Star and protoplanetary disk properties in Orion's suburbs

(Note: this is a shortened version of the original "structured" A&A format abstract.) We performed a large optical spectroscopic and photometric survey of the Lynds~1630N and 1641 clouds. We provide a catalog of 132 confirmed young stars in L1630N and 267 such objects in L1641. We identify 28 transition disk systems, 20 of which were previously unknown, as well as 42 new transition disk candidates for which we have broad-band photometry but no optical spectroscopy. We estimate mass accretion rates M_acc from the equivalent widths of the H_alpha, H_beta, and HeI 5876\AA emission lines, and find a dependence on stellar mass of M_acc propto Mstar^alpha, with alpha~3.1 in the subsolar mass range that we probe. An investigation of a large literature sample of mass accretion rate estimates yields a similar slope of alpha~2.8 in the subsolar regime, but a shallower slope of alpha~2.0 if the whole mass range of 0.04 M_sun-5 Msun is included. Among the transition disk objects, the fraction of stars that show significant accretion activity is relatively low compared to stars with still optically thick disks (26\pm11% vs. 57\pm6%, respectively). However, those transition disks that do show significant accretion have the same median accretion rate as normal optically thick disks of 3-4*10^{-9} M_sun/yr. We find that the ages of the transition disks and the WTTSs without disks are statistically indistinguishable, and both groups are significantly older than the CTTSs. These results argue against disk-binary interaction or gravitational instability as mechanisms causing a transition disk appearance. Our observations indicate that disk lifetimes in the clustered population are shorter than in the distributed population. We propose refined Halpha equivalent width criteria to distinguish WTTSs from CTTSs.Comment: 52 pages, 16 tables, 29 figures. Accepted by A&A. Table numbering error correcte

Site-specific Photocross-linking Reveals That SecGlp and TRAM Contact Different Regions of a Membrane-inserted Signal Sequence

A chemically charged amber suppressor tRNA was used to introduce the photoactivatable amino acid (Tmd)Phe at a selected position within the signal sequence of the secretory protein preprolactin. This allowed the interactions of the NH -terminal, the central, and the COOH-terminal regions of the signal sequence to be investigated during insertion into the membrane of the endoplasmic reticulum (ER). We found that different regions of the nascent chains were photocross-linked to different ER proteins. The TRAM protein (translocating chain-associating membrane protein) contacts the NHz-terminal region of the signal sequence while the mammalian Sec6lp contacts the hydrophobic core of the signal sequence and regions COOH-terminal of this. These results suggest that the ER translocation complex is composed of heterologous protein subunits which contadcti stinct regions of nascent polypeptides during their membrane insertion

Enhanced X-ray variability from V1647 Ori, the young star in outburst illuminating McNeil's Nebula

We report a ~38 ks X-ray observation of McNeil's Nebula obtained with XMM on 2004 April 4. V1647 Ori, the young star in outburst illuminating McNeil's Nebula, is detected with XMM and appears variable in X-rays. We investigate the hardness ratio variability and time variations of the event energy distribution with quantile analysis, and show that the large increase of the count rate from V1647 Ori observed during the second half of the observation is not associated with any large plasma temperature variations as for typical X-ray flares from young low-mass stars. X-ray spectral fitting shows that the bulk (~75%) of the intrinsic X-ray emission in the 0.5-8 keV energy band comes from a soft plasma component (0.9 keV) reminiscent of the X-ray spectrum of the classical T Tauri star TW Hya, for which X-ray emission is believed to be generated by an accretion shock onto the photosphere of a low-mass star. The hard plasma component (4.2 keV) contributes ~25% of the total X-ray emission, and can be understood only in the framework of plasma heating sustained by magnetic reconnection events. We find a hydrogen column density of NH=4.1E22 cm-2, which points out a significant excess of hydrogen column density compared to the value derived from optical/IR observations, consistent with the picture of the rise of a wind/jet unveiled from ground optical spectroscopy. The X-ray flux observed with XMM ranges from roughly the flux observed by Chandra on 2004 March 22 (~10 times greater than the pre-outburst X-ray flux) to a value two times greater than that caught by Chandra on 2004 March 7 (~200 times greater than the pre-outburst X-ray flux). We have investigated the possibility that V1647 Ori displays a periodic variation in X-ray brightness as suggested by the combined Chandra+XMM data set (abridged).Comment: 11 pages and 8 Figures. Accepted for publication by Astronomy & Astrophysic

