Présence de Frambocythere COLIN, 1980, (ostracode limnique) dans le Maastrich-tien des Monts du Zagros, Iran : un nouveau relais entre l'Europe méridionale et l'Extrême-Orient

L'ostracode limnique Frambocythere tumiensis zagrosensis nov. subsp. (Limnocytheridae, Timiriaseviinae) a été trouvé pour la première fois en Iran. Les niveaux contenant cette espèce pro-viennent de la partie inférieure de la Formation de Tarbur dans les Fars intérieurs des Monts Zagros. L'âge maastrichtien est donné par les rudistes, les grands foraminifères (Omphalocyclus macroporus, Loftusia spp.) et les foraminifères planctoniques (Zone à Contusotruncana contusa-Racemiguembelina fructicosa) dans les niveaux de la partie supérieure de la Formation de Tarbur. L'âge maastrichtien est aussi conforté par la présence dans les mêmes niveaux des charophytes Platychara shanii, Peckichara cristellata et Stephanochara cf. producta. Le genre Frambocythere COLIN, 1980, n'était jusqu'à présent connu que du Maastrichtien supérieur à l'Éocène moyen en Europe méridionale, Inde et Chine, ainsi que dans l'Albien de la République Démocratique du Congo. La présence de Frambocythere gr. tumiensis en Iran est donc un nouveau relais entre l'Europe méridionale et l'Extrême-Orient (Chine).The limnic ostracode Frambocythere tumiensis zagrosensis subsp. nov. (Limnocytheridae, Timiriaseviinae), has been found for the first time in Iran. The strata containing this species are in the lower part of the Tarbur Formation in the interior Fars of the Zagros Mountains. The Late Maastrichtian age is indicated by rudists, larger foraminifers (Omphalocyclus macroporus, Loftusia spp.) and plank-tonic foraminifers(Contusotruncana contusa-Racemiguembelina fructicosa Zone) present in the upper part of the Tarbur Formation. The Maastrichtian age is confirmed by the occurrence in the same strata of the charophytes Platychara shanii, Peckichara cristellata and Stephanochara cf. producta. The genus Frambocythere COLIN, 1980, was until now known mostly from the Upper Maastrichtian to Middle Eoce-ne of southern Europe, India and China, as well as the Albian of the Democratic Republic of Congo. The presence of Frambocythere gr. tumiensis in Iran is therefore a newly recognized link between southern Europe and the Far East (China)

The global burden of cancer attributable to risk factors, 2010-19 : a systematic analysis for the Global Burden of Disease Study 2019

Background Understanding the magnitude of cancer burden attributable to potentially modifiable risk factors is crucial for development of effective prevention and mitigation strategies. We analysed results from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019 to inform cancer control planning efforts globally. Methods The GBD 2019 comparative risk assessment framework was used to estimate cancer burden attributable to behavioural, environmental and occupational, and metabolic risk factors. A total of 82 risk-outcome pairs were included on the basis of the World Cancer Research Fund criteria. Estimated cancer deaths and disability-adjusted life-years (DALYs) in 2019 and change in these measures between 2010 and 2019 are presented. Findings Globally, in 2019, the risk factors included in this analysis accounted for 4.45 million (95% uncertainty interval 4.01-4.94) deaths and 105 million (95.0-116) DALYs for both sexes combined, representing 44.4% (41.3-48.4) of all cancer deaths and 42.0% (39.1-45.6) of all DALYs. There were 2.88 million (2.60-3.18) risk-attributable cancer deaths in males (50.6% [47.8-54.1] of all male cancer deaths) and 1.58 million (1.36-1.84) risk-attributable cancer deaths in females (36.3% [32.5-41.3] of all female cancer deaths). The leading risk factors at the most detailed level globally for risk-attributable cancer deaths and DALYs in 2019 for both sexes combined were smoking, followed by alcohol use and high BMI. Risk-attributable cancer burden varied by world region and Socio-demographic Index (SDI), with smoking, unsafe sex, and alcohol use being the three leading risk factors for risk-attributable cancer DALYs in low SDI locations in 2019, whereas DALYs in high SDI locations mirrored the top three global risk factor rankings. From 2010 to 2019, global risk-attributable cancer deaths increased by 20.4% (12.6-28.4) and DALYs by 16.8% (8.8-25.0), with the greatest percentage increase in metabolic risks (34.7% [27.9-42.8] and 33.3% [25.8-42.0]). Interpretation The leading risk factors contributing to global cancer burden in 2019 were behavioural, whereas metabolic risk factors saw the largest increases between 2010 and 2019. Reducing exposure to these modifiable risk factors would decrease cancer mortality and DALY rates worldwide, and policies should be tailored appropriately to local cancer risk factor burden. Copyright (C) 2022 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license.Peer reviewe

