The Ursinus Weekly, March 6, 1969

Officers inducted; Emig emphasizes new responsibility • American dream, brotherhood highlight Festival of the Arts • USGA officers interviewed; Communication gap stressed • Placement interviews scheduled • 200 attend Lorelei; Fischer crowned king • Semi-formal ball highlights junior-senior weekend • Editorial: Potpourri - Or, Could this ever happen here? • State set to punish protestors; Laws threaten civil liberties • Letters to the editor • Remark • Lantern literary lapse termed titanic bomb • Staying out of uniform: A practical guide for the Ursinus male, part I • Whose risk? • Columnist proposes solution to UC\u27s dearth of black students • Albright draws Fifth Dimension • Racism symposium set for March 20 with Lincoln Univ. • Dorm lounges opened; Slacks rule slackened • Rice discusses status for Phi Beta Kappa • Ursinus grapplers rally to win over Drexel, 22-13 • New gym complex to include pool • Carson paces Bearettes over Gettysburg • Badminton team wins six in row • Trackmen run at Swarthmore and Delaware • Gillespie hits 37 points to lead Bears over Swarthmore in finale • Girl swimmers win over Penn and Elizabethtown • Junior varsity hoopmen finish with 11-6 record • Dickinson frat system defended • UC celebrates centennial with unique innovation • Forum features Howellhttps://digitalcommons.ursinus.edu/weekly/1171/thumbnail.jp

The complete genome sequence of the carcinogenic bacterium \u3cem\u3eHelicobacter hepaticus\u3c/em\u3e

Helicobacter hepaticus causes chronic hepatitis and liver cancer in mice. It is the prototype enterohepatic Helicobacter species and a close relative of Helicobacter pylori, also a recognized carcinogen. Here we report the complete genome sequence of H. hepaticus ATCC51449. H. hepaticus has a circular chromosome of 1,799,146 base pairs, predicted to encode 1,875 proteins. A total of 938, 953, and 821 proteins have orthologs in H. pylori, Campylobacter jejuni, and both pathogens, respectively. H. hepaticus lacks orthologs of most known H. pylori virulence factors, including adhesins, the VacA cytotoxin, and almost all cag pathogenicity island proteins, but has orthologs of the C. jejuni adhesin PEB1 and the cytolethal distending toxin (CDT). The genome contains a 71-kb genomic island (HHGI1) and several genomic islets whose G+C content differs from the rest of the genome. HHGI1 encodes three basic components of a type IV secretion system and other virulence protein homologs, suggesting a role of HHGI1 in pathogenicity. The genomic variability of H. hepaticus was assessed by comparing the genomes of 12 H. hepaticus strains with the sequenced genome by microarray hybridization. Although five strains, including all those known to have caused liver disease, were indistinguishable from ATCC51449, other strains lacked between 85 and 229 genes, including large parts of HHGI1, demonstrating extensive variation of genome content within the species