Preliminary study of rodents from the Golliher B assemblage of Meade County, Kansas, USA indicates an intense cold period near the end of the Pleistocene

Submission: 15 June 2007. Acceptance: 18 May 2011An assemblage of rodents recovered from a thin layer of sediments along Sand Creek on the Golliher Ranch in Meade County, Kansas, indicates that cold steppe conditions likely prevailed for a brief time near the close of the Pleistocene around 12,500 radiocarbon years ago. This environment is suggested by the northern disjunct rodents Zapus princeps, Microtus pennsylvanicus, Thomomys cf. talpoides and the presumed cold steppe vole Microtus (Pedomys) parmaleei, n. sp., plus the absence of cotton rats. Comparison of meadow vole m1 crown morphology diversity through the late Pleistocene in Kansas shows that the modern pattern of diversity developed in a brief period of 1500 years, possibly during the Younger Dryas interval. A cement-filled prism fold, a feature commonly encountered in extinct species of Mimomys with rooted molars, appears in three rootless first lower molars of Microtus pennsylvanicus. The Golliher B assemblage helps to fill in the late Pleistocene history of rodents in the ongoing Meade Basin Rodent Project.Peer reviewe

Long-Baseline Neutrino Facility (LBNF) and Deep Underground Neutrino Experiment (DUNE) Conceptual Design Report Volume 2: The Physics Program for DUNE at LBNF

The Physics Program for the Deep Underground Neutrino Experiment (DUNE) at the Fermilab Long-Baseline Neutrino Facility (LBNF) is described

Neurexin-1 and Frontal Lobe White Matter: An Overlapping Intermediate Phenotype for Schizophrenia and Autism Spectrum Disorders

Background: Structural variation in the neurexin-1 (NRXN1) gene increases risk for both autism spectrum disorders (ASD) and schizophrenia. However, the manner in which NRXN1 gene variation may be related to brain morphology to confer risk for ASD or schizophrenia is unknown. Method/Principal Findings: 53 healthy individuals between 18–59 years of age were genotyped at 11 single nucleotide polymorphisms of the NRXN1 gene. All subjects received structural MRI scans, which were processed to determine cortical gray and white matter lobar volumes, and volumes of striatal and thalamic structures. Each subject’s sensorimotor function was also assessed. The general linear model was used to calculate the influence of genetic variation on neural and cognitive phenotypes. Finally, in silico analysis was conducted to assess potential functional relevance of any polymorphisms associated with brain measures. A polymorphism located in the 39 untranslated region of NRXN1 significantly influenced white matter volumes in whole brain and frontal lobes after correcting for total brain volume, age and multiple comparisons. Follow-up in silico analysis revealed that this SNP is a putative microRNA binding site that may be of functional significance in regulating NRXN1 expression. This variant also influenced sensorimotor performance, a neurocognitive function impaired in both ASD and schizophrenia. Conclusions: Our findings demonstrate that the NRXN1 gene, a vulnerability gene for SCZ and ASD, influences brai

The phenotype of floating-harbor syndrome:clinical characterization of 52 individuals with mutations in exon 34 of SRCAP

Background\ud Floating-Harbor syndrome (FHS) is a rare condition characterized by short stature, delays in expressive language, and a distinctive facial appearance. Recently, heterozygous truncating mutations in SRCAP were determined to be disease-causing. With the availability of a DNA based confirmatory test, we set forth to define the clinical features of this syndrome.\ud \ud Methods and results\ud Clinical information on fifty-two individuals with SRCAP mutations was collected using standardized questionnaires. Twenty-four males and twenty-eight females were studied with ages ranging from 2 to 52 years. The facial phenotype and expressive language impairments were defining features within the group. Height measurements were typically between minus two and minus four standard deviations, with occipitofrontal circumferences usually within the average range. Thirty-three of the subjects (63%) had at least one major anomaly requiring medical intervention. We did not observe any specific phenotype-genotype correlations.\ud \ud Conclusions\ud This large cohort of individuals with molecularly confirmed FHS has allowed us to better delineate the clinical features of this rare but classic genetic syndrome, thereby facilitating the development of management protocols.The authors would like to thank the families for their cooperation and permission to publish these findings. SdM would like to thank Barto Otten. Funding was provided by the Government of Canada through Genome Canada, the Canadian Institutes of Health Research (CIHR) and the Ontario Genomics Institute (OGI-049), by Genome Québec and Genome British Columbia, and the Manton Center for Orphan Disease Research at Children’s Hospital Boston. KMB is supported by a Clinical Investigatorship Award from the CIHR Institute of Genetics. AD is supported by NIH grant K23HD073351. BBAdV and HGB were financially supported by the AnEUploidy project (LSHG-CT-2006-37627). This work was selected for study by the FORGE Canada Steering Committee, which consists of K. Boycott (University of Ottawa), J. Friedman (University of British Columbia), J. Michaud (University of Montreal), F. Bernier (University of Calgary), M. Brudno (University of Toronto), B. Fernandez (Memorial University), B. Knoppers (McGill University), M. Samuels (Université de Montréal), and S. Scherer (University of Toronto). We thank the Galliera Genetic Bank - “Telethon Genetic Biobank Network” supported by Italian Telethon grants (project no. GTB07001) for providing us with specimens

