Modelling Social Structures and Hierarchies in Language Evolution

Language evolution might have preferred certain prior social configurations over others. Experiments conducted with models of different social structures (varying subgroup interactions and the role of a dominant interlocutor) suggest that having isolated agent groups rather than an interconnected agent is more advantageous for the emergence of a social communication system. Distinctive groups that are closely connected by communication yield systems less like natural language than fully isolated groups inhabiting the same world. Furthermore, the addition of a dominant male who is asymmetrically favoured as a hearer, and equally likely to be a speaker has no positive influence on the disjoint groups.Comment: 14 pages, 3 figures, 1 table. In proceedings of AI-2010, The Thirtieth SGAI International Conference on Innovative Techniques and Applications of Artificial Intelligence, Cambridge, England, UK, 14-16 December 201

Campus Vol IV N 3

Hawk, Bob. Adventures of a Private Eye . Prose. 3. Gillies, Jean. The Fine Arts . Prose. 4. Hauser, Bill. After Hours Almanac . Prose. 5. Chase, Dick. Admirals of the Inland Lake . Prose. 6. Runkle, Pete. They Float Through the Air With the Greatest . Prose. 8. Barton, Rusty. Threads For the Female . Prose. 10. Crocker, Larry. Innocents Abroad . Prose. 11. Wilson, Bob. The Drums of Port Au Prince . Prose. 12. Johnston, Ed. Threads For the Male . Prose. 14. Kreuger, Ben. Column For Contributors . 15. Rounds, Dave. Untitled. Cartoon. 21. Taggart, Marilou. Nightmare . Poem. 22. Thompson, Rolan. Cover. Picture. 0. Cover, Frank and John Trimble. Campus Congratulates Emotion . Picture. 2. Rees, Tom. Our March Pin-Up Girl . Picture. 7. Rees, Tom. They Fly Through the Air With the Greatest . Picture. 8. McGlone, Joe and Tom Rees. Threads for Females . Picture. 10

Campus Vol IV N 2

Hodgson, Don. Big Red On The Radio . Prose. 2. Hauser, Bill. After Hours Almanac . Prose. 4. Ide, Don and Bob Porter. I Remember D-Day . Picture. 6. Hawk, Bob. The Shysters: Drama in The Counselor\u27s Office a la Hemingway . Prose. 7. McGlone, Joe and Tom Rees. Terpischore Takes Over . Picture. 8. Parker, Chris. Nuns Fret Not . Prose. 9. Johnston, Ed. Fashions For Men . Prose. 10. Barton, Rusty. Fashions For Women . Prose. 11. Matthews, Jack and Joe McGlone. Campus Congratulates . Picture. 12. Rossi, Bob. Doane * 9:55 . Picture. 14. Bedell, Barrie and John Hodges. Ballroom to Boudoir . 15. Anonymous. Calender Girls For \u2750 . Picture. 16. Wittich, Hugh. Prelude . Prose. 20. Chase, Dick. The Intramural Saga . Prose. 21. Kruger, Ben. Column For Contributors . Prose. 22. Taggart, Marilou. Leaves, Oh Man! . Poem. 22. Taggart, Marilou. Christmas Fugue . Poem. 22. Froth. Untitled. Prose. 24. Anonymous. Untitled. Cartoon. 24. Optekar, Pat. Polyphemis\u27 Wrath . Prose. 5

Seniors with Parkinson's Disease: Initial Medical Treatment

Parkinson's disease most often presents after age 60, and patients in this age group are best managed with levodopa therapy as the primary treatment modality. Unlike young-onset parkinsonism (onset <age 40), this older age group is much less prone to subsequent development of levodopa responsive instability (dyskinesias, fluctuations). When these problems do occur in seniors, they usually can be managed by medication adjustments. The treatment goal is to keep patients active and engaged; levodopa dosage should be guided by the patients' responses and not arbitrarily limited to low doses, which may compromise patients' lives

Implanted reuptake-deficient or wild-type dopaminergic neurons improve ON l-dopa dyskinesias without OFF-dyskinesias in a rat model of Parkinson's disease

OFF-l-dopa dyskinesias have been a surprising side-effect of intrastriatal foetal ventral mesencephalic transplantation in patients with Parkinson's disease. It has been proposed that excessive and unregulated dopaminergic stimulation of host post-synaptic striatal neurons by the grafts could be responsible for these dyskinesias. To address this issue we transplanted foetal dopaminergic neurons from mice lacking the dopamine transporter (DATKO) or from wild-type mice, into a rat model of Parkinson's disease and l-dopa-induced dyskinesias. Both wild-type and DATKO grafts reinnervated the host striatum to a similar extent, but DATKO grafts produced a greater and more diffuse increase in extra-cellular striatal dopamine levels. Interestingly, grafts containing wild-type dopaminergic neurons improved parkinsonian signs to a similar extent as DATKO grafts, but provided a more complete reduction of l-dopa induced dyskinesias. Neither DATKO nor wild-type grafts induced OFF-l-dopa dyskinesias. Behavioural and receptor autoradiography analyses demonstrated that DATKO grafts induced a greater normalization of striatal dopaminergic receptor supersensitivity than wild-type grafts. Both graft types induced a similar downregulation and normalization of PEnk and fosb/Δfosb in striatal neurons. In summary, DATKO grafts causing high and diffuse extra-cellular dompamine levels do not per se alter graft-induced recovery or produce OFF-l-dopa dyskinesias. Wild-type dopaminergic neurons appear to be the most effective neuronal type to restore function and reduce l-dopa-induced dyskinesias

