163 research outputs found

    Stripped of illusions? Exploring system justification processes in Capitalist and post-Communist societies

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    Sociologists and political scientists have often observed that citizens of Central and Eastern Europe express high levels of disillusionment with their social, economic and political systems, in comparison with citizens of Western capitalist societies. In this review, we analyze system legitimation and delegitimation in post-Communist societies from a social psychological perspective. We draw on system justification theory, which seeks to understand how, when and why people do (and do not) defend, bolster and justify existing social systems. We review some of the major tenets and findings of the theory and compare research on system-justifying beliefs and ideologies in traditionally Capitalist and post-Communist countries to determine: (1) whether there are robust differences in the degree of system justification in post-Communist and Capitalist societies, and (2) the extent to which hypotheses derived from system justification theory receive support in the post-Communist context. To this end, we summarize research findings from over 20 countries and cite previously unpublished data from a public opinion survey conducted in Poland. Our analysis confirms that there are lower levels of system justification in post-Communist countries. At the same time, we find that system justification possesses similar social and psychological antecedents, manifestations and consequences in the two types of societies. We offer potential explanations for these somewhat complicated patterns of results and conclude by addressing implications for theory and research on system justification and system change (or transition)

    A 4-wk high-fructose diet alters lipid metabolism without affecting insulin sensitivity or ectopic lipids in healthy humans

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    BACKGROUND: High fructose consumption is suspected to be causally linked to the epidemics of obesity and metabolic disorders. In rodents, fructose leads to insulin resistance and ectopic lipid deposition. In humans, the effects of fructose on insulin sensitivity remain debated, whereas its effect on ectopic lipids has never been investigated. OBJECTIVE: We assessed the effect of moderate fructose supplementation on insulin sensitivity (IS) and ectopic lipids in healthy male volunteers (n = 7). DESIGN: IS, intrahepatocellular lipids (IHCL), and intramyocellular lipids (IMCL) were measured before and after 1 and 4 wk of a high-fructose diet containing 1.5 g fructose . kg body wt(-1) . d(-1). Adipose tissue IS was evaluated from nonesterified fatty acid suppression, hepatic IS from suppression of hepatic glucose output (6,6-2H2-glucose), and muscle IS from the whole-body glucose disposal rate during a 2-step hyperinsulinemic euglycemic clamp. IHCL and IMCL were measured by 1H magnetic resonance spectroscopy. RESULTS: Fructose caused significant (P < 0.05) increases in fasting plasma concentrations of triacylglycerol (36%), VLDL-triacylglycerol (72%), lactate (49%), glucose (5.5%), and leptin (48%) without any significant changes in body weight, IHCL, IMCL, or IS. IHCL were negatively correlated with triacylglycerol after 4 wk of the high-fructose diet (r = -0.78, P < 0.05). CONCLUSION: Moderate fructose supplementation over 4 wk increases plasma triacylglycerol and glucose concentrations without causing ectopic lipid deposition or insulin resistance in healthy humans

    Using HbA1c to Diagnose Diabetes in the UC, Davis-Type 2 Diabetes Mellitus Rat Model

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    With disease progression, type 2 diabetes mellitus (T2DM) leads to debilitating complications arising from damage to nerves and blood vessels. Importantly, investigations focusing on T2DM progression have the capacity to distinguish individuals at greater risk for these severe complications through the identification of predictive biomarkers. Hence, the accurate diagnosis of T2DM is critical to such investigations. UC Davis (UCD) T2DM rats are born without diabetes and develop the disease over time with a similar pathophysiology to that in humans. This unique rat model allows researchers to investigate predictive biomarkers linked to the progression of T2D; however, such investigations require an accurate diagnosis of T2DM onset. PURPOSE: To determine the most accurate measure to diagnose T2DM using UCD-T2DM rats. METHODS: 10 male UCD-T2DM rats were used in this study. Glucose and HbA1c were measured weekly from the tail beginning at 16 wks of age (before onset) and continuing until 25 wks of age (all rats had become diabetic). These measures were taken under both fasted (8 hrs) and random conditions as well as in the morning (AM) and afternoon (PM). A two-way repeated measures ANOVA was run with condition [fasted (FG) vs random (RG)] and time (AM vs PM) as factors, followed by Holm Sidak post hoc analyses. In addition, growth curves were fit to the data for all rats to estimate the trajectories of RG and HbA1c. RESULTS: We found that RG was more variable compared to FG (FG: 116±46 vs RG: 216±94 mg/dL; n=10). However, HbA1c was stable across both conditions (fasted HbA1c: 6.0±0.8 vs random HbA1c: 6.0±1.0%; n=10). In addition, both FG and RG morning levels were significantly lower compared to afternoon (FG AM: 99±6 vs FG PM: 133±19 mg/dL; n=10; p0.05). In addition, the location on the growth curve where RG crossed 200 mg/dL (currently the most common diagnostic criteria used) corresponded to a HbA1c of 5.6%. CONCLUSION: A HbA1c of 5.6% may provide a more accurate measure to diagnose the onset of diabetes in the UCD-T2DM rat model

