471 research outputs found
Ascaroside Signaling Is Widely Conserved among Nematodes
Background: Nematodes are among the most successful animals on earth and include important human pathogens, yet little is known about nematode pheromone systems. A group of small molecules called ascarosides has been found to mediate mate finding, aggregation, and developmental diapause in Caenorhabditis elegans, but it is unknown whether ascaroside signaling exists outside of the genus Caenorhabditis.
Results: To determine whether ascarosides are used as signaling molecules by other nematode species, we performed a mass spectrometry-based screen for ascarosides in secretions from a variety of both free-living and parasitic (plant, insect, and animal) nematodes. We found that most of the species analyzed, including nematodes from several different clades, produce species-specific ascaroside mixtures. In some cases, ascaroside biosynthesis patterns appear to correlate with phylogeny, whereas in other cases, biosynthesis seems to correlate with lifestyle and ecological niche. We further show that ascarosides mediate distinct nematode behaviors, such as retention, avoidance, and long-range attraction, and that different nematode species respond to distinct, but overlapping, sets of ascarosides.
Conclusions: Our findings indicate that nematodes utilize a conserved family of signaling molecules despite having evolved to occupy diverse ecologies. Their structural features and level of conservation are evocative of bacterial quorum sensing, where acyl homoserine lactones (AHLs) are both produced and sensed by many species of gram-negative bacteria. The identification of species-specific ascaroside profiles may enable pheromone-based approaches to interfere with reproduction and survival of parasitic nematodes, which are responsible for significant agricultural losses and many human diseases worldwide
Towards Physical Hybrid Systems
Some hybrid systems models are unsafe for mathematically correct but
physically unrealistic reasons. For example, mathematical models can classify a
system as being unsafe on a set that is too small to have physical importance.
In particular, differences in measure zero sets in models of cyber-physical
systems (CPS) have significant mathematical impact on the mathematical safety
of these models even though differences on measure zero sets have no tangible
physical effect in a real system. We develop the concept of "physical hybrid
systems" (PHS) to help reunite mathematical models with physical reality. We
modify a hybrid systems logic (differential temporal dynamic logic) by adding a
first-class operator to elide distinctions on measure zero sets of time within
CPS models. This approach facilitates modeling since it admits the verification
of a wider class of models, including some physically realistic models that
would otherwise be classified as mathematically unsafe. We also develop a proof
calculus to help with the verification of PHS.Comment: CADE 201
Saturation of a spin 1/2 particle by generalized Local control
We show how to apply a generalization of Local control design to the problem
of saturation of a spin 1/2 particle by magnetic fields in Nuclear Magnetic
Resonance. The generalization of local or Lyapunov control arises from the fact
that the derivative of the Lyapunov function does not depend explicitly on the
control field. The second derivative is used to determine the local control
field. We compare the efficiency of this approach with respect to the
time-optimal solution which has been recently derived using geometric methods.Comment: 12 pages, 4 figures, submitted to new journal of physics (2011
Sharper and Simpler Nonlinear Interpolants for Program Verification
Interpolation of jointly infeasible predicates plays important roles in
various program verification techniques such as invariant synthesis and CEGAR.
Intrigued by the recent result by Dai et al.\ that combines real algebraic
geometry and SDP optimization in synthesis of polynomial interpolants, the
current paper contributes its enhancement that yields sharper and simpler
interpolants. The enhancement is made possible by: theoretical observations in
real algebraic geometry; and our continued fraction-based algorithm that rounds
off (potentially erroneous) numerical solutions of SDP solvers. Experiment
results support our tool's effectiveness; we also demonstrate the benefit of
sharp and simple interpolants in program verification examples
South Korea's automotive labour regime, Hyundai Motors’ global production network and trade‐based integration with the European Union
This article explores the interrelationship between global production networks(GPNs) and free trade agreements (FTAs) in the South Korean auto industry and its employment relations. It focuses on the production network of the Hyundai Motor Group (HMG) — the third biggest automobile manufacturer in the world — and the FTA between the EU and South Korea. This was the first of the EU’s ‘new generation’ FTAs, which among other things contained provisions designed to protect and promote labour standards. The article’s argument is twofold. First, that HMG’s production network and Korea’s political economy (of which HMG is a crucial part) limited the possibilities for the FTA’s labour provisions to take effect. Second, that the commercial provisions in this same FTA simultaneously eroded HMG’s domestic market and corporate profitability, leading to adverse consequences for auto workers in the more
