Infrared Search for Young Brown Dwarf Companions around Young Stellar Objects in the rho Ophiucus Molecular Cloud and the Serpens Molecular Cloud

We conducted an infrared search for faint companions around 351 young stellar objects in the rho Ophiucus molecular cloud and the Serpens molecular cloud. Nine objects in the Spitzer/IRAC archival images were identified as young stellar companion candidates. They showed an intrinsic infrared excess; one object was extremely red both in the [3.6] - [4.5] color and in the [4.5] - [5.8] color, and two objects were red in the [4.5] - [5.8] color. They were as faint as 15 mag in the [3.6] band. Follow-up K-band spectroscopy revealed that three objects had deep water absorption bands, indicative of low effective temperatures. By comparing the spectra and infrared spectral energy distributions with synthesized spectra of low-temperature objects, we derived the effective temperatures and continuum excess for these objects. It seems highly likely that one of the three objects is a low-mass stellar companion and two objects are young brown dwarf companions associated with the young stellar objects.Comment: 11 pages, 7 figures. P.A.S.J. accepte

PTBDにおけるVirtual Fluoroscopic Preprocedural Planningの有用性の検討

Purpose: To retrospectively evaluate the usefulness of virtual fluoroscopic preprocedural planning (VFPP) in the percutaneous transhepatic biliary drainage (PTBD) procedure. Materials and Methods: Twenty-two patients who were treated by PTBD were included in this study. Twelve patients were treated using PTBD intraoperative referencing coronal computed tomography (CT) images (i.e., coronal CT group), and 10 patients were treated using PTBD intraoperative referencing VFPP images (i.e., VFPP group). To analyze the effect of the intraoperative referencing VFPP image, the VFPP group was retrospectively compared with the coronal CT group. Results: The characteristics of both patient groups were not statistically significantly different. There were no significant differences in the targeted bile duct, diameter and depth of the target bile, breath-holding ability, number of targeted bile duct puncture attempts, change in the targeted bile duct, and exchange of the drainage catheter. However, the X-ray fluoroscopy time and the procedure time were significantly shorter in the VFPP group than in the coronal CT group (196 vs. 334 seconds, P < 0.05; and 16.0 vs. 27.2 minutes, P < 0.05). Conclusion: Intraoperative referencing using the VFPP imaging in PTBD intuitively can be a useful tool for better localization of the guidewire in the bile duct, and therebyshorten the X-ray fluoroscopy time and procedure 1 time while minimizing radiation exposure and complications

Searching for planetary-mass T-dwarfs in the core of Serpens

We searched for isolated planetary-mass T-dwarfs in the 3Myr old Serpens Core cluster. We performed a deep imaging survey of the central part of this cluster using the WIRCam camera at the CFHT. Observations were performed through the narrow-band CH4_off and CH4_on filters, to identify young T-dwarfs from their 1.6micr methane absorption bands, and the broad-band JHK filters, to better characterize the selected candidates. We complemented our WIRCam photometry with optical imaging data from MegaCam at CFHT and Suprime-Cam at the Subaru telescope and mid-IR flux measurements from the Spitzer c2d Legacy Survey. We report four faint T-dwarf candidates in the direction of the Serpens Core with CH4_on-CH4_off above 0.2 mag, estimated visual extinction in the range 1-9 mag and spectral type in the range T1-T5 based on their dereddened CH4_on-CH4_off colors. Comparisons with T-dwarf spectral models and optical to mid-IR color-color and color-magnitude diagrams, indicate that two of our candidates (ID1 and 2) are background contaminants (most likely heavily reddened low-redshift quasars). The properties of the other two candidates (ID3 and 4) are consistent with them being young members of the Serpens Core cluster, although our analysis can not be considered conclusive. In particular, ID3 may also be a foreground T-dwarf. It is detected by the Spitzer c2d survey but only flux upper limits are available above 5.8 microns and, hence, we can not assess the presence of a possible disk around this object. However, it presents some similarities with other young T-dwarf candidates (SOri70 in the Sigma Ori cluster and CFHTJ0344+3206 in the direction of IC348). If ID3 and 4 belong to Serpens, they would have a mass of a few Jupiter masses and would be amongst the youngest, lowest mass objects detected in a star-forming region so far.Comment: 11 Pages, 7 Figures, Accepted for publication on A&

