A Tapestry of People: The Growth of Population in the Province of the Western Cape

The best place to begin a study of human settlement is with climate. Most of the Western Cape province - the land lying north of a line running parallel to the southern coast approximately 100 kilometers inland, from Worcester to Uniondale - is too dry for arable farming. And the rain which does fall south of the long range of mountains tends to come in the winter months which is suitable for wheat but not for tropical cereals. Thus when ironworking, Bantu-speaking, people began to move east and then south from the Niger-Congo area in a great wave of migration that began some 2000 years ago they moved into the wetter eastern part of what is now South Africa where there was good grazing for their cattle and where the crops they knew - sorghum, millet and, later maize, - would grow...

1.1mm Bolocam observations of the Sunyaev Zel'dovich increment in Abell 1835

Over recent years, there has been an increasing level of interest in the cosmological significance of observations of the Sunyaev Zel'dovich (SZ) effect in galaxy clusters. Al though the SZ effect has been known about for around fifty years, observations of it have only become mainstream recently. The SZ effect refers to the redistribution of energy of Cosmic Microwave Background (CMB) photons due to inverse Compton scattering off populations of free electrons, most commonly in galaxy clusters. The SZ acts as an artificial 'emitter' or 'absorber' along the line of sight to a cluster once other back grounds have been removed. SZ measurements suffer from a range of systematic effects that have made observations in the region of the spectrum where the SZ simulates an 'emitter' (above 220 GHz) particularly challenging. Nevertheless, the scientific potential of large-scale SZ surveys is large. In particular, the SZ distortion to the CMB is independent of redshift and limited only by the mass of the clusters being observed. This makes SZ surveys useful for making detailed observations of the evolution of large-scale structure of the Universe, which depends sensitively on cosmological parameters. Knowledge of the spectrum of the SZ effect can also be used to constrain the peculiar velocity of galaxy clusters, which has the potential to provide information about the nature of dark energy. This thesis describes the observation, mapping and detailed analysis of the cluster Abell 1835 at 1.1 mm, where the SZ acts as an 'emitter'. An estimate of the SZ emission from Abell 1835 is obtained and combined with other measurements of the cluster to generate a spectrum, from which one of the most precise limits on a cluster's peculiar velocity to date is obtained

2008 LC18: a potentially unstable Neptune Trojan

The recent discovery of the first Neptune Trojan at the planet's trailing (L5) Lagrange point, 2008 LC18, offers an opportunity to confirm the formation mechanism of a member of this important tracer population for the Solar system's dynamical history. We tested the stability of 2008 LC18's orbit through a detailed dynamical study, using test particles spread across the orbital uncertainties in a, e, i and {\Omega}. This showed that the wide uncertainties of the published orbit span regions of both extreme dynamical instability, with lifetimes 1 Gyr lifetimes). The stability of 2008 LC18's clones is greatly dependent on their semi-major axis and only weakly correlated with their eccentricity. Test particles on orbits with an initial semi-major axis less than 29.91 AU have dynamical half-lives shorter than 100 Myr; in contrast, particles with an initial semi-major axis greater than 29.91 AU exhibit such strong dynamical stability that almost all are retained over the 1 Gyr of our simulations. More observations of this object are necessary to improve the orbit. If 2008 LC18 is in the unstable region, then our simulations imply that it is either a temporary Trojan capture, or a representative of a slowly decaying Trojan population (like its sibling the L4 Neptunian Trojan 2001 QR322), and that it may not be primordial. Alternatively, if the orbit falls into the larger, stable region, then 2008 LC18 is a primordial member of the highly stable and highly inclined component of the Neptune Trojan population, joining 2005 TN53 and 2007 VL305. We attempted to recover 2008 LC18 using the 2.3m telescope at Siding Spring Observatory to provide this astrometry, but were unsuccessful due to the high stellar density of its current sky location near the galactic centre. The recovery of this object will require a telescope in the 8m class.Comment: 11 pages, 3 figures, 1 table, accepted for publication in Monthly Notices of the Royal Astronomical Societ

An online study combining the constructs from the theory of planned behaviour and protection motivation theory in predicting intention to test for chlamydia in two testing contexts

Chlamydia is a common sexually-transmitted infection that has potentially serious consequences unless detected and treated early. The health service in the UK offers clinic-based testing for chlamydia but uptake is low. Identifying the predictors of testing behaviours may inform interventions to increase uptake. Self-tests for chlamydia may facilitate testing and treatment in people who avoid clinic-based testing. Self-testing and being tested by a health care professional (HCP) involve two contrasting contexts that may influence testing behaviour. However, little is known about how predictors of behaviour differ as a function of context. In this study, theoretical models of behaviour were used to assess factors that may predict intention to test in two different contexts: self-testing and being tested by a HCP. Individuals searching for, or reading about chlamydia testing online were recruited using Google Adwords. Participants completed an online questionnaire that addressed previous testing behaviour and measured constructs of the Theory of Planned Behaviour and Protection Motivation Theory, which propose a total of eight possible predictors of intention. The questionnaire was completed by 310 participants. Sufficient data for multiple regression were provided by 102 and 118 respondents for self-testing and testing by a HCP respectively. Intention to self-test was predicted by vulnerability and self-efficacy, with a trend-level effect for response efficacy. Intention to be tested by a HCP was predicted by vulnerability, attitude and subjective norm. Thus, intentions to carry out two testing behaviours with very similar goals can have different predictors depending on test context. We conclude that interventions to increase self-testing should be based on evidence specifically related to test context

