114 research outputs found
How many calories were in those hamburgers again? Distribution density biases recall of attribute values
Decisions that consumers make often rest on evaluations of attributes, such as how large, expensive, good, or fattening an option seems. Extant research has demonstrated that these evaluations in turn depend upon the recently experienced distribution of attribute values (e.g., positively or negatively skewed). In many situations decisions rely on recalling the attribute values of each option, a process that has been neglected in much of the previous literature. In two experiments, participants learned attribute information for labeled stimuli presented within either a positively or negatively skewed distribution and then they recalled values from labels after approximately one minute. The results demonstrated effects that are inconsistent with predictions of the category-adjustment model (Duffy, Huttenlocher, Hedges & Crawford, 2010) that recalled values would shift toward the mean of the distribution of values presented. Instead, results were consistent with predictions of the comparison-induced distortion model (Choplin & Hummel, 2002) that remembered values would depend on the density of stimuli within the attribute range. Reasons for these results, alternative models, and implications for decision-making are discussed
Does the i-process operate at nearly solar metallicity?
A sample of 895 s-process-rich candidates has been found among the 454180
giant stars surveyed by LAMOST at low spectral resolution (R~1800). In a
previous study, taking advantage of the higher resolution (R~86 000) offered by
the the HERMES-Mercator spectrograph, we performed the re-analysis of 15 among
the brightest stars of this sample. Among these 15 program stars, having
close-to-solar metallicities, 11 showed mild to strong heavy element
overabundances. The nucleosynthesis process(es) at the origin of these
overabundances were however not questioned in our former study. We derive the
abundances in s- and r-process elements of the 15 targets in order to
investigate whether some stars also show an i-process signature, as sometimes
found in their lower metallicity counterparts (namely, the Carbon-Enhanced
Metal-Poor (CEMP)-rs stars). Abundances are derived from the high-resolution
HERMES spectra for Pr, Nd, Sm, and Eu, using the TURBOSPECTRUM radiative
transfer LTE code with MARCS model atmospheres. Using the new classification
scheme proposed in our recent study we find that two stars show overabundances
in both s- and r-process elements well above the level expected from the
Galactic chemical evolution, an analogous situation to the one of CEMP-rs stars
at lower metallicities. We compare the abundances of the most enriched stars
with the nucleosynthetic predictions from the STAREVOL stellar evolutionary
code and find abundances compatible with an i-process occurring in AGB stars.
Despite a larger number of heavy elements to characterize the enrichment
pattern, the limit between CEMP-s and CEMP-rs stars remains fuzzy. It is
however interesting to note that an increasing number of extrinsic stars are
found to have abundances better reproduced by an i-process pattern even at
close-to-solar metallicities.Comment: Accepted for publication in A&A, 9 pages, 9 figures including the two
in appendi
Nuclear Level Density and -ray Strength Function of and the impact on the i-process
Proton- coincidences from reactions between
a beam and a deuterated polyethylene target have been
analyzed with the inverse Oslo method to find the nuclear level density (NLD)
and -ray strength function (SF) of . The
capture cross section has been calculated
using the Hauser-Feshbach model in TALYS using the measured NLD and SF
as constraints. We confirm that acts as a
bottleneck when relying on one-zone nucleosynthesis calculations. However, we
find that the impact of this reaction is strongly damped in multi-zone
low-metallicity AGB stellar models experiencing i-process nucleosynthesis.Comment: Submitted to Phys. Rev.
Development and validation of a computerized expert system for evaluation of automated visual fields from the Ischemic Optic Neuropathy Decompression Trial
BACKGROUND: The objective of this report is to describe the methods used to develop and validate a computerized system to analyze Humphrey visual fields obtained from patients with non-arteritic anterior ischemic optic neuropathy (NAION) and enrolled in the Ischemic Optic Neuropathy Decompression Trial (IONDT). The IONDT was a multicenter study that included randomized and non-randomized patients with newly diagnosed NAION in the study eye. At baseline, randomized eyes had visual acuity of 20/64 or worse and non-randomized eyes had visual acuity of better than 20/64 or were associated with patients refusing randomization. Visual fields were measured before treatment using the Humphrey Field Analyzer with the 24-2 program, foveal threshold, and size III stimulus. METHODS: We used visual fields from 189 non-IONDT eyes with NAION to develop the computerized classification system. Six neuro-ophthalmologists ("expert panel") described definitions for visual field patterns defects using 19 visual fields representing a range of pattern defect types. The expert panel then used 120 visual fields, classified using these definitions, to refine the rules, generating revised definitions for 13 visual field pattern defects and 3 levels of severity. These definitions were incorporated into a rule-based computerized classification system run on Excel(® )software. The computerized classification system was used to categorize visual field defects for an additional 95 NAION visual fields, and the expert panel was asked to independently classify the new fields and subsequently whether they agreed with the computer classification. To account for test variability over time, we derived an adjustment factor from the pooled short term fluctuation. We examined change in defects with and without adjustment in visual fields of study participants who demonstrated a