“Desiderio in Search of a Master”: Desire and the Quest for Recognition in Angela Carter’s The Infernal Desire Machines of Doctor Hoffman

This essay examines the manner in which desire and Hegelian recognition intersect in Angela Carter’s 1972 novel, The Infernal Desire Machines of Doctor Hoffman. After providing a brief description of Hegel’s famous account of the interaction between the lord and the bondsman, the essay goes on to discuss the manner in which the novel invests the figure of the love-object with the potential to become an ideal master. The image of the reflecting eye, which recurs throughout Carter’s text, is then analyzed as an enactment of, and a commentary upon, the desiring gaze

Realising young children's rights: Researching conversations with rights respecting early childhood leaders

Children in the UK have been rights bearing citizens since ratification of the United Nations Convention on the Rights of the Child (UNCRC, 1991). Between 1996-2017 the Department of Education, published 5 iterations of a curriculum for children younger than statutory school age. Since 2006 compliance, of settings, with Early Years Foundation Stage (EYFS) has been mandatory. National, and international, reports record low levels of well-being and increasing levels of mental distress amongst children in the UK. Since publication of UNCRC a range of research practices which respect young children’s agency have been developed. These, divergent, trajectories rest on competing discourses; children as agents, children as performers. This professional study intertwines understanding rights respecting identities with the case for realising young children’s rights in early years settings. A catalyst for the research conversations was the author’s experience of rights disrespecting behaviours whilst a pupil, teacher and lecturer. Alongside the substantive foci the study responds to two questions; an entreaty from Goodson and Ball (1981), to integrate, ‘the biographical with the situational‘ when researching teachers’ lives and Mannion’s query from 2007 what, exactly, is it that childhood researchers are supposed to do in their empirical studies? The response of this study has been to fashion research conversations focused on the development and enactment of early years leaders’ rights respecting praxes.Set within an interpretative conceptual framework refining a respectful, responsive methodology was imperative. Following a practise interview research conversations provided an opportunity to two early years leaders to share formative experiences from their educational biographies to which they attribute the development of rights respecting values. Analysis of the conversations was undertaken using a bespoke, inductive process denoted by a metaphor of Egyptian rope-making. The rich, joint meaning making which characterised the conversations supported the value of integrating the biographical with the situational and indicated purposeful directions for supporting training, and qualified, early years educators in realising young children’s rights

“Desiderio in Search of a Master”: Desire and the Quest for Recognition in Angela Carter’s The Infernal Desire Machines of Doctor Hoffman

This essay examines the manner in which desire and Hegelian recognition intersect in Angela Carter’s 1972 novel, The Infernal Desire Machines of Doctor Hoffman. After providing a brief description of Hegel’s famous account of the interaction between the lord and the bondsman, the essay goes on to discuss the manner in which the novel invests the figure of the love-object with the potential to become an ideal master. The image of the reflecting eye, which recurs throughout Carter’s text, is then analyzed as an enactment of, and a commentary upon, the desiring gaze

An integrative review exploring the impact of Electronic Health Records (EHR) on the quality of nurse–patient interactions and communication

Aim. To explore how nurses' use of electronic health records impacts on the quality of nurse–patient interactions and communication. Design. An integrative review. Data sources. MEDLINE®, CINAHL®, PscyINFO, PubMed, BNI and Cochrane Library databases were searched for papers published between January 2005 and April 2022. Review methods. Following a comprehensive search, the studies were appraised using a tool appropriate to the study design. Data were extracted from the studies that met the inclusion criteria relating to sample characteristics, methods and the strength of evidence. Included empirical studies had to examine interactions or communication between a nurse and patient while electronic health records were being used in any healthcare setting. Findings were synthesized using a thematic approach. Results. One thousand nine hundred and twenty articles were initially identified but only eight met the inclusion criteria of this review. Thematic analysis revealed four key themes, indicating that EHR: impedes on face-to-face communication, promotes task-orientated and formulaic communication and impacts on types of communication patterns. Conclusion. Research examining nurse–patient interactions and communication when nurses' use electronic health records is limited but evidence suggests that closed nurse–patient communications, reflecting a task-driven approach, were predominantly used when nurses used electronic health records, although some nurses were able to overcome logistical barriers and communicate more openly. Nurses' use of electronic health records impacts on the flow, nature and quality of communication between a nurse and patient. Impact. The move to electronic health records has taken place largely without consideration of the impact that this might have on nurse–patient interaction and communication. There is evidence of impact but also evidence of how this might be mitigated. Nurses must focus future research on examining the impact that these systems have, and to develop strategies and practice that continue to promote the importance of nurse–patient interactions and communication. Patient or Public contribution. Studies examined within this review included patient participants that informed the analysis and interpretation of data