Global, regional, and national burden of disorders affecting the nervous system, 1990–2021: a systematic analysis for the Global Burden of Disease Study 2021

BackgroundDisorders affecting the nervous system are diverse and include neurodevelopmental disorders, late-life neurodegeneration, and newly emergent conditions, such as cognitive impairment following COVID-19. Previous publications from the Global Burden of Disease, Injuries, and Risk Factor Study estimated the burden of 15 neurological conditions in 2015 and 2016, but these analyses did not include neurodevelopmental disorders, as defined by the International Classification of Diseases (ICD)-11, or a subset of cases of congenital, neonatal, and infectious conditions that cause neurological damage. Here, we estimate nervous system health loss caused by 37 unique conditions and their associated risk factors globally, regionally, and nationally from 1990 to 2021.MethodsWe estimated mortality, prevalence, years lived with disability (YLDs), years of life lost (YLLs), and disability-adjusted life-years (DALYs), with corresponding 95% uncertainty intervals (UIs), by age and sex in 204 countries and territories, from 1990 to 2021. We included morbidity and deaths due to neurological conditions, for which health loss is directly due to damage to the CNS or peripheral nervous system. We also isolated neurological health loss from conditions for which nervous system morbidity is a consequence, but not the primary feature, including a subset of congenital conditions (ie, chromosomal anomalies and congenital birth defects), neonatal conditions (ie, jaundice, preterm birth, and sepsis), infectious diseases (ie, COVID-19, cystic echinococcosis, malaria, syphilis, and Zika virus disease), and diabetic neuropathy. By conducting a sequela-level analysis of the health outcomes for these conditions, only cases where nervous system damage occurred were included, and YLDs were recalculated to isolate the non-fatal burden directly attributable to nervous system health loss. A comorbidity correction was used to calculate total prevalence of all conditions that affect the nervous system combined.FindingsGlobally, the 37 conditions affecting the nervous system were collectively ranked as the leading group cause of DALYs in 2021 (443 million, 95% UI 378–521), affecting 3·40 billion (3·20–3·62) individuals (43·1%, 40·5–45·9 of the global population); global DALY counts attributed to these conditions increased by 18·2% (8·7–26·7) between 1990 and 2021. Age-standardised rates of deaths per 100 000 people attributed to these conditions decreased from 1990 to 2021 by 33·6% (27·6–38·8), and age-standardised rates of DALYs attributed to these conditions decreased by 27·0% (21·5–32·4). Age-standardised prevalence was almost stable, with a change of 1·5% (0·7–2·4). The ten conditions with the highest age-standardised DALYs in 2021 were stroke, neonatal encephalopathy, migraine, Alzheimer's disease and other dementias, diabetic neuropathy, meningitis, epilepsy, neurological complications due to preterm birth, autism spectrum disorder, and nervous system cancer.InterpretationAs the leading cause of overall disease burden in the world, with increasing global DALY counts, effective prevention, treatment, and rehabilitation strategies for disorders affecting the nervous system are needed

Global burden of 288 causes of death and life expectancy decomposition in 204 countries and territories and 811 subnational locations, 1990–2021: a systematic analysis for the Global Burden of Disease Study 2021

