The Impact of Growth Hormone Therapy on Sleep-Related Health Outcomes in Children with Prader–Willi Syndrome: A Review and Clinical Analysis

This literature review of growth hormone (GH) therapy and sleep-related health outcomes in children diagnosed with Prader–Willi syndrome (PWS) assembles evidence for the consequences of sleep deprivation and poor sleep quality: difficulty concentrating and learning at school, behavioral problems, diminished quality of life, and growth impairment. Sleep-disordered breathing (SDB) is another factor that impacts a child’s well-being. We searched the electronic databases Medline PubMed Advanced Search Builder, Scopus, and Web of Science using MeSH terms and text words to retrieve articles on GH deficiency, recombinant human growth hormone (rhGH) therapy, sleep quality, SDB, and PWS in children. The censor date was April 2023. The initial search yielded 351 articles, 23 of which were analyzed for this review. The study findings suggest that while GH may have a role in regulating sleep, the relationship between GH treatment and sleep in patients with PWS is complex and influenced by GH dosage, patient age, and type and severity of respiratory disorders, among other factors. GH therapy can improve lung function, linear growth, and body composition in children with PWS; however, it can also trigger or worsen obstructive sleep apnea or hypoventilation in some. Long-term GH therapy may contribute to adenotonsillar hypertrophy and exacerbate sleep apnea in children with PWS. Finally, GH therapy can improve sleep quality in some patients but it can also cause or worsen SDB in others, leading to diminished sleep quality and overall quality of life. The current evidence suggests that the initial risk of worsening SDB may improve with long-term therapy. In conclusion, rhGH is the standard for managing patients with PWS. Nonetheless, its impact on respiratory function during sleep needs to be thoroughly evaluated. Polysomnography is advisable to assess the need for adenotonsillectomy before initiating rhGH therapy. Close monitoring of sleep disorders in patients with PWS receiving GH therapy is essential to ensure effective and safe treatment

Large-scale retrospective relative spectro-photometric self-calibration in space

We consider the application of relative self-calibration using overlap regions to spectroscopic galaxy surveys that use slit-less spectroscopy. This method is based on that developed for the SDSS by Padmanabhan at al. (2008) in that we consider jointly fitting and marginalising over calibrator brightness, rather than treating these as free parameters. However, we separate the calibration of the detector-to-detector from the full-focal-plane exposure-to-exposure calibration. To demonstrate how the calibration procedure will work, we simulate the procedure for a potential implementation of the spectroscopic component of the wide Euclid survey. We study the change of coverage and the determination of relative multiplicative errors in flux measurements for different dithering configurations. We use the new method to study the case where the flat-field across each exposure or detector is measured precisely and only exposure-to-exposure or detector-to-detector variation in the flux error remains. We consider several base dither patterns and find that they strongly influence the ability to calibrate, using this methodology. To enable self-calibration, it is important that the survey strategy connects different observations with at least a minimum amount of overlap, and we propose an "S"-pattern for dithering that fulfills this requirement. The final survey strategy adopted by Euclid will have to optimise for a number of different science goals and requirements. The large-scale calibration of the spectroscopic galaxy survey is clearly cosmologically crucial, but is not the only one.Comment: 23 pages, 19 figures, Accepted for publication in MNRAS, 201

Worldwide Interest in Vitamin D, Negative Effects on Kidneys, and Bone Density: Analysis of Google Trends Data

Background: Besides its role in calcium homeostasis and bone mineralization, vitamin D may also reduce the risk of cancer, cardiovascular and autoimmune diseases. Excessive vitamin D intake can lead to life-threatening hypercalcemia and toxicity, however. Here, we wanted to determine the relative search volume (RSV) of interest in vitamin D and its adverse biological effects (hypercalcemia, renal failure, kidney stones, bone density).Methods: We used data from Google Trends to assess changes in RSV trends across the world's regions. Data were extracted via the search terms "cholecalciferol", "ergocalciferol, "hypercalcemia", "acute renal failure", "kidney stones", and "bone density" from queries in English from 1 January 2004 to 1 October 2018 in the tool's related query database. Statistical analysis was performed using SPSS (R) 22.0 for Windows (IBM Inc., Armonk, NY, USA, 10504-1722).Results: There was a correlation between the RSV of cholecalciferol and ergocalciferol (Spearman's correlation) and the RSV of hypercalcemia, renal failure, kidney stones, and bone density. As measured by the change in RSV score, the trend for interest in kidney stones increased more rapidly than that for the other search terms. There was a positive correlation between the RSV score for cholecalciferol (or ergocalciferol) and renal failure and between the RSV score for cholecalciferol (or ergocalciferol) and kidney stones, whereas there was a negative correlation between cholecalciferol and hypercalcemia. The interest of ergocalciferol increased in parallel with the interest in bone density. The highest concentration of interest in cholecalciferol occurred in North America, Europe, India and Australia, whereas interest in ergocalciferol was greater in Central and South America, Spain, and Thailand. Interest in kidney stones was greater than cholecalciferol in North America, Brazil, India, and Australia, while interest in bone density was greater than cholecalciferol in North America, Brazil, Italy, Spain, South Africa, and Australia.Conclusions: In the pre-pandemic COVID-19 (COronaVIrus Disease 19) era, our preliminary results showed a positive correla-tion between global interest in cholecalciferol and kidney stones and renal failure, respectively. However, we found an unexpected negative correlation between global interest in cholecalciferol and hypercalcemia. Additionally, we found a positive correlation between global interest in ergocalciferol and bone density. These correlations can inform health interventions and education

