Test techniques for evaluating flight displays

The rapid development of graphics technology allows for greater flexibility in aircraft displays, but display evaluation techniques have not kept pace. Historically, display evaluation has been based on subjective opinion and not on the actual aircraft/pilot performance. Existing electronic display specifications and evaluation techniques are reviewed. A display rating technique analogous to handling qualities ratings was developed and is recommended for future evaluations. The choice of evaluation pilots is also discussed and the use of a limited number of trained evaluators is recommended over the use of a large number of operational pilots

Earth Science and the Law of the Sea: Keys to Canada's Offshore Energy and Mineral Resources beyond 200 Nautical Miles

Article 76 of the United Nations Convention on the Law of the Sea allows Canada to establish sovereignty over resources of the seabed beyond the customary 200 nautical mile limit, when certain bathymetric and geological criteria are satisfied.This paper outlines the procedures for meeting those criteria, and describes the mutual benefits that can accrue to the earth sciences and the Law of the Sea through programs for collecting and analyzing the necessary data. In the Atlantic and Arctic oceans, this work could allow Canada to extend energy and mineral jurisdiction into seabed areas that approach the size of the three Prairie Provinces combined. Résumé L'article 76 de la Convention des Nations Unies sur le droit de la mer permet au Canada d'établir sa souveraineté sur les ressources des fonds marins au-delà de la limite bien connue des 200 miles nautiques, sous réserve de certains critères bathymétriques et géologiques. Le présent article décrit les procédures auxquelles il faut se plier, de même que les retombées positives qui découlent de la cueillette et l'analyse des données nécessaires, autant pour les sciences de la Terre que pour le droit de la mer. En ce qui a trait aux océans Atlantique et Arctique, le Canada pourrait voir sa juridiction s'appliquer à un territoire dont la dimension correspondrait à peu près à l'étendue des trois provinces des Prairies ensembles

Probing vibrational modes in silica glass using inelastic neutron scattering with mass contrast

The effective vibrational density of states (VDOS) has been derived from inelastic neutron-scattering data, for isotopically substituted Si O 18 2 and Si O 16 2 glasses, to gain information about the relative contribution to the Si and O partial VDOS. This is a necessary point of comparison for vibrational mode analyses of molecular-dynamics models. The mass contrast has led to a measurable shift between vibrational mode frequencies in the effective VDOS of Si O 18 2 and Si O 16 2, which is well reproduced in an ab initio simulation. The vibrational band centered at 100.2 meV is confirmed to have significantly lower contribution from the oxygen partial VDOS, than the higher (150.3 and 135.8 meV) and lower energy bands (53.3 meV)

Epigenome-wide profiling identifies significant differences in DNA methylation between matched-pairs of T- and B-lymphocytes from healthy individuals

Multiple reports now describe changes to the DNA methylome in rheumatoid arthritis and in many cases have analyzed methylation in mixed cell populations from whole blood. However, these approaches may preclude the identification of cell type-specific methylation, which may subsequently bias identification of disease-specific changes. To address this possibility, we conducted genome-wide DNA methylation profiling using HumanMethylation450 BeadChips to identify differences within matched pairs of T-lymphocytes and B-lymphocytes isolated from the peripheral blood of 10 healthy females. Array data were processed and differential methylation identified using NIMBL software. Validation of array data was performed by bisulfite Pyrosequencing. Genome-wide DNA methylation was initially determined by analysis of LINE-1 sequences and was higher in B-lymphocytes than matched T-lymphocytes (69.8 vs. 65.2%, p ≤ 0.01). Pairwise analysis identified 679 CpGs, representing 250 genes, which were differentially methylated between T-lymphocytes and B-lymphocytes. The majority of sites (76.6%) were hypermethylated in B-lymphocytes. Pyrosequencing of selected candidates confirmed the array data in all cases. Hierarchical clustering revealed perfect segregation of samples into two distinct clusters based on cell type. Differentially methylated genes showed enrichment for biological functions/pathways associated with leukocytes and T-lymphocytes. Our work for the first time shows that T-lymphocytes and B-lymphocytes possess intrinsic differences in DNA methylation within a restricted set of functionally-related genes. These data provide a foundation for investigating DNA methylation in diseases in which these cell types play important and distinct roles

