A worldwide bibliometric analysis of malignant peripheral nerve sheath tumors from 2000 to 2022

BackgroundCurrently, malignant peripheral nerve sheath tumors (MPNST) are the subject of intense research interest. However, bibliometric studies have not been conducted in this field. The purpose of the study was to identify historical trends and presents a bibliometric analysis of the MPNST literature from 2000 to 2022.MethodsFor the bibliometric analysis, publications were retrieved from the Web of Science database based on the following search terms: [TI = (MPNST) OR TI= (malignant peripheral nerve sheath tumors) AND PY = (2000–2022)]. The following information was collected for each document: the publication trends and geographical distribution, important authors and collaboration, keyword distribution and evaluation, most popular journals, and most influential articles.ResultsWe included 1400 documents for bibliometric analysis, covering five categories: 824 articles, 17 proceedings papers, 68 letters, 402 meeting abstracts, and 89 reviews. Corrections, editorials, book chapters, data papers, publications with expressed concerns, and retractions were excluded from our research.ConclusionSince 2000, the number of publications on MPNST has continuously increased. Among all countries that contributed to the MPNST research, the USA, Japan, and China were the three most productive countries. The journal Modern Pathology has the most publications on MPNST, while those in the Cancer Research journal were the most frequently cited. The University of Texas MD Anderson Cancer Center may be a good partner to collaborate with. Recent research trends in MPNST have focused on tumorigenesis, clinical management, and predictive biomarkers

Design, synthesis and in vitro anti-Zika virus evaluation of novel Sinefungin derivatives

We report herein the design and synthesis of a series of novel Sinefungin (SIN) derivatives, based on the structures of SIN and its analogue EPZ004777. Our results reveal that target compounds 1ad-af, 1ba-bb and 1bf-bh show better activity (IC50 = 4.56–20.16 μM) than EPZ004777 (IC50 = 35.19 μM). Surprisingly, SIN was founded to be not as active (IC50 > 50 μM) as we and other research groups predicted. Interestingly, the intermediates 9a-b and 11b display potent anti-ZIKV potency (IC50 = 6.33–29.98 μM), and compound 9a also exhibits acceptable cytotoxicity (CC50 > 200 μM), suggesting their promising potential to be leads for further development

Robust estimation of bacterial cell count from optical density

Optical density (OD) is widely used to estimate the density of cells in liquid culture, but cannot be compared between instruments without a standardized calibration protocol and is challenging to relate to actual cell count. We address this with an interlaboratory study comparing three simple, low-cost, and highly accessible OD calibration protocols across 244 laboratories, applied to eight strains of constitutive GFP-expressing E. coli. Based on our results, we recommend calibrating OD to estimated cell count using serial dilution of silica microspheres, which produces highly precise calibration (95.5% of residuals <1.2-fold), is easily assessed for quality control, also assesses instrument effective linear range, and can be combined with fluorescence calibration to obtain units of Molecules of Equivalent Fluorescein (MEFL) per cell, allowing direct comparison and data fusion with flow cytometry measurements: in our study, fluorescence per cell measurements showed only a 1.07-fold mean difference between plate reader and flow cytometry data

High Electrocatalytic Activity of Silver-Doped Manganese Dioxide toward Oxygen Reduction Reaction in Aluminum-Air Battery

The development of the efficient and economical catalysts for the oxygen reduction reaction (ORR) is an important issue for the commercialization of metal-air batteries. Herein, a silver-doped d-MnO2 dispersed on carbon powder (Ag-MnO2/C) was synthesized by a facile route. The specific surface area of Ag-MnO2/C is more than three times higher than that of MnO2/C. Moreover, Ag-MnO2/C shows much higher catalytic activity toward ORR than MnO2/C or Ag/C. The half-wave potential of Ag-MnO2/C is much more positive compared with that of 20% Pt/C. Ag-MnO2/C also exhibits an excellent long-term stability and the ORR current retention keeps 97.1% after aging for 45000 s. Using Ag-MnO2/C as the ORR catalyst, the peak power density of Al-air battery reaches 315 mW cm(-2) which is almost the highest record. (C) 2017 The Electrochemical Society. All rights reserved

IDRiD: Diabetic Retinopathy – Segmentation and Grading Challenge

International audienc