The discontinuous nature of chromospheric activity evolution

Chromospheric activity has been thought to decay smoothly with time and, hence, to be a viable age indicator. Measurements in solar type stars in open clusters seem to point to a different conclusion: chromospheric activity undergoes a fast transition from Hyades level to that of the Sun after about 1 Gyr of main--sequence lifetime and any decaying trend before or after this transition must be much less significant than the short term variations.Comment: 6 pages, 1 figure, to be published in Astrophysics and Space Scienc

Metallicities and Radial Velocities of Five Open Clusters Including a New Candidate Member of the Monoceros Stream

Near infrared spectra of 133 red giant stars from ten Galactic open clusters and two Galactic globular clusters spanning 2.2 dex in metallicity and 11 Gyr in age are presented. We combine this sample with ten clusters from Cole and collaborators to investigate the Ca II triplet line strengths and their relation to cluster metallicity and position along the red giant branch. We show that characterizing the stellar surface gravity using Ks band photometry (relative to the horizontal branch) taken from the Two Micron All-Sky Survey allows for metallicity measurements at least as precise as those derived using V or I band data. This has the great advantage that uniform photometry and reliable astrometry is available for a large number of clusters. Using Ks band photometry also reduces the effect of differential reddening within a given cluster. We find no significant evidence for age or metallicity effects to the linear Ca II triplet - metallicity relationship over the small range in magnitudes studied when homogeneous reference metallicities are used. We derive the first spectroscopic metallicity and new radial velocity estimates for five open clusters: Berkeley 81, Berkeley 99, IC 1311, King 2, and NGC 7044. King 2 has an anomalous radial velocity compared with the local disk population. We discuss the possibility that it is part of the Monoceros tidal stream.Comment: 35 pages, 14 figures, 9 tables. Accepted for publication in MNRA

The 2022 World Health Organization Classification of Tumours of the Urinary System and Male Genital Organs-Part A: Renal, Penile, and Testicular Tumours.

The fifth edition of the World Health Organization (WHO) classification of urogenital tumours (WHO "Blue Book"), published in 2022, contains significant revisions. This review summarises the most relevant changes for renal, penile, and testicular tumours. In keeping with other volumes in the fifth edition series, the WHO classification of urogenital tumours follows a hierarchical classification and lists tumours by site, category, family, and type. The section "essential and desirable diagnostic criteria" included in the WHO fifth edition represents morphologic diagnostic criteria, combined with immunohistochemistry and relevant molecular tests. The global introduction of massive parallel sequencing will result in a diagnostic shift from morphology to molecular analyses. Therefore, a molecular-driven renal tumour classification has been introduced, taking recent discoveries in renal tumour genomics into account. Such novel molecularly defined epithelial renal tumours include SMARCB1-deficient medullary renal cell carcinoma (RCC), TFEB-altered RCC, Alk-rearranged RCC, and ELOC-mutated RCC. Eosinophilic solid and cystic RCC is a novel morphologically defined RCC entity. The diverse morphologic patterns of penile squamous cell carcinomas are grouped as human papillomavirus (HPV) associated and HPV independent, and there is an attempt to simplify the morphologic classification. A new chapter with tumours of the scrotum has been introduced. The main nomenclature of testicular tumours is retained, including the use of the term "germ cell neoplasia in situ" (GCNIS) for the preneoplastic lesion of most germ cell tumours and division from those not derived from GCNIS. Nomenclature changes include replacement of the term "primitive neuroectodermal tumour" by "embryonic neuroectodermal tumour" to separate these tumours clearly from Ewing sarcoma. The term "carcinoid" has been changed to "neuroendocrine tumour", with most examples in the testis now classified as "prepubertal type testicular neuroendocrine tumour"