ホウシャセン チリョウ ガ コウカテキ デ アッタ チョクチョウナイ ブンピツ サイボウ ガン ノ 1 レイ

A 54-year-old woman was seen at the hospital because of anal bleeding. Colonoscopy examination showed a type 2 tumor in the lower rectum and the histological diagnosis from the biopsy specimen was undifferenciated adenocarcinoma. Abdomino-perineal amputation of the rectum were performed. The resected specimen was positive for synaptophysin stain immunohistochemically and we diagnosed it as an endocrine cell carcinoma. We underwent adjuvant chemotherapy by bolus CPT-11, and the post operative course was uneventful. Intra-pelvic recurrence was observed 15 months after operation, and further 4 months later, metastasis developed around the pancreas. And we noticed the tumor in supraclavicular region 21 months after operation. The tumor was sensitive to chemotherapy, but continued to progress. So we underwent radiotherapy for each lesion. The lesion treated with radiotherapy were controlled until she died of cancer, 31 months after the operation. As a result of autopsy, an exellent effect of radiotherapy was confirmed

Lenvatinib versus Sorafenib as first-line treatment in hepatocellular carcinoma: A multi-institutional matched case-control study

Background: Advanced Hepatocarcinoma (HCC) is an important health problem worldwide. Recently, the REFLECT trial demonstrated the non-inferiority of Lenvatinib compared to Sorafenib in I line setting, thus leading to the approval of new first-line standard of care, along with Sorafenib. Aims and methods: With aim to evaluate the optimal choice between Sorafenib and Lenvatinib as primary treatment in clinical practice, we performed a multicentric analysis with the propensity score matching on 184 HCC patients. Results: The median overall survival (OS) were 15.2 and 10.5&nbsp;months for Lenvatinib and Sorafenib arm, respectively. The median progression-free survival (PFS) was 7.0 and 4.5&nbsp;months for Lenvatinib and Sorafenib arm, respectively. Patients treated with Lenvatinib showed a 36% reduction of death risk (p&nbsp;=&nbsp;0.0156), a 29% reduction of progression risk (p&nbsp;=&nbsp;0.0446), a higher response rate (p&nbsp;&lt;&nbsp;0.00001) and a higher disease control rate (p&nbsp;=&nbsp;0.002). Sorafenib showed to be correlated with more hand-foot skin reaction and Lenvatinib with more hypertension and fatigue. We highlighted the prognostic role of Barcelona Clinic Liver Cancer (BCLC) stage, Eastern Cooperative Oncology Group Performance Status (ECOG-PS), bilirubin, alkaline phosphatase and eosinophils for Sorafenib. Conversely, albumin, aspartate aminotransferase (AST), alkaline phosphatase and Neutrophil-Lymphocyte Ratio (NLR) resulted prognostic in Lenvatinib arm. Finally, we highlighted the positive predictive role of albumin&nbsp;&gt;&nbsp;Normal Value (NV), ECOG&nbsp;&gt;&nbsp;0, NLR&nbsp;&lt;&nbsp;3, absence of Hepatitis C Virus positivity, and presence of portal vein thrombosis in favor of Lenvatinib arm. Eosinophil&nbsp;&lt;&nbsp;50 and ECOG&nbsp;&gt;&nbsp;0 negatively predicted the response to Sorafenib. Conclusion: SLenvatinib showed to better perform in a real-word setting compared to Sorafenib. More researches are needed to validate the predictor factors of response to Lenvatinib rather than Sorafenib

Percutaneous drainage of psoas and iliopsoas muscle abscesses with a one-step technique under real-time computed tomography fluoroscopic guidance

PURPOSE : To evaluate the utility and safety of drainage catheter installation for psoas/iliopsoas muscle abscesses using a one-step technique under the guidance of real-time computed tomography (CT) fluoroscopy. MATERIALS and METHODS : Ten psoas or iliopsoas muscle abscesses in 7 patients that were treated with percutaneous drainage were included in this study. All drainage procedures were carried out using a one-step technique under real-time CT fluoroscopic guidance. RESULTS : The drainage catheter insertion was performed successfully with the one-step technique in all lesions. Improvements in the patients’ symptoms and blood test results were seen after the drainage procedure in all cases. In addition, postoperative CT scans demonstrated that the abscesses had reduced in size or disappeared in all but one patient, who was transferred to another institution while the drainage catheter was still in place. No major complications were seen in any case. CONCLUSION : The one-step procedure is simple to perform. The percutaneous drainage of psoas or iliopsoas muscle abscesses with the one-step technique under real-time CT fluoroscopic guidance is accurate and safe. Moreover, compared with the two-step technique the one-step procedure results in a shorter drainage procedure and exposes the patient and operator to lower amounts of radiation