Fabry Perot Halpha Observations of the Barred Spiral NGC 3367

We report the gross properties of the velocity field of the barred spiral galaxy NGC 3367. The following values were found: inclination with respect to the plane of the sky, i=30 deg; position angle (PA) of receding semi major axis PA=51 and systemic velocity V(sys)=3032 km/s. Large velocity dispersion are observed of upt o 120 km/s in the nuclear region, of up to 70 km/s near the eastern bright sources just beyond the edge of the stellar bar where three spiral arms seem to start and in the western bright sources at about 10 kpc. Deviations from normal circular velocities are observed from all the disk but mainly from the semi circle formed by the string of south western Halpha sources. An estimate of the dynamical mass is M(dyn)=2x10^11 Msolar.Comment: Accepted to be published in May 2001 issue in the A.J. 19 pages, 7 figure

The first Infrared study of the close environment of a long Gamma-Ray Burst

We present a characterization of the close environment of GRB980425 based on 5-160mic spectro-imaging obtained with Spitzer. The Gamma-Ray Burst GRB980425 occurred in a nearby (z=0.0085) SBc-type dwarf galaxy, at a projected distance of 900pc from an HII region with strong signatures of Wolf-Rayet (WR) stars. While this "WR region" produces less than 5% of the B-band emission of the host, we find that it is responsible for 45+/-10% of the total infrared luminosity, with a maximum contribution reaching 75% at 25-30mic. This atypical property is rarely observed among morphologically-relaxed dwarves, suggesting a strong causal link with the GRB event. The luminosity of the WR region (L_8-1000mic=4.6x10^8 Lsol), the peak of its spectral energy distribution at <~100mic and the presence of highly-ionized emission lines (e.g., [NeIII]) also reveal extremely young (<5Myr) star-forming activity, with a typical time-scale of only 47Myr to double the stellar mass already built. Finally, the mid-IR over B-band luminosity ratio in this region is substantially higher than in star-forming galaxies with similar L_IR, but it is lower than in young dust-enshrouded stellar clusters. Considering the modest obscuration measured from the silicate features (tau_9.7mic ~ 0.015), this suggests that the WR region is dominated by one or several star clusters that have either partly escaped or cleared out their parent molecular cloud. Combined with the properties characterizing the whole population of GRB hosts, our results reinforce the idea that long GRBs mostly happen within or in the vicinity of relatively unobscured galactic regions harboring very recent star formation.Comment: ApJ in press, 14 pages, 2 tables, 7 figure

Extreme right-wing voting in Western Europe

In this study we explain extreme right-wing voting behaviour in the countries of the European Union and Norway from a micro and macro perspective. Using a multidisciplinary multilevel approach, we take into account individual-level social background characteristics and public opinion alongside country characteristics and characteristics of extreme right-wing parties themselves. By making use of large-scale survey data (N = 49,801) together with country-level statistics and expert survey data, we are able to explain extreme right-wing voting behaviour from this multilevel perspective. Our results show that cross-national differences in support of extreme right-wing parties are particularly due to differences in public opinion on immigration and democracy, the number of non-Western residents in a country and, above all, to party characteristics of the extreme right-wing parties themselves

Post-Transplant Outcomes in High-Risk Compared with Non-High-Risk Multiple Myeloma: A CIBMTR Analysis.

