37 research outputs found

    Genetic Sharing with Cardiovascular Disease Risk Factors and Diabetes Reveals Novel Bone Mineral Density Loci.

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    Bone Mineral Density (BMD) is a highly heritable trait, but genome-wide association studies have identified few genetic risk factors. Epidemiological studies suggest associations between BMD and several traits and diseases, but the nature of the suggestive comorbidity is still unknown. We used a novel genetic pleiotropy-informed conditional False Discovery Rate (FDR) method to identify single nucleotide polymorphisms (SNPs) associated with BMD by leveraging cardiovascular disease (CVD) associated disorders and metabolic traits. By conditioning on SNPs associated with the CVD-related phenotypes, type 1 diabetes, type 2 diabetes, systolic blood pressure, diastolic blood pressure, high density lipoprotein, low density lipoprotein, triglycerides and waist hip ratio, we identified 65 novel independent BMD loci (26 with femoral neck BMD and 47 with lumbar spine BMD) at conditional FDR < 0.01. Many of the loci were confirmed in genetic expression studies. Genes validated at the mRNA levels were characteristic for the osteoblast/osteocyte lineage, Wnt signaling pathway and bone metabolism. The results provide new insight into genetic mechanisms of variability in BMD, and a better understanding of the genetic underpinnings of clinical comorbidity

    Meteor radar observations at middle and Arctic latitudes. Part 1: Mean temperatures

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    Observations with a Meteor radar operating at 32.55 MHz have been used to derive daily atmospheric temperature data for an altitude of 90 km at mid-latitudes during November 1999 until August 2001, and at high latitudes during September 2001 until December 2002. The neutral air temperatures are derived from determination of the ambipolar diffusion coefficient variation as a function of height, and are then corrected by application of a temperature-gradient model. The seasonal variations at both latitudes are characterized by high temperatures in winter and markedly smaller ones during summer. Whereas the winter temperatures at high latitudes are slightly warmer than at mid-latitudes by about 10 K, during summer the temperatures at high latitudes are colder by up to about 40 K. The majority of the variation in temperatures measured by this technique is due to variations in the ambipolar diffusion coefficient, but the accuracy of the temperature gradient model is important for second-order corrections. The meteor technique is valuable toot to study the short time temperature variability. The temperature data derived in this manner are in reasonable agreement with independent experimental results from different rocket, satellite and ground-based measurements, as well as with theoretical results obtained from calculations with the global circulation model COMMA-IAP

    Relationship between variability of the semidiurnal tide in the Northern Hemisphere mesosphere and quasi-stationary planetary waves throughout the global middle atmosphere

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    To investigate possible couplings between planetary waves and the semidiurnal tide (SDT), this work examines the statistical correlations between the SDT amplitudes observed in the Northern Hemisphere (NH) mesosphere and stationary planetary wave (SPW) with wavenumber S=1 (SPW1) amplitudes throughout the global stratosphere and mesosphere. The latter are derived from the Aura-MLS temperature measurements. During NH summer-fall (July–October), the mesospheric SDT amplitudes observed at Svalbard (78° N) and Eureka (80° N) usually do not show persistent correlations with the SPW1 amplitudes in the opposite hemisphere. Although the SDT amplitudes observed at lower latitudes (~50–70° N), especially at Saskatoon (52° N), are often shown to be highly and positively correlated with the SPW1 amplitudes in high southern latitudes, these correlations cannot be sufficiently explained as evidence for a direct physical link between the Southern Hemisphere (SH) winter-early spring SPW and NH summer-early fall mesospheric SDT. This is because the migrating tide's contribution is usually dominant in the mid-high latitude (~50–70° N) NH mesosphere during the local late summer-early fall (July–September). The numerical correlation is dominated by similar low-frequency variability or trends between the amplitudes of the NH SDT and SH SPW1 during the respective equinoctial transitions. In contradistinction, during NH winter (November–February), the mesospheric SDT amplitudes at northern mid-high latitudes (~50–80° N) are observed to be significantly and positively correlated with the SPW1 amplitudes in the same hemisphere in most cases. Because both the SPW and migrating SDT are large in the NH during the local winter, a non-linear interaction between SPW and migrating SDT probably occurs, thus providing a global non-migrating SDT. This is consistent with observations of SDT in Antarctica that are large in summer than in winter. It is suggested that climatological hemispheric asymmetry, e.g. the SH and NH winter characteristics are substantially different, lead to differences in the inter-hemispheric SPW-tide physical links

    Climatology of quasi-2-day wave structure and variability at middle latitudes in the northern and southern hemispheres.

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    Climatological structure of the quasi-2-day wave (Q2DW) at middle latitudes in temperature and horizontal winds in the mesosphere and lower thermosphere (MLT) was compared between the northern and southern hemispheres. Determination of the Q2DW in temperature was based on observation data by the Microwave Limb Sounder (MLS) onboard NASA's Earth Observing System (EOS) Aura satellite over 17 years from 2004 to 2021 and the Q2DW in horizontal winds was derived from Aura/MLS geopotential height data using balance equations. Amplitudes were maximized in summer in the southern hemisphere and in the meridional wind in the northern hemisphere, but in winter in the zonal wind in the northern hemisphere. Summer amplitudes were larger in the meridional wind than the zonal wind in the southern hemisphere, but zonal amplitudes in winter were larger than meridional amplitudes in summer in the northern hemisphere. Westward propagating zonal wavenumber 3 (W3) was largest in both hemispheres, but in addition to well-known W4, W3, W2 and eastward propagating zonal wavenumber 2 (E2), we also found W1, zonally symmetric standing (S0), and E1. Eliassen-Palm fluxes were derived for each mode. W3, W2, W1, and E2 fluxes were exhibited upward and poleward in January in the southern hemisphere while only W3 fluxes were exhibited clearly upward and poleward in July in the northern hemisphere. Comparison between Q2DW balance winds and radar winds showed modulations in amplitudes and phase of the Q2DW from the W3 by accumulating other modes. Furthermore, the balance winds and radar winds agreed in both amplitude and phase in the southern hemisphere and at lower latitudes in the northern hemisphere in January, and at lower latitudes in both hemispheres in July

    Detrital events and hydroclimate variability in the Romanian Carpathians during the mid-to-late Holocene

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    The Romanian Carpathians are located at the confluence of three major atmospheric pressure fields: the North Atlantic, the Mediterranean and the Siberian. Despite its importance for understanding past human impact and climate change, high-resolution palaeoenvironmental reconstructions of Holocene hydroclimate variability, and in particular records of extreme precipitation events in the area, are rare. Here we present a 7500-year-long high-resolution record of past climatic change and human impact recorded in a peatbog from the Southern Carpathians, integrating palynological, geochemical and sedimentological proxies. Natural climate fluctuations appear to be dominant until 4500 years before present (yr BP), followed by increasing importance of human impact. Sedimentological and geochemical analyses document regular minerogenic deposition within the bog, linked to periods of high precipitation. Such minerogenic depositional events began 4000 yr BP, with increased depositional rates during the Medieval Warm Period (MWP), the Little Ice Age (LIA) and during periods of societal upheaval (e.g. the Roman conquest of Dacia). The timing of minerogenic events appears to indicate a teleconnection between major shifts in North Atlantic Oscillation (NAO) and hydroclimate variability in southeastern Europe, with increased minerogenic deposition correlating to low NAO index values. By linking the minerogenic deposition to precipitation variability, we state that this link persists throughout the mid-to-late Holocene
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