Haemorrhagic pneumonia caused by Stenotrophomonas maltophilia in two newborns

WOS: 000358599500013PubMed: 25989175Invasive procedures and antibiotic treatment increase the risk of nosocomial infections in neonatal intensive care units. Early identification and appropriate treatment is important. Herein we report two cases of massive hemorrhagic pneumonia caused by Stenotrophomonas maltophilia. The first case was diagnosed with congenital pneumonia; a chest tube was inserted because of pneumothorax on the third day of life. The second case had been referred with respiratory distress syndrome, and bilateral pneumothorax was present on admission. Upon follow up, the cases' clinical condition worsened; acute respiratory distress syndrome and massive pulmonary haemorrhage developed. After Stenotrophomonas maltophilia was isolated in blood cultures, the cases were treated successfully using a combination of trimethoprim/sulfamethoxazole and fluoroquinolone

A novel mutation which causes a frameshift in the PHOX2B gene causes Haddad syndrome

PubMed: 32073407[No abstract available

Serum procalcitonin level in monitorization of surgical site infections in neonates

A retrospective study was performed to evaluate the role of white blood cell (WBC), C-reactive protein (CRP) and procalcitonin (PCT) levels in the follow-up and treatment of surgical site infections (SSI) in neonates. Neonates who underwent surgical intervention (n: 34) were evaluated for gestational age, sex, diagnosis, inflammatory markers (WBC, CRP, PCT), clinical findings, results of cultures and response to antimicrobial treatment. Records of 34 neonates and 36 surgical interventions were included to the study. Twenty (58.8%) of patients had SSI. Postoperatively CRP, WBC and PCT levels were increased (77%, 77%, 77% respectively) in patients with SSI. Postoperatively CRP, and WBC levels were increased (57% and 64% respectively) in patients without SSI. In conclusion, CRP levels and WBC count were significantly increased in 77% of cases after surgery. Increased PCT levels were detected only in patients with SSI. PCT levels may be considered as the most valuable marker to monitor SSI in neonates after surgery. © 2016 OMU

Incidence, risk factors and severity of retinopathy of prematurity in Turkey (TR-ROP study): a prospective, multicentre study in 69 neonatal