An activating mutation in the CRHR1 gene is rarely associated with pituitary-dependent hyperadrenocorticism in poodles

OBJECTIVES: Pituitary-dependent hyperadrenocorticism is the most common cause of naturally occurring hypercortisolism in dogs. CRHR1 expression in human and dog corticotrophinomas suggested that this gene affects pituitary tumorigenesis. The present study aimed to investigate mutations in the CRHR1 coding region in poodles with pituitary-dependent hyperadrenocorticism. METHODS: Fifty poodles with pituitary-dependent hyperadrenocorticism and 50 healthy poodles were studied. Genomic DNA was amplified by PCR and analyzed by Sanger sequencing. RESULTS: The novel CRHR1 p.V97M mutation was identified in one dog. This valine residue, located in the amino-terminal extracellular domain, exhibits high affinity for its corticotropin-releasing hormone (CRH) ligand. Bioinformatic analysis revealed structural rearrangements in the mutant protein, with a 17% increase in the surface binding affinity between CRHR1 and CRH. In vitro functional studies showed that mutant CRHR1 induced higher ACTH secretion than the wild type after stimulation with human CRH. CONCLUSION: These results suggest that germline activating mutations in CRHR1 may be a rare cause of pituitary hyperadrenocorticism in poodles

Complex relationship between growth hormone and sleep in children: insights, discrepancies, and implications

Growth hormone (GH) is crucial to growth and development. GH secretion is regulated by a complex feedback system involving the pituitary gland, hypothalamus, and other organs, and predominantly occurs during deep sleep. Isolated and idiopathic growth hormone deficiency (GHD) is a condition characterized by GHD without any other signs or symptoms associated with a specific syndrome or disease. The aim of this narrative review was to evaluate the relationship between GH and sleep in children using published data. Various databases (Medline/PubMed, Scopus, and Web of Science) were systematically searched for relevant English language articles published up to April 2023. Search strategies included the terms ‘children/pediatric’, ‘growth hormone’, ‘growth hormone deficiency’ and ‘sleep’. Data were extracted by two independent reviewers; 185 papers were identified of which 58 were duplicates and 118 were excluded (unrelated n=83, syndromic/genetic GHD n=17, non-English n=13, abstract n=1, case report n=1). Overall, nine studies (six clinical studies, two case series, and one survey) were included. GHD appears to have an adverse effect on sleep in children, and GH therapy has only been shown to have a beneficial effect on sleep parameters in some individuals. Notably, identified data were limited, old/poor quality, and heterogenous/inconsistent. Further research of GHD in pediatric populations is necessary to improve the understanding of GHD impact on sleep and its underlying mechanisms, and to determine the specific impacts of GH therapy on sleep in children

does a mediterranean model of family functioning in the perception of italian and spanish adolescents exist a cross national study

The current study explored the influence of belonging to a different areas, South of Italy and Spain, on perception of parenting and family functioning adolescents in order to highlight the similarities and differences among two samples and verify if Mediterranean model of family exists". Empirical evidence of the existence of a Mediterranean family model has been conducted to verify which common and differentiating features exist in the perception of family ties among adolescents. Data highlighted that adolescents belonging to these areas report similar levels in different component of familial ties that can be defined as "Links and Roles": On the contrary, important differences were underlined on the perception of levels of rigidity and enmeshment within family: on the base of Marcia's model of identity status, we called this dimension "Foreclosure status". DOI: 10.5901/mjss.2014.v5n1p37

Structure formation in Multiple Dark Matter cosmologies with long-range scalar interactions

(Abridged) An interaction between Cold Dark Matter (CDM) and a classical scalar field playing the role of the cosmic dark energy (DE) might provide long-range dark interactions without conflicting with solar system bounds. Although presently available observations allow to constrain such interactions to a few percent of the gravitational strength, some recent studies have shown that if CDM is composed by two different particle species having opposite couplings to the DE field, such tight constraints can be considerably relaxed, allowing for long-range scalar forces of order gravity without significantly affecting observations both at the background and at the linear perturbations level. In the present work, we extend the investigation of such Multiple Dark Matter scenarios to the nonlinear regime of structure formation, by presenting the first N-body simulations ever performed for these cosmologies. Our results highlight some characteristic footprints of long-range scalar forces that arise only in the nonlinear regime for specific models that would be otherwise practically indistinguishable from the standard LCDM scenario both in the background and in the growth of linear density perturbations. Among these effects, the formation of "mirror" cosmic structures in the two CDM species, the suppression of the nonlinear matter power spectrum at k > 1 h/Mpc, and the fragmentation of collapsed halos, represent peculiar features that might provide a direct way to constrain this class of cosmological models.Comment: 11 pages, 4 figures. Submitted to MNRA