68 research outputs found
Indigenous Methodology in Practice: Starting a Community-Based Research Center on the Yakama Reservation
In our paper, we examine the process, possibilities, and tensions of building a new community-based research center at a small liberal arts college on the Yakama Reservation. We view our work with the Center for Native Health & Culture as an example of human rights-based educational transformation, as our work is about honoring indigenous land, community, and values. This mission stands at odds with Western educational approaches, which typically view indigenous peoples, cultures, and well-being as a side note to frequently marginalized campus diversity initiatives. Our work to establish the new research center takes up the challenge of placing indigenous peoplesâ health and culture at the center of the academic enterprise. We, as academics engaging in this work on traditional Yakama homeland, are uniquely situated to analyze and articulate this form of academic decolonization work. We draw from the interwoven liberation model proposed by FalcĂłn and Jacob to critically examine our centerâs work process and product to articulate our indigenous methodology in practice. Our indigenous methodology is guided by three principles: (a) understanding the importance of partnerships; (b) viewing our work in terms of building on existing strengths within campus and local tribal communities; (c) engaging in work that promotes a vision of academic excellence that has a âgood spiritâ and inspires all parties involved. We conclude by discussing some of the challenges faced in doing decolonizing work, and affirm the urgent need to further indigenize the academy
Researching Moslem-Christian Marriages: Extrapolating From Mixed-Faith Couples Towards the Practices of Convivencia
Partner notification in the clinician's office: patient health, public health and interventions
Quantifying gravel overlap and dislodgement forces on natural river bars: implications for particle entrainment
Antiviral prodrugs â the development of successful prodrug strategies for antiviral chemotherapy
Following the discovery of the first effective antiviral compound (idoxuridine) in 1959, nucleoside analogues, especially acyclovir (ACV) for the treatment of herpesvirus infections, have dominated antiviral therapy for several decades. However, ACV and similar acyclic nucleosides suffer from low aqueous solubility and low bioavailability following oral administration. Derivatives of acyclic nucleosides, typically esters, were developed to overcome this problem and valaciclovir, the valine ester of ACV, was among the first of a new series of compounds that were readily metabolized upon oral administration to produce the antiviral nucleoside in vivo, thus increasing the bioavailility by several fold. Concurrently, famciclovir was developed as an oral formulation of penciclovir. These antiviral âprodrugs' thus established a principle that has led to many successful drugs including both nucleoside and nucleotide analogues for the control of several virus infections, notably those caused by herpes-, retro- and hepatitisviruses. This review will chart the origins and development of the most important of the antiviral prodrugs to date
Efficacy of Topical Acyclovir Monophosphate, Acyclovir, or Penciclovir in Orofacial HSV-1 Infections of Mice and Genital HSV-2 Infections of Guinea Pigs
Music of Today Series presents Music by Harry Partch (1901-1974) performed on the Harry Partch Instruments May 26, 2015
Concert ProgramMusic of Today Series presents Music by Harry Partch (1901-1974) performed on the Harry Partch Instruments May 26, 201
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