156 research outputs found
Numerical simulation of non-Fickian transport in geological formations with multiple-scale heterogeneities
We develop a numerical method to model contaminant transport in heterogeneous geological formations. The method is based on a unified framework that takes into account the different levels of uncertainty often associated with characterizing heterogeneities at different spatial scales. It treats the unresolved, small-scale heterogeneities (residues) probabilistically using a continuous time random walk (CTRW) formalism and the largescale heterogeneity variations (trends) deterministically. This formulation leads to a Fokker-Planck equation with a memory term (FPME) and a generalized concentration flux term. The former term captures the non-Fickian behavior arising from the residues, and the latter term accounts for the trends, which are included with explicit treatment at the heterogeneity interfaces. The memory term allows a transition between non-Fickian and Fickian transport, while the coupling of these dynamics with the trends quantifies the unique nature of the transport over a broad range of temporal and spatial scales. The advection-dispersion equation (ADE) is shown to be a special case of our unified framework. The solution of the ADE is used as a reference for the FPME solutions for the same formation structure. Numerical treatment of the equations involves solution for the Laplace transformed concentration by means of classical finite element methods, and subsequent inversion in the time domain. We use the numerical method to quantify transport in a two-dimensional domain for different expressions for the memory term. The parameters defining these expressions are measurable quantities. The calculations demonstrate long tailing arising (principally) from the memory term and the effects on arrival times that are controlled largely by the generalized concentration flux term.Pubblicat
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Controlling Spatiotemporal Chaos in a Realistic El Niño Prediction Model
A method for controlling low-order chaotic behavior of continuous spatiotemporal systems is developed and demonstrated in a complex, realistic 3D partial differential equation model that is used successfully for predicting El Niño events in the equatorial Pacific. An unstable periodic orbit that involves a full-domain oscillation is stabilized using a feedback control applied to a single degree of freedom at a carefully chosen single “choke point” in space. A general criterion is presented for determining the optimal points in reconstructed delay-coordinate phase space at which to apply the feedback control.Earth and Planetary Science
Physical Pictures of Transport in Heterogeneous Media: Advection-Dispersion, Random Walk and Fractional Derivative Formulations
The basic conceptual picture and theoretical basis for development of
transport equations in porous media are examined. The general form of the
governing equations is derived for conservative chemical transport in
heterogeneous geological formations, for single realizations and for ensemble
averages of the domain. The application of these transport equations is focused
on accounting for the appearance of non-Fickian (anomalous) transport behavior.
The general ensemble-averaged transport equation is shown to be equivalent to a
continuous time random walk (CTRW) and reduces to the conventional forms of the
advection-dispersion equation (ADE) under highly restrictive conditions.
Fractional derivative formulations of the transport equations, both temporal
and spatial, emerge as special cases of the CTRW. In particular, the use in
this context of L{\'e}vy flights is critically examined. In order to determine
chemical transport in field-scale situations, the CTRW approach is generalized
to non-stationary systems. We outline a practical numerical scheme, similar to
those used with extended geological models, to account for the often important
effects of unresolved heterogeneities.Comment: 14 pages, REVTeX4, accepted to Wat. Res. Res; reference adde
Laboratory experiments on dispersive transport across interfaces: The role of flow direction
Abstract. We present experimental evidence of asymmetrical dispersive transport of a conservative tracer across interfaces between different porous materials. Breakthrough curves are measured for tracer pulses that migrate in a steady-state flow field through a column that contains adjacent segments of coarse and fine porous medium. The breakthrough curves show significant differences in behavior, with tracer migrating from fine medium to coarse medium arriving significantly faster than from coarse medium to fine medium. As the flow rate increases, the differences between the breakthrough curves diminish. We argue that this behavior indicates the occurrence of significant, time-dependent tracer accumulation in the resident concentration profile across the heterogeneity interface. Conventional modeling using the advection-dispersion equation is demonstrated to be unable to capture this asymmetric behavior. However, tracer accumulation at the interface has been observed in particle tracking simulations, which may be related to the asymmetry in the observed breakthrough curves
Laboratory experiments on dispersive transport across interfaces: The role of flow direction
We present experimental evidence of asymmetrical dispersive transport of a conservative tracer across interfaces between different porous materials. Breakthrough curves are measured for tracer pulses that migrate in a steady state flow field through a column that contains adjacent segments of coarse and fine porous media. The breakthrough curves show significant differences in behavior, with tracers migrating from fine medium to coarse medium arriving significantly faster than those from coarse medium to fine medium. As the flow rate increases, the differences between the breakthrough curves diminish. We argue that this behavior indicates the occurrence of significant, time-dependent tracer accumulation in the resident concentration profile across the heterogeneity interface. Conventional modeling using the advection-dispersion equation is demonstrated to be unable to capture this asymmetric behavior. However, tracer accumulation at the interface has been observed in particle-tracking simulations, which may be related to the asymmetry in the observed breakthrough curves