Shape-Dependent Thermodynamics and Non-Local Hydrodynamics in a Non-Gibbsian Steady-State of a Drift-Diffusion System

Shape-dependent thermodynamics and non-local hydrodynamics are argued to occur in dissipative steady states of driven diffusive systems. These predictions are confirmed by numerical simulations. Unlike power-law correlations, these phenomena cannot be explained by a hypothesis of ``criticality''. Instead, they require the effective Hamiltonian of the system to contain very long-range potentials, making the invariant probability measures formally ``non-Gibbsian''.Comment: 4 pages, Latex Version 2.09, 1 Postscript figur

Sensitivity and Insensitivity of Galaxy Cluster Surveys to New Physics

We study the implications and limitations of galaxy cluster surveys for constraining models of particle physics and gravity beyond the Standard Model. Flux limited cluster counts probe the history of large scale structure formation in the universe, and as such provide useful constraints on cosmological parameters. As a result of uncertainties in some aspects of cluster dynamics, cluster surveys are currently more useful for analyzing physics that would affect the formation of structure than physics that would modify the appearance of clusters. As an example we consider the Lambda-CDM cosmology and dimming mechanisms, such as photon-axion mixing.Comment: 24 pages, 8 eps figures. References added, discussion of scatter in relations between cluster observables lengthene

ATF3 is a novel nuclear marker for migrating ependymal stem cells in the rat spinal cord

The present study identified ATF3 as a novel dynamic marker for ependymal stem/progenitor cells (nestin, vimentin and SOX2 positive) around the central canal of the neonatal or adult rat spinal cord. While quiescent ependymal cells showed cytoplasmic ATF3 expression, during 6-24. h in vitro these cells mobilized and acquired intense nuclear ATF3 staining. Their migratory pattern followed a centrifugal pathway toward the dorsal and ventral funiculi, reminiscent of the rostral migratory stream of the brain subventricular stem cells. Thus, the chain cell formation was, by analogy, termed funicular migratory stream (FMS). The FMS process preceded the strong proliferation of ependymal cells occurring only after 24. h in vitro. Pharmacological inhibition of MAPK-p38 and JNK/c-Jun (upstream effectors of ATF3 activation) prevented the FMS mobilization of ATF3 nuclear-positive cells. Excitotoxicity or ischemia-like conditions, reported to evoke neuronal and glial injury, did not further enhance migration of ependymal cells at 24. h, suggesting that, at this early stage of damage, the FMS phenomenon had peaked and that more extensive repair processes are delayed beyond this time point. ATF3 is, therefore, useful to identify activation and migration of endogenous stem cells of the rat spinal cord in vitro. \ua9 2014

Chlamydia trachomatis Incidence and Re-Infection among Young Women – Behavioural and Microbiological Characteristics

This study aimed to estimate rates of chlamydia incidence and re-infection and to investigate the dynamics of chlamydia organism load in prevalent, incident and re-infections among young Australian women.1,116 women aged 16 to 25 years were recruited from primary care clinics in Australia. Vaginal swabs were collected at 3 to 6 month intervals for chlamydia testing. Chlamydia organism load was measured by quantitative PCR.There were 47 incident cases of chlamydia diagnosed and 1,056.34 person years of follow up with a rate of 4.4 per 100 person years (95% CI: 3.3, 5.9). Incident infection was associated with being aged 16 to 20 years [RR = 3.7 (95%CI: 1.9, 7.1)], being employed [RR = 2.4 (95%CI: 1.1, 4.9)] and having two or more new sex partners [RR = 5.5 (95%CI: 2.6, 11.7)]. Recent antibiotic use was associated with a reduced incidence [RR:0.1 (95%CI: 0.0, 0.5)]. There were 14 re-infections with a rate of 22.3 per 100 person years (95%CI: 13.2, 37.6). The median time to re-infection was 4.6 months. Organism load was higher for prevalent than incident infections (p<0.01) and for prevalent than re-infections (p<0.01).Chlamydia is common among young women and a high proportion of women are re-infected within a short period of time, highlighting the need for effective partner treatment and repeat testing. The difference in organism load between prevalent and incident infections suggests prevalent infection may be more important for ongoing transmission of chlamydia