Spatial and Temporal Analysis of the Morphological and Land use Characteristics of the Buffalo River Watershed

The Buffalo River was established by Congress iQ. 1972 as the first National River in the United States. The Buffalo River, which originates in the higher elevations of the Boston Mountains in Newton County, is one of the few remaining free-flowing streams in Arkansas. It is considered to be one of Arkansas\u27 greatest natural treasures, and thus, there is strong interest in protecting it from anthropogenic influences. An initial characterization of the soil taxonomic units, watershed boundaries, topography and physiographic units in the Buffalo River Watershed was presented by Scott and Smith (1994). The spatial distribution of the geologic units in the watershed was presented by Hofer et al. (1995)

Spatial Distribution of the Surface Geology and 1992 Land Use of the Buffalo River Watershed

The Buffalo River was established by Congress in 1972 as the first National River in the United States and is one of the few remaining free-flowing streams in Arkansas . The Buffalo River flows through the three major physiographic provinces of northern Arkansas, originating in the higher elevations of the Boston Mountains, and flowing generally northeastward to cut through the Springfield and Salem Plateaus. It drops from approximately 2000 feet in the headwaters to around 500 feet above sea level at its confluence with the White River in Marion County. The Buffalo River is considered to be one of Arkansas\u27 greatest natural treasures; thus there is strong interest in protecting it from undue anthropogenic influences. A general description of the area within the Buffalo River Watershed was given by Smith (1967)

Spatial and Temporal Analyses of the Morphological and Land Use Characteristics of the Buffalo River Watershed

The Buffalo River was established by Congress it11972 as the first National River in the United States. The Buffalo River, which originates in the higher elevations of the Boston Mountains in Newton County, is one of the few remaining free-flowing streams in Arkansas. It is considered to be one of Arkansas\u27 greatest natural treasures, and thus, there is strong interest in protecting it from anthropogenic influences. An initial characterization of the soil taxonomic units, watershed boundaries, topography and physiographic units in the Buffalo River Watershed was presented by Scott and Smith (1994). The spatial distribution of the geologic units in the watershed was presented by Hofer et al. (1995)

Global prevalence and genotype distribution of hepatitis C virus infection in 2015 : A modelling study

Publisher Copyright: © 2017 Elsevier LtdBackground The 69th World Health Assembly approved the Global Health Sector Strategy to eliminate hepatitis C virus (HCV) infection by 2030, which can become a reality with the recent launch of direct acting antiviral therapies. Reliable disease burden estimates are required for national strategies. This analysis estimates the global prevalence of viraemic HCV at the end of 2015, an update of—and expansion on—the 2014 analysis, which reported 80 million (95% CI 64–103) viraemic infections in 2013. Methods We developed country-level disease burden models following a systematic review of HCV prevalence (number of studies, n=6754) and genotype (n=11 342) studies published after 2013. A Delphi process was used to gain country expert consensus and validate inputs. Published estimates alone were used for countries where expert panel meetings could not be scheduled. Global prevalence was estimated using regional averages for countries without data. Findings Models were built for 100 countries, 59 of which were approved by country experts, with the remaining 41 estimated using published data alone. The remaining countries had insufficient data to create a model. The global prevalence of viraemic HCV is estimated to be 1·0% (95% uncertainty interval 0·8–1·1) in 2015, corresponding to 71·1 million (62·5–79·4) viraemic infections. Genotypes 1 and 3 were the most common cause of infections (44% and 25%, respectively). Interpretation The global estimate of viraemic infections is lower than previous estimates, largely due to more recent (lower) prevalence estimates in Africa. Additionally, increased mortality due to liver-related causes and an ageing population may have contributed to a reduction in infections. Funding John C Martin Foundation.publishersversionPeer reviewe

Discovery of common and rare genetic risk variants for colorectal cancer.

To further dissect the genetic architecture of colorectal cancer (CRC), we performed whole-genome sequencing of 1,439 cases and 720 controls, imputed discovered sequence variants and Haplotype Reference Consortium panel variants into genome-wide association study data, and tested for association in 34,869 cases and 29,051 controls. Findings were followed up in an additional 23,262 cases and 38,296 controls. We discovered a strongly protective 0.3% frequency variant signal at CHD1. In a combined meta-analysis of 125,478 individuals, we identified 40 new independent signals at P < 5 × 10-8, bringing the number of known independent signals for CRC to ~100. New signals implicate lower-frequency variants, Krüppel-like factors, Hedgehog signaling, Hippo-YAP signaling, long noncoding RNAs and somatic drivers, and support a role for immune function. Heritability analyses suggest that CRC risk is highly polygenic, and larger, more comprehensive studies enabling rare variant analysis will improve understanding of biology underlying this risk and influence personalized screening strategies and drug development.Goncalo R Abecasis has received compensation from 23andMe and Helix. He is currently an employee of Regeneron Pharmaceuticals. Heather Hampel performs collaborative research with Ambry Genetics, InVitae Genetics, and Myriad Genetic Laboratories, Inc., is on the scientific advisory board for InVitae Genetics and Genome Medical, and has stock in Genome Medical. Rachel Pearlman has participated in collaborative funded research with Myriad Genetics Laboratories and Invitae Genetics but has no financial competitive interest