Review of: Ralph L. Barnett & Steven R. Schmid, Safeguard Evaluation Protocol - A Decision Tree for Standardizing, Optionalizing, Prohibiting, Ignoring, Enhancing or Characterizing Safeguards (Triodyne Inc., 1995)

Review of: Ralph L. Barnett & Steven R. Schmid, Safeguard Evaluation Protocol - A Decision Tree for Standardizing, Optionalizing, Prohibiting, Ignoring, Enhancing or Characterizing Safeguards (Triodyne Inc., 1995). Figures, references, table. ISSN 1041-9489. [14 pp. $25.00. 5950 W. Touhy, Niles, IL 60714.

Review of: The Genetic Frontier: Ethics, Law, and Policy (Mark S. Frankel & Albert Teich eds., American Association for the Advancement of Science 1994)

Review of: The Genetic Frontier: Ethics, Law, and Policy (Mark S. Frankel & Albert Teich eds., American Association for the Advancement of Science 1994). Acknowledgments, appendix, contributors, figures, index, introduction, notes, references, tables. LC 93-37230, ISBN 0-87168-526-4. [260 pp. Paper $22.95. 1333 H St., NW, Washington DC 20005.

Neural Nets via Forward State Transformation and Backward Loss Transformation

This article studies (multilayer perceptron) neural networks with an emphasis on the transformations involved --- both forward and backward --- in order to develop a semantical/logical perspective that is in line with standard program semantics. The common two-pass neural network training algorithms make this viewpoint particularly fitting. In the forward direction, neural networks act as state transformers. In the reverse direction, however, neural networks change losses of outputs to losses of inputs, thereby acting like a (real-valued) predicate transformer. In this way, backpropagation is functorial by construction, as shown earlier in recent other work. We illustrate this perspective by training a simple instance of a neural network

Promoting and Managing Genome Innovation

An introduction to the symposium, Promoting and Managing Genome Innovation held October 1995. The conference was organized by Professor Thomas G. Field, Jr. and Gianna Julian-Arnold. The conference was funded in part by the Ethical, Legal and Social Issues component of the D.O.E. Human Genome Program; Nixon, Hargrave, Devans & Doyle L.L.P., Rochester, N.Y.; and Human Genome Sciences

Partial Preparation of 1-Anilino-8-(Mercaptoamino)-1,8-Octadione as a Potential Therapeutic Agent for the Treatment of Huntington’s Disease and Selected Cancers

We are proposing 1-anilino-8-(mercaptoamino)-1,8-octadione as a compound of potential pharmaceutical value. The addition of carbon disulfide to sodium trimethylsilanolate to yield a xanthate product has been analyzed and refined to a 70% yield. Several methods of aminating the xanthate product to yield a sulfenamide have been attempted and analyzed. Multiple attempts have been made to benzoylate the sulfenamide product with little success, with many concerns stemming from the unsuccessful amination reactions