Forest Certification and Nonindustrial Private Forest Landowners: Who Will Consider Certifying and Why?

Nonindustrial private forest owners in western Tennessee who own 40 or more acres of forestland were sent a mail survey to assess their awareness, acceptance, and perception of forest certification. More than eight in 10 participants indicated a willingness to consider certification. Landowners who would most likely consider certifying their forest were typically well-educated new forest owners, and had received advice or information about their forestland. They would certify for both utilitarian and environmental reasons, and they most trust the State Division of Forestry and consulting foresters as potential third-party certifiers

Public Perceptions of Values Associated with Wildfire Protection at the Wildland-Urban Interface: A Synthesis of National Findings

The wildland-urban interface (WUI) continues to transform rural landscapes as previously undeveloped areas are populated with residential and commercial structures which, in turn, impact ecosystems and create landscapes of risk. Within this context, the science of wildfire risk mitigation has experienced renewed and enhanced support among scientists and managers. However, risk mitigation measures have not found purchase in either the public’s acceptance or involvement in this new role of and for fire. This may partially result from little regard for the effects of wildfire prevention efforts on values other than protecting homes and other structures. We report findings from qualitative interviews conducted across the United States to identify and define various values at risk from wildfire. Values influencing risk mitigation emerged from the biophysical, sociodemographic, and sociocultural contexts of wildfire. Findings demonstrate how wildfire is intertwined with diverse sets of risks experienced in daily life. We provide a discussion of how this research impacts the transformation of landscapes and risk management strategies. Identifying and better understanding the effects of values associated with wildfire—and landscape change in the WUI—will allow natural resource managers and decision makers to develop more effective fuel treatment programs and land use policies

Valuing Diversity and Spatial Pattern of Open Space Plots in Urban Neighborhoods

Abstract This study evaluates the diversity, spatial configuration, and pattern of open spaces in urban neighborhoods. Empirical evidence from hedonic modeling reveals that urban residents positively value the varieties of open space but negatively value the diversity within developed land uses. Square shaped plots of open spaces with smooth, as well straight edge are preferred to those of complex and convoluted shapes with irregular edges

Mendelian adult-onset leukodystrophy genes in Alzheimer´s disease. Critical influence of CSF1R and NOTCH3

Mendelian adult-onset leukodystrophies are a spectrum of rare inherited progressive neurodegenerative disorders affecting the white matter of the central nervous system. Among these, Cerebral Autosomal Dominant and Recessive Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL and CARASIL), Cerebroretinal vasculopathy (CRV), Metachromatic leukodystrophy (MLD), Hereditary diffuse Leukoencephalopathy with spheroids (HDLS), Vanishing white matter disease (VWM) present with rapidly progressive dementia as dominant feature and are caused by mutations in NOTCH3, HTRA1, TREX1, ARSA, CSF1R, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, respectively. Given the rare incidence of these disorders and the lack of unequivocally diagnostic features, leukodystrophies are frequently misdiagnosed with common sporadic dementing diseases such as Alzheimer’s disease (AD), raising the question of whether these overlapping phenotypes may be explained by shared genetic risk factors. To investigate this intriguing hypothesis, we have combined gene expression analysis 1) in 6 different AD mouse strains (APPPS1, HOTASTPM, HETASTPM, TPM, TAS10 and TAU), at 5 different developmental stages (Embryo [E15], 2 months, 4 months, 8 months and 18 months), 2) in APPPS1 primary cortical neurons under stress conditions (oxygen-glucose deprivation) and single-variant and single-gene (c-alpha and SKAT tests) based genetic screening in a cohort composed of 332 Caucasian late-onset AD patients and 676 Caucasian elderly controls. Csf1r was significantly overexpressed (Log2FC>1, adj. p-val<0.05) in the cortex and hippocampus of aged HOTASTPM mice with extensive Aβ core dense plaque pathology. We identified 3 likely pathogenic mutations in CSF1R TK domain (p.L868R, p.Q691H and p.H703Y) in our discovery and validation cohort, composed of 465 AD and MCI Caucasian patients from the UK. Moreover, NOTCH3 was a significant hit in the c-alpha test (adj p-val = 0.01). Adult onset Mendelian leukodystrophy genes are not common factors implicated in AD. Nevertheless, our study suggests a potential pathogenic link between NOTCH3, CSF1R and sporadic LOAD, that warrants further investigation

Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease

We identified rare coding variants associated with Alzheimer’s disease (AD) in a 3-stage case-control study of 85,133 subjects. In stage 1, 34,174 samples were genotyped using a whole-exome microarray. In stage 2, we tested associated variants (P<1×10-4) in 35,962 independent samples using de novo genotyping and imputed genotypes. In stage 3, an additional 14,997 samples were used to test the most significant stage 2 associations (P<5×10-8) using imputed genotypes. We observed 3 novel genome-wide significant (GWS) AD associated non-synonymous variants; a protective variant in PLCG2 (rs72824905/p.P522R, P=5.38×10-10, OR=0.68, MAFcases=0.0059, MAFcontrols=0.0093), a risk variant in ABI3 (rs616338/p.S209F, P=4.56×10-10, OR=1.43, MAFcases=0.011, MAFcontrols=0.008), and a novel GWS variant in TREM2 (rs143332484/p.R62H, P=1.55×10-14, OR=1.67, MAFcases=0.0143, MAFcontrols=0.0089), a known AD susceptibility gene. These protein-coding changes are in genes highly expressed in microglia and highlight an immune-related protein-protein interaction network enriched for previously identified AD risk genes. These genetic findings provide additional evidence that the microglia-mediated innate immune response contributes directly to AD development

Learning Poisson Binomial Distributions

We consider a basic problem in unsupervised learning: learning an unknown \emph{Poisson Binomial Distribution}. A Poisson Binomial Distribution (PBD) over $\{0,1,\dots,n\}$ is the distribution of a sum of $n$ independent Bernoulli random variables which may have arbitrary, potentially non-equal, expectations. These distributions were first studied by S. Poisson in 1837 \cite{Poisson:37} and are a natural $n$-parameter generalization of the familiar Binomial Distribution. Surprisingly, prior to our work this basic learning problem was poorly understood, and known results for it were far from optimal. We essentially settle the complexity of the learning problem for this basic class of distributions. As our first main result we give a highly efficient algorithm which learns to \eps-accuracy (with respect to the total variation distance) using \tilde{O}(1/\eps^3) samples \emph{independent of $n$}. The running time of the algorithm is \emph{quasilinear} in the size of its input data, i.e., \tilde{O}(\log(n)/\eps^3) bit-operations. (Observe that each draw from the distribution is a $\log(n)$-bit string.) Our second main result is a {\em proper} learning algorithm that learns to \eps-accuracy using \tilde{O}(1/\eps^2) samples, and runs in time (1/\eps)^{\poly (\log (1/\eps))} \cdot \log n. This is nearly optimal, since any algorithm {for this problem} must use \Omega(1/\eps^2) samples. We also give positive and negative results for some extensions of this learning problem to weighted sums of independent Bernoulli random variables.Comment: Revised full version. Improved sample complexity bound of O~(1/eps^2

Multiancestry analysis of the HLA locus in Alzheimer’s and Parkinson’s diseases uncovers a shared adaptive immune response mediated by HLA-DRB1*04 subtypes

Across multiancestry groups, we analyzed Human Leukocyte Antigen (HLA) associations in over 176,000 individuals with Parkinson’s disease (PD) and Alzheimer’s disease (AD) versus controls. We demonstrate that the two diseases share the same protective association at the HLA locus. HLA-specific fine-mapping showed that hierarchical protective effects of HLA-DRB1*04 subtypes best accounted for the association, strongest with HLA-DRB1*04:04 and HLA-DRB1*04:07, and intermediary with HLA-DRB1*04:01 and HLA-DRB1*04:03. The same signal was associated with decreased neurofibrillary tangles in postmortem brains and was associated with reduced tau levels in cerebrospinal fluid and to a lower extent with increased Aβ42. Protective HLA-DRB1*04 subtypes strongly bound the aggregation-prone tau PHF6 sequence, however only when acetylated at a lysine (K311), a common posttranslational modification central to tau aggregation. An HLA-DRB1*04-mediated adaptive immune response decreases PD and AD risks, potentially by acting against tau, offering the possibility of therapeutic avenues

Reducing the environmental impact of surgery on a global scale: systematic review and co-prioritization with healthcare workers in 132 countries

Abstract Background Healthcare cannot achieve net-zero carbon without addressing operating theatres. The aim of this study was to prioritize feasible interventions to reduce the environmental impact of operating theatres. Methods This study adopted a four-phase Delphi consensus co-prioritization methodology. In phase 1, a systematic review of published interventions and global consultation of perioperative healthcare professionals were used to longlist interventions. In phase 2, iterative thematic analysis consolidated comparable interventions into a shortlist. In phase 3, the shortlist was co-prioritized based on patient and clinician views on acceptability, feasibility, and safety. In phase 4, ranked lists of interventions were presented by their relevance to high-income countries and low–middle-income countries. Results In phase 1, 43 interventions were identified, which had low uptake in practice according to 3042 professionals globally. In phase 2, a shortlist of 15 intervention domains was generated. In phase 3, interventions were deemed acceptable for more than 90 per cent of patients except for reducing general anaesthesia (84 per cent) and re-sterilization of ‘single-use’ consumables (86 per cent). In phase 4, the top three shortlisted interventions for high-income countries were: introducing recycling; reducing use of anaesthetic gases; and appropriate clinical waste processing. In phase 4, the top three shortlisted interventions for low–middle-income countries were: introducing reusable surgical devices; reducing use of consumables; and reducing the use of general anaesthesia. Conclusion This is a step toward environmentally sustainable operating environments with actionable interventions applicable to both high– and low–middle–income countries