visual acuity decrease within 30 days of NAION onset (progressive NAION). RESULTS: Despite an agreed upon set of rules, there was not good agreement among the expert panel when their independent visual classifications were compared. A majority did concur with the computer classification for 91 of 95 visual fields. Remaining classification discrepancies could not be resolved without modifying existing definitions. Without using the adjustment factor, visual fields of 63.6% (14/22) patients with progressive NAION and no central defect, and all (7/7) patients with a paracentral defect, worsened within 30 days of NAION onset. After applying the adjustment factor, the visual fields of the same patients with no initial central defect and 5/7 of the patients with a paracentral defect were seen to worsen. CONCLUSION: The IONDT developed a rule-based computerized system that consistently defines pattern and severity of visual fields of NAION patients for use in a research setting
Recommendations for Diagnosis and Treatment of Pseudohypoparathyroidism and Related Disorders : An Updated Practical Tool for Physicians and Patients
Patients affected by pseudohypoparathyroidism (PHP) or related disorders are characterized by physical findings that may include brachydactyly, a short stature, a stocky build, early-onset obesity, ectopic ossifications, and neurodevelopmental deficits, as well as hormonal resistance most prominently to parathyroid hormone (PTH). In addition to these alterations, patients may develop other hormonal resistances, leading to overt or subclinical hypothyroidism, hypogonadism and growth hormone (GH) deficiency, impaired growth without measurable evidence for hormonal abnormalities, type 2 diabetes, and skeletal issues with potentially severe limitation of mobility. PHP and related disorders are primarily clinical diagnoses. Given the variability of the clinical, radiological, and biochemical presentation, establishment of the molecular diagnosis is of critical importance for patients. It facilitates management, including prevention of complications, screening and treatment of endocrine deficits, supportive measures, and appropriate genetic counselling. Based on the first international consensus statement for these disorders, this article provides an updated and ready-to-use tool to help physicians and patients outlining relevant interventions and their timing. A life-long coordinated and multidisciplinary approach is recommended, starting as far as possible in early infancy and continuing throughout adulthood with an appropriate and timely transition from pediatric to adult care.Peer reviewe
Diagnosis and management of pseudohypoparathyroidism and related disorders : first international Consensus Statement
This Consensus Statement covers recommendations for the diagnosis and management of patients with pseudohypoparathyroidism (PHP) and related disorders, which comprise metabolic disorders characterized by physical findings that variably include short bones, short stature, a stocky build, early-onset obesity and ectopic ossifications, as well as endocrine defects that often include resistance to parathyroid hormone (PTH) and TSH. The presentation and severity of PHP and its related disorders vary between affected individuals with considerable clinical and molecular overlap between the different types. A specific diagnosis is often delayed owing to lack of recognition of the syndrome and associated features. The participants in this Consensus Statement agreed that the diagnosis of PHP should be based on major criteria, including resistance to PTH, ectopic ossifications, brachydactyly and early-onset obesity. The clinical and laboratory diagnosis should be confirmed by a molecular genetic analysis. Patients should be screened at diagnosis and during follow-up for specific features, such as PTH resistance, TSH resistance, growth hormone deficiency, hypogonadism, skeletal deformities, oral health, weight gain, glucose intolerance or type 2 diabetes mellitus, and hypertension, as well as subcutaneous and/or deeper ectopic ossifications and neurocognitive impairment. Overall, a coordinated and multidisciplinary approach from infancy through adulthood, including a transition programme, should help us to improve the care of patients affected by these disorders.Peer reviewe
Diagnosis and management of pseudohypoparathyroidism and related disorders: first international Consensus Statement
This Consensus Statement covers recommendations for the diagnosis and management of patients with pseudohypoparathyroidism (PHP) and related disorders, which comprise metabolic disorders characterized by physical findings that variably include short bones, short stature, a stocky build, early-onset obesity and ectopic ossifications, as well as endocrine defects that often include resistance to parathyroid hormone (PTH) and TSH. The presentation and severity of PHP and its related disorders vary between affected individuals with considerable clinical and molecular overlap between the different types. A specific diagnosis is often delayed owing to lack of recognition of the syndrome and associated features. The participants in this Consensus Statement agreed that the diagnosis of PHP should be based on major criteria, including resistance to PTH, ectopic ossifications, brachydactyly and early-onset obesity. The clinical and laboratory diagnosis should be confirmed by a molecular genetic analysis. Patients should be screened at diagnosis and during follow-up for specific features, such as PTH resistance, TSH resistance, growth hormone deficiency, hypogonadism, skeletal deformities, oral health, weight gain, glucose intolerance or type 2 diabetes mellitus, and hypertension, as well as subcutaneous and/or deeper ectopic ossifications and neurocognitive impairment. Overall, a coordinated and multidisciplinary approach from infancy through adulthood, including a transition programme, should help us to improve the care of patients affected by these disorders
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