Patients’ experiences of attending an adapted cardiac rehabilitation programme for heart failure in a day hospice

Background. Heart Failure is highly prevalent with poor outcomes yet only a small proportion of patients receive specialist palliative care services. Aim. To explore if a programme focussing on support and symptom management of people with heart failure in a hospice environment would be acceptable and of benefit to patients. Methods: A pre/post intervention study design using mixed methods was used to evaluate the programme. The programme was delivered in two-hour time slots over a period of 8 weeks. Participants completed 3 questionnaires pre and post and were interviewed within one week of completion. The study was conducted between June 2014 and January 2015. Findings. A response rate of 51.7% gave a final sample size of 12 patients. The questionnaire results showed a positive impact on participants’ well-being and views regarding the use of a hospice, but a desire for greater focus on emotional support. Four key themes emerged from inductive qualitative analysis: demystifying perceptions about hospice; positivity about well-being; learning together and consideration of end of life preparation. Conclusion. This adapted programme provides a useful model for the increased integration of palliative care into the provisions for those living with advancing heart failure

Arterial spin labelling shows functional depression of non-lesion tissue in chronic Wernicke’s aphasia

Behavioural impairment post-stroke is a consequence of structural damage and altered functional network dynamics. Hypoperfusion of intact neural tissue is frequently observed in acute stroke, indicating reduced functional capacity of regions outside the lesion. However, cerebral blood flow is rarely investigated in chronic stroke. This study investigated cerebral blood flow in individuals with chronic Wernicke’s aphasia and examined the relationship between lesion, cerebral blood flow and neuropsychological impairment. Arterial spin labelling cerebral blood flow imaging and structural MRIs were collected in 12 individuals with chronic Wernicke’s aphasia and 13 age-matched control participants. Joint independent component analysis (jICA) investigated the relationship between structural lesion and hypoperfusion. Partial correlations explored the relationship between lesion, hypoperfusion and language measures. Joint ICA revealed significant differences between the control and WA groups reflecting a large area of structural lesion in the left posterior hemisphere and an associated area of hypoperfusion extending into grey matter surrounding the lesion. Small regions of remote cortical hypoperfusion were observed, ipsilateral and contralateral to the lesion. Significant correlations were observed between the neuropsychological measures (naming, repetition, reading and semantic association) and the jICA component of interest in the WA group. Additional ROI analyses found a relationship between perfusion surrounding the core lesion and the same neuropsychological measures

A 3D cellular context for the macromolecular world

We report the outcomes of the discussion initiated at the workshop entitled A 3D Cellular Context for the Macromolecular World and propose how data from emerging three-dimensional (3D) cellular imaging techniques—such as electron tomography, 3D scanning electron microscopy and soft X-ray tomography—should be archived, curated, validated and disseminated, to enable their interpretation and reuse by the biomedical community

Healthy ageing and depletion of intracellular glutathione influences T cell membrane thioredoxin-1 levels and cytokine secretion

Background: During ageing an altered redox balance has been observed in both intracellular and extracellular compartments, primarily due to glutathione depletion and metabolic stress. Maintaining redox homeostasis is important for controlling proliferation and apoptosis in response to specific stimuli for a variety of cells. For T cells, the ability to generate specific response to antigen is dependent on the oxidation state of cell surface and cytoplasmic protein-thiols. Intracellular thiols are maintained in their reduced state by a network of redox regulating peptides, proteins and enzymes such as glutathione, thioredoxins and thioredoxin reductase. Here we have investigated whether any relationship exists between age and secreted or cell surface thioredoxin-1, intracellular glutathione concentration and T cell surface thioredoxin 1 (Trx-1) and how this is related to interleukin (IL)-2 production.Results: Healthy older adults have reduced lymphocyte surface expression and lower circulating plasma Trx-1 concentrations. Using buthionine sulfoximine to deplete intracellular glutathione in Jurkat T cells we show that cell surface Trx-1 is lowered, secretion of Trx-1 is decreased and the response to the lectin phytohaemagglutinin measured as IL-2 production is also affected. These effects are recapitulated by another glutathione depleting agent, diethylmaleate.Conclusion: Together these data suggest that a relationship exists between the intracellular redox compartment and Trx-1 proteins. Loss of lymphocyte surface Trx-1 may be a useful biomarker of healthy ageing. © 2013 Carilho Torrao et al.; licensee Chemistry Central Ltd