Conventional cytogenetics and interphase fluorescence in situ hybridization (FISH) identify high-risk multiple myeloma (HRM) populations characterized by poor outcomes. We analyzed these differences among HRM versus non-HRM populations after upfront autologous hematopoietic cell transplantation (autoHCT). Between 2008 and 2012, 715 patients with multiple myeloma identified by FISH and/or cytogenetic data with upfront autoHCT were identified in the Center for International Blood and Marrow Transplant Research database. HRM was defined as del17p, t(4;14), t(14;16), hypodiploidy (-Y) or chromosome 1 p and 1q abnormalities; all others were non-HRM. Among 125 HRM patients (17.5%), induction with bortezomib and immunomodulatory agents (imids) was higher compared with non-HRM (56% versus 43%, P \u3c .001) with similar pretransplant complete response (CR) rates (14% versus 16%, P .1). At day 100 post-transplant, at least a very good partial response was 59% in HRM and 61% in non-HRM (P = .6). More HRM patients received post-transplant therapy with bortezomib and imids (26% versus 12%, P = .004). Three-year post-transplant progression-free (PFS) and overall survival (OS) rates in HRM versus non-HRM were 37% versus 49% (P \u3c .001) and 72% versus 85% (P \u3c .001), respectively. At 3 years, PFS for HRM patients with and without post-transplant therapy was 46% (95% confidence interval [CI], 33 to 59) versus 14% (95% CI, 4 to 29) and in non-HRM patients with and without post-transplant therapy 55% (95% CI, 49 to 62) versus 39% (95% CI, 32 to 47); rates of OS for HRM patients with and without post-transplant therapy were 81% (95% CI, 70 to 90) versus 48% (95% CI, 30 to 65) compared with 88% (95% CI, 84 to 92) and 79% (95% CI, 73 to 85) in non-HRM patients with and without post-transplant therapy, respectively. Among patients receiving post-transplant therapy, there was no difference in OS between HRM and non-HRM (P = .08). In addition to HRM, higher stage, less than a CR pretransplant, lack of post-transplant therapy, and African American race were associated with worse OS. In conclusion, we show HRM patients achieve similar day 100 post-transplant responses compared with non-HRM patients, but these responses are not sustained. Post-transplant therapy appeared to improve the poor outcomes of HRM

Close Galaxy Pairs at z = 3: A Challenge to UV Luminosity Abundance Matching

We use a sample of z~3 Lyman Break Galaxies (LBGs) to examine close pair clustering statistics in comparison to LCDM-based models of structure formation. Samples are selected by matching the LBG number density and by matching the observed LBG 3-D correlation function of LBGs over the two-halo term region. We show that UV-luminosity abundance matching cannot reproduce the observed data, but if subhalos are chosen to reproduce the observed clustering of LBGs we are able to reproduce the observed LBG pair fraction, (Nc), defined as the average number of companions per galaxy. This model suggests an over abundance of LBGs by a factor of ~5 over those observed, suggesting that only 1 in 5 halos above a fixed mass hosts a galaxy with LBG-like UV luminosity detectable via LBG selection techniques. We find a total observable close pair fraction of 23 \pm 0.6% (17.7 \pm 0.5%) using a prototypical cylinder radius in our overdense fiducial model and 8.3 \pm 0.5% (5.6 \pm 0.2%) in an abundance matched model (impurity corrected). For the matched spectroscopic slit analysis, we find Ncs = 5.1\pm0.2% (1.68\pm0.02%), the average number of companions observed serendipitously in our for fiducial slits (abundance matched), whereas the observed fraction of serendipitous spectroscopic close pairs is 4.7\pm1.5 per cent using the full LBG sample and 7.1\pm2.3% for a subsample with higher signal-to-noise ratio. We show that the standard method of halo assignment fails to reproduce the break in the LBG close pair behavior at small scale. To reconcile these discrepancies we suggest that a plausible fraction of LBGs in close pairs with lower mass than our sample experience interaction-induced enhanced star formation that boosts their luminosity sufficiently to be detected in observational sample but are not included in the abundance matched simulation sample.Comment: 18 pages, 12 figures, 1 table, published in MNRA