Cross section predictions for hydrostatic and explosive burning

We review different models used for reactions involved in nuclear astrophysics. The reaction rate is defined for resonant as well as for non-resonant processes. For low-density nuclei, we describe the DWBA method, the potential model, the R-matrix method, and microscopic cluster models. The statistical model is developed for high-level densities. Details of calculations in the low- and high-density regimes are illustrated with new results concerning transfer reactions and level densities.Comment: 25 pages, 3 figures, invited article to appear in Nucl. Phys.

Specific Thiazolidinediones Inhibit Ovarian Cancer Cell Line Proliferation and Cause Cell Cycle Arrest in a PPARγ Independent Manner

Peroxisome Proliferator Activated Receptor gamma (PPARγ) agonists, such as the thiazolinediones (TZDs), have been studied for their potential use as cancer therapeutic agents. We investigated the effect of four TZDs--Rosiglitazone (Rosi), Ciglitazone (CGZ), Troglitazone (TGZ), and Pioglitazone (Pio)--on ovarian cancer cell proliferation, PPARγ expression and PPAR luciferase reporter activity. We explored whether TZDs act in a PPARγ dependent or independent manner by utilizing molecular approaches to inhibit or overexpress PPARγ activity.Treatment with CGZ or TGZ for 24 hours decreased proliferation in three ovarian cancer cell lines, Ovcar3, CaOv3, and Skov3, whereas Rosi and Pio had no effect. This decrease in Ovcar3 cell proliferation was due to a higher fraction of cells in the G(0)/G(1) stage of the cell cycle. CGZ and TGZ treatment increased apoptosis after 4 hours of treatment but not after 8 or 12 hours. Treatment with TGZ or CGZ increased PPARγ mRNA expression in Ovcar3 cells; however, protein levels were unchanged. Surprisingly, luciferase promoter assays revealed that none of the TZDs increased PPARγ activity. Overexpression of wild type PPARγ increased reporter activity. This was further augmented by TGZ, Rosi, and Pio indicating that these cells have the endogenous capacity to mediate PPARγ transactivation. To determine whether PPARγ mediates the TZD-induced decrease in proliferation, cells were treated with CGZ or TGZ in the absence or presence of a dominant negative (DN) or wild type overexpression PPARγ construct. Neither vector changed the TZD-mediated cell proliferation suggesting this effect of TZDs on ovarian cancer cells may be PPARγ independent.CGZ and TGZ cause a decrease in ovarian cancer cell proliferation that is PPARγ independent. This concept is supported by the finding that a DN or overexpression of the wild type PPARγ did not affect the changes in cell proliferation and cell cycle

Distribution of the Octopamine Receptor AmOA1 in the Honey Bee Brain

Octopamine plays an important role in many behaviors in invertebrates. It acts via binding to G protein coupled receptors located on the plasma membrane of responsive cells. Several distinct subtypes of octopamine receptors have been found in invertebrates, yet little is known about the expression pattern of these different receptor subtypes and how each subtype may contribute to different behaviors. One honey bee (Apis mellifera) octopamine receptor, AmOA1, was recently cloned and characterized. Here we continue to characterize the AmOA1 receptor by investigating its distribution in the honey bee brain. We used two independent antibodies produced against two distinct peptides in the carboxyl-terminus to study the distribution of the AmOA1 receptor in the honey bee brain. We found that both anti-AmOA1 antibodies revealed labeling of cell body clusters throughout the brain and within the following brain neuropils: the antennal lobes; the calyces, pedunculus, vertical (alpha, gamma) and medial (beta) lobes of the mushroom body; the optic lobes; the subesophageal ganglion; and the central complex. Double immunofluorescence staining using anti-GABA and anti-AmOA1 receptor antibodies revealed that a population of inhibitory GABAergic local interneurons in the antennal lobes express the AmOA1 receptor in the cell bodies, axons and their endings in the glomeruli. In the mushroom bodies, AmOA1 receptors are expressed in a subpopulation of inhibitory GABAergic feedback neurons that ends in the visual (outer half of basal ring and collar regions) and olfactory (lip and inner basal ring region) calyx neuropils, as well as in the collar and lip zones of the vertical and medial lobes. The data suggest that one effect of octopamine via AmOA1 in the antennal lobe and mushroom body is to modulate inhibitory neurons