability of research findings, but comparatively little attention has been devoted to the validity of inferences based on those findings. Using an example from cognitive psychology, we demonstrate a blinded-inference paradigm for assessing the quality of theoretical inferences from data. Our results reveal substantial variability in experts’ judgments on the very same data, hinting at a possible inference crisis

    Microwave and Computational Study of Methanesulfonic Acid and Its Complex with Water

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    Spectra of methanesulfonic acid (CH3SO3H, MSA) and its complex with water have been studied by microwave spectroscopy and density functional theory calculations. For the monomer, spectra were obtained for both the parent and −OD isotopologues and, in each case, revealed a pair of tunneling states that are attributed to large amplitude motion of the hydroxyl hydrogen about the S–O(H) bond. Transitions crossing between tunneling states were not found in the parent spectrum and are estimated to be outside the range of the spectrometer, thus precluding the direct determination of the tunneling energy. For the −OD form, however, the tunneling energy was determined to be ΔE = 6471.9274(18) MHz from direct measurement of the cross-state c-type transitions. In its complex with water, the acidic hydrogen of the MSA forms a hydrogen bond with the water oxygen. A secondary hydrogen bond involving the water hydrogen and an SO3 oxygen completes a six-membered ring, forming a cyclic structure typical of hydrated oxyacids. No evidence of internal motion was observed. Rotational spectra of the CH3SO3H···D2O and CH3SO3D···D2O isotopologues were also obtained and analyzed. Comparison with theoretical calculations confirms the cyclic structure, though the orientation of the unbound water hydrogen is ambiguous

    The Effect of Early List Manipulations On the DRM Illusion

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    The Deese–Roediger–McDermott (DRM) paradigm is widely used to study false memory in the laboratory. It tests memory for lists of semantically related words (correct list item memories) and their non-presented associates (false lure memories). Evidence suggests that early items in DRM lists could make an especially significant contribution to false memories of lures, as they may critically influence the underlying associative activation and/or gist extraction processes. The present study tested this suggestion by using two manipulations that were intended to affect processing of early DRM list items. The first was interpolation of a semantically unrelated distractor item among the list items (Experiments 1 and 2). The second was arranging for these items to be either the strongest or weakest associates of the lure (Experiment 2). In Experiment 1, a distractor item reduced both list item and lure recall when presented early in a DRM list, but selectively disrupted list item recall when presented late in the list. In Experiment 2, arranging for the early list items to be the weakest associates of the lure reduced false recall of the lure but had no effect on list item recall. The findings are discussed with respect to theories that explain false memory in the DRM protocol, including fuzzy trace theory (FTT) and activation–monitoring theory (AMT). They are also discussed with respect to general theories of memory and the potential role of category/context information in generating false memories
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