BACKGROUND Regular, detailed reporting on population health by underlying cause of death is fundamental for public health decision making. Cause-specific estimates of mortality and the subsequent effects on life expectancy worldwide are valuable metrics to gauge progress in reducing mortality rates. These estimates are particularly important following large-scale mortality spikes, such as the COVID-19 pandemic. When systematically analysed, mortality rates and life expectancy allow comparisons of the consequences of causes of death globally and over time, providing a nuanced understanding of the effect of these causes on global populations. METHODS The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2021 cause-of-death analysis estimated mortality and years of life lost (YLLs) from 288 causes of death by age-sex-location-year in 204 countries and territories and 811 subnational locations for each year from 1990 until 2021. The analysis used 56 604 data sources, including data from vital registration and verbal autopsy as well as surveys, censuses, surveillance systems, and cancer registries, among others. As with previous GBD rounds, cause-specific death rates for most causes were estimated using the Cause of Death Ensemble model-a modelling tool developed for GBD to assess the out-of-sample predictive validity of different statistical models and covariate permutations and combine those results to produce cause-specific mortality estimates-with alternative strategies adapted to model causes with insufficient data, substantial changes in reporting over the study period, or unusual epidemiology. YLLs were computed as the product of the number of deaths for each cause-age-sex-location-year and the standard life expectancy at each age. As part of the modelling process, uncertainty intervals (UIs) were generated using the 2·5th and 97·5th percentiles from a 1000-draw distribution for each metric. We decomposed life expectancy by cause of death, location, and year to show cause-specific effects on life expectancy from 1990 to 2021. We also used the coefficient of variation and the fraction of population affected by 90% of deaths to highlight concentrations of mortality. Findings are reported in counts and age-standardised rates. Methodological improvements for cause-of-death estimates in GBD 2021 include the expansion of under-5-years age group to include four new age groups, enhanced methods to account for stochastic variation of sparse data, and the inclusion of COVID-19 and other pandemic-related mortality-which includes excess mortality associated with the pandemic, excluding COVID-19, lower respiratory infections, measles, malaria, and pertussis. For this analysis, 199 new country-years of vital registration cause-of-death data, 5 country-years of surveillance data, 21 country-years of verbal autopsy data, and 94 country-years of other data types were added to those used in previous GBD rounds. FINDINGS The leading causes of age-standardised deaths globally were the same in 2019 as they were in 1990; in descending order, these were, ischaemic heart disease, stroke, chronic obstructive pulmonary disease, and lower respiratory infections. In 2021, however, COVID-19 replaced stroke as the second-leading age-standardised cause of death, with 94·0 deaths (95% UI 89·2-100·0) per 100 000 population. The COVID-19 pandemic shifted the rankings of the leading five causes, lowering stroke to the third-leading and chronic obstructive pulmonary disease to the fourth-leading position. In 2021, the highest age-standardised death rates from COVID-19 occurred in sub-Saharan Africa (271·0 deaths [250·1-290·7] per 100 000 population) and Latin America and the Caribbean (195·4 deaths [182·1-211·4] per 100 000 population). The lowest age-standardised death rates from COVID-19 were in the high-income super-region (48·1 deaths [47·4-48·8] per 100 000 population) and southeast Asia, east Asia, and Oceania (23·2 deaths [16·3-37·2] per 100 000 population). Globally, life expectancy steadily improved between 1990 and 2019 for 18 of the 22 investigated causes. Decomposition of global and regional life expectancy showed the positive effect that reductions in deaths from enteric infections, lower respiratory infections, stroke, and neonatal deaths, among others have contributed to improved survival over the study period. However, a net reduction of 1·6 years occurred in global life expectancy between 2019 and 2021, primarily due to increased death rates from COVID-19 and other pandemic-related mortality. Life expectancy was highly variable between super-regions over the study period, with southeast Asia, east Asia, and Oceania gaining 8·3 years (6·7-9·9) overall, while having the smallest reduction in life expectancy due to COVID-19 (0·4 years). The largest reduction in life expectancy due to COVID-19 occurred in Latin America and the Caribbean (3·6 years). Additionally, 53 of the 288 causes of death were highly concentrated in locations with less than 50% of the global population as of 2021, and these causes of death became progressively more concentrated since 1990, when only 44 causes showed this pattern. The concentration phenomenon is discussed heuristically with respect to enteric and lower respiratory infections, malaria, HIV/AIDS, neonatal disorders, tuberculosis, and measles. INTERPRETATION Long-standing gains in life expectancy and reductions in many of the leading causes of death have been disrupted by the COVID-19 pandemic, the adverse effects of which were spread unevenly among populations. Despite the pandemic, there has been continued progress in combatting several notable causes of death, leading to improved global life expectancy over the study period. Each of the seven GBD super-regions showed an overall improvement from 1990 and 2021, obscuring the negative effect in the years of the pandemic. Additionally, our findings regarding regional variation in causes of death driving increases in life expectancy hold clear policy utility. Analyses of shifting mortality trends reveal that several causes, once widespread globally, are now increasingly concentrated geographically. These changes in mortality concentration, alongside further investigation of changing risks, interventions, and relevant policy, present an important opportunity to deepen our understanding of mortality-reduction strategies. Examining patterns in mortality concentration might reveal areas where successful public health interventions have been implemented. Translating these successes to locations where certain causes of death remain entrenched can inform policies that work to improve life expectancy for people everywhere. FUNDING Bill & Melinda Gates Foundation

