Acknowledgments This work was supported by grants from the Medical Research Council, British Heart Foundation, Arthritis Research UK, National Osteoporosis Society, International Osteoporosis Foundation, NIHR Southampton Biomedical Research Centre, University of Southampton and University Hospital Southampton NHS Foundation Trust, and NIHR Musculoskeletal Biomedical Research Unit, University of Oxford. This research has been conducted using the UK Biobank Resource. Compliance with ethical standards.Peer reviewedPublisher PD

A Svedbom

AW Al-Allaf

Blair H. Smith

C Angeletti

Cyrus Cooper

D Buskila

F Wolfe

G Wynne-Jones

Gareth T. Jones

Gary J. Macfarlane

Georgia Ntani

GJ Macfarlane

GP Kurita

GT Jones

H Kasch

HI Andersson

IM Hunt

J McBeth

Karen Walker-Bone

KL Holliday

LM Arnold

LM Romero

MA Cimmino

N Harvey

N Torrance

NC Harvey

Nicholas C. Harvey

P Lyon

P Phillimore

S Satoh

SA McLean

SG Leveille

SR Crozier

Tannaze Tinati

W Ollier

Archives of Osteoporosis

PubMed

Summary: In this cross-sectional analysis of the UK Biobank cohort, a history of fracture was associated with increased risk of current widespread chronic pain. Purpose/Introduction: We aimed to test the hypothesis that a history of fracture is associated with reporting chronic widespread bodily pain (CWBP), using baseline data from the UK Biobank cohort, comprising 502,656 people aged 40–69 years. Methods: The case definition of current chronic widespread bodily pain was based on a response of ‘yes’ to the question ‘do you have pain all over the body?’ and ‘yes’ to ‘and have you experienced pain all over the body for more than 3 months?’ Multivariable Poisson regression with robust standard errors was used to test the relationship between fracture (occurring within 5 years prior to the baseline interview, and recorded by self-report) at the spine, hip, upper limb or lower limb and CWBP, adjusting for confounders. Results: Of 501,733 participants (mean age 56.5 years), 7130 individuals reported CWBP and 23,177 had a history of fracture affecting the upper limb, lower limb, spine and/or hip. Individuals with prior fracture were significantly more likely to report CWBP than those without. After adjustment for potential risk factors (age, gender, demographic, lifestyle and socioeconomic, and psychological), risk ratios were attenuated but remained statistically significant with a more than doubling of risk for CWBP with spine fractures in men (risk ratio (RR) 2.67, 95 % confidence interval (CI) 1.66–4.31; p &lt; 0.001) and women (RR 2.13, 95 % CI 1.35–3.37, p = 0.001) and with hip fractures in women (RR 2.19, 95 % CI 1.33–3.59; p = 0.002). Conclusions: In this cross-sectional analysis, previous fracture is associated with an increased likelihood of chronic widespread bodily pain, particularly with hip fractures in women, and spine fractures in both sexes. If replicated, these findings may help inform the identification of those most at risk of chronic widespread pain post-fracture, allowing preventative measures to be targeted.</p

Walker-Bone, Karen

Harvey, Nicholas C.

Ntani, Georgia

Tinati, Tannaze

Jones, Gareth T.

Smith, Blair H.

Macfarlane, Gary J.

Cooper, Cyrus

University of Dundee Online Publications

English

Chronic widespread bodily pain is increased among individuals with history of fracture:findings from UK Biobank

Springer - Publisher Connector

Chronic widespread bodily pain is increased among individuals with history of fracture: findings from UK Biobank

Acknowledgments This work was supported by grants from the Medical Research Council, British Heart Foundation, Arthritis Research UK, National Osteoporosis Society, International Osteoporosis Foundation, NIHR Southampton Biomedical Research Centre, University of Southampton and University Hospital Southampton NHS Foundation Trust, and NIHR Musculoskeletal Biomedical Research Unit, University of Oxford. This research has been conducted using the UK Biobank Resource. Compliance with ethical standards.Peer reviewe

Harvey, Nicholas C

Jones, Gareth T

Smith, Blair H

Macfarlane, Gary J

Aberdeen University Research

Chronic widespread bodily pain is increased among individuals with history of fracture : findings from UK Biobank

Crossref

SummaryIn this cross-sectional analysis of the UK Biobank cohort, a history of fracture was associated with increased risk of current widespread chronic pain.Purpose/ IntroductionWe aimed to test the hypothesis that a history of fracture is associated with reporting chronic widespread bodily pain (CWBP), using baseline data from the UK Biobank cohort, comprising 502,656 people aged 40-69 years. MethodsThe case definition of current chronic widespread bodily pain was based on a response of ‘yes’ to the questions: “do you have pain all over the body?” and ‘yes’ to “and have you experienced pain all over the body for more than 3 months?” Multivariable Poisson regression with robust standard errors was used to test the relationship between fracture (occurring within 5 years prior to the baseline interview, and recorded by self-report) at the spine, hip, upper limb or lower limb, and CWBP, adjusting for confounders. ResultsOf 501,733 participants (mean age 56.5 years), 7,130 individuals reported CWBP and 23,177 had a history of fracture affecting the upper limb, lower limb, spine and/or hip. Individuals with prior fracture were significantly more likely to report CWBP than those without. After adjustment for potential risk factors (age, gender, demographic, lifestyle and socioeconomic, and psychological), risk ratios were attenuated but remained statistically significant with a more than doubling of risk for CWBP with spine fractures in men (Risk ratio (RR) 2.67, 95% CI 1.66-4.31; p&lt;0.001) and women (RR 2.13, 95% CI 1.35-3.37, P=0.001) and with hip fractures in women (RR 2.19, 95% CI 1.33-3.59; p=0.002).ConclusionsIn this cross-sectional analysis, previous fracture is associated with an increased likelihood of chronic widespread bodily pain, particularly with hip fractures in women, and spine fractures in both sexes. If replicated, these findings may help inform the identification of those most at risk of chronic widespread pain post fracture, allowing preventative measures to be targeted

Walker-Bone, K.

Harvey, N.C.

Ntani, G.

Tinati, T.

Jones, G.T.

Smith, B.H.

Macfarlane, G.J.

Cooper, C.

Southampton (e-Prints Soton)

http://dx.doi.org/10.1007/s11657-015-0252-1

Chronic widespread bodily pain is increased among individuals with history of fracture:findings from UK Biobank

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University of Dundee Online Publications

Springer - Publisher Connector

Aberdeen University Research

University of Dundee Online Publications

Crossref

Southampton (e-Prints Soton)