925 research outputs found

    Fostering collective intelligence education

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    New educational models are necessary to update learning environments to the digitally shared communication and information. Collective intelligence is an emerging field that already has a significant impact in many areas and will have great implications in education, not only from the side of new methodologies but also as a challenge for education. This paper proposes an approach to a collective intelligence model of teaching using Internet to combine two strategies: idea management and real time assessment in the class. A digital tool named Fabricius has been created supporting these two elements to foster the collaboration and engagement of students in the learning process. As a result of the research we propose a list of KPI trying to measure individual and collective performance. We are conscious that this is just a first approach to define which aspects of a class following a course can be qualified and quantified.Postprint (published version

    Intra-amniotic delivery of CFTR-expressing adenovirus does not reverse cystic fibrosis phenotype in inbred CFTR-knockout mice

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    This article is available open access through the publisher’s website at the link below. Copyright © 2008 The American Society of Gene Therapy.Due to its early onset and severe prognosis, cystic fibrosis (CF) has been suggested as a candidate disease for in utero gene therapy. In 1997, a study was published claiming that to how transient prenatal expression of CF transmembrane conductance regulator (CFTR) from an in utero –injected adenovirus vector could achieve permanent reversal of the CF intestinal pathology in adult CF knockout mice, despite the loss of CFTR transgene expression by birth. This would imply that the underlying cause of CF is a prenatal defect for which lifelong cure can be achieved by transient prenatal expression of CFTR. Despite criticism at the time of publication, no independent verification of this contentious finding has been published so far. This is vital for the development of future therapeutic strategies as it may determine whether CF gene therapy should be performed prenatally or postnatally. We therefore reinvestigated this finding with an identical adenoviral vector and a knockout CF mouse line (CftrtmlCam) with a completely inbred genetic background to eliminate any effects due to genetic variation. After delivery of the CFTR-expressing adenovirus to the fetal mouse, both vector DNA and transgenic CFTR expression were detected in treated animals postpartum but statistically no significant difference in survival was observed between the Cftr–/– mice treated with the CFTR-adenovirus and those treated with the control vector.Sport Aiding Medical Research for Kids, the Cystic Fibrosis Trust, and the Katharine Dormandy Trust

    The remnants of galaxy formation from a panoramic survey of the region around M31

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    In hierarchical cosmological models, galaxies grow in mass through the continual accretion of smaller ones. The tidal disruption of these systems is expected to result in loosely bound stars surrounding the galaxy, at distances that reach 10−10010 - 100 times the radius of the central disk. The number, luminosity and morphology of the relics of this process provide significant clues to galaxy formation history, but obtaining a comprehensive survey of these components is difficult because of their intrinsic faintness and vast extent. Here we report a panoramic survey of the Andromeda galaxy (M31). We detect stars and coherent structures that are almost certainly remnants of dwarf galaxies destroyed by the tidal field of M31. An improved census of their surviving counterparts implies that three-quarters of M31's satellites brighter than MV<−6M_V < -6 await discovery. The brightest companion, Triangulum (M33), is surrounded by a stellar structure that provides persuasive evidence for a recent encounter with M31. This panorama of galaxy structure directly confirms the basic tenets of the hierarchical galaxy formation model and reveals the shared history of M31 and M33 in the unceasing build-up of galaxies.Comment: Published in Nature. Supplementary movie available at https://www.astrosci.ca/users/alan/PANDAS/Latest%20news%3A%20movie%20of%20orbit.htm

    Assessing Fish and Motile Fauna around Offshore Windfarms Using Stereo Baited Video

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    There remains limited knowledge of how offshore windfarm developments influence fish assemblages, particularly at a local scale around the turbine structures. Considering the existing levels of anthropogenic pressures on coastal fish populations it is becoming increasingly important for developers and environmental regulators to gain a more comprehensive understanding of the factors influencing fish assemblages. Improving our ability to assess such fish populations in close proximity to structures will assist in increasing this knowledge. In the present study we provide the first trial use of Baited Remote Underwater Stereo-Video systems (stereo BRUVs) for the quantification of motile fauna in close proximity to offshore wind turbines. The study was conducted in the Irish Sea and finds the technique to be a viable means of assessing the motile fauna of such environments. The present study found a mixture of species including bottom dwellers, motile crustaceans and large predatory fish. The majority of taxa observed were found to be immature individuals with few adult individuals recorded. The most abundant species were the angular crab (Goneplax rhomboides) and the small-spotted catshark (Scyliorhinus canicula). Of note in this study was the generally low abundance and diversity of taxa recorded across all samples, we hypothesise that this reflects the generally poor state of the local fauna of the Irish Sea. The faunal assemblages sampled in close proximity to turbines were observed to alter with increasing distance from the structure, species more characteristic of hard bottom environments were in abundance at the turbines (e.g. Homarus gammarus, Cancer pagarus, Scyliorhinus spp.) and those further away more characteristic of soft bottoms (e.g. Norwegian Lobster). This study highlights the need for the environmental impacts of offshore renewables on motile fauna to be assessed using targeted and appropriate tools. Stereo BRUVs provide one of those tools, but like the majority of methods for sampling marine biota, they have limitations. We conclude our paper by providing a discussion of the benefits and limitations of using this BRUV technique for assessing fauna within areas close to offshore windfarms

    What we talk about when we talk about "global mindset": managerial cognition in multinational corporations

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    Recent developments in the global economy and in multinational corporations have placed significant emphasis on the cognitive orientations of managers, giving rise to a number of concepts such as “global mindset” that are presumed to be associated with the effective management of multinational corporations (MNCs). This paper reviews the literature on global mindset and clarifies some of the conceptual confusion surrounding the construct. We identify common themes across writers, suggesting that the majority of studies fall into one of three research perspectives: cultural, strategic, and multidimensional. We also identify two constructs from the social sciences that underlie the perspectives found in the literature: cosmopolitanism and cognitive complexity and use these two constructs to develop an integrative theoretical framework of global mindset. We then provide a critical assessment of the field of global mindset and suggest directions for future theoretical and empirical research

