A Histological Examination of \u3cem\u3eOdocoileus virginianus\u3c/em\u3e for Forensic Application

Few researchers have endeavored to approach the issue of bone histology in non-human specimen. In the forensic setting, it is oftentimes the norm to establish the origin of fragmentary remains as human or non-human; if the fragments are non-human then the analysis is usually said to be finished. If the specimen does prove to be non-human, it is useful and important to learn the identity of the faunal species. The white-tailed deer (Odocoileus virginianus) is common to the Eastern United States and is very often found in forensic settings, commingled with or alongside of human remains. This study thoroughly examines the histological character of the white-tailed deer so that it may be identified with confidence in the forensic field or in an archaeological setting. To assess the white-tailed deer femora and humeri were procured from five deer of varying ages -- the goal being to understand histological changes within bones from the same specimen and between bones of deer at different stages of maturity. With the aid of a Buehler Isomet 1000 saw, two 0.08mm sections were cut at three-centimeter intervals on each diaphysis of the femur and humerus for each deer. These thin-sections were examined under a Leica DMRX light microscope at 100x magnification. The presence of all histological structures was noted for each slide and when evidence of bone remodeling was recorded, area measurements were taken on secondary osteons and Haversian canals. The observations and measurement data from each femur and humerus of the deer samples were compared in a statistical analysis to assess inter- and intra-bone variability among the deer. A repeated measures ANOVA examined the differences in osteon and Haversian canal area across the segments of the femoral and humeri shafts and between ages. These results indicate whether or not the histological character of the white-tailed deer differs depending on the age, the bone, or the specific location on a bone. The results indicate no significant mean differences within shafts or across ages for osteon area in the femur. No differences exist within the shafts of the humeri. Notable variations in osteon area do exist between ages in the humerus -- the 3-year-old deer diverged from both the 1.5-year-old and the 2.5-year-old. The results also indicated no significant mean differences intra-shaft or across ages for Haversian canal areas in the femur. A significance difference was noted between the Haversian canal areas in the nine-month deer and the 2.5-year-old deer humeri. Based on the findings a blind test was performed on four unidentified bones samples to discern deer from other ungulates based on osteon areas. The methodology and results of this research were successfully utilized to distinguish white-tailed deer bone from pig, sheep, and goat at the histological level

Double-heterostructure cavities: from theory to design

We derive a frequency-domain-based approach for radiation (FAR) from double-heterostructure cavity (DHC) modes. We use this to compute the quality factors and radiation patterns of DHC modes. The semi-analytic nature of our method enables us to provide a general relationship between the radiation pattern of the cavity and its geometry. We use this to provide general designs for ultrahigh quality factor DHCs with radiation patterns that are engineered to emit vertically

Transdisciplinary and arts-centred approaches to stewardship and sustainability of urban nature.

This paper explores case studies of how artists working with scientists and land managers affiliated with the Urban Field Station Collaborative Arts Program (UFS Arts) are fostering new relations of care with urban nature and thereby informing landscape decisions. The 'wicked' problems related to sustainability demand novel, holistic approaches to transformation that engage multiple ways of knowing. We present 4 examples from UFS Arts by triangulating data across programmatic documentation, evaluation, and ethnographic materials from 2016-present. Matthew López-Jensen's Tree Love and Nikki Lindt’s Underground Sound Project sensitise us to the capacities of trees and forests through image and sound. Mary Mattingly’s Swale is a floating food forest that enacts new forms of community stewardship. The exhibition Who Takes Care of New York? maps the stories and practices of civic environmental groups. Three themes in these works suggest opportunities for transformation throughout the knowledge production cycle: posing novel questions, engaging multiple methodologies, and communicating ideas with the public. Through these transdisciplinary works, we learn things we could not have learned via traditional disciplinary or interdisciplinary work and assert that stewardship offers a pathway towards sustainability transforming management practices and landscape decisions by reshaping our relationships to community and the land

