Analog signal integration and reconstruction system Patent

Data acquisition system for converting displayed analog signal to digital value

High speed television camera system processes photographic film data for digital computer analysis

Data acquisition system translates and processes graphical information recorded on high speed photographic film. It automatically scans the film and stores the information with a minimal use of the computer memory

Prominence-cavity regions observed using SWAP 174A filtergrams and simultaneous eclipse flash spectra

Images from the SWAP (Proba 2 mission) taken at 174A in the Fe IX/X lines are compared to simultaneous slitless flash spectra taken during the last solar total eclipse of July, 11th 2010. Many faint low excitation emission lines together with the HeI and HeII Paschen Alpha chromospheric lines are recorded on eclipse spectra where regions of limb prominences are obtained with space-borne imagers. We consider a deep flash spectrum obtained by summing 80 individual spectra to show the intensity modulations of the continuum. Intensity depressions are observed around the prominences in both eclipse and SWAP images. The prominence cavities are interpreted as a relative depression of plasma density, produced inside the corona surrounding the prominences. Photometric measurements are shown at different scales and different, spectrally narrow, intervals for both the prominences and the coronal background.Comment: 22 pages, 14 figures, accepted to publish in Sol. Phy

Sudden cardiac death athletes: a systematic review

Previous events evidence that sudden cardiac death (SCD) in athletes is still a reality and it keeps challenging cardiologists. Considering the importance of SCD in athletes and the requisite for an update of this matter, we endeavored to describe SCD in athletes. The Medline (via PubMed) and SciELO databases were searched using the subject keywords "sudden death, athletes and mortality". The incidence of SCD is expected at one case for each 200,000 young athletes per year. Overall it is resulted of complex dealings of factors such as arrhythmogenic substrate, regulator and triggers factors. In great part of deaths caused by heart disease in athletes younger than 35 years old investigations evidence cardiac congenital abnormalities. Athletes above 35 years old possibly die due to impairments of coronary heart disease, frequently caused by atherosclerosis. Myocardial ischemia and myocardial infarction are responsible for the most cases of SCD above this age (80%). Pre-participatory athletes' evaluation helps to recognize situations that may put the athlete's life in risk including cardiovascular diseases. In summary, cardiologic examinations of athletes' pre-competition routine is an important way to minimize the risk of SCD

Origins of the Ambient Solar Wind: Implications for Space Weather

The Sun's outer atmosphere is heated to temperatures of millions of degrees, and solar plasma flows out into interplanetary space at supersonic speeds. This paper reviews our current understanding of these interrelated problems: coronal heating and the acceleration of the ambient solar wind. We also discuss where the community stands in its ability to forecast how variations in the solar wind (i.e., fast and slow wind streams) impact the Earth. Although the last few decades have seen significant progress in observations and modeling, we still do not have a complete understanding of the relevant physical processes, nor do we have a quantitatively precise census of which coronal structures contribute to specific types of solar wind. Fast streams are known to be connected to the central regions of large coronal holes. Slow streams, however, appear to come from a wide range of sources, including streamers, pseudostreamers, coronal loops, active regions, and coronal hole boundaries. Complicating our understanding even more is the fact that processes such as turbulence, stream-stream interactions, and Coulomb collisions can make it difficult to unambiguously map a parcel measured at 1 AU back down to its coronal source. We also review recent progress -- in theoretical modeling, observational data analysis, and forecasting techniques that sit at the interface between data and theory -- that gives us hope that the above problems are indeed solvable.Comment: Accepted for publication in Space Science Reviews. Special issue connected with a 2016 ISSI workshop on "The Scientific Foundations of Space Weather." 44 pages, 9 figure

Multiobjective Design Optimization using Nash Games

International audienceIn the area of pure numerical simulation of multidisciplinary coupled systems, the computational cost to evaluate a configuration may be very high. A fortiori, in multi- disciplinary optimization, one is led to evaluate a number of different configurations to iterate on the design parameters. This observation motivates the search for the most in- novative and computationally efficient approaches in all the sectors of the computational chain : at the level of the solvers (using a hierarchy of physical models), the meshes and geometrical parameterizations for shape, or shape deformation, the implementation (on a sequential or parallel architecture; grid computing), and the optimizers (deterministic or semi-stochastic, or hybrid; synchronous, or asynchronous). In the present approach, we concentrate on situations typically involving a small number of disciplines assumed to be strongly antagonistic, and a relatively moderate number of related objective functions. However, our objective functions are functionals, that is, PDE-constrained, and thus costly to evaluate. The aerodynamic and structural optimization of an aircraft configuration is a prototype of such a context, when these disciplines have been reduced to a few major objectives. This is the case when, implicitly, many subsystems are taken into account by local optimizations. Our developments are focused on the question of approximating the Pareto set in cases of strongly-conflicting disciplines. For this purpose, a general computational technique is proposed, guided by a form of sensitivity analysis, with the additional objective to be more economical than standard evolutionary approaches

Tamoxifen metabolism predicts drug concentrations and outcome in premenopausal patients with early breast cancer

Tamoxifen is the standard-of-care treatment for estrogen receptor-positive premenopausal breast cancer. We examined tamoxifen metabolism via blood metabolite concentrations and germline variations of CYP3A5, CYP2C9, CYP2C19 and CYP2D6 in 587 premenopausal patients (Asians, Middle Eastern Arabs, Caucasian-UK; median age 39 years) and clinical outcome in 306 patients. N-desmethyltamoxifen (DM-Tam)/(Z)-endoxifen and CYP2D6 phenotype significantly correlated across ethnicities (R2: 53%, P<10?77). CYP2C19 and CYP2C9 correlated with norendoxifen and (Z)-4-hydroxytamoxifen concentrations, respectively (P<0.001). DM-Tam was influenced by body mass index (P<0.001). Improved distant relapse-free survival (DRFS) was associated with decreasing DM-Tam/(Z)-endoxifen (P=0.036) and increasing CYP2D6 activity score (hazard ratio (HR)=0.62; 95% confidence interval (CI), 0.43–0.91; P=0.013). Low (<14?nM) compared with high (>35?nM) endoxifen concentrations were associated with shorter DRFS (univariate P=0.03; multivariate HR=1.94; 95% CI, 1.04–4.14; P=0.064). Our data indicate that endoxifen formation in premenopausal women depends on CYP2D6 irrespective of ethnicity. Low endoxifen concentration/formation and decreased CYP2D6 activity predict shorter DRFS

Solar Coronal Plumes

Polar plumes are thin long ray-like structures that project beyond the limb of the Sun polar regions, maintaining their identity over distances of several solar radii. Plumes have been first observed in white-light (WL) images of the Sun, but, with the advent of the space era, they have been identified also in X-ray and UV wavelengths (XUV) and, possibly, even in in situ data. This review traces the history of plumes, from the time they have been first imaged, to the complex means by which nowadays we attempt to reconstruct their 3-D structure. Spectroscopic techniques allowed us also to infer the physical parameters of plumes and estimate their electron and kinetic temperatures and their densities. However, perhaps the most interesting problem we need to solve is the role they cover in the solar wind origin and acceleration: Does the solar wind emanate from plumes or from the ambient coronal hole wherein they are embedded? Do plumes have a role in solar wind acceleration and mass loading? Answers to these questions are still somewhat ambiguous and theoretical modeling does not provide definite answers either. Recent data, with an unprecedented high spatial and temporal resolution, provide new information on the fine structure of plumes, their temporal evolution and relationship with other transient phenomena that may shed further light on these elusive features

Understanding coronal heating and solar wind acceleration: Case for in situ near‐Sun measurements

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/94903/1/rog1641.pd