A systematic review of the experience, occurrence, and controllability of flow states in elite sport

Objectives: This study aimed to provide an up-to-date summary of the literature on flow in elite sport, specifically relating to: (i) how flow is experienced; (ii) how these states occur; and (iii) the potential controllability of flow. Design: Systematic review. Methods: A comprehensive literature search of SPORTdiscus, PsycINFO, SAGE journals online, INGENTA connect, and Web of Knowledge was completed in August, 2011, and yielded 17 empirical studies published between 1992 and 2011. The primarily qualitative findings were analysed thematically and synthesised using a narrative approach. Results: Findings indicated that: (i) some flow dimensions appear to be experienced more consistently than others; (ii) key factors were consistently reported to induce or inhibit flow occurrence; and (iii) the perception that flow experiences could be controllable to some extent, and are not merely ‘coincidental’. Additionally, it is appears that physiology is also relevant in flow, and these experiences may be psychophysiological. Conclusions: Based on these findings, recommendations are made including the need for researchers to move from description to explanation of flow, the use of new methodologies, greater focus on the role of personality factors, and possible refinements of existing flow theory to be more specific to sport

Multiple Stellar Fly-Bys Sculpting the Circumstellar Architecture in RW Aurigae

We present high-resolution ALMA Band 6 and 7 observations of the tidally disrupted protoplanetary disks of the RW Aurigae binary. Our observations reveal the presence of additional tidal streams to the previously observed tidal arm around RW Aur A. The observed configuration of tidal streams surrounding RW Aur A and B is incompatible with a single star--disk tidal encounter, suggesting that the RW Aurigae system has undergone multiple fly-by interactions. We also resolve the circumstellar disks around RW Aur A and B, with CO radii of 58 au and 38 au consistent with tidal truncation, and 2.5 times smaller dust emission radii. The disks appear misaligned by 12$^{\circ}$ or 57$^{\circ}$. Using new photometric observations from the American Association of Variable Star Observers (AAVSO) and All Sky Automated Survey for SuperNovae (ASAS-SN) archives, we have also identified an additional dimming event of the primary that began in late 2017 and is currently ongoing. With over a century of photometric observations, we are beginning to explore the same spatial scales as ALMA

Participant acceptability of digital footprint data collection strategies:an exemplar approach to participant engagement and involvement in the ALSPAC birth cohort study

INTRODUCTION: Digital footprint records – the tracks and traces amassed by individuals as a result of their interactions with the internet, digital devices and services – can provide ecologically valid data on individual behaviours. These could enhance longitudinal population study databanks; but few UK longitudinal studies are attempting this. When using novel sources of data, study managers must engage with participants in order to develop ethical data processing frameworks that facilitate data sharing whilst safeguarding participant interests. OBJECTIVES: This paper aims to summarise the participant involvement approach used by the ALSPAC birth cohort study to inform the development of a framework for using linked participant digital footprint data, and provide an exemplar for other data linkage infrastructures. METHODS: The paper synthesises five qualitative forms of inquiry. Thematic analysis was used to code transcripts for common themes in relation to conditions associated with the acceptability of sharing digital footprint data for longitudinal research. RESULTS: We identified six themes: participant understanding; sensitivity of location data; concerns for third parties; clarity on data granularity; mechanisms of data sharing and consent; and trustworthiness of the organisation. For cohort members to consider the sharing of digital footprint data acceptable, they require information about the value, validity and risks; control over sharing elements of the data they consider sensitive; appropriate mechanisms to authorise or object to their records being used; and trust in the organisation. CONCLUSION: Realising the potential for using digital footprint records within longitudinal research will be subject to ensuring that this use of personal data is acceptable; and that rigorously controlled population data science benefiting the public good is distinguishable from the misuse and lack of personal control of similar data within other settings. Participant co-development informs the ethical-governance framework for these novel linkages in a manner which is acceptable and does not undermine the role of the trusted data custodian