463 research outputs found
Vestibular Stimulation for ADHD: Randomized Controlled Trial of Comprehensive Motion Apparatus
Objective:
This research evaluates effects of vestibular stimulation by Comprehensive Motion Apparatus
(CMA) in ADHD.
Method:
Children ages 6 to 12 (48 boys, 5 girls) with ADHD were randomized to thrice-weekly 30-min
treatments for 12 weeks with CMA, stimulating otoliths and semicircular canals, or a single-blind control of
equal duration and intensity, each treatment followed by a 20-min typing tutorial.
Results:
In intent-to-treat analysis (n = 50), primary outcome improved significantly in both groups (p =
.0001, d = 1.09 to 1.30), but treatment difference not significant (p = .7). Control children regressed by
follow-up (difference p = .034, d = 0.65), but overall difference was not significant (p = .13, d = .47). No
measure showed significant treatment differences at treatment end, but one did at follow-up. Children with
IQ-achievement discrepancy ≥ 1 SD showed significantly more CMA advantage on three measures.
Conclusion:
This study illustrates the importance of a credible control condition of equal duration and intensity
in trials of novel treatments. CMA treatment cannot be recommended for combined-type ADHD without
learning disorder
Power Law Scaling for a System of Interacting Units with Complex Internal Structure
We study the dynamics of a system composed of interacting units each with a
complex internal structure comprising many subunits. We consider the case in
which each subunit grows in a multiplicative manner. We propose a model for
such systems in which the interaction among the units is treated in a mean
field approximation and the interaction among subunits is nonlinear. To test
the model, we identify a large data base spanning 20 years, and find that the
model correctly predicts a variety of empirical results.Comment: 4 pages with 4 postscript figures (uses Revtex 3.1, Latex2e,
multicol.sty, epsf.sty and rotate.sty). Submitted to PR
Mental health, well-being, and experiences of the COVID-19 pandemic: a mixed methods practice-based study
First author draf
Universal features in the growth dynamics of complex organizations
We analyze the fluctuations in the gross domestic product (GDP) of 152
countries for the period 1950--1992. We find that (i) the distribution of
annual growth rates for countries of a given GDP decays with ``fatter'' tails
than for a Gaussian, and (ii) the width of the distribution scales as a power
law of GDP with a scaling exponent . Both findings are in
surprising agreement with results on firm growth. These results are consistent
with the hypothesis that the evolution of organizations with complex structure
is governed by similar growth mechanisms.Comment: 4 pages, 7 ps figures, using Latex2e with epsf rotate and multicol
style files. Submitted to PR
Rare Charm Decays in the Standard Model and Beyond
We perform a comprehensive study of a number of rare charm decays,
incorporating the first evaluation of the QCD corrections to the short distance
contributions, as well as examining the long range effects. For processes
mediated by the transitions, we show that sensitivity to
short distance physics exists in kinematic regions away from the vector meson
resonances that dominate the total rate. In particular, we find that
and are sensitive to non-universal
soft-breaking effects in the Minimal Supersymmetric Standard Model with
R-parity conservation. We separately study the sensitivity of these modes to
R-parity violating effects and derive new bounds on R-parity violating
couplings. We also obtain predictions for these decays within extensions of the
Standard Model, including extensions of the Higgs, gauge and fermion sectors,
as well as models of dynamical electroweak symmetry breaking.Comment: 45 pages, typos fixed, discussions adde
Impaired expression of metallothioneins contributes to allergen-induced inflammation in patients with atopic dermatitis
Regulation of cutaneous immunity is severely compromised in inflammatory skin disease. To investigate the molecular crosstalk underpinning tolerance versus inflammation in atopic dermatitis, we utilise a human in vivo allergen challenge study, exposing atopic dermatitis patients to house dust mite. Here we analyse transcriptional programmes at the population and single cell levels in parallel with immunophenotyping of cutaneous immunocytes revealed a distinct dichotomy in atopic dermatitis patient responsiveness to house dust mite challenge. Our study shows that reactivity to house dust mite was associated with high basal levels of TNF-expressing cutaneous Th17 T cells, and documents the presence of hub structures where Langerhans cells and T cells co-localised. Mechanistically, we identify expression of metallothioneins and transcriptional programmes encoding antioxidant defences across all skin cell types, that appear to protect against allergen-induced inflammation. Furthermore, single nucleotide polymorphisms in the MTIX gene are associated with patients who did not react to house dust mite, opening up possibilities for therapeutic interventions modulating metallothionein expression in atopic dermatitis
