16 research outputs found
Incidence and Etiology of Drug-Induced Liver Injury in Mainland China
Background & Aims: We performed a nationwide, retrospective study to determine the incidence and causes of drug-induced liver injury (DILI) in mainland China.Methods: We collected data on a total of 25,927 confirmed DILI cases, hospitalized from 2012 through 2014 at 308 medical centers in mainland China. We collected demographic, medical history, treatment, laboratory, disease severity, and mortality data from all patients. Investigators at each site were asked to complete causality assessments for each case whose diagnosis at discharge was DILI (n=29,478) according to the Roussel Uclaf Causality Assessment Method.Results: Most cases of DILI presented with hepatocellular injury (51.39%; 95% CI, 50.76â52.03), followed by mixed injury (28.30%; 95% CI, 27.73â28.87) and cholestatic injury (20.31%; 95% CI, 19.80â20.82). The leading single classes of implicated drugs were traditional Chinese medicines or herbal and dietary supplements (26.81%) and anti-tuberculosis medications (21.99%). Chronic DILI occurred in 13.00% of the cases and, although 44.40% of the hepatocellular DILI cases fulfilled Hyâs Law criteria, only 280 cases (1.08%) progressed to hepatic failure, 2 cases underwent liver transplantation (0.01%), and 102 patients died (0.39%). Among deaths, DILI was judged to have a primary role in 72 (70.59%), a contributory role in 21 (20.59%), and no role in 9 (8.82%). Assuming the proportion of DILI in the entire hospitalized population of China was represented by that observed in the 66 centers where DILI capture was complete, we estimated the annual incidence in the general population to be 23.80 per 100,000 persons (95% CI, 20.86â26.74). Only hospitalized patients were included in this analysis, so the true incidence is likely to be higher.Conclusions: In a retrospective study to determine the incidence and causes of drug-induced liver injury (DILI) in mainland China, the annual incidence in the general population was estimated to be 23.80 per 100,000 personsâhigher than that reported from western countries. Traditional Chinese medicines, herbal and dietary supplements, and anti-tuberculosis drugs were the leading causes of DILI in mainland Chin
Growth and characterization of high-Curie temperature Pb(Lu1/2Nb1/2)O3âPb(Mg1/3Nb2/3)O3âPbTiO3 ternary single crystal by modified Bridgman technique
Urban CO2 emissions in Xiâan and Bangalore by commuters: implications for controlling urban transportation carbon dioxide emissions in developing countries
Thermal Stability of Zone Melting p-Type (Bi, Sb)2Te3 Ingots and Comparison with the Corresponding Powder Metallurgy Samples
Early Palaeozoic high-pressure granulites from the Dunhuang block, northeastern Tarim Craton: constraints on continental collision in the southern Central Asian Orogenic Belt
Public perceptions and preferences regarding lawns and their alternatives in China: A case study of Xiâan
Profiles of antibiotic resistome with animal manure application in black soils of northeast China
Evaluation on exposures to particulate matter at a junior secondary school: a comprehensive study on health risks and effective inflammatory responses in Northwestern China
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