The clinical effectiveness of magnets for people with osteoarthritis:A systematic review and meta-analysis

Osteoarthritis is the most prevalent musculoskeletal disorder, affecting millions of people worldwide. There has been limited consensus on the use of magnets for this condition. This study specifically assessed the evidence pertaining to the use of static magnets to manage symptoms in people with osteoarthritis. A systematic review of the published (AMED, CINAHL, MEDLINE, EMBASE, PubMed and the Cochrane Library) and unpublished literature (WHO International Clinical Trials Registry Platform, Current Controlled Trials and the United States National Institute of Health Trials Registry, Open Grey) was undertaken to July 2013. All studies assessing the clinical effects of static magnets as a therapeutic intervention for adults with osteoarthritis were included. Methodological quality was assessed using the PEDro appraisal tool. When appropriate, meta-analysis was conducted to pool data. From a total of 301 citations, six studies met the eligibility criteria. These included 374 participants, 220 allocated to a magnet group, 154 to a placebo control. The findings indicated that magnets did not significantly reduce pain or medicine requirement nor enhanced function, joint proprioception or muscle strength compared to placebo (p>0.05). There was limited evidence that higher strength magnets may have a greater effect on pain than lower field strength magnets. However, the quality of the current evidence-base was limited and underpowered. The longer-term outcomes of magnet use and limited control of field strength within the current literature suggests that further, adequately sample-sized, randomised controlled trials to assess dose-response are initially required to begin to rigorously assess the efficacy of this intervention with people with osteoarthritis

Femoral neck narrowing following hip resurfacing using posterior and Ganz approaches at two years

We report a retrospective review of femoral head/neck ratios on post-operative and two year follow-up radiographs following hip resurfacing arthroplasty. The patients were in two matched groups, having had surgery through a posterior approach or via a Ganz trochanteric flip. There was no significant difference in femoral neck narrowing at follow up between the two surgical approaches. However, we found significant narrowing of the femoral neck in both groups by the time of the two year follow-up radiograph

Fixed versus mobile bearing unincompartmental knee replacement : a meta-analysis.

SummaryThis systematic review compares the clinical, radiological and kinematic outcomes of fixed compared to mobile bearing unicompartmental knee replacements (UKRs). A meta-analysis of pooled mean difference and relative risk data was undertaken following a review of electronic databases. Five studies were identified. Analysis suggested that there was no significant difference in clinical outcome or complication rate between mobile and fixed bearing UKR. However, the evidence reviewed presented with a number of methodological limitations. Areas for further study are recommended.Level of evidenceLevel I

Exome-wide association analysis reveals novel coding sequence variants associated with lipid traits in Chinese

Blood lipids are important risk factors for coronary artery disease (CAD). Here we perform an exome-wide association study by genotyping 12,685 Chinese, using a custom Illumina HumanExome BeadChip, to identify additional loci influencing lipid levels. Single-variant association analysis on 65,671 single nucleotide polymorphisms reveals 19 loci associated with lipids at exome-wide significance (P<2.69 × 10−7), including three Asian-specific coding variants in known genes (CETP p.Asp459Gly, PCSK9 p.Arg93Cys and LDLR p.Arg257Trp). Furthermore, missense variants at two novel loci—PNPLA3 p.Ile148Met and PKD1L3 p.Thr429Ser—also influence levels of triglycerides and low-density lipoprotein cholesterol, respectively. Another novel gene, TEAD2, is found to be associated with high-density lipoprotein cholesterol through gene-based association analysis. Most of these newly identified coding variants show suggestive association (P<0.05) with CAD. These findings demonstrate that exome-wide genotyping on samples of non-European ancestry can identify additional population-specific possible causal variants, shedding light on novel lipid biology and CAD