Freedom of speech

Free speech is a familiar concept. It is an established ideal of liberalism and democratic politics, and the subject of political debate and conflict across diverse historical and cultural contexts. Free speech has not primarily been considered, however, as a set of lived, valued, and contested practices, mediated by various linguistic, ethical, and material forms. While anthropology has not traditionally occupied itself with free speech, it has extensive tools for bringing free speech into view beyond its quality as an abstract ideal or legal category. This entry borrows theoretical perspectives, as well as ethnographic examples produced by anthropologists, to shed light on free speech within a broader comparative frame. It begins by focusing on free speech as a dynamic value or virtue, asking: what is it about ‘free’ or ‘direct’ speech that people value when they value it? Secondly, the entry casts critical light on the idea of an individual as the universal ‘free speaker’, demonstrating how collective or disaggregated subjects can also practice free speech. Thirdly, it explores the material settings, contexts, or technologies through which free speech is curtailed or realised. Finally, the entry considers the idea of ‘voice’ as signalling modes of embodiment, and auditory phenomena such as noise, sound, and silence, which are not spoken language but can inform and expand our understanding of free speech

Global existence of solutions to 2-D Navier-Stokes flow with non-decaying initial data in half-plane

We investigate the Navier-Stokes initial boundary value problem in the half-plane $R^2_+$ with initial data $u_0 \in L^\infty(R^2_+)\cap J_0^2(R^2_+)$ or with non decaying initial data $u_0\in L^\infty(R^2_+) \cap J_0^p(R^2_+), p > 2$ . We introduce a technique that allows to solve the two-dimesional problem, further, but not least, it can be also employed to obtain weak solutions, as regards the non decaying initial data, to the three-dimensional Navier-Stokes IBVP. This last result is the first of its kind

Variation in the distribution and properties of Circumpolar Deep Water in the eastern Amundsen Sea, on seasonal timescales, using seal‐borne tags

In the Amundsen Sea, warm saline Circumpolar Deep Water (CDW) crosses the continental shelf toward the vulnerable West Antarctic ice shelves, contributing to their basal melting. Due to lack of observations, little is known about the spatial and temporal variability of CDW, particularly seasonally. A new dataset of 6704 seal‐tag temperature and salinity profiles in the easternmost trough between February and December 2014 reveals a CDW layer on average 49 db thicker in late winter (August to October) than in late summer (February to April), the reverse seasonality of that seen at moorings in the western trough. This layer contains more heat in winter, but on the 27.76 kg/m3 density surface CDW is 0.32° C warmer in summer than winter, across the northeastern Amundsen sea, which may indicate wintertime shoaling offshelf changes CDW properties onshelf. In Pine Island Bay these seasonal changes on density surfaces are reduced, likely by gyre circulation

The relation between the diffuse X-ray luminosity and the radio power of the central AGN in galaxy groups

Our understanding of how active galactic nucleus feedback operates in galaxy clusters has improved in recent years owing to large efforts in multiwavelength observations and hydrodynamical simulations. However, it is much less clear how feedback operates in galaxy groups, which have shallower gravitational potentials. In this work, using very deep Very Large Array and new MeerKAT observations from the MIGHTEE survey, we compiled a sample of 247 X-ray selected galaxy groups detected in the COSMOS field. We have studied the relation between the X-ray emission of the intra-group medium and the 1.4 GHz radio emission of the central radio galaxy. For comparison, we have also built a control sample of 142 galaxy clusters using ROSAT and NVSS data. We find that clusters and groups follow the same correlation between X-ray and radio emission. Large radio galaxies hosted in the centres of groups and merging clusters increase the scatter of the distribution. Using statistical tests and Monte Carlo simulations, we show that the correlation is not dominated by biases or selection effects. We also find that galaxy groups are more likely than clusters to host large radio galaxies, perhaps owing to the lower ambient gas density or a more efficient accretion mode. In these groups, radiative cooling of the intra-cluster medium could be less suppressed by active galactic nucleus heating. We conclude that the feedback processes that operate in galaxy clusters are also effective in groups.Peer reviewe

Glacial meltwater identification in the Amundsen Sea

Pine Island Ice Shelf, in the Amundsen Sea, is losing mass because of warm ocean waters melting the ice from below. Tracing meltwater pathways from ice shelves is important for identifying the regions most affected by the increased input of this water type. Here, optimum multiparameter analysis is used to deduce glacial meltwater fractions from water mass characteristics (temperature, salinity, and dissolved oxygen concentrations), collected during a ship-based campaign in the eastern Amundsen Sea in February–March 2014. Using a one-dimensional ocean model, processes such as variability in the characteristics of the source water masses on shelf and biological productivity/respiration are shown to affect the calculated apparent meltwater fractions. These processes can result in a false meltwater signature, creating misleading apparent glacial meltwater pathways. An alternative glacial meltwater calculation is suggested, using a pseudo–Circumpolar Deep Water endpoint and using an artificial increase in uncertainty of the dissolved oxygen measurements. The pseudo–Circumpolar Deep Water characteristics are affected by the under ice shelf bathymetry. The glacial meltwater fractions reveal a pathway for 2014 meltwater leading to the west of Pine Island Ice Shelf, along the coastline

mRNA therapy corrects defective glutathione metabolism and restores ureagenesis in preclinical argininosuccinic aciduria

The urea cycle enzyme argininosuccinate lyase (ASL) enables the clearance of neurotoxic ammonia and the biosynthesis of arginine. Patients with ASL deficiency present with argininosuccinic aciduria, an inherited metabolic disease with hyperammonemia and a systemic phenotype coinciding with neurocognitive impairment and chronic liver disease. Here, we describe the dysregulation of glutathione biosynthesis and upstream cysteine utilization in ASL-deficient patients and mice using targeted metabolomics and in vivo positron emission tomography (PET) imaging using ( S)-4-(3-18F-fluoropropyl)-l-glutamate ([18F]FSPG). Up-regulation of cysteine metabolism contrasted with glutathione depletion and down-regulated antioxidant pathways. To assess hepatic glutathione dysregulation and liver disease, we present [18F]FSPG PET as a noninvasive diagnostic tool to monitor therapeutic response in argininosuccinic aciduria. Human hASL mRNA encapsulated in lipid nanoparticles improved glutathione metabolism and chronic liver disease. In addition, hASL mRNA therapy corrected and rescued the neonatal and adult Asl-deficient mouse phenotypes, respectively, enhancing ureagenesis. These findings provide mechanistic insights in liver glutathione metabolism and support clinical translation of mRNA therapy for argininosuccinic aciduria. </p

Vigorous lateral export of the meltwater outflow from beneath an Antarctic ice shelf

The instability and accelerated melting of the Antarctic Ice Sheet are among the foremost elements of contemporary global climate change1, 2. The increased freshwater output from Antarctica is important in determining sea level rise1, the fate of Antarctic sea ice and its effect on the Earth’s albedo4, 5, ongoing changes in global deep-ocean ventilation6, and the evolution of Southern Ocean ecosystems and carbon cycling7, 8. A key uncertainty in assessing and predicting the impacts of Antarctic Ice Sheet melting concerns the vertical distribution of the exported meltwater. This is usually represented by climate-scale models3–5, 9 as a near-surface freshwater input to the ocean, yet measurements around Antarctica reveal the meltwater to be concentrated at deeper levels10, 11, 12, 13, 14. Here we use observations of the turbulent properties of the meltwater outflows from beneath a rapidly melting Antarctic ice shelf to identify the mechanism responsible for the depth of the meltwater. We show that the initial ascent of the meltwater outflow from the ice shelf cavity triggers a centrifugal overturning instability that grows by extracting kinetic energy from the lateral shear of the background oceanic flow. The instability promotes vigorous lateral export, rapid dilution by turbulent mixing, and finally settling of meltwater at depth. We use an idealized ocean circulation model to show that this mechanism is relevant to a broad spectrum of Antarctic ice shelves. Our findings demonstrate that the mechanism producing meltwater at depth is a dynamically robust feature of Antarctic melting that should be incorporated into climate-scale models

Metabolite and lipoprotein profiles reveal sex-related oxidative stress imbalance in de novo drug-naive Parkinson's disease patients

Parkinson's disease (PD) is the neurological disorder showing the greatest rise in prevalence from 1990 to 2016. Despite clinical definition criteria and a tremendous effort to develop objective biomarkers, precise diagnosis of PD is still unavailable at early stage. In recent years, an increasing number of studies have used omic methods to unveil the molecular basis of PD, providing a detailed characterization of potentially pathological alterations in various biological specimens. Metabolomics could provide useful insights to deepen our knowledge of PD aetiopathogenesis, to identify signatures that distinguish groups of patients and uncover responsive biomarkers of PD that may be significant in early detection and in tracking the disease progression and drug treatment efficacy. The present work is the first large metabolomic study based on nuclear magnetic resonance (NMR) with an independent validation cohort aiming at the serum characterization of de novo drug-naive PD patients. Here, NMR is applied to sera from large training and independent validation cohorts of German subjects. Multivariate and univariate approaches are used to infer metabolic differences that characterize the metabolite and the lipoprotein profiles of newly diagnosed de novo drug-naive PD patients also in relation to the biological sex of the subjects in the study, evidencing a more pronounced fingerprint of the pathology in male patients. The presence of a validation cohort allowed us to confirm altered levels of acetone and cholesterol in male PD patients. By comparing the metabolites and lipoproteins levels among de novo drug-naive PD patients, age- and sex-matched healthy controls, and a group of advanced PD patients, we detected several descriptors of stronger oxidative stress