Late Devonian (Famennian) to Carboniferous (Mississippian-Pennsylvanian) conodonts from the Anarak section, Central Iran

A relatively complete conodont record from Famennian to the Mississippian/Pennsylvanian boundary was investigated in the Anarak section, Central Iran. The studied interval belongs to the Bahram, Shishtu, Ghaleh and Absheni formations. The Famennian part of the section (Bahram Formation) ranges from the Palmatolepis triangularis Zone into the Bispathodus ultimus Zone. Not all conodont zones could be defined due to the lack of indicative species. Furthermore, it seems likely that a hiatus occurs around the Devonian/Carboniferous (D/C) boundary (most probably from the Siphonodella praesulcata to the ?Siphonodella sulcata–early Siphonodella crenulata conodont zones) based on the lack of stratigraphically important conodonts as well as on sedimentological criteria. The lack of representative siphonodellids and protognathodids at the base of the Mississippian prevents detailed stratigraphic position of the D/C boundary. Lower Carboniferous (Mississippian) rocks are characterized by red nodular limestone which is unique in comparison with other studied sections of the same age in Central Iran. Within the studied section, we could define the Mississippian/Pennsylvanian boundary. The mid-Carboniferous boundary was defined by the occurrence of Declinognathus noduliferus s.l. Conodont biofacies changes (Mississippian genera Gnathodus and Lochriea have been replaced by Pennsylvanian genera Declinognathus and Idiognathodus) are recognized in this section as well.Ministry of Science Research and Technology (IR

Planktonic foraminiferal turnover across the Cenomanian – Turonian boundary (OAE2) in the northeast of the Tethys realm, Kopet-Dagh Basin

Two Late Cenomanian – Early Turonian (C–T) intervals of the eastern part of the Kopet-Dagh basin, NE Iran have been investigated to evaluate the response of planktonic foraminifera to the geological event OAE2. The Gharesu and Taherabad sections with the thicknesses of 30 m and 22.5 m are composed of shale and marl interbedded with glauconitic sandstone. Three biozones Rotalipora cushmani, Whiteinella archaeocretacea and Helvetoglobotruncana helvetica were recognized based on study of planktonic foraminifera, in these sections. We observed the patterns of planktonic foraminiferal assemblage changes around the C–T boundary and divided this succession into several successive intervals. This study confirms that OAE2 was a long term event. A gradual perturbation in the study successions starts in the interval 1 with low abundance and diversity of planktonic foraminifera. An enhanced oxygen minimum zone (OMZ) occurs in the interval 3 which coincides with a temporary absence of planktonic foraminifera and sedimentation of framboidal pyrite. High diversity of planktonic foraminifera and appearance of new genera in the interval 5 indicate return of normal conditions to the basin. A significant short-term sea surface temperature cooling is also indicated by planktonic foraminiferal turnover and carbonate contents in the interval 2 which is comparable with other parts of the Tethys Ocean, Boreal sea and Atlantic region

