123 research outputs found
HI in the Outskirts of Nearby Galaxies
The HI in disk galaxies frequently extends beyond the optical image, and can
trace the dark matter there. I briefly highlight the history of high spatial
resolution HI imaging, the contribution it made to the dark matter problem, and
the current tension between several dynamical methods to break the disk-halo
degeneracy. I then turn to the flaring problem, which could in principle probe
the shape of the dark halo. Instead, however, a lot of attention is now devoted
to understanding the role of gas accretion via galactic fountains. The current
cold dark matter theory has problems on galactic scales, such as
the core-cusp problem, which can be addressed with HI observations of dwarf
galaxies. For a similar range in rotation velocities, galaxies of type Sd have
thin disks, while those of type Im are much thicker. After a few comments on
modified Newtonian dynamics and on irregular galaxies, I close with statistics
on the HI extent of galaxies.Comment: 38 pages, 17 figures, invited review, book chapter in "Outskirts of
Galaxies", Eds. J. H. Knapen, J. C. Lee and A. Gil de Paz, Astrophysics and
Space Science Library, Springer, in pres
New scenario for the accumulation and release of radiation damage in rock salt and related materials
Validating epilepsy diagnoses in routinely collected data
Purpose: Anonymised, routinely-collected healthcare data is increasingly being used for epilepsy
research. We validated algorithms using general practitioner (GP) primary healthcare records to identify
people with epilepsy from anonymised healthcare data within the Secure Anonymised Information
Linkage (SAIL) databank in Wales, UK.
Method: A reference population of 150 people with definite epilepsy and 150 people without epilepsy was
ascertained from hospital records and linked to records contained within SAIL (containing GP records for
2.4 million people). We used three different algorithms, using combinations of GP epilepsy diagnosis and
anti-epileptic drug (AED) prescription codes, to identify the reference population.
Results: Combining diagnosis and AED prescription codes had a sensitivity of 84% (95% ci 77â90) and
specificity of 98% (95â100) in identifying people with epilepsy; diagnosis codes alone had a sensitivity of
86% (80â91) and a specificity of 97% (92â99); and AED prescription codes alone achieved a sensitivity of
92% (70â83) and a specificity of 73% (65â80). Using AED codes only was more accurate in children
achieving a sensitivity of 88% (75â95) and specificity of 98% (88â100).
Conclusion: GP epilepsy diagnosis and AED prescription codes can be confidently used to identify people
with epilepsy using anonymised healthcare records in Wales, U
An updated radiocarbon-based ice margin chronology for the last deglaciation of the North American Ice Sheet Complex
The North American Ice Sheet Complex (NAISC; consisting of the Laurentide, Cordilleran and Innuitian ice sheets) was the largest ice mass to repeatedly grow and decay in the Northern Hemisphere during the Quaternary. Understanding its pattern of retreat following the Last Glacial Maximum is critical for studying many facets of the Late Quaternary, including ice sheet behaviour, the evolution of Holocene landscapes, sea level, atmospheric circulation, and the peopling of the Americas. Currently, the most up-to-date and authoritative margin chronology for the entire ice sheet complex is featured in two publications (Geological Survey of Canada Open File 1574 [Dyke et al., 2003]; âQuaternary Glaciations â Extent and Chronology, Part IIâ [Dyke, 2004]). These often-cited datasets track ice margin recession in 36 time slices spanning 18 ka to 1 ka (all ages in uncalibrated radiocarbon years) using a combination of geomorphology, stratigraphy and radiocarbon dating. However, by virtue of being over 15 years old, the ice margin chronology requires updating to reflect new work and important revisions. This paper updates the aforementioned 36 ice margin maps to reflect new data from regional studies. We also update the original radiocarbon dataset from the 2003/2004 papers with 1541 new ages to reflect work up to and including 2018. A major revision is made to the 18 ka ice margin, where Banks and Eglinton islands (once considered to be glacial refugia) are now shown to be fully glaciated. Our updated 18 ka ice sheet increased in areal extent from 17.81 to 18.37 million km2, which is an increase of 3.1% in spatial coverage of the NAISC at that time. Elsewhere, we also summarize, region-by-region, significant changes to the deglaciation sequence. This paper integrates new information provided by regional experts and radiocarbon data into the deglaciation sequence while maintaining consistency with the original ice margin positions of Dyke et al. (2003) and Dyke (2004) where new information is lacking; this is a pragmatic solution to satisfy the needs of a Quaternary research community that requires up-to-date knowledge of the pattern of ice margin recession of what was once the worldâs largest ice mass. The 36 updated isochrones are available in PDF and shapefile format, together with a spreadsheet of the expanded radiocarbon dataset (n = 5195 ages) and estimates of uncertainty for each interval
