Trapped in texture bias? A large scale comparison of deep instance segmentation

Do deep learning models for instance segmentation generalize to novel objects in a systematic way? For classification, such behavior has been questioned. In this study, we aim to understand if certain design decisions such as framework, architecture or pre-training contribute to the semantic understanding of instance segmentation. To answer this question, we consider a special case of robustness and compare pre-trained models on a challenging benchmark for object-centric, out-of-distribution texture. We do not introduce another method in this work. Instead, we take a step back and evaluate a broad range of existing literature. This includes Cascade and Mask R-CNN, Swin Transformer, BMask, YOLACT(++), DETR, BCNet, SOTR and SOLOv2. We find that YOLACT++, SOTR and SOLOv2 are significantly more robust to out-of-distribution texture than other frameworks. In addition, we show that deeper and dynamic architectures improve robustness whereas training schedules, data augmentation and pre-training have only a minor impact. In summary we evaluate 68 models on 61 versions of MS COCO for a total of 4148 evaluations.Comment: Accepted at ECCV 2022. Code: https://github.com/JohannesTheo/trapped-in-texture-bia

Verfahren der Willensbildung und Selbstverwaltung im Internet: das Beispiel ICANN und die At-Large-Membership

"Die vorliegende Studie befasst sich mit einem Experiment im Bereich transnationaler demokratischer Willensbildung. Im Mittelpunkt der Untersuchung steht die Internet Corporation for Assigned Names and Numbers (ICANN), ein 1998 gegründetes gemeinnütziges Unternehmen mit Sitz in Kalifornien, das die Aufsicht und Verwaltung des Domainnamensystems sowie die Kontrolle über den numerischen Adressraum des Internet ausübt. Die ursprüngliche Satzung von ICANN sah vor, dass neun von 19 Direktoriumsmitgliedern durch die Internetnutzer bestimmt werden sollten. Aus diesem Grund veranstaltete ICANN im Jahr 2000 die erste weltweite Wahl im Internet. Bei dieser Wahl wurden in fünf durch ICANN bestimmte 'Weltregionen' insgesamt fünf sogenannte At-Large Direktoren gewählt. Die Studie besteht aus zwei Teilen. Im ersten Teil wird die Struktur von ICANN anhand ihrer Satzung analysiert. Der zweite Teil besteht aus einer Fallstudie, die den Planungsprozess und Ablauf der Wahl im Einzelnen schildert und kritisch bewertet. Die Untersuchung stellt die erste deutschsprachige Studie über die ICANN Wahl im Jahr 2000 dar." (Autorenreferat)"This study looks at an experiment in transnational democracy. The Internet Corporation for Assigned Names and Numbers (ICANN) held in the year 2000 the first global elections on the Internet. Five At Large directors coming from five world regions were selected by Internet users who had signed up as members with ICANN. ICANN, the California based non-profit company, has been founded in 1998. ICANN is responsible for the oversight and administration of the Domain Name system as well as for the allocation of numeric Internet addresses. The original version of ICANN's bylaws determine that nine of its 19 directors should be selected by users. The study consists of two parts. The first part descibes ICANN's bylaws and analyses its institutional structure. The second part is a case study that aims to comprehend the entire progression of the ICANN elections. Starting with the first At Large membership committees initiated by ICANN staff, the case study gives special attention to the decision making processes accompanying the election." (author's abstract

Actin Re-Organization Induced by Chlamydia trachomatis Serovar D - Evidence for a Critical Role of the Effector Protein CT166 Targeting Rac