Climate Science Special Report: Fourth National Climate Assessment (NCA4), Volume I
New observations and new research have increased our understanding of past, current, and future climate change since the Third U.S. National Climate Assessment (NCA3) was published in May 2014. This Climate Science Special Report (CSSR) is designed to capture that new information and build on the existing body of science in order to summarize the current state of knowledge and provide the scientific foundation for the Fourth National Climate Assessment (NCA4)
Towards an Economy of Higher Education
This paper draws a distinction between ways thinking and acting, and hence of policy and practice in higher education, in terms of different kinds of economy: economies of exchange and economies of excess. Crucial features of economies of exchange are outlined and their presence in prevailing conceptions of teaching and learning is illustrated. These are contrasted with other possible forms of practice, which in turn bring to light the nature of an economy of excess. In more philosophical terms, and to expand on the picture, economies of excess are elaborated with reference, first, to the understanding of alterity in the work of Emmanuel Levinas and, second, to the idea of Dionysian intensity that is to be found in Nietzsche. In the light of critical comment on some current directions in policy and practice, the implications of these ways of thinking for the administrator, the teacher and the student in higher education are explored
The Seventh Data Release of the Sloan Digital Sky Survey
This paper describes the Seventh Data Release of the Sloan Digital Sky Survey
(SDSS), marking the completion of the original goals of the SDSS and the end of
the phase known as SDSS-II. It includes 11663 deg^2 of imaging data, with most
of the roughly 2000 deg^2 increment over the previous data release lying in
regions of low Galactic latitude. The catalog contains five-band photometry for
357 million distinct objects. The survey also includes repeat photometry over
250 deg^2 along the Celestial Equator in the Southern Galactic Cap. A
coaddition of these data goes roughly two magnitudes fainter than the main
survey. The spectroscopy is now complete over a contiguous area of 7500 deg^2
in the Northern Galactic Cap, closing the gap that was present in previous data
releases. There are over 1.6 million spectra in total, including 930,000
galaxies, 120,000 quasars, and 460,000 stars. The data release includes
improved stellar photometry at low Galactic latitude. The astrometry has all
been recalibrated with the second version of the USNO CCD Astrograph Catalog
(UCAC-2), reducing the rms statistical errors at the bright end to 45
milli-arcseconds per coordinate. A systematic error in bright galaxy photometr
is less severe than previously reported for the majority of galaxies. Finally,
we describe a series of improvements to the spectroscopic reductions, including
better flat-fielding and improved wavelength calibration at the blue end,
better processing of objects with extremely strong narrow emission lines, and
an improved determination of stellar metallicities. (Abridged)Comment: 20 pages, 10 embedded figures. Accepted to ApJS after minor
correction
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Evidence for changes in stratospheric transport and mixing over the past three decades based on multiple data sets and tropical leaky pipe analysis
Variability in the strength of the stratospheric Lagrangian mean meridional or Brewer-Dobson circulation and horizontal mixing into the tropics over the past three decades are examined using observations of stratospheric mean age of air and ozone. We use a simple representation of the stratosphere, the tropical leaky pipe (TLP) model, guided by mean meridional circulation and horizontal mixing changes in several reanalyses data sets and chemistry climate model (CCM) simulations, to help elucidate reasons for the observed changes in stratospheric mean age and ozone. We find that the TLP model is able to accurately simulate multiyear variability in ozone following recent major volcanic eruptions and the early 2000s sea surface temperature changes, as well as the lasting impact on mean age of relatively short-term circulation perturbations. We also find that the best quantitative agreement with the observed mean age and ozone trends over the past three decades is found assuming a small strengthening of the mean circulation in the lower stratosphere, a moderate weakening of the mean circulation in the middle and upper stratosphere, and a moderate increase in the horizontal mixing into the tropics. The mean age trends are strongly sensitive to trends in the horizontal mixing into the tropics, and the uncertainty in the mixing trends causes uncertainty in the mean circulation trends. Comparisons of the mean circulation and mixing changes suggested by the measurements with those from a recent suite of CCM runs reveal significant differences that may have important implications on the accurate simulation of future stratospheric climate
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