Milk yield and milk fatty acids from crossbred F1 dairy cows fed on tropical grasses and supplemented with different levels of concentrate

The objective of this study was to determine milk fatty acids from crossbred F1 dairy cows fed on tropical grasses and supplemented with different levels of concentrate. Twelve dairy cows (50% Holstein x 50% Brahman) with 60 days of lactation grazing tropical grasses were assigned to a Switchback design, with three periods of 15 days with different concentrate levels: 0, 150, 300 and 450 g /kg. Milk samples were obtained on the last five days of each experimental period. Milk yield and milk composition were not affected. Cows fed with 300 g/kg of concentrate had higher contents of C15:0 (p = 0.004), C22:0 (p = 0.031), and C24:0 (p = 0.013). C17:1 cis9 was higher (p = 0.039) with 150 g/kg and lowest with 450 g/kg. C18:1 cis9 was higher (p = 0.042) with 150 g/kg. C18:2n6trans was higher (p = 0.05) with 300 g/kg and lower (p = 0.018) with 450 g/kg. This study shows that adding up to 450 g/kg of concentrate to crossbred F1 dairy cows fed on tropical grasses does not have negative effects on milk yield and milk quality. Therefore, under these production conditions, farmers can rely on tropical grasses and reduce feeding costs

Complete response under sorafenib in patients with hepatocellular carcinoma: Relationship with dermatologic adverse events.

The clinical benefit of sorafenib in patients with hepatocellular carcinoma (HCC) has been undervalued due to the absence of complete responses, even though patients who develop early dermatologic reactions have shown to have a positive outcome. In addition, sorafenib is described as an antiangiogenic drug, but it also acts on immunological cells. Thus, the goal of this study was to assess the complete response rate in a retrospective cohort of HCC patients treated with sorafenib and to describe the profile of the patients who achieve complete response for identifying factors related to this event and their connection with the immunological profile of sorafenib. Ten Spanish centers submitted cases of complete response under sorafenib. The baseline characteristics, development of early dermatologic reactions, and cause of treatment discontinuation were annotated. Radiological images taken before starting sorafenib, at first control, after starting sorafenib, at the time of complete response, and at least 1 month after treatment were centrally reviewed. Of the 1119 patients studied, 20 had been classified as complete responders by the centers, but eight of these patients were excluded after central review. Ten patients had complete disappearance of all tumor sites, and two had just a small residual fibrotic scar. Thus, 12 patients were classified as complete responders (58% HCV, median age 59.7 years, 83.4% Child-Pugh class A, Eastern Cooperative Oncology Group performance status 0 91.7%, and Barcelona Clinic Liver Cancer stage C 83.3%). The median overall survival and treatment duration were 85.8 and 40.1 months, respectively. All but one patient developed early dermatologic reactions, and seven patients discontinued sorafenib after achieving complete response due to adverse events, patient decision, or liver decompensation. CONCLUSION: Complete response affects 1% of patients with HCC who are treated with sorafenib. The association of complete response with early dermatologic reactions supports the role of a specific immune/inflammatory patient profile in the improved response to sorafenib

Therapeutic Exercise Interventions through Telerehabilitation in Patients with Post COVID-19 Symptoms: A Systematic Review

The worldwide incidence of COVID-19 has generated a pandemic of sequelae. These sequelae require multidisciplinary rehabilitative work to address the multisystemic symptoms that patients will present with now and in the future. The aim of the present systematic review is to analyze the current situation of telerehabilitation in patients with COVID-19 sequelae and its effectiveness. Searches were conducted on the following databases: PubMed, Scopus, PEDro, and Web of Science (WOS). There was no complete homogeneity among the five selected articles, so we differentiated two clinical subgroups for the clustering of outcome measures: (group one) patients with post-discharge symptoms and (group two) patients with permanent symptoms or “long COVID-19” defined as persistent symptoms > 2 months. For group one, post-discharge sequelae, improvements were obtained in cardiovascular parameters, and physical test studies in group two presented very favorable results in all the cardiorespiratory measures and physical tests evaluated. Telerehabilitation through therapeutic exercise based on mixed protocols of aerobic, respiratory, and low-load strength exercises appear to be an effective and safe strategy for the recovery of short- and long-term post-COVID-19 sequelae

Produção de carne nos trópicos secos de Tamaulipas, México: cruzamento de Bos taurus e Bos indicus

