Density PDFs of diffuse gas in the Milky Way

The probability distribution functions (PDFs) of the average densities of the diffuse ionized gas (DIG) and the diffuse atomic gas are close to lognormal, especially when lines of sight at |b|5 degree are considered separately. Our results provide strong support for the existence of a lognormal density PDF in the diffuse ISM, consistent with a turbulent origin of density structure in the diffuse gas.Comment: 4 pages, 1 figure. To be published in the proceedings of the August 2008 conference (held in Eapinho, Portugal) "The Role of Disk-Halo Interaction in Galaxy Evolution: Outflow vs Infall?", Ed. M. A. de Avillez, EAS Publications Serie

Valence band study of thermoelectric Zintl-phase SrZn_2Sb_2 and YbZn_2Sb_2: X-ray photoelectron spectroscopy and density functional theory

The electronic structure of SrZn_2Sb_2 and YbZn_2Sb_2 is investigated using density functional theory and high-resolution x-ray photoemission spectroscopy. Both traditional Perdew-Burke-Ernzerhof and state-of-the-art hybrid Heyd-Scuseria-Ernzerhof functionals have been employed to highlight the importance of proper treatment of exchange-dependent Zn  3d states, Yb 4f states, and band gaps. The role of spin-orbit corrections in light of first-principles transport calculations are discussed and previous claims of Yb^(3+) valence are investigated with the assistance of photoelectron as well as scanning and transmission electron microscopy

Interstellar H2 toward HD 37903

We present an analysis of interstellar H2 toward HD 37903, which is a hot, B 1.5 V star located in the NGC 2023 reflection nebula. Meyer et al. (2001) have used a rich spectrum of vibrationally excited H2 observed by the HST to calculate a model of the interstellar cloud toward HD 37903. We extend Mayer's analysis by including the v"=0 vibrational level observed by the FUSE satellite. The T01 temperature should not be interpreted as a rotational temperature, but rather as a temperature of thermal equilibrium between the ortho and para H2. The ortho to para H2 ratio is lower for collisionally populated levels than for the levels populated by fluorescence. The PDR model of the cloud located in front of HD 37903 points to a gas temperature Tkin=110-377 K, hydrogen density nH=1874-544 cm^-3 and the star-cloud distance of 0.45 pc

On the impulse criterion for entrainment of coarse grains in air

River hydrodynamicsTurbulent open channel flow and transport phenomen

Composition and structure of Pd nanoclusters in SiOx_x thin film

The nucleation, distribution, composition and structure of Pd nanocrystals in SiO$_2$ multilayers containing Ge, Si, and Pd are studied using High Resolution Transmission Electron Microscopy (HRTEM) and X-ray Photoelectron Spectroscopy (XPS), before and after heat treatment. The Pd nanocrystals in the as deposited sample seem to be capped by a layer of PdO$_x$. A 1-2 eV shift in binding energy was found for the Pd-3d XPS peak, due to initial state Pd to O charge transfer in this layer. The heat treatment results in a decomposition of PdO and Pd into pure Pd nanocrystals and SiO$_2$

Clinical importance of clonal hematopoiesis in metastatic gastrointestinal tract cancers

IMPORTANCE: Clonal hematopoiesis (CH) has been associated with development of atherosclerosis and leukemia and worse survival among patients with cancer; however, the association with cancer therapy efficacy, in particular immune checkpoint blockade (ICB), and toxicity has not yet been established. Given the widespread use of ICB and the critical role hematopoietic stem cell-derived lymphocytes play in mediating antitumor responses, CH may be associated with therapeutic efficacy and hematologic toxicity. OBJECTIVE: To determine the association between CH and outcomes, hematologic toxicity, and therapeutic efficacy in patients with metastatic gastrointestinal tract cancers being treated with systemic therapy, both in the first-line metastatic treatment setting and in ICB. DESIGN, SETTING, AND PARTICIPANTS: This retrospective cohort study included 633 patients with stage IV colorectal (CRC) and esophagogastric (EGC) cancer who were treated with first-line chemotherapy and/or ICB at Memorial Sloan Kettering Cancer Center. Patients underwent matched tumor and peripheral blood DNA sequencing using the Memorial Sloan Kettering-Integrated Mutation Profiling of Actionable Cancer Targets next-generation sequencing assay between January 1, 2006, and December 31, 2020. EXPOSURES: Clonal hematopoiesis-related genetic alterations were identified by next-generation sequencing of patients\u27 tumor and normal blood buffy coat samples, with a subset of these CH alterations annotated as likely putative drivers (CH-PD) based upon previously established criteria. MAIN OUTCOMES AND MEASURES: Patients with CH and CH-PD in peripheral blood samples were identified, and these findings were correlated with survival outcomes (progression-free survival [PFS] and overall survival [OS]) during first-line chemotherapy and ICB, as well as baseline white blood cell levels and the need for granulocyte colony-stimulating factor (G-CSF) support. RESULTS: Among the 633 patients included in the study (390 men [61.6%]; median age, 58 [IQR, 48-66] years), the median age was 52 (IQR, 45-63) years in the CRC group and 61 (IQR, 53-69) years in the EGC group. In the CRC group, 161 of 301 patients (53.5%) were men, compared with 229 of 332 patients (69.0%) in the EGC group. Overall, 62 patients (9.8%) were Asian, 45 (7.1%) were Black or African American, 482 (76.1%) were White, and 44 (7.0%) were of unknown race or ethnicity. Presence of CH was identified in 115 patients with EGC (34.6%) and 83 with CRC (27.6%), with approximately half of these patients harboring CH-PD (CRC group, 44 of 83 [53.0%]; EGC group, 55 of 115 [47.8%]). Patients with EGC and CH-PD exhibited a significantly worse median OS of 16.0 (95% CI, 11.6-22.3) months compared with 21.6 (95% CI, 19.6-24.3) months for those without CH-PD (P = .01). For patients with CRC and EGC, CH and CH-PD were not associated with PFS differences in patients undergoing ICB or first-line chemotherapy. Neither CH nor CH-PD were correlated with baseline leukocyte levels or increased need for G-CSF support. CONCLUSIONS AND RELEVANCE: These findings suggest CH and CH-PD are not directly associated with the treatment course of patients with metastatic gastrointestinal tract cancer receiving cancer-directed therapy

Effects of spatial variability on the estimation of erosion rates for cohesive riverbanks

River morphodynamics and sediment transportBank erosion and protectio