insecure and low-paid jobs. In making this argument, the article advances a multiscalar conceptualization of the labour regime as an analytical intermediary between GPNs and FTAs. It also provides one of the first empirical studies of the EU–South Korea FTA in terms of employment relations, drawing on 105 interviews with trade unions, employer associations, automobile companies and state officials across both parties
Epigenetic modifications associated with maternal anxiety during pregnancy and children's behavioral measures
Epigenetic changes are associated with altered behavior and neuropsychiatric disorders and they modify the trajectory of aging. Maternal anxiety during pregnancy is a common environmental challenge for the fetus, causing changes in DNA methylation. Here, we determined the mediating role of DNA methylation and the moderating role of offspring sex on the association between maternal anxiety and children’s behavioral measures. In 83 mother–child dyads, maternal anxiety was assessed in each trimester of pregnancy when the child was four years of age. Children’s behavioral measures and children’s buccal DNA methylation levels (NR3C1, IGF2/H19 ICR, and LINE1) were examined. Higher maternal anxiety during the third trimester was associated with more methylation levels of the NR3C1. Moderating effects of sex on the association between maternal anxiety and methylation were found for IGF2/H19 and LINE1 CpGs. Mediation analysis showed that methylation of NR3C1 could buffer the effects of maternal anxiety on children’s behavioral measures, but this effect did not remain significant after controlling for covariates. In conclusion, our data support an association between maternal anxiety during pregnancy and DNA methylation. The results also underscore the importance of sex differences and timing effects. However, DNA methylation as underlying mechanism of the effect of maternal anxiety during pregnancy on offspring’s behavioral measures was not supported
An Experimental and Numerical Investigation of Flapping-Wing Propulsion
AIAA Paper No. 99-0995, 37th AIAA Aerospace Sciences Meeting, Reno, Nevada, Jan. 1999.Flapping-wing propulsion is investigated experimentally and numerically with direct comparisons between experimental and numerical thrust measurements for several geometrically simple configurations. Numerical simulations are performed using linear theory, and a previously developed, unsteady panel method that models one or two independently moving airfoils with three-degrees of freedom and non-linear deforming wakes. Experiments are carried out in the Naval Postgraduate School 5'×5' low-speed tunnel. A flapping mechanism that approximates the two-dimensional motions modeled by the panel code is suspended with cables in the wind tunnel, and thrust measurements are made by measuring the streamwise displacement of the model using a laser range-finder. The experimental flapping mechanism utilizes variable aspect-ratio wings and optional tip plates to investigate the effect of three-dimensionality. The device flaps two airfoils, each with two degrees of freedom and adjustable pitch and plunge amplitudes, and additional stationary wings may be attached up and/or downstream of the flapping wings to investigate interference effects
The COMPASS Experiment at CERN
The COMPASS experiment makes use of the CERN SPS high-intensitymuon and
hadron beams for the investigation of the nucleon spin structure and the
spectroscopy of hadrons. One or more outgoing particles are detected in
coincidence with the incoming muon or hadron. A large polarized target inside a
superconducting solenoid is used for the measurements with the muon beam.
Outgoing particles are detected by a two-stage, large angle and large momentum
range spectrometer. The setup is built using several types of tracking
detectors, according to the expected incident rate, required space resolution
and the solid angle to be covered. Particle identification is achieved using a
RICH counter and both hadron and electromagnetic calorimeters. The setup has
been successfully operated from 2002 onwards using a muon beam. Data with a
hadron beam were also collected in 2004. This article describes the main
features and performances of the spectrometer in 2004; a short summary of the
2006 upgrade is also given.Comment: 84 papes, 74 figure
First Measurement of the Transverse Spin Asymmetries of the Deuteron in Semi-Inclusive Deep Inelastic Scattering
First measurements of the Collins and Sivers asymmetries of charged hadrons
produced in deep-inelastic scattering of muons on a transversely polarized
6-LiD target are presented. The data were taken in 2002 with the COMPASS
spectrometer using the muon beam of the CERN SPS at 160 GeV/c. The Collins
asymmetry turns out to be compatible with zero, as does the measured Sivers
asymmetry within the present statistical errors.Comment: 6 pages, 2 figure
Gluon polarization in the nucleon from quasi-real photoproduction of high-pT hadron pairs
We present a determination of the gluon polarization Delta G/G in the
nucleon, based on the helicity asymmetry of quasi-real photoproduction events,
Q^2<1(GeV/c)^2, with a pair of large transverse-momentum hadrons in the final
state. The data were obtained by the COMPASS experiment at CERN using a 160 GeV
polarized muon beam scattered on a polarized 6-LiD target. The helicity
asymmetry for the selected events is = 0.002 +- 0.019(stat.) +-
0.003(syst.). From this value, we obtain in a leading-order QCD analysis Delta
G/G=0.024 +- 0.089(stat.) +- 0.057(syst.) at x_g = 0.095 and mu^2 =~ 3
(GeV}/c)^2.Comment: 10 pages, 3 figure
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