The objective of this study was evaluated the productive performance in Charolais (CH), Simmental (SM) and Braunvieh (BR) sires and Zebu, (ZE), Suiss (SU) x ZE and CH x ZE dams, among birth and weaning calves weights. The environment is dry tropical with summer rains. The livestock grassing in a introducing grasses Star grass (Cynodon nlemfuensis) y Guinea (Panicum maximun). The reproduction was artificial insemination with CH, SM and BR semen and natural insemination with CH sires after insemination. The calves were identificated at birth with the mother number and were weighted in the first 24 ours. The data were analyzed with minimum squares method to determinate, season (SE), calf sex (SX) and dam age (DE). The average for birth weight (BW) was 34.6 kg and only the SE were statistical significant (P < 0.05) for this characteristic. For weaning weight (WW) the mean was 165.7 kg and SE and DE and were statistical significant (P < 0.05). The conclusion is that the environmental effects in this study was more important than genetics effects both BW and WW variables.El objetivo del presente estudio fue evaluar la productividad de toros Charoláis (CH), Simmental (SM) y Pardo Suizo (PS) con vacas Cebú (CE), PS x CE y CH x CE a través del peso al nacimiento y al destete de los becerros. El rancho contaba con praderas de Estrella de África (Cynodon nlemfuensis) y Guinea (Panicum maximun), utilizadas con pastoreo rotacional. La reproducción de las vacas fue a través de inseminación artificial con semen de SM, CH y PS y fueron repasadas por toros CH. Los becerros fueron tatuados en la oreja con el número de la madre y se pesaron en las primeras 24 h después del nacimiento. Los datos fueron analizados por el método de cuadrados mínimos para determinar los efectos de año (AN) y estación de nacimiento (EN), sexo de la cría (SX) y edad de la vaca (EV). La media general para peso al nacimiento fue 34.6 kg, solo los efectos de AN y EN influenciaron (P < 0.05) el peso al nacimiento. El mayor peso se observó en los becerros nacidos en 1994 durante la época de lluvias. Para el caso del PD la media fue de 165.7 kg, los efectos de AN, EN, EV y la correlación de AN x EN fueron estadísticamente significativos (P < 0.05), donde los mayores pesos fueron de los becerros nacidos en el año 1994 durante la época de sequía. Se puede concluir que en este trabajo los factores medioambientales fueron más importantes que los factores genéticos para ambas variables.Resumo. O objetivo deste trabalho foi avaliar a produtividade de touros Charolês (CH), Simental (SM) e Pardo Suíço (PS) com vacas Zebu (CE), PS x CE e CH x CE através dos pesos ao nascimento e à desmama dos bezerros. A fazenda possuía pastagens African Star (Cynodon nlemfuensis) e Guinea (Panicum maximun), utilizadas com pastejo rotacionado. As vacas foram cruzadas por inseminação artificial com sêmen de SM, CH e PS e foram cruzadas com touros CH. Os bezerros foram tatuados na orelha com o número da mãe e pesados nas primeiras 24 horas após o nascimento. Os dados foram analisados pelo método dos mínimos quadrados para determinar os efeitos da estação de nascimento (EN), sexo do bezerro (SX) e idade da vaca (EV). A média geral para os pesos ao desmame dos bezerros foi de 34,6 kg, apenas os efeitos da EN influenciaram (P < 0,05) o peso ao nascer. Os maiores pesos foram observados nos bezerros nascidos na estação chuvosa. Para PD a média foi de 165,7 kg, os efeitos de EN e EV foram estatisticamente significativos (P < 0,05), onde os maiores pesos foram dos bezerros nascidos na estação seca. Pode-se concluir que neste trabalho os fatores ambientais foram mais importantes que os fatores genéticos para ambas as variáveis

IT and Multi-layer Online Resource Allocation and Offline Planning in Metropolitan Networks

Metropolitan networks are undergoing a major technological breakthrough leveraging the capabilities of software-defined networking (SDN) and network function virtualization (NFV). NFV permits the deployment of virtualized network functions (VNFs) on commodity hardware appliances which can be combined with SDN flexibility and programmability of the network infrastructure. SDN/NFV-enabled networks require decision-making in two time scales: short-term online resource allocation and mid-to-long term offline planning. In this paper, we first tackle the dimensioning of SDN/NFV-enabled metropolitan networks paying special attention to the role that latency plays in the capacity planning. We focus on a specific use-case: the metropolitan network that covers the Murcia - Alicante Spanish regions. Then, we propose a latency-aware multilayer service-chain allocation (LA-ML-SCA) algorithm to explore a range of maximum latency requirements and their impact on the resources for dimensioning the metropolitan network. We observe that design costs increase for low latency requirements as more data center facilities need to be spread to get closer to the network edge, reducing the economies of scale on the IT infrastructure. Subsequently, we review our recent joint computation of multi-site VNF placement and multilayer resource allocation in the deployment of a network service in a metro network. Specifically, a set of subroutines contained in LA-ML-SCA are experimentally validated in a network optimization-as-a-service architecture that assists an Open-Source MANO instance, virtual infrastructure managers and WAN controllers in a metro network test-bed.Grant numbers : Go2Edge - Engineering Future Edge Computing Networks, Systems and Services.@ 2020 IEEE. Personal use of this material is permitted. Permission from IEEE must be obtained for all other uses, in any current or future media, including reprinting/republishing this material for advertising or promotional purposes, creating new collective works, for resale or redistribution to servers or lists, or reuse of any copyrighted component of this work in other works

