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Variable Spaced Particle in Meshfree Method to handle wave‐floating body interactions
In this work, the motion of a two‐dimensional rectangular freely floating body under waves is simulated using Improved Meshless Local Petrov‐Galerkin method with Rankine Source function (IMLPG_R) with variable spacing resolutions. The IMLPG_R method is a particle method that solves Navier–Stokes equations using the fractional step method to capture the wave properties. However, many existing particle methods are computationally intensive to model the wave‐floating body due to the requirement of fine particles, needing uniform distribution throughout the domain. To improve the computational efficiency and capture the body response properly, variable spaced particle distribution with fine resolution near the floating body and coarse resolution far from the body is implemented. Numerical schemes to handle variable resolutions are reported. An iterative scheme to handle the wave‐floating body is implemented in the particle method. Two test cases, one with small wave and another with steep waves, are simulated for uniform particle distribution and the result shows good agreement with literature. Based on this, the performance of the variable spaced particle distribution is tested in coupling with floating body solver. The application of the method for wave impact load from the green water loading of the floating structure is also simulated
Thoracoscopic Surgical Treatment of Spontaneous Pneumothorax: Selection of Surgical Therapy According to Thoracoscopic Findings
We report our experience with thoracoscopy used for the treatment of spontaneous pneumothorax
and idiopathic emphysematous bullae. Fifty-one patients with pneumothorax were admitted to the
hospital and received a pleurography and CT scanning before thoracoscopy. End-GIA resection or
end-loop ligation were used alone or in combination, with or without laser coagulation. Only one patient
developed recurrent pneumothorax, whereas another required repeated resection. Our results
indicate that surgical treatment of pneumothorax using thoracoscopy results in a rapid expansion of
the lung, minimum postoperative pain, early hospital discharge, and return of normal activity
Energy scalable terahertz-wave parametric oscillator using surface-emitted configuration
We experimentally demonstrated the scalability of the terahertz-wave parametric oscillator by using a pump beam with a wide aperture and a high pulse energy. Terahertz-wave absorption by the LiNbO3 crystal in the oscillator is substantially suppressed by employing a surface-emitting cavity configuration. We also improved the conversion efficiency by increasing the parametric interaction in the noncollinear phase-matching geometry. A pump depletion of 54% and a conversion efficiency of 0.9 × 10-6 are achieved. A maximum terahertz output of 382 nJ/pulse was achieved at 1.46 THz using a 8.0-mm-diameter pump beam with a pulse energy of 465 mJ/pulse
Nonpolar optical scattering of positronium in magnesium fluoride
We report the results of the analysis of the temperature broadening of the
momentum distribution of delocalized Positronium (Ps) in Magnesium Fluoride in
terms of optical deformation-potential scattering model (long-wavelength
optical phonons). The Ps optical deformation-potential coupling constant
in MgF has been determined to be eV/cm.
We also show that the Ps momentum distribution is sensitive to second-order
phase transitions in those crystals where optical deformation-potential
scattering is allowed in one and forbidden in another crystalline phase
Mixed brittle and viscous strain localisation in pelagic sediments seaward of the Hikurangi margin, New Zealand
Calcareous‐pelagic input sediments are present at several subduction zones and deform differently to their siliciclastic counterparts. We investigate deformation in calcareous‐pelagic sediments drilled ~20 km seaward of the Hikurangi megathrust toe at Site U1520 during IODP Expeditions 372 and 375. Clusters of normal faults and subhorizontal stylolites in the sediments indicate both brittle faulting and viscous pressure solution operated at 150°C where frictional (possibly seismic) slip likely predominates. Plain Language Summary The type of sediments entering subduction zones will influence the way the plates in the subduction zone slide past one another. We looked at limestones in sediments drilled before they reach the subduction zone and found that because of the pressure they are under, they begin to crack and dissolve at very shallow depths. Most of the dissolution happens on thin layers where it concentrates clay by removing other, more soluble minerals. We compare how much vertical shortening we see in the sediments to a computer model. The model overestimates vertical shortening over the history of the sediment unless either high pressure fluids reduce the pressure felt by the sediments, or dissolution is governed by the largest sediment grains rather than their average size. Dissolving and cracking make the sediments weaker by concentrating soft materials such as clay. When these sediments enter the subduction zone, the two plates might slip past one another more easily on these weak regions, possibly during slow slip events
Frictional Behavior of Input Sediments to the Hikurangi Trench, New Zealand
AbstractThe Hikurangi subduction zone hosts shallow slow‐slip events, possibly extending to the seafloor. The mechanisms allowing for this behavior are poorly understood but are likely a function of the frictional properties of the downgoing seafloor sediments. We conducted friction experiments at a large range of effective stresses, temperatures, and velocities on incoming sediment to the Hikurangi subduction zone to explore the possible connection of frictional properties to slow‐slip events. These experiments were conducted on multiple apparatuses, allowing us to access a wider range of deformation conditions than is available on any one machine. We find that the material frictionally weakens and becomes less velocity strengthening with increasing effective stress, whereas temperature has only a small effect on both friction and frictional stability. When driven at the plate convergence rate, the sediment exhibits velocity‐weakening behavior. These results imply that the frictional properties of the sediment package subducting at Hikurangi could promote slow‐slip events at the pressures, temperatures, and strain rates expected along the plate boundary thrust up to 10‐km depth without requiring elevated pore fluid pressures. The transition to velocity‐strengthening behavior at faster slip rates could provide a mechanism for limiting unstable slip to slow‐sliding velocities, rather than accommodating deformation through ordinary earthquakes
Study of the plutino object (208996) 2003 AZ84 from stellar occultations: size, shape and topographic features
We present results derived from four stellar occultations by the plutino
object (208996) 2003~AZ, detected at January 8, 2011 (single-chord
event), February 3, 2012 (multi-chord), December 2, 2013 (single-chord) and
November 15, 2014 (multi-chord). Our observations rule out an oblate spheroid
solution for 2003~AZ's shape. Instead, assuming hydrostatic equilibrium,
we find that a Jacobi triaxial solution with semi axes ~km % axis ratios and
, can better account for all our occultation observations.