Anomalous transport in disordered fracture networks: Spatial Markov model for dispersion with variable injection modes
We investigate tracer transport on random discrete fracture networks that are characterized by the statistics of the fracture geometry and hydraulic conductivity. While it is well known that tracer transport through fractured media can be anomalous and particle injection modes can have major impact on dispersion, the incorporation of injection modes into effective transport modeling has remained an open issue. The fundamental reason behind this challenge is that-even if the Eulerian fluid velocity is steady-the Lagrangian velocity distribution experienced by tracer particles evolves with time from its initial distribution, which is dictated by the injection mode, to a stationary velocity distribution. We quantify this evolution by a Markov model for particle velocities that are equidistantly sampled along trajectories. This stochastic approach allows for the systematic incorporation of the initial velocity distribution and quantifies the interplay between velocity distribution and spatial and temporal correlation. The proposed spatial Markov model is characterized by the initial velocity distribution, which is determined by the particle injection mode, the stationary Lagrangian velocity distribution, which is derived from the Eulerian velocity distribution, and the spatial velocity correlation length, which is related to the characteristic fracture length. This effective model leads to a time-domain random walk for the evolution of particle positions and velocities, whose joint distribution follows a Boltzmann equation. Finally, we demonstrate that the proposed model can successfully predict anomalous transport through discrete fracture networks with different levels of heterogeneity and arbitrary tracer injection modes. © 2017 Elsevier Ltd.PKK and SL acknowledge a grant (16AWMP-
B066761-04) from the AWMP Program funded by the Ministry of Land,
Infrastructure and Transport of the Korean government and the support
from Future Research Program (2E27030) funded by the Korea Institute of
Science and Technology (KIST). PKK and RJ acknowledge a MISTI Global
Seed Funds award. MD acknowledges the support of the European Research
Council (ERC) through the project MHetScale (617511). TLB acknowledges
the support of European Research Council (ERC) through the project Re-
activeFronts (648377). RJ acknowledges the support of the US Department
of Energy through a DOE Early Career Award (grant DE-SC0009286). The
data to reproduce the work can be obtained from the corresponding author.N
Concentration of antibodies against Porphyromonas gingivalis is increased before the onset of symptoms of rheumatoid arthritis
The impact of viral mutations on recognition by SARS-CoV-2 specific T cells.
We identify amino acid variants within dominant SARS-CoV-2 T cell epitopes by interrogating global sequence data. Several variants within nucleocapsid and ORF3a epitopes have arisen independently in multiple lineages and result in loss of recognition by epitope-specific T cells assessed by IFN-γ and cytotoxic killing assays. Complete loss of T cell responsiveness was seen due to Q213K in the A∗01:01-restricted CD8+ ORF3a epitope FTSDYYQLY207-215; due to P13L, P13S, and P13T in the B∗27:05-restricted CD8+ nucleocapsid epitope QRNAPRITF9-17; and due to T362I and P365S in the A∗03:01/A∗11:01-restricted CD8+ nucleocapsid epitope KTFPPTEPK361-369. CD8+ T cell lines unable to recognize variant epitopes have diverse T cell receptor repertoires. These data demonstrate the potential for T cell evasion and highlight the need for ongoing surveillance for variants capable of escaping T cell as well as humoral immunity.This work is supported by the UK Medical Research Council (MRC); Chinese Academy of Medical Sciences(CAMS) Innovation Fund for Medical Sciences (CIFMS), China; National Institute for Health Research (NIHR)Oxford Biomedical Research Centre, and UK Researchand Innovation (UKRI)/NIHR through the UK Coro-navirus Immunology Consortium (UK-CIC). Sequencing of SARS-CoV-2 samples and collation of data wasundertaken by the COG-UK CONSORTIUM. COG-UK is supported by funding from the Medical ResearchCouncil (MRC) part of UK Research & Innovation (UKRI),the National Institute of Health Research (NIHR),and Genome Research Limited, operating as the Wellcome Sanger Institute. T.I.d.S. is supported by a Well-come Trust Intermediate Clinical Fellowship (110058/Z/15/Z). L.T. is supported by the Wellcome Trust(grant number 205228/Z/16/Z) and by theUniversity of Liverpool Centre for Excellence in Infectious DiseaseResearch (CEIDR). S.D. is funded by an NIHR GlobalResearch Professorship (NIHR300791). L.T. and S.C.M.are also supported by the U.S. Food and Drug Administration Medical Countermeasures Initiative contract75F40120C00085 and the National Institute for Health Research Health Protection Research Unit (HPRU) inEmerging and Zoonotic Infections (NIHR200907) at University of Liverpool inpartnership with Public HealthEngland (PHE), in collaboration with Liverpool School of Tropical Medicine and the University of Oxford.L.T. is based at the University of Liverpool. M.D.P. is funded by the NIHR Sheffield Biomedical ResearchCentre (BRC – IS-BRC-1215-20017). ISARIC4C is supported by the MRC (grant no MC_PC_19059). J.C.K.is a Wellcome Investigator (WT204969/Z/16/Z) and supported by NIHR Oxford Biomedical Research Centreand CIFMS. The views expressed are those of the authors and not necessarily those of the NIHR or MRC
Impact of Dissolved Organic Matter on Bacterial Tactic Motility, Attachment, and Transport
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