    The "lipid accumulation product" performs better than the body mass index for recognizing cardiovascular risk: a population-based comparison

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    BACKGROUND: Body mass index (BMI, kg/m(2)) may not be the best marker for estimating the risk of obesity-related disease. Consistent with physiologic observations, an alternative index uses waist circumference (WC) and fasting triglycerides (TG) concentration to describe lipid overaccumulation. METHODS: The WC (estimated population minimum 65 cm for men and 58 cm for women) and TG concentration from the third National Health and Nutrition Examination Survey (N = 9,180, statistically weighted to represent 100.05 million US adults) were used to compute a "lipid accumulation product" [LAP = (WC-65) × TG for men and (WC-58) × TG for women] and to describe the population distribution of LAP. LAP and BMI were compared as categorical variables and as log-transformed continuous variables for their ability to identify adverse levels of 11 cardiovascular risk factors. RESULTS: Nearly half of the represented population was discordant for their quartile assignments to LAP and BMI. When 23.54 million with ordinal LAP quartile > BMI quartile were compared with 25.36 million with ordinal BMI quartile > LAP quartile (regression models adjusted for race-ethnicity and sex) the former had more adverse risk levels than the latter (p < 0.002) for seven lipid variables, uric acid concentration, heart rate, systolic and diastolic blood pressure. Further adjustment for age did not materially alter these comparisons except for blood pressures (p > 0.1). As continuous variables, LAP provided a consistently more adverse beta coefficient (slope) than BMI for nine cardiovascular risk variables (p < 0.01), but not for blood pressures (p > 0.2). CONCLUSION: LAP (describing lipid overaccumulation) performed better than BMI (describing weight overaccumulation) for identifying US adults at cardiovascular risk. Compared to BMI, LAP might better predict the incidence of cardiovascular disease, but this hypothesis needs prospective testing

    Subverting space : Private, public and power in three Czechoslovak films from the 1960s and 70s

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    This paper focuses on three Czechoslovak films from the Communist era: two New Wave features, the Oscar-winning Ostre SledovanéVlaky/Closely Observed Trains (Jirí Menzel, 1966) and O Slavnosti A Hostech/The Party And The Guests (Jan Nĕmec, 1966), plus a key post-Prague Spring film, Ucho/The Ear (Karel Kachyňa, 1970). All three films were banned following the 1968 Soviet invasion. This paper considers the films in the light of their use of spatial constructions and narratives; it argues that the films’ inherent subversive content is primarily articulated through spatial strategies, which also provide the films with their main motivation. Specifically, the paper examines a filmic discourse of political and social subversion which hinges on the negotiation and appropriation of space. Starting from the notion that space is produced by social agency and interaction, and from Michael Foucault’s assertion that ‘we do not live inside a void, inside of which we could place individuals and things […] we live inside a set of relations’, this paper will look at the dynamic relationship of the films’ characters to their allotted spatial situations. At the same time, narrative and visual texts will be contextualized, by relating the films’ representation of private and public space to the national context in which the films were made.PostprintPeer reviewe

    Applications of Optical Spectroscopy to Protein Conformational Transitions

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    Where Are the Nanodrugs? An Industry Perspective on Development of Drug Products Containing Nanomaterials

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