Youth at Risk: Part 1, 2012 Massachusetts Family Impact Seminar

The youth of Massachusetts are of primary concern to legislators and citizens. This briefing report features three essays by experts – Lisa Jones, Ramon Borges-Mendez, and Janis Wolak – who focus on three aspects of youth wellbeing: youth victimization and other indicators of psychological health, youth unemployment, and online sexual predators of youth. Although youth well-being is of primary concern, the worrisome stories about crimes against children that regularly fill the media have unfortunately obscured some more positive news from statistical reports on these same issues. Child victimizations of various types – i.e., child sexual abuse, witnessing domestic violence, child physical abuse, sexual assaults of teenagers, physical assaults and robberies of teenagers, and homicides of teenagers – have been declining nationwide and in Massachusetts since the early 1990s, in some cases declining dramatically

Patient safety and quality improvement education: a cross-sectional study of medical students' preferences and attitudes

Abstract Background Recent educational initiatives by both the World Health Organization and the American Association of Medical Colleges have endorsed integrating teaching of patient safety and quality improvement (QI) to medical students. Curriculum development should take into account learners’ attitudes and preferences. We surveyed students to assess preferences and attitudes about QI and patient safety education. Methods An electronic survey was developed through focus groups, literature review, and local expert opinion and distributed via email to all medical students at a single medical school in the spring of 2012. Results A greater proportion of students reported previous exposure to patient safety than to quality improvement topics (79% vs. 47%). More than 80% of students thought patient safety was of the same or greater importance than basic science or clinical skills whereas quality improvement was rated as the same or more important by about 70% of students. Students rated real life examples of quality improvement projects and participation in these projects with actual patients as potentially the most helpful (mean scores 4.2/5 and 3.9/5 respectively). For learning about patient safety, real life examples of mistakes were again rated most highly (mean scores 4.5/5 for MD presented mistakes and 4.1/5 for patient presented mistakes). Students rated QI as very important to their future career regardless of intended specialty (mean score 4.5/5). Conclusions Teaching of patient safety and quality improvement to medical students will be best received if it is integrated into clinical education rather than solely taught in pre-clinical lectures or through independent computer modules. Students recognize that these topics are important to their careers as future physicians regardless of intended specialty

The function-dominance correlation drives the direction and strength of biodiversity-ecosystem functioning relationships

Community composition is a primary determinant of how biodiversity change influences ecosystem functioning and, therefore, the relationship between biodiversity and ecosystem functioning (BEF). We examine the consequences of community composition across six structurally realistic plant community models. We find that a positive correlation between species' functioning in monoculture versus their dominance in mixture with regard to a specific function (the "function-dominance correlation") generates a positive relationship between realised diversity and ecosystem functioning across species richness treatments. However, because realised diversity declines when few species dominate, a positive function-dominance correlation generates a negative relationship between realised diversity and ecosystem functioning within species richness treatments. Removing seed inflow strengthens the link between the function-dominance correlation and BEF relationships across species richness treatments but weakens it within them. These results suggest that changes in species' identities in a local species pool may more strongly affect ecosystem functioning than changes in species richness

Commentary on Coram et al. (2021) on the use of Facebook to understand marine mammal stranding issues in Southeast Asia

We reviewed Coram et al. (Biodivers Conserv 30:2341–2359, 2021, https://doi.org/10.1007/s10531-021-02196-6), a paper that highlights the use of social media data to understand marine litter and marine mammals in Southeast Asia. While we commend its intent, we find that the methodology used and conclusions drawn portray an incomplete and inaccurate perception of how strandings, stranding response, and analysis of stranding data have been conducted in the region. By focusing on investigative results revealed by a very limited search of one social media platform (Facebook), using only English keywords, and insuffcient ground-truthing, Coram et al. (2021) have, unintentionally, given the perception that Southeast Asian scientists have not conducted even the bare minimum of investigation required to better understand the issue of marine litter and its impact on marine mammals. In this commentary we provide a more accurate account of strandings research in Asia and include recommendations to improve future studies using social media to assess conservation issues