An X-ray Outburst from the Rapidly Accreting Young Star That Illuminates McNeil's Nebula

Young, low-mass stars are luminous X-ray sources whose powerful X-ray flares may exert a profound influence over the process of planet formation. The origin of such emission is uncertain. Although many or perhaps most recently formed, low-mass stars emit X-rays as a consequence of solar-like coronal activity, it has also been suggested that X-ray emission may be a direct result of mass accretion onto the forming star. Here we report X-ray imaging spectroscopy observations which reveal a factor ~50 increase in the X-ray flux from a young star that is presently undergoing a spectacular optical/IR outburst. The outburst is thought to be due to the sudden onset of a phase of rapid accretion. The coincidence of a surge in X-ray brightness with the optical/IR eruption demonstrates that strongly enhanced high-energy emission from young stars can occur as a consequence of high accretion rates. We suggest that such accretion- enhanced X-ray emission from erupting young stars may be short-lived, because intense star-disk magnetospheric interactions are quenched rapidly by the subsequent accretion flood.Comment: 15 pages, 3 figures; published in Natur

WHO Classification of Tumours fifth edition: evolving issues in the classification, diagnosis, and prognostication of prostate cancer

The fifth edition of the WHO Classification of Tumours of the Urinary and Male Genital Systems encompasses several updates to the classification and diagnosis of prostatic carcinoma as well as incorporating advancements in the assessment of its prognosis, including recent grading modifications. Some of the salient aspects include: (1) recognition that prostatic intraepithelial neoplasia (PIN)-like carcinoma is not synonymous with a pattern of ductal carcinoma, but better classified as a subtype of acinar adenocarcinoma; (2) a specific section on treatment-related neuroendocrine prostatic carcinoma in view of the tight correlation between androgen deprivation therapy and the development of prostatic carcinoma with neuroendocrine morphology, and the emerging data on lineage plasticity; (3) a terminology change of basal cell carcinoma to "adenoid cystic (basal cell) cell carcinoma" given the presence of an underlying MYB::NFIB gene fusion in many cases; (4) discussion of the current issues in the grading of acinar adenocarcinoma and the prognostic significance of cribriform growth patterns; and (5) more detailed coverage of intraductal carcinoma of prostate (IDC-P) reflecting our increased knowledge of this entity, while recommending the descriptive term atypical intraductal proliferation (AIP) for lesions falling short of IDC-P but containing more atypia than typically seen in high-grade prostatic intraepithelial neoplasia (HGPIN). Lesions previously regarded as cribriform patterns of HGPIN are now included in the AIP category. This review discusses these developments, summarising the existing literature, as well as the emerging morphological and molecular data that underpins the classification and prognostication of prostatic carcinoma. Keywords: WHO Classification; pathology; prostate carcinoma

Historical Temperature Variability Affects Coral Response to Heat Stress

Coral bleaching is the breakdown of symbiosis between coral animal hosts and their dinoflagellate algae symbionts in response to environmental stress. On large spatial scales, heat stress is the most common factor causing bleaching, which is predicted to increase in frequency and severity as the climate warms. There is evidence that the temperature threshold at which bleaching occurs varies with local environmental conditions and background climate conditions. We investigated the influence of past temperature variability on coral susceptibility to bleaching, using the natural gradient in peak temperature variability in the Gilbert Islands, Republic of Kiribati. The spatial pattern in skeletal growth rates and partial mortality scars found in massive Porites sp. across the central and northern islands suggests that corals subject to larger year-to-year fluctuations in maximum ocean temperature were more resistant to a 2004 warm-water event. In addition, a subsequent 2009 warm event had a disproportionately larger impact on those corals from the island with lower historical heat stress, as indicated by lower concentrations of triacylglycerol, a lipid utilized for energy, as well as thinner tissue in those corals. This study indicates that coral reefs in locations with more frequent warm events may be more resilient to future warming, and protection measures may be more effective in these regions