Impacts of climate change, population growth, and power sector decarbonization on urban building energy use

Climate, technologies, and socio-economic changes will influence future building energy use in cities. However, current low-resolution regional and state-level analyses are insufficient to reliably assist city-level decision-making. Here we estimate mid-century hourly building energy consumption in 277 U.S. urban areas using a bottom-up approach. The projected future climate change results in heterogeneous changes in energy use intensity (EUI) among urban areas, particularly under higher warming scenarios, with on average 10.1–37.7% increases in the frequency of peak building electricity EUI but over 110% increases in some cities. For each 1 °C of warming, the mean city-scale space-conditioning EUI experiences an average increase/decrease of ~14%/ ~ 10% for space cooling/heating. Heterogeneous city-scale building source energy use changes are primarily driven by population and power sector changes, on average ranging from –9% to 40% with consistent south–north gradients under different scenarios. Across the scenarios considered here, the changes in city-scale building source energy use, when averaged over all urban areas, are as follows: –2.5% to –2.0% due to climate change, 7.3% to 52.2% due to population growth, and –17.1% to –8.9% due to power sector decarbonization. Our findings underscore the necessity of considering intercity heterogeneity when developing sustainable and resilient urban energy systems.<br/

Ebp2 and Brx1 function cooperatively in 60S ribosomal subunit assembly in Saccharomyces cerevisiae

The yeast protein Ebp2 is required for early steps in production of 60S ribosomal subunits. To search for cofactors with which Ebp2 functions, or substrates on which it acts, we screened for mutants that were synthetically lethal (sl) with the ebp2-14 mutation. Four different mutant alleles of the 60S ribosomal subunit assembly factor Brx1 were found. To investigate defects of the double mutant, we constructed strains conditional for the ebp2-14 brx1- synthetic lethal phenotype. These ebp2-14 brx1 mutants were defective in processing of 27S pre-rRNA and production of 60S subunits, under conditions where each single mutant was not. Ebp2 and Brx1 exhibit a strong two-hybrid interaction, which is eliminated by some combinations of brx1 and ebp2 mutations. In one such mutant, Ebp2 and Brx1 can still associate with pre-ribosomes, but subunit maturation is perturbed. Depletion of either Ebp2 or Brx1 revealed that Brx1 requires Ebp2 for its stable association with pre-ribosomes, but Ebp2 does not depend on the presence of Brx1 to enter pre-ribosomes. These results suggest that assembly of 60S ribosomal subunits requires cooperation of Ebp2 with Brx1, together with other molecules present in pre-ribosomes, potentially including several found in assembly subcomplexes with Brx1 and Ebp2

Pvrchas his Pilgrimage, or, Relations of the world and the religions obserued in all ages and places discouered, from the creation vnto this present : contayning a theologicall and geographicall historie of Asia, Africa, and America, with the ilands adiacent : declaring the ancient religions before the flovd, the heathenish, Iewish, and Saracenicall in all ages since, in those parts professed, with their seuerall opinions ... with briefe descriptions of the countries, nations, states, discoueries, priuate and publike customes, and the most remarkable rarities of natvre, or humane industrie, in the same /

Signatures: [paragraph sign]¡ 2[paragraph sign]¡ A* B-4P¡ 4Q* 4R-4S¡ 4T* 4U-4Y♯ 4Z¡.Errors in pagination. Quire Y numbered: 241, 242, 241-246, 245, 248-250; quire 3I numbered: 635-636, 635-644. Text is continuous.STC 20508Sabin 66682Church, E.D. Discovery, 401AKraus, H.P. Sir Francis Drake, no. 40"The catalogve of the avthors": p. [31-38] (1st group)"Two relations, one of the northeasterne parts, extracted ovt of Sir Ierome Horsey ... the other, of the sovtheasterne parts, viz. Golchonda ... written by Mr. William Methold": p. [969]-1007, incl. special t.p."The Saracentical historie ... written in Arabike by George Elmacin ... and translated into Latine by Thomas Erpenius ... Englished, abridged, and continued to the end of the Chalifa's, by Samuel Purchas": p. [1009]-1047, incl. special t.p.Includes bibliographical references and index.LC copy of the single vol. of the Pvrchas his Pilgrimage and the four vols. of the author's Haklvtvs posthumus ([London] : Imprinted at London for Henry Fetherston at y[e]e signe of the rose in Pauls Churchyard, 1625) are bound in the same manner subsequent to publication. The spines of all five vols. are lettered, "Purchas's Pilgrims," and are numbered I, II, III, IV, V (i.e., the author's single vol. of Pvrchas his Pilgrimage is numbered "VOL. V"). DL