Facies analysis of the Asmari Formation in central and north-central Zagros basin, southwest Iran: Biostratigraphy, paeleoecology and diagenesis

Three sections of the Oligocene-Miocene Asmari Formation, crossing central and north-central Zagros foreland basin in SW Iran, were measured and studied in order to interpret the biostratigraphy, paleoecology (based on distribution of benthic foraminifera) and diagenesis. Forty-three foraminifer genera and species were encountered in the studied areas and the following assemblage zones have been defined: 1) Nummulites vascus-Nummulites fichteli, 2) Lepidocyclina-Operculina-Ditrupa, 3) Archaias asmaricus-Archaias hensoni-Miogypsinoides complanatus, 4) Miogypsina-Elphidium sp. 14 - Peneroplis farsenensis, and 5) Borelis melo curdica-Borelis melo melo. According to this study, deposition of the Asmari Formation with association of hyaline, lamellar, perforate large and flat foraminifera first started in the basin and slope environments during the Rupelian in Dehdez and Tufe-Sefid areas. Lagoon depositional environment colonized by sea-grass epiphytic foraminifera was encountered during Chattian and Aquitanian in Bagh-e Malek and Dehdez areas and mostly lagoon and slope environments prevailed during Burdigalian in Bagh-e Malek and Dehdez areas, respectively. The main diagenetic processes that affected the Asmari Formation were dolomitization (replacement and cementation), compaction (stylolitization) and dissolution. The extent of these diagenetic overprinting seems to be mainly facies controlled.Tres secciones de la Formación Asmari del Oligoceno-Mioceno, que cruza la region central y nor-central de la Cuenca de Zagros en el SE de Irán, fueron medidas y estudiadas, a fin de interpretar su bioestratigrafía, paleoecología (con base en la distribución de foraminíferos bentónicos) y diagénesis. Cuarenta y tres géneros y species de foraminíferos fueron encontrados en las áreas de estudio, y las siguientes zonas de composición fueron definidas: 1) Nummulites vascus-Nummulites fichteli, 2) Lepidocyclina- Operculina�Ditrupa, 3) Archaias asmaricus-Archaias hensoni-Miogypsinoides complanatus, 4) Miogypsina-Elphidium sp. 14 - Peneroplis farsenensis y 5) Borelis melo curdica-Borelis melo melo. De acuerdo con este estudio, el depósito de la Formación Asmari, en asociación con grandes foraminiífe- ros aplanados, hialinos, lamelares y perforados, comenzó inicialmente en ambientes de cuenca y talud continental durante el Rupeliano en las áreas de Dehdez and y Tufe-Sefid. Un ambiente de depósito de laguna, colonizada por foraminíferos epifíticos de pastos marinos, fue encontrado durante el Chattiano y Aquitaniano en las áreas de Bagh-e Malek y Dehdez, y principalmente ambientes lagunares y de talud continental prevalecieron durante el Burdigaliano en las áreas de Bagh-e Malek y Dehdez, respectivamente. Los principales procesos diagenéticos que afectaron a la Formación Asmari fueron dolomitización (reemplazamiento y cementación, compactación (stilolitización) y disolución. La extensión de estos efectos diagenéticos, parece haber sido controlada principalmente por los tipos de facies

Late Devonian (Famennian) to Carboniferous (Mississippian-Pennsylvanian) conodonts from the Anarak section, Central Iran