The intracellular bacterium Chlamydia trachomatis causes infections of urogenital tract, eyes or lungs. Alignment reveals homology of CT166, a putative effector protein of urogenital C. trachomatis serovars, with the N-terminal glucosyltransferase domain of clostridial glucosylating toxins (CGTs). CGTs contain an essential DXD-motif and mono-glucosylate GTP-binding proteins of the Rho/Ras families, the master regulators of the actin cytoskeleton. CT166 is preformed in elementary bodies of C. trachomatis D and is detected in the host-cell shortly after infection. Infection with high MOI of C. trachomatis serovar D containing the CT166 ORF induces actin re-organization resulting in cell rounding and a decreased cell diameter. A comparable phenotype was observed in HeLa cells treated with the Rho-GTPase-glucosylating Toxin B from Clostridium difficile (TcdB) or HeLa cells ectopically expressing CT166. CT166 with a mutated DXD-motif (CT166-mut) exhibited almost unchanged actin dynamics, suggesting that CT166-induced actin re-organization depends on the glucosyltransferase motif of CT166. The cytotoxic necrotizing factor 1 (CNF1) from E. coli deamidates and thereby activates Rho-GTPases and transiently protects them against TcdB-induced glucosylation. CNF1-treated cells were found to be protected from TcdB- and CT166-induced actin re-organization. CNF1 treatment as well as ectopic expression of non-glucosylable Rac1-G12V, but not RhoA-G14A, reverted CT166-induced actin re-organization, suggesting that CT166-induced actin re-organization depends on the glucosylation of Rac1. In accordance, over-expression of CT166-mut diminished TcdB induced cell rounding, suggesting shared substrates. Cell rounding induced by high MOI infection with C. trachomatis D was reduced in cells expressing CT166-mut or Rac1-G12V, and in CNF1 treated cells. These observations indicate that the cytopathic effect of C. trachomatis D is mediated by CT166 induced Rac1 glucosylation. Finally, chlamydial uptake was impaired in CT166 over-expressing cells. Our data strongly suggest CT166's participation as an effector protein during host-cell entry, ensuring a balanced uptake into host-cells by interfering with Rac-dependent cytoskeletal changes

Loop formation in graphitic nanoribbon edges using furnace heating or Joule heating

"Here the authors report the use of either furnace heating or Joule heating to pacify the exposed graphene edges by loop formation in a novel graphitic nanoribbon material, grown by chemical vapor deposition. The edge energy minimization process involves the formation of loops between adjacent graphene layers within the nanoribbons. A comparison is made of the similarities and differences between the loop structures formed using these two methods. An estimation of the temperature of these graphitic nanoribbons during Joule heating is also reported based on the melting and evaporation of Pt nanoparticles.

Strategies for Understanding and Reducing the Plasmodium vivax and Plasmodium ovale Hypnozoite Reservoir in Papua New Guinean Children: A Randomised Placebo-Controlled Trial and Mathematical Model

The undetectable hypnozoite reservoir for relapsing Plasmodium vivax and P. ovale malarias presents a major challenge for malaria control and elimination in endemic countries. This study aims to directly determine the contribution of relapses to the burden of P. vivax and P. ovale infection, illness, and transmission in Papua New Guinean children.; From 17 August 2009 to 20 May 2010, 524 children aged 5-10 y from East Sepik Province in Papua New Guinea (PNG) participated in a randomised double-blind placebo-controlled trial of blood- plus liver-stage drugs (chloroquine [CQ], 3 d; artemether-lumefantrine [AL], 3 d; and primaquine [PQ], 20 d, 10 mg/kg total dose) (261 children) or blood-stage drugs only (CQ, 3 d; AL, 3 d; and placebo [PL], 20 d) (263 children). Participants, study staff, and investigators were blinded to the treatment allocation. Twenty children were excluded during the treatment phase (PQ arm: 14, PL arm: 6), and 504 were followed actively for 9 mo. During the follow-up time, 18 children (PQ arm: 7, PL arm: 11) were lost to follow-up. Main primary and secondary outcome measures were time to first P. vivax infection (by qPCR), time to first clinical episode, force of infection, gametocyte positivity, and time to first P. ovale infection (by PCR). A basic stochastic transmission model was developed to estimate the potential effect of mass drug administration (MDA) for the prevention of recurrent P. vivax infections. Targeting hypnozoites through PQ treatment reduced the risk of having at least one qPCR-detectable P. vivax or P. ovale infection during 8 mo of follow-up (P. vivax: PQ arm 0.63/y versus PL arm 2.62/y, HR = 0.18 [95% CI 0.14, 0.25], p < 0.001; P. ovale: 0.06 versus 0.14, HR = 0.31 [95% CI 0.13, 0.77], p = 0.011) and the risk of having at least one clinical P. vivax episode (HR = 0.25 [95% CI 0.11, 0.61], p = 0.002). PQ also reduced the molecular force of P. vivax blood-stage infection in the first 3 mo of follow-up (PQ arm 1.90/y versus PL arm 7.75/y, incidence rate ratio [IRR] = 0.21 [95% CI 0.15, 0.28], p < 0.001). Children who received PQ were less likely to carry P. vivax gametocytes (IRR = 0.27 [95% CI 0.19, 0.38], p < 0.001). PQ had a comparable effect irrespective of the presence of P. vivax blood-stage infection at the time of treatment (p = 0.14). Modelling revealed that mass screening and treatment with highly sensitive quantitative real-time PCR, or MDA with blood-stage treatment alone, would have only a transient effect on P. vivax transmission levels, while MDA that includes liver-stage treatment is predicted to be a highly effective strategy for P. vivax elimination. The inclusion of a directly observed 20-d treatment regime maximises the efficiency of hypnozoite clearance but limits the generalisability of results to real-world MDA programmes.; These results suggest that relapses cause approximately four of every five P. vivax infections and at least three of every five P. ovale infections in PNG children and are important in sustaining transmission. MDA campaigns combining blood- and liver-stage treatment are predicted to be a highly efficacious intervention for reducing P. vivax and P. ovale transmission.; ClinicalTrials.gov NCT02143934