52 Genetic Loci Influencing Myocardial Mass.
BACKGROUND: Myocardial mass is a key determinant of cardiac muscle function and hypertrophy. Myocardial depolarization leading to cardiac muscle contraction is reflected by the amplitude and duration of the QRS complex on the electrocardiogram (ECG). Abnormal QRS amplitude or duration reflect changes in myocardial mass and conduction, and are associated with increased risk of heart failure and death. OBJECTIVES: This meta-analysis sought to gain insights into the genetic determinants of myocardial mass. METHODS: We carried out a genome-wide association meta-analysis of 4 QRS traits in up to 73,518 individuals of European ancestry, followed by extensive biological and functional assessment. RESULTS: We identified 52 genomic loci, of which 32 are novel, that are reliably associated with 1 or more QRS phenotypes at p < 1 à 10(-8). These loci are enriched in regions of open chromatin, histone modifications, and transcription factor binding, suggesting that they represent regions of the genome that are actively transcribed in the human heart. Pathway analyses provided evidence that these loci play a role in cardiac hypertrophy. We further highlighted 67 candidate genes at the identified loci that are preferentially expressed in cardiac tissue and associated with cardiac abnormalities in Drosophila melanogaster and Mus musculus. We validated the regulatory function of a novel variant in the SCN5A/SCN10A locus in vitro and in vivo. CONCLUSIONS: Taken together, our findings provide new insights into genes and biological pathways controlling myocardial mass and may help identify novel therapeutic targets
Size Doesn't Matter: Towards a More Inclusive Philosophy of Biology
notes: As the primary author, OâMalley drafted the paper, and gathered and analysed data (scientific papers and talks). Conceptual analysis was conducted by both authors.publication-status: Publishedtypes: ArticlePhilosophers of biology, along with everyone else, generally perceive life to fall into two broad categories, the microbes and macrobes, and then pay most of their attention to the latter. âMacrobeâ is the word we propose for larger life forms, and we use it as part of an argument for microbial equality. We suggest that taking more notice of microbes â the dominant life form on the planet, both now and throughout evolutionary history â will transform some of the philosophy of biologyâs standard ideas on ontology, evolution, taxonomy and biodiversity. We set out a number of recent developments in microbiology â including biofilm formation, chemotaxis, quorum sensing and gene transfer â that highlight microbial capacities for cooperation and communication and break down conventional thinking that microbes are solely or primarily single-celled organisms. These insights also bring new perspectives to the levels of selection debate, as well as to discussions of the evolution and nature of multicellularity, and to neo-Darwinian understandings of evolutionary mechanisms. We show how these revisions lead to further complications for microbial classification and the philosophies of systematics and biodiversity. Incorporating microbial insights into the philosophy of biology will challenge many of its assumptions, but also give greater scope and depth to its investigations
Genome-wide selection in dairy cattle: use of genetic algorithms in the estimation of molecular breeding values
A procedure has been developed for the prediction of genetic merit and the simultaneous assessment of multiple genotypes for subsequent use in gene detection. The system utilises a large volume of genotype information but ignores pedigree. With a simple additive model of inheritance, high correlations
between estimates of molecular breeding value and highly reliable progeny test estimated breeding values were observed (0.70â0.77)
Kinetics of the peritectic phase transformation: in-situ measurements and phase field modeling
An experimental study has been conducted into the role of cooling rate on the kinetics of the peritectic phase transformation in a Fe-C alloy. The interfacial growth velocities of the peritectic phase transformation were measured in situ for cooling rates of 100, 50, and 10 K/min. In-situ observations were obtained using high-temperature laser scanning confocal microscopy (HTLSCM) in a concentric solidification configuration. The experimentally measured interface velocities of the liquid/austenite (L/Îł) and austenite/delta-ferrite (Îł/ÎŽ) interphase boundaries were observed to increase with higher cooling rates. A unique finding of this study was that as the cooling rate increased, there was a transition point where the L/Îł interface propagated at a higher velocity than the Îł/ÎŽ interface, contrary to the findings of previous researchers. Phase field modeling was conducted using a commercial multicomponent, multiphase package. Good correlation was obtained between model predictions and experimental observations in absolute values of interface velocities and the effect of cooling rate. Analysis of the simulated microsegregation in front of the L/Îł and Îł/ÎŽ interfaces as a function of cooling rate revealed the importance of solute pileup. This microsegregation plays a pivotal role in the propagation of interfaces; thus, earlier modeling work in which complete diffusion in the liquid phase was assumed cannot fully describe the rate of propagation of the L/Îł and ÎŽ/Îł interfaces during the course of the peritectic transformation
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