Searching for planetary-mass T-dwarfs in the core of Serpens

We searched for isolated planetary-mass T-dwarfs in the 3Myr old Serpens Core cluster. We performed a deep imaging survey of the central part of this cluster using the WIRCam camera at the CFHT. Observations were performed through the narrow-band CH4_off and CH4_on filters, to identify young T-dwarfs from their 1.6micr methane absorption bands, and the broad-band JHK filters, to better characterize the selected candidates. We complemented our WIRCam photometry with optical imaging data from MegaCam at CFHT and Suprime-Cam at the Subaru telescope and mid-IR flux measurements from the Spitzer c2d Legacy Survey. We report four faint T-dwarf candidates in the direction of the Serpens Core with CH4_on-CH4_off above 0.2 mag, estimated visual extinction in the range 1-9 mag and spectral type in the range T1-T5 based on their dereddened CH4_on-CH4_off colors. Comparisons with T-dwarf spectral models and optical to mid-IR color-color and color-magnitude diagrams, indicate that two of our candidates (ID1 and 2) are background contaminants (most likely heavily reddened low-redshift quasars). The properties of the other two candidates (ID3 and 4) are consistent with them being young members of the Serpens Core cluster, although our analysis can not be considered conclusive. In particular, ID3 may also be a foreground T-dwarf. It is detected by the Spitzer c2d survey but only flux upper limits are available above 5.8 microns and, hence, we can not assess the presence of a possible disk around this object. However, it presents some similarities with other young T-dwarf candidates (SOri70 in the Sigma Ori cluster and CFHTJ0344+3206 in the direction of IC348). If ID3 and 4 belong to Serpens, they would have a mass of a few Jupiter masses and would be amongst the youngest, lowest mass objects detected in a star-forming region so far.Comment: 11 Pages, 7 Figures, Accepted for publication on A&

Lenvatinib versus Sorafenib as first-line treatment in hepatocellular carcinoma: A multi-institutional matched case-control study

Background: Advanced Hepatocarcinoma (HCC) is an important health problem worldwide. Recently, the REFLECT trial demonstrated the non-inferiority of Lenvatinib compared to Sorafenib in I line setting, thus leading to the approval of new first-line standard of care, along with Sorafenib. Aims and methods: With aim to evaluate the optimal choice between Sorafenib and Lenvatinib as primary treatment in clinical practice, we performed a multicentric analysis with the propensity score matching on 184 HCC patients. Results: The median overall survival (OS) were 15.2 and 10.5 months for Lenvatinib and Sorafenib arm, respectively. The median progression-free survival (PFS) was 7.0 and 4.5 months for Lenvatinib and Sorafenib arm, respectively. Patients treated with Lenvatinib showed a 36% reduction of death risk (p = 0.0156), a 29% reduction of progression risk (p = 0.0446), a higher response rate (p < 0.00001) and a higher disease control rate (p = 0.002). Sorafenib showed to be correlated with more hand-foot skin reaction and Lenvatinib with more hypertension and fatigue. We highlighted the prognostic role of Barcelona Clinic Liver Cancer (BCLC) stage, Eastern Cooperative Oncology Group Performance Status (ECOG-PS), bilirubin, alkaline phosphatase and eosinophils for Sorafenib. Conversely, albumin, aspartate aminotransferase (AST), alkaline phosphatase and Neutrophil-Lymphocyte Ratio (NLR) resulted prognostic in Lenvatinib arm. Finally, we highlighted the positive predictive role of albumin > Normal Value (NV), ECOG > 0, NLR < 3, absence of Hepatitis C Virus positivity, and presence of portal vein thrombosis in favor of Lenvatinib arm. Eosinophil < 50 and ECOG > 0 negatively predicted the response to Sorafenib. Conclusion: SLenvatinib showed to better perform in a real-word setting compared to Sorafenib. More researches are needed to validate the predictor factors of response to Lenvatinib rather than Sorafenib

Correlation and prediction of solute transfer to chloroalkanes from both water and the gas phase

Article discussing research on the correlation and prediction of solute transfer to chloroalkanes from both water and the gas phase