    The United Kingdoms Eurosceptic political economy

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    This article explores how a political economy approach can explicate recent events in the United Kingdom’s relation to the European Union. The proposition is that neither critical nor comparative approaches do justice to the extent to which British elites have sought to differentiate the UK from the EU. The UK is here understood as a Eurosceptic political economy, constructed in opposition to European integration and, in particular, Economic and Monetary. The article explores how we have witnessed a hardening of this Eurosceptic political economy in the context of the Eurozone crisis. The most distinctive feature of which, as seen in the referendum campaign, is the extent to which the economic case for withdrawal has been established as part of the mainstream of British political debate

    Chronic widespread bodily pain is increased among individuals with history of fracture:findings from UK Biobank

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    Acknowledgments This work was supported by grants from the Medical Research Council, British Heart Foundation, Arthritis Research UK, National Osteoporosis Society, International Osteoporosis Foundation, NIHR Southampton Biomedical Research Centre, University of Southampton and University Hospital Southampton NHS Foundation Trust, and NIHR Musculoskeletal Biomedical Research Unit, University of Oxford. This research has been conducted using the UK Biobank Resource. Compliance with ethical standards.Peer reviewedPublisher PD

    Ambipolar Electric Field and Potential in the Solar Wind Estimated from Electron Velocity Distribution Functions

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    The solar wind escapes from the solar corona and is accelerated, over a short distance, to its terminal velocity. The energy balance associated with this acceleration remains poorly understood. To quantify the global electrostatic contribution to the solar wind dynamics, we empirically estimate the ambipolar electric field (E∄) and potential (Ίr,∞). We analyze electron velocity distribution functions (VDFs) measured in the near-Sun solar wind between 20.3 RS and 85.3 RS by the Parker Solar Probe. We test the predictions of two different solar wind models. Close to the Sun, the VDFs exhibit a suprathermal electron deficit in the sunward, magnetic-field-aligned part of phase space. We argue that the sunward deficit is a remnant of the electron cutoff predicted by collisionless exospheric models. This cutoff energy is directly linked to Ίr,∞. Competing effects of E∄ and Coulomb collisions in the solar wind are addressed by the Steady Electron Runaway Model (SERM). In this model, electron phase space is separated into collisionally overdamped and underdamped regions. We assume that this boundary velocity at small pitch angles coincides with the strahl break-point energy, which allows us to calculate E∄. The obtained Ίr,∞ and E∄ agree well with theoretical expectations. They decrease with radial distance as power-law functions with indices αΊ = −0.66 and αE = −1.69. We finally estimate the velocity gained by protons from electrostatic acceleration, which equals 77% calculated from the exospheric models, and 44% from the SERM model

    The Radial Dependence of Proton-scale Magnetic Spectral Break in Slow Solar Wind during PSP Encounter 2

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    International audienceMagnetic field fluctuations in the solar wind are commonly observed to follow a power-law spectrum. Near proton-kinetic scales, a spectral break occurs that is commonly interpreted as a transition to kinetic turbulence. However, this transition is not yet entirely understood. By studying the scaling of the break with various plasma properties, it may be possible to constrain the processes leading to the onset of kinetic turbulence. Using data from the Parker Solar Probe, we measure the proton-scale break over a range of heliocentric distances, enabling a measurement of the transition from inertial to kinetic-scale turbulence under various plasma conditions. We find that the break frequency f(b) increases as the heliocentric distance r decreases in the slow solar wind following a power law of f(b) similar to r(-1.11). We also compare this to the characteristic plasma ion scales to relate the break to the possible physical mechanisms occurring at this scale. The ratio f(b)/f(c) (f(c) for Doppler-shifted ion cyclotron resonance scale) is close to unity and almost independent of plasma beta(p). While f(b)/f(p) (f(p) for Doppler-shifted proton thermal gyroradius) increases with beta(p) approaching to unity at larger beta(p), f(b)/f(d) (f(d) for Doppler-shifted proton inertial length) decreases with beta(p) from unity at small beta(p). Due to the large comparable Alfven and solar wind speeds, we analyze these results using both the standard and modified Taylor hypotheses, demonstrating the robust statistical results

    Cross Helicity Reversals in Magnetic Switchbacks

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    International audienceWe consider 2D joint distributions of normalized residual energy, sigma(r)(s, t), and cross helicity, sigma(c)(s, t), during one day of Parker Solar Probe's (PSP's) first encounter as a function of wavelet scale s. The broad features of the distributions are similar to previous observations made by Helios in slow solar wind, namely well-correlated and fairly Alfvenic wind, except for a population with negative cross helicity that is seen at shorter wavelet scales. We show that this population is due to the presence of magnetic switchbacks, or brief periods where the magnetic field polarity reverses. Such switchbacks have been observed before, both in Helios data and in Ulysses data in the polar solar wind. Their abundance and short timescales as seen by PSP in its first encounter is a new observation, and their precise origin is still unknown. By analyzing these MHD invariants as a function of the wavelet scale, we show that magnetohydrodynamic (MHD) waves do indeed follow the local mean magnetic field through switchbacks, with a net Elsasser flux propagating inward during the field reversal and that they, therefore, must be local kinks in the magnetic field and not due to small regions of opposite polarity on the surface of the Sun. Such observations are important to keep in mind as computing cross helicity without taking into account the effect of switchbacks may result in spurious underestimation of sigma(c) as PSP gets closer to the Sun in later orbits
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