The past, present, and future of the Brain Imaging Data Structure (BIDS)

The Brain Imaging Data Structure (BIDS) is a community-driven standard for the organization of data and metadata from a growing range of neuroscience modalities. This paper is meant as a history of how the standard has developed and grown over time. We outline the principles behind the project, the mechanisms by which it has been extended, and some of the challenges being addressed as it evolves. We also discuss the lessons learned through the project, with the aim of enabling researchers in other domains to learn from the success of BIDS

Long-Baseline Neutrino Facility (LBNF) and Deep Underground Neutrino Experiment (DUNE) Conceptual Design Report Volume 1: The LBNF and DUNE Projects

This document presents the Conceptual Design Report (CDR) put forward by an international neutrino community to pursue the Deep Underground Neutrino Experiment at the Long-Baseline Neutrino Facility (LBNF/DUNE), a groundbreaking science experiment for long-baseline neutrino oscillation studies and for neutrino astrophysics and nucleon decay searches. The DUNE far detector will be a very large modular liquid argon time-projection chamber (LArTPC) located deep underground, coupled to the LBNF multi-megawatt wide-band neutrino beam. DUNE will also have a high-resolution and high-precision near detector

Long-Baseline Neutrino Facility (LBNF) and Deep Underground Neutrino Experiment (DUNE) Conceptual Design Report, Volume 4 The DUNE Detectors at LBNF

A description of the proposed detector(s) for DUNE at LBN

A generic revision of the Protolabidini (Mammalia, Camelidae) with a description of two new protolabidines. Bulletin of the AMNH ; v. 161, article 3

p. 369-425 : ill. ; 26 cm.Includes bibliographical references (p. 423-425)."A revised diagnosis of the Protolabidini characterizes the tribe as having a narrow rostrum and laterally expanded anterior nares. Tanymykter, new genus, possess the above derived features and is included in the Protolabidini as the primitive sister taxon to Protolabis. The morphological features that separate Tanymykter from Protolabis are all primitive except for the derived condition of closely appressed P[superscript]1[subscript]1 roots. Based upon new material from the Milk Creek Formation, morphological distinctions between Protolabis and Procamelus are clarified. The principal derived features of Protolabis coartatus that differ from Procamelus are extreme constriction of the rostrum, lateral expansion of the anterior nares, P[subscript]1 and P[subscript]2 small and sometimes absent, and a mandibular angle with extreme lateral flare and a prominent mesial tuberosity. Although the above derived features are less pronounced, they are still present in Protolabis heterodontus and other undescribed samples in the collection of the American Museum of Natural History. Thus, Stirton's species, coartatus, which has previously confused the generic concept of Procamelus, is transferred to Protolabis. The small size of the cranium and coronoid process is correlated with the strong lateral and mesial flare of the mandibular angle in P. coartatus. This reflects increased emphasis on the masseter and pterygoid muscles in mastication and less emphasis on the temporalis. In contrast, the large coronoid process in Procamelus indicates greater emphasis on the temporalis muscle. Oxydactylus exilis Matthew is transferred to Michenia because it shares the derived features of a narrow rostrum, incisiform upper canine, and a shallow symphysis. A new species, Michenia yavapaiensis, with P[subscript]1 unerupted, P[subscript]2 small, unerupted or absent, and tall-crowned molars is described from the Milk Creek Formation. Finally, a cladogram of proposed relationships of the Protolabidini is presented, including Tanymykter, new genus, Protolabis and Michenia with supporting evidence for this tribe being a monophyletic group. The relationship of other members of the Camelinae to the Protolabidini is also discussed. A short section detailing the stratigraphic framework of the Milk Creek Formation, Yavapai County, Arizona is included"--P. 371