<jats:title>Abstract</jats:title><jats:p>A relatively complete conodont record from Famennian to the Mississippian/Pennsylvanian boundary was investigated in the Anarak section, Central Iran. The studied interval belongs to the Bahram, Shishtu, Ghaleh and Absheni formations. The Famennian part of the section (Bahram Formation) ranges from the <jats:italic>Palmatolepis triangularis</jats:italic> Zone into the <jats:italic>Bispathodus ultimus</jats:italic> Zone. Not all conodont zones could be defined due to the lack of indicative species. Furthermore, it seems likely that a hiatus occurs around the Devonian/Carboniferous (D/C) boundary (most probably from the <jats:italic>Siphonodella praesulcata</jats:italic> to the ?<jats:italic>Siphonodella sulcata</jats:italic>–early <jats:italic>Siphonodella crenulata</jats:italic> conodont zones) based on the lack of stratigraphically important conodonts as well as on sedimentological criteria. The lack of representative siphonodellids and protognathodids at the base of the Mississippian prevents detailed stratigraphic position of the D/C boundary. Lower Carboniferous (Mississippian) rocks are characterized by red nodular limestone which is unique in comparison with other studied sections of the same age in Central Iran. Within the studied section, we could define the Mississippian/Pennsylvanian boundary. The mid-Carboniferous boundary was defined by the occurrence of <jats:italic>Declinognathus noduliferus</jats:italic> s.l. Conodont biofacies changes (Mississippian genera <jats:italic>Gnathodus</jats:italic> and <jats:italic>Lochriea</jats:italic> have been replaced by Pennsylvanian genera <jats:italic>Declinognathus</jats:italic> and <jats:italic>Idiognathodus</jats:italic>) are recognized in this section as well.</jats:p&gt

Biostratigraphy, microfacies and paleoecology of the Asmari Formation, Interior Fars province, Zagros Basin, Iran

International audienceThe Pir-Sabz Section of the Asmari Formation is located in the Interior Fars province, Zagros Basin (Iran). The Asmari Formation at the study area is 312 m in thickness and formed by massive bedded limestone. According to the identified index microfossils, three Oligocene assemblage biozones were recorded: 1) Globigerina spp., 2) Lepidocyclina – Operculina – Ditrupa, and 3) Archaias asmaricus – Archaias hensoni. Twelve facies types were recognized according to their texture, occurrence and abundance of foraminifera, scleractinian corals and other skeletal grains: F1 Bioclastic planktonic foraminiferal wackestone–packstone, F2 Bioclastic planktonic foraminiferal echinoid packstone, F3 Bioclastic Operculina packstone, F4 Bioclastic Lepidocyclinidae packstone–rudstone, F5 Bioclastic coralline algal Lepidocyclinidae packstone–rudstone, F6 Bioclastic Lepidocyclinidae – Nummulitidae wackestone–packstone–grainstone, F7 Bioclastic Lepidocyclinidae – Neorotalia – coral packstone–rudstone, F8 Coral boundstone, F9 Bioclastic porcellaneous foraminifera – coral packstone, F10 Bioclastic coralline algal bryozoan wackestone–packstone, F11 Bioclastic benthic foraminifera (perforate and imperforate) wackestone–packstone, and F12 Bioclastic benthic foraminifera (imperforate) wackestone–packstone. From the base to the top of the section the facies types indicate: F1 aphotic zone and outer shelf; F2 aphotic to oligophotic zones on the outer and middle shelf (distal); F3 and F4 oligophotic zone and distal middle shelf; F5, F6 and F7 mesophotic zone situated on the middle shelf (proximal); F8, F9, F10 and F11 euphotic zone and inner shelf (open marine), F12 euphotic zone and inner shelf (slightly restricted). The Pir-Sabz coral fauna has a clear Mediterranean affinity and is represented by at least six different scleractinian species which formed a non-reefal coral community on the proximal middle-shelf