Combining these dimensions with the rotation period of the body (6.75~h) and
the amplitude of its rotation light curve, we derive a density ~g~cm a geometric albedo . A grazing chord
observed during the 2014 occultation reveals a topographic feature along
2003~AZ's limb, that can be interpreted as an abrupt chasm of width
~km and depth ~km or a smooth depression of width ~km
and depth ~km (or an intermediate feature between those two extremes)
Evidence of seismic slip on a large splay fault in the Hikurangi subduction zone
The Hikurangi subduction zone is capable of producing moderate to large earthquakes as well as regularly repeating slow slip events. However, it is unclear what structures host these different slip styles along the margin. Here we address whether splay faults can host seismic slip at shallow (1 m as observed in the 1947 Poverty and Tolaga Bay earthquakes
Brain structural covariance networks in obsessive-compulsive disorder: a graph analysis from the ENIGMA Consortium.
Brain structural covariance networks reflect covariation in morphology of different brain areas and are thought to reflect common trajectories in brain development and maturation. Large-scale investigation of structural covariance networks in obsessive-compulsive disorder (OCD) may provide clues to the pathophysiology of this neurodevelopmental disorder. Using T1-weighted MRI scans acquired from 1616 individuals with OCD and 1463 healthy controls across 37 datasets participating in the ENIGMA-OCD Working Group, we calculated intra-individual brain structural covariance networks (using the bilaterally-averaged values of 33 cortical surface areas, 33 cortical thickness values, and six subcortical volumes), in which edge weights were proportional to the similarity between two brain morphological features in terms of deviation from healthy controls (i.e. z-score transformed). Global networks were characterized using measures of network segregation (clustering and modularity), network integration (global efficiency), and their balance (small-worldness), and their community membership was assessed. Hub profiling of regional networks was undertaken using measures of betweenness, closeness, and eigenvector centrality. Individually calculated network measures were integrated across the 37 datasets using a meta-analytical approach. These network measures were summated across the network density range of K = 0.10-0.25 per participant, and were integrated across the 37 datasets using a meta-analytical approach. Compared with healthy controls, at a global level, the structural covariance networks of OCD showed lower clustering (P < 0.0001), lower modularity (P < 0.0001), and lower small-worldness (P = 0.017). Detection of community membership emphasized lower network segregation in OCD compared to healthy controls. At the regional level, there were lower (rank-transformed) centrality values in OCD for volume of caudate nucleus and thalamus, and surface area of paracentral cortex, indicative of altered distribution of brain hubs. Centrality of cingulate and orbito-frontal as well as other brain areas was associated with OCD illness duration, suggesting greater involvement of these brain areas with illness chronicity. In summary, the findings of this study, the largest brain structural covariance study of OCD to date, point to a less segregated organization of structural covariance networks in OCD, and reorganization of brain hubs. The segregation findings suggest a possible signature of altered brain morphometry in OCD, while the hub findings point to OCD-related alterations in trajectories of brain development and maturation, particularly in cingulate and orbitofrontal regions
Genome-Wide Association Study and Gene Expression Analysis Identifies CD84 as a Predictor of Response to Etanercept Therapy in Rheumatoid Arthritis
Anti-tumor necrosis factor alpha (anti-TNF) biologic therapy is a widely used treatment for rheumatoid arthritis (RA). It is unknown why some RA patients fail to respond adequately to anti-TNF therapy, which limits the development of clinical biomarkers to predict response or new drugs to target refractory cases. To understand the biological basis of response to anti-TNF therapy, we conducted a genome-wide association study (GWAS) meta-analysis of more than 2 million common variants in 2,706 RA patients from 13 different collections. Patients were treated with one of three anti-TNF medications: etanercept (n = 733), infliximab (n = 894), or adalimumab (n = 1,071). We identified a SNP (rs6427528) at the 1q23 locus that was associated with change in disease activity score (ΔDAS) in the etanercept subset of patients (P = 8×10-8), but not in the infliximab or adalimumab subsets (P>0.05). The SNP is predicted to disrupt transcription factor binding site motifs in the 3′ UTR of an immune-related gene, CD84, and the allele associated with better response to etanercept was associated with higher CD84 gene expression in peripheral blood mononuclear cells (P = 1×10-11 in 228 non-RA patients and P = 0.004 in 132 RA patients). Consistent with the genetic findings, higher CD84 gene expression correlated with lower cross-sectional DAS (P = 0.02, n = 210) and showed a non-significant trend for better ΔDAS in a subset of RA patients with gene expression data (n = 31, etanercept-treated). A small, multi-ethnic replication showed a non-significant trend towards an association among etanercept-treated RA patients of Portuguese ancestry (n = 139, P = 0.4), but no association among patients of Japanese ancestry (n = 151, P = 0.8). Our study demonstrates that an allele associated with response to etanercept therapy is also associated with CD84 gene expression, and further that CD84 expression correlates with disease activity. These findings support a model in which CD84 genotypes and/or expression may serve as a useful biomarker for response to etanercept treatment in RA patients of European ancestry. © 2013 Cui et al
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