Evaluating Reflective Writing in Pre-Service Teachers: The Potential of a Mixed-Methods Approach

Reflective writing is a relevant aspect of pre-service teachers’ professionalization. Evaluating reflective writing in teacher education is demanding due to a shortage of resources. Hence, this study explores the practical possibilities of evaluating reflective writing using a mixed-methods approach to analyze reflective writing from 198 pre-service teachers at a German university. We used qualitative content analysis, computational linguistic approaches, and BERTopic. Results of qualitative content analysis results indicated primarily descriptive and low-level participants’ reflective writing. Next, computational linguistic analyses revealed that affective and cognitive terminology utilization differed across varying levels of reflection, with a higher frequency of such terms correlating with deeper levels of reflection. BERTopic results showed that reflective content mainly centered on learning materials and shifted toward affective and motivational themes related to higher levels of reflection. This study demonstrates that reflective writing can be evaluated across reflection levels and cognitive, affective, and thematic dimensions, combining qualitative content analysis, computational linguistic approaches, and BERTopic.</jats:p

BCL6 enables Ph+ acute lymphoblastic leukaemia cells to survive BCR-ABL1 kinase inhibition.

Tyrosine kinase inhibitors (TKIs) are widely used to treat patients with leukaemia driven by BCR-ABL1 (ref. 1) and other oncogenic tyrosine kinases. Recent efforts have focused on developing more potent TKIs that also inhibit mutant tyrosine kinases. However, even effective TKIs typically fail to eradicate leukaemia-initiating cells (LICs), which often cause recurrence of leukaemia after initially successful treatment. Here we report the discovery of a novel mechanism of drug resistance, which is based on protective feedback signalling of leukaemia cells in response to treatment with TKI. We identify BCL6 as a central component of this drug-resistance pathway and demonstrate that targeted inhibition of BCL6 leads to eradication of drug-resistant and leukaemia-initiating subclones

Thermo-optical performance of molecular solar thermal energy storage films

Due to their potential for solar energy harvesting and storage, molecular solar thermal energy storage (MOST) materials are receiving wide attention from both the research community and the public. MOST materials absorb photons and convert their energy to chemical energy, which is contained within the bonds of the MOST molecules. Depending on the molecular structure, these materials can store up to 1 MJ/kg, at ambient temperature and with storage times ranging from minutes to several years. This work is the first to thoroughly investigate the potential of MOST materials for the development of energy saving windows. To this end, the MOST molecules are integrated into thin, optically transparent films, which store solar energy during the daytime and release heat at a later point in time. A combined experimental and modeling approach is used to verify the system\u27s basic functionality and identify key parameters. Multi-physics modeling and simulation were conducted to evaluate the interaction of MOST films with light, both monochromatic and the entire solar spectrum, as well as the corresponding dynamic energy storage. The model was experimentally verified by studying the optical response of thin MOST films containing norbornadiene derivatives as a functional system. We found that the MOST films act as excellent UV shield and can store up to 0.37 kWh/m2 for optimized MOST molecules. Further, this model allowed us to screen various material parameters and develop guidelines on how to optimize the performance of MOST window films

Die Toten der spätneolithischen Tellsiedlung von Okolište / Bosnien-Herzegowina: Massaker, Seuche oder Bestattungsbrauch?

The following paper deals with the human skeletal remains of at least 14 individuals that were found during excavations in 2004 and 2006 in one of the surrounding ditches of the late Neolithic tell settlement of Okolište / Bosnia-Herzegovina. Based on the archaeological findings and the anthropological analysis it is proposed that these human remains are rather not the outcome of specific burial practices but have to been seen in connection with a short-termed, though not punctuated event. However, it is not very likely that the dead are casualties of warlike operations; instead, we think it more probable that they fell victim to some kind of epidemic or famine. However, because of the poor preservation of bone in other parts of the ditch, it cannot be ruled out completely that the skeletal remains were the result of some kind of yet unknown burial practice