A Practical Approach to Genetic Hypokalemia

Mutations in genes encoding ion channels, transporters, exchangers, and pumps in human tissues have been increasingly reported to cause hypokalemia. Assessment of history and blood pressure as well as the K+ excretion rate and blood acid-base status can help differentiate between acquired and inherited causes of hypokalemia. Familial periodic paralysis, Andersen's syndrome, congenital chloride-losing diarrhea, and cystic fibrosis are genetic causes of hypokalemia with low urine K+ excretion. With respect to a high rate of K+ excretion associated with faster Na+ disorders (mineralocorticoid excess states), glucoricoid-remediable aldosteronism and congenital adrenal hyperplasia due to either 11β-hydroxylase and 17α-hydroxylase deficiencies in the adrenal gland, and Liddle's syndrome and apparent mineralocorticoid excess in the kidney form the genetic causes. Among slow Cl- disorders (normal blood pressure, low extracellular fluid volume), Bartter's and Gitelman's syndrome are most common with hypochloremic metabolic alkalosis. Renal tubular acidosis caused by mutations in the basolateral Na+/HCO3- cotransporter (NBC1) in the proximal tubules, apical H+-ATPase pump, and basolateral Cl-/HCO3- exchanger (anion exchanger 1, AE1) in the distal tubules and carbonic anhydroase II in both are genetic causes with hyperchloremic metabolic acidosis. Further work on genetic causes of hypokalemia will not only provide a much better understanding of the underlying mechanisms, but also set the stage for development of novel therapies in the future

Enceladus and Titan: Emerging Worlds of the Solar System (ESA Voyage 2050 White Paper)

Some of the major discoveries of the recent Cassini-Huygens mission have put Titan and Enceladus firmly on the Solar System map. The mission has revolutionised our view of Solar System satellites, arguably matching their scientific importance with that of their planet. While Cassini-Huygens has made big surprises in revealing Titan's organically rich environment and Enceladus' cryovolcanism, the mission's success naturally leads us to further probe these findings. We advocate the acknowledgement of Titan and Enceladus science as highly relevant to ESA's long-term roadmap, as logical follow-on to Cassini-Huygens. In this white paper, we will outline important science questions regarding these satellites and identify the pertinent science themes we recommend ESA cover during the Voyage 2050 planning cycle. Addressing these science themes would make major advancements to the present knowledge we have about the Solar System, its formation, evolution and likelihood that other habitable environments exist outside the Earth's biosphere

CPR in medical schools: learning by teaching BLS to sudden cardiac death survivors – a promising strategy for medical students?

BACKGROUND: Cardiopulmonary resuscitation (CPR) training is gaining more importance for medical students. There were many attempts to improve the basic life support (BLS) skills in medical students, some being rather successful, some less. We developed a new problem based learning curriculum, where students had to teach CPR to cardiac arrest survivors in order to improve the knowledge about life support skills of trainers and trainees. METHODS: Medical students who enrolled in our curriculum had to pass a 2 semester problem based learning session about the principles of cardiac arrest, CPR, BLS and defibrillation (CPR-D). Then the students taught cardiac arrest survivors who were randomly chosen out of a cardiac arrest database of our emergency department. Both, the student and the Sudden Cardiac Death (SCD) survivor were asked about their skills and knowledge via questionnaires immediately after the course. The questionnaires were then used to evaluate if this new teaching strategy is useful for learning CPR via a problem-based-learning course. The survey was grouped into three categories, namely "Use of AED", "CPR-D" and "Training". In addition, there was space for free answers where the participants could state their opinion in their own words, which provided some useful hints for upcoming programs. RESULTS: This new learning-by-teaching strategy was highly accepted by all participants, the students and the SCD survivors. Most SCD survivors would use their skills in case one of their relatives goes into cardiac arrest (96%). Furthermore, 86% of the trainees were able to deal with failures and/or disturbances by themselves. On the trainer's side, 96% of the students felt to be well prepared for the course and were considered to be competent by 96% of their trainees. CONCLUSION: We could prove that learning by teaching CPR is possible and is highly accepted by the students. By offering a compelling appreciation of what CPR can achieve in using survivors from SCD as trainees made them go deeper into the subject of resuscitation, what also might result in a longer lasting benefit than regular lecture courses in CPR