A cohort study of 30 day mortality after NON-EMERGENCY surgery in a COVID-19 cold site

BACKGROUND: Two million non-emergency surgeries are being cancelled globally every week due to the COVID-19 pandemic, which will have a major impact on patients and healthcare systems. METHODS: During the peak of the pandemic in the United Kingdom, we set up a multicentre cancer network amongst 14 National Health Service institutions, performing urological, thoracic, gynaecological and general surgical urgent and cancer operations at a central COVID-19 cold site. This is a cohort study of 500 consecutive patients undergoing surgery in this network. The primary outcome was 30-day mortality from COVID-19. Secondary outcomes included all-cause mortality and post-operative complications at 30-days. RESULTS: 500 patients underwent surgery with median age 62.5 (IQR 51-71). 65% were male, 60% had a known diagnosis of cancer and 61% of surgeries were considered complex or major. No patient died from COVID-19 at 30-days. 30-day all-cause mortality was 3/500 (1%). 10 (2%) patients were diagnosed with COVID-19, 4 (1%) with confirmed laboratory diagnosis and 6 (1%) with probable COVID-19. 33/500 (7%) of patients developed Clavien-Dindo grade 3 or higher complications, with 1/33 (3%) occurring in a patient with COVID-19. CONCLUSION: It is safe to continue cancer and urgent surgery during the COVID-19 pandemic with appropriate service reconfiguration

The worldwide marine radiocarbon reservoir effect: definitions, mechanisms, and prospects

When a carbon reservoir has a lower radiocarbon content than the atmosphere, this is referred to as a reservoir effect. This is expressed as an offset between the radiocarbon ages of samples from the two reservoirs at a single point in time. The marine reservoir effect (MRE) has been a major concern in the radiocarbon community, as it introduces an additional source of error that is often difficult to accurately quantify. For this reason, researchers are often reluctant to date marine material where they have another option. The influence of this phenomenon makes the study of the MRE important for a broad range of applications. The advent of Accelerator Mass Spectrometry (AMS) has reduced sample size requirements and increased measurement precision, in turn increasing the number of studies seeking to measure marine samples. These studies rely on overcoming the influence of the MRE on marine radiocarbon dates through the worldwide quantification of the local parameter ΔR, that is, the local variation from the global average MRE. Furthermore, the strong dependence on ocean dynamics makes the MRE a useful indicator for changes in oceanic circulation, carbon exchange between reservoirs, and the fate of atmospheric CO2, all of which impact Earth's climate. This article explores data from the Marine Reservoir Database and reviews the place of natural radiocarbon in oceanic records, focusing on key questions (e.g., changes in ocean dynamics) that have been answered by MRE studies and on their application to different subjects

Multi-site investigation of strategies for the clinical implementation of CYP2D6 genotyping to guide drug prescribing

PURPOSE: A number of institutions have clinically implemented CYP2D6 genotyping to guide drug prescribing. We compared implementation strategies of early adopters of CYP2D6 testing, barriers faced by both early adopters and institutions in the process of implementing CYP2D6 testing, and approaches taken to overcome these barriers. METHODS: We surveyed eight early adopters of CYP2D6 genotyping and eight institutions in the process of adoption. Data were collected on testing approaches, return of results procedures, applications of genotype results, challenges faced, and lessons learned. RESULTS: Among early adopters, CYP2D6 testing was most commonly ordered to assist with opioid and antidepressant prescribing. Key differences among programs included test ordering and genotyping approaches, result reporting, and clinical decision support. However, all sites tested for copy-number variation and nine common variants, and reported results in the medical record. Most sites provided automatic consultation and had designated personnel to assist with genotype-informed therapy recommendations. Primary challenges were related to stakeholder support, CYP2D6 gene complexity, phenotype assignment, and sustainability. CONCLUSION: There are specific challenges unique to CYP2D6 testing given the complexity of the gene and its relevance to multiple medications. Consensus lessons learned may guide those interested in pursuing similar clinical pharmacogenetic programs