Clinical Efficacy and Safety of Fanhdi^®, a Plasma-Derived VWF/Factor VIII Concentrate, in von Willebrand Disease in Spain: A Retrospective Study

Objective: To evaluate the efficacy and safety of a plasma-derived factor VIII concentrate containing von Willebrand Factor (pdVWF/FVIII) in standard clinical practice in von Willebrand Disease (VWD) patients. Methods: A retrospective, multicentric, observational study of VWD patients treated with Fanhdi®, a pdVWF/FVIII concentrate, from January 2011 to December 2017 was conducted at 14 centers in Spain. Efficacy and safety were evaluated for acute bleeding episodes, for prevention of bleeding in surgeries, and for secondary long-term prophylaxis. Results: Seventy-two eligible patients, type 1, 2, 3 VWD (25%/38.9%/36.1%) were treated for spontaneous and traumatic bleeding (140 episodes, n = 41 patients), to prevent surgical bleeding (69 episodes, n = 43 patients); and for secondary long-term prophylaxis (18 programs, n = 13 patients). Replacement therapy with pdVWF/FVIII showed an excellent to good clinical efficacy in 96.7% of the bleeding episodes, 100% during surgical procedures and 100% during prophylaxis. No adverse events (AEs), nor serious AEs related to the product were observed. Conclusions: Fanhdi® was effective, safe and well tolerated in the management of bleeding episodes, the prevention of bleeding during surgeries, and for secondary long-term prophylaxis in VWD patientsThe author(s) disclosed receipt of the followingfinancial support forthe research, authorship, and/or publication of this article: This workwas supported by Grifols, manufacturer of the pdVWF/FVIII,Fanhdi

Reducing residual thrombotic risk in patients with peripheral artery disease : impact of the COMPASS trial

Altres ajuts: Writing and editorial assistance was funded by Bayer Hispania.Patients with peripheral artery disease (PAD) are at a high risk not only for the classical cardiovascular (CV) outcomes (major adverse cardiovascular events; MACE) but also for vascular limb events (major adverse limb events; MALE). Therefore, a comprehensive approach for these patients should include both goals. However, the traditional antithrombotic approach with only antiplatelet agents (single or dual antiplatelet therapy) does not sufficiently reduce the risk of recurrent thrombotic events. Importantly, the underlying cause of atherosclerosis in patients with PAD implies both platelet activation and the initiation and promotion of coagulation cascade, in which Factor Xa plays a key role. Therefore, to reduce residual vascular risk, it is necessary to address both targets. In the Cardiovascular Outcomes for People Using Anticoagulation Strategies (COMPASS) trial that included patients with stable atherosclerotic vascular disease, the rivaroxaban plus aspirin strategy (versus aspirin) markedly reduced the risk of both CV and limb outcomes, and related complications, with a good safety profile. In fact, the net clinical benefit outcome composed of MACE; MALE, including major amputation, and fatal or critical organ bleeding was significantly reduced by 28% with the COMPASS strategy, (hazard ratio: 0.72; 95% confidence interval: 0.59-0.87). Therefore, the rivaroxaban plus aspirin approach provides comprehensive protection and should be considered for most patients with PAD at high risk of such events

New Polyether Triterpenoids from Laurencia viridis and Their Biological Evaluation

The red seaweed Laurencia viridis is a rich source of secondary metabolites derived from squalene. New polyethers, such as iubol (2), 22-hydroxy-15(28)- dehydrovenustatriol (3), 1,2-dehydropseudodehydrothyrsiferol (4), and secodehydrothyrsiferol (5) have been isolated and characterized from this alga. The structures were determined through the interpretation of NMR spectroscopic data and the relative configuration was proposed on the basis of NOESY spectrum and biogenetic considerations. All new compounds exhibited significant cytotoxic activity against a panel of cancer cell lines