Online review courses as preparation for first term remedial exams

[EN] At Universidad Carlos III de Madrid we have developed a review course (R-Course) with a SPOC structure intended for students who failed the first term regular exams. The purpose of the course is to help students prepare for the remedial exams at the same time they study the second term courses. The R-Course is implemented in an Open-EDX platform that holds digital documents, both theory and solved exercise videos, platform integrated exercises, and forums. The content of the course is divided in videos of less than 10 minutes in length, allowing students to include the R-Course in any schedule and making it compatible with the second term courses. Interactive platform integrated exercises have been devised under different types of methodologies to increase the motivation of the students, and the platform forums give students and tutors a space to discuss and interact for a well-rounded academic experience.The authors wish to acknowledge the financial and structural support from Universidad Carlos III the Madrid, in particular from the UTEID (Unidad de Tecnología Educativa e Innovación Docente) and the encouragement from professors Carlos Delgado-Kloos and Luis Raúl Sánchez Fernández.Domínguez-Reyes, R.; Meléndez, J.; Hernández-Pérez, A. (2015). Online review courses as preparation for first term remedial exams. Multidisciplinary Journal for Education, Social and Technological Sciences. 2(2):139-152. doi:10.4995/muse.2015.3687.SWORD1391522

Influence of a football match on landing biomechanics and jump performance in female football players

This study aimed to assess the acute effect of a competitive football match on jump performance and kinematic parameters during jump landing in semiprofessional female football players. Twenty-two semiprofessional players (20 ± 3 years) underwent a drop jump task for a posterior video analysis of the landing phase. These measurements were obtained at (1) baseline, (2) after, and (3) 48 h after a competitive football match. A one-way ANOVA with repeated measures was employed to detect differences over the time. There was a main effect of time for maximal knee flexion angle during drop landing (p = 0.001). In comparison with baseline, maximal knee flexion angle was reduced immediately post-match and was still reduced 48 h after the match (63.4 ± 8.6 vs 57.0 ± 11.7 vs 48.9 ± 19.1, p ≤ 0.038). There was also a main effect of time for drop jump height (p < 0.001). Drop jump height was reduced immediately post-match and remained low 48 h after the match in comparison with baseline (27.3 ± 3.6 vs 24.5 ± 2.8 ~ 25.5 ± 3.0 cm, p ≤ 0.002). There was a main effect of time on hip flexion angle during landing (p = 0.001), but the pairwise comparison revealed that this variable was not affected immediately post-match but was lower 48 h after the match than at baseline (50.1 ± 10.1 ~ 50.8 ± 13.2 vs 38.1 ± 17.8 °, p ≤ 0.005). A competitive football match worsened jump performance and several landing biomechanical parameters in female football players, which were still decreased in comparison with baseline even 48 h after the match

Impacto de la Biodiversidad de Cultivos en un Clima Cambiante

Debido a la agricultura intensiva con actividades de ganadería y producción de monocultivos y a la industria, la producción de gases nocivos como el CO2 ha aumentado, causando un aumento en las temperaturas globales, con impacto en los ecosistemas. La producción actual de cultivos se encuentra influenciada por variaciones climáticas y es afectada por esquemas de manejo con grandes cantidades de insumos agrícolas y tecnológicos que causan la degradación del suelo y el agua. Como consecuencia, las plantas presentan condiciones de estrés debido a la sequía, el aumento de CO2 y temperatura, las olas de calor, las inundaciones, los efectos nocivos del aumento de la población de plagas y la falta de horas frías en las zonas templadas. Los resultados de estos impactos negativos son cambios bioquímicos, fisiológicos y morfológicos en los cultivos, implicando adelantos en fenología, diferente composición biomolecular y baja producción en calidad y cantidad de productos. También se presenta una disminución en las poblaciones de insectos beneficiosos necesarios para la mayoría de los cultivos. En conjunto, esto afecta la seguridad alimentaria. Una alternativa para enfrentar la adversidad climática es la diversidad de cultivos que permite aumentar la población de insectos beneficiosos y genera recursos ecosistémicos más integrados respetando los ciclos naturales del agua y preserva la calidad de los suelos. La diversidad de cultivos ofrece una mayor resistencia a la variabilidad climática e incrementa la seguridad alimentaria al producir una mayor variación de los productos agrícolas. Esta es la razón por la cual es necesario identificar las áreas óptimas para el establecimiento de cultivos más adecuados a las condiciones hídricas, edáficas y climáticas. Esto se logra a través de la zonificación agroecológica. Sin embargo, no se han realizado estudios de zonificación para diversas especies. Este ensayo revela la importancia de realizar esta investigación para una biodiversidad de cultivos planificada

Diagnostic performance of intraoperative assessment in grade 2 endometrioid endometrial carcinoma

