64 research outputs found
Time to death in a prospective cohort of 252 patients treated for fracture of the proximal femur in a major hospital in Portugal
Ameliorating antipsychotic-induced weight gain by betahistine: Mechanisms and clinical implications
Distribution and Modulation of Histamine H3 Receptors in Basal Ganglia and Frontal Cortex of Healthy Controls and Patients with Parkinson's Disease
Pharmacological effects of the dansylated neuropeptide FF analogues on body temperature and morphine analgesia
Inhibition of neuropeptide FF (NPFF)-induced hypothermia and anti-morphine analgesia by RF9, a new selective NPFF receptors antagonist
Regulation of cerebral microvascular permeability by histamine in the anaesthetized rat
The permeability response of slightly leaky pial venular capillaries to histamine was investigated using the single microvessel occlusion technique.Histamine dose-response curves showed that concentrations between 5 nm and 5 μm increased permeability, while concentrations from 50 μm to 5 mm reduced it.The H2 receptor antagonist cimetidine (2 μm) blocked the effects of lower concentrations of histamine, while the H1 receptor antagonist mepyramine (3 nm) blocked those of higher concentrations of histamine.The effects of lower doses of histamine were mimicked by the H2 receptor agonist dimaprit, and the effects of higher doses of histamine were mimicked by the H1 receptor agonist α-2-(2-aminoethyl)pyridine (AEP).Low concentrations of histamine, which normally increase the permeability of Lucifer Yellow (PLY), reduced it when co-applied with the phosphodiesterase 4 (PDE4) inhibitor rolipram. Rolipram also potentiated the response to AEP, but had no effect on that to dimaprit.The effects of dimaprit were blocked by reducing extracellular Ca2+ from 2.5 mm to nominally Ca2+ free, or by applying the calcium entry blocker SKF 96365
Histamine-immunoreactive cells in the superior cervical ganglion and in the coeliac-superior mesenteric ganglion complex of the rat
Electrophysiological effects of pressure-ejected bombesin-like peptides on hamster suprachiasmatic nucleus neurons in vitro
Derivation of male germ cells from induced pluripotent stem cells in vitro and in reconstituted seminiferous tubules
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