Background Endometrial carcinoma is the most common gynecologic malignancy in developed countries. Grade 2 carcinoma is associated with pelvic lymph-node metastasis, depending on selected risk factors. Intraoperative assessment (IOA) can identify patients at risk for lymph node metastasis who should undergo staging surgery. Our objective was to establish the diagnostic precision of IOA in determining the need for surgical staging in grade 2 endometrioid endometrial carcinoma. Methods Two hundred twenty-two patients underwent IOA. Results were compared to the final pathology report. The accuracy of the IOA parameters was calculated. Variables were evaluated in patients with positive versus negative IOA. Overall and disease-free survivals were calculated according to IOA, lymphadenectomy, and nodal metastasis. Results IOA was positive in 80 patients. It showed an accuracy of 76.13% when compared with the postoperative assessment. The best individual parameter was myometrial invasion. Nodal metastasis was observed in 16 patients in the positive IOA group and 7 patients in the negative group. Patients with lymph node metastasis had a 5-year overall survival rate of 80.9%, whereas patients without metastasis had a 5-year overall survival rate of 97.9%. Conclusions IOA is an adequate tool to identify high-risk patients in grade 2 endometrial carcinoma. Myometrial invasion is the individual parameter that yields the highest diagnostic precision

Pharmacokinetic Comparability of a Biosimilar Trastuzumab Anticipated from Its Physicochemical and Biological Characterization

Comparability between a biosimilar and its reference product requires the evaluation of critical quality attributes that may impact on its pharmacological response. Herein we present a physicochemical characterization of a biosimilar trastuzumab focused on the attributes related to the pharmacokinetic response. Capillary isoelectrofocusing (cIEF) and cation exchange chromatography (CEX) were used to evaluate charge heterogeneity; glycosylation profiles were assessed through hydrophilic interaction liquid chromatography (HILIC); aggregates content was evaluated through size exclusion chromatography (SEC) while binding affinity to FcRn was evaluated using isothermal titration calorimetry (ITC). The biosimilar trastuzumab and its reference product exhibited a high degree of similarity for the evaluated attributes. In regard to the pharmacokinetic parameters, randomized, double blind, and two-arm parallel and prospective study was employed after the administration of a single intravenous dose in healthy volunteers. No significant differences were found between the pharmacokinetic profiles of both products. Our results confirm that similarity of the critical quality attributes between a biosimilar product, obtained from a different manufacturing process, and the reference product resulted in comparable pharmacokinetic profiles, diminishing the uncertainty related to the biosimilar&apos;s safety and efficacy

Minecraft para diseños HDL: flujo de síntesis de Verilog para circuitos de redstone

Memoria ID-076. Ayudas de la Universidad de Salamanca para la innovación docente, curso 2019-2020.[ES]El objetivo de este proyecto es crear un espacio virtual mediante la utilización de tecnología Minecraft que permita al estudiante aumentar el contenido académico relacionado con los conocimientos impartidos en las distintas ramas de las asignaturas de electrónica-física de la Universidad de Salamanca

Extinction risk of Mesoamerican crop wild relatives

Ensuring food security is one of the world's most critical issues as agricultural systems are already being impacted by global change. Crop wild relatives (CWR)—wild plants related to crops—possess genetic variability that can help adapt agriculture to a changing environment and sustainably increase crop yields to meet the food security challenge. Here we report the results of an extinction risk assessment of 224 wild relatives of some of the world's most important crops (i.e. chilli pepper, maize, common bean, avocado, cotton, potato, squash, vanilla and husk tomato) in Mesoamerica—an area of global significance as a centre of crop origin, domestication and of high CWR diversity. We show that 35% of the selected CWR taxa are threatened with extinction according to The International Union for Conservation of Nature (IUCN) Red List demonstrates that these valuable genetic resources are under high anthropogenic threat. The dominant threat processes are land use change for agriculture and farming, invasive and other problematic species (e.g. pests, genetically modified organisms) and use of biological resources, including overcollection and logging. The most significant drivers of extinction relate to smallholder agriculture—given its high incidence and ongoing shifts from traditional agriculture to modern practices (e.g. use of herbicides)—smallholder ranching and housing and urban development and introduced genetic material. There is an urgent need to increase knowledge and research around different aspects of CWR. Policies that support in situ and ex situ conservation of CWR and promote sustainable agriculture are pivotal to secure these resources for the benefit of current and future generations

Reducing the environmental impact of surgery on a global scale: systematic review and co-prioritization with healthcare workers in 132 countries

Abstract Background Healthcare cannot achieve net-zero carbon without addressing operating theatres. The aim of this study was to prioritize feasible interventions to reduce the environmental impact of operating theatres. Methods This study adopted a four-phase Delphi consensus co-prioritization methodology. In phase 1, a systematic review of published interventions and global consultation of perioperative healthcare professionals were used to longlist interventions. In phase 2, iterative thematic analysis consolidated comparable interventions into a shortlist. In phase 3, the shortlist was co-prioritized based on patient and clinician views on acceptability, feasibility, and safety. In phase 4, ranked lists of interventions were presented by their relevance to high-income countries and low–middle-income countries. Results In phase 1, 43 interventions were identified, which had low uptake in practice according to 3042 professionals globally. In phase 2, a shortlist of 15 intervention domains was generated. In phase 3, interventions were deemed acceptable for more than 90 per cent of patients except for reducing general anaesthesia (84 per cent) and re-sterilization of ‘single-use’ consumables (86 per cent). In phase 4, the top three shortlisted interventions for high-income countries were: introducing recycling; reducing use of anaesthetic gases; and appropriate clinical waste processing. In phase 4, the top three shortlisted interventions for low–middle-income countries were: introducing reusable surgical devices; reducing use of consumables; and reducing the use of general anaesthesia. Conclusion This is a step toward environmentally sustainable operating environments with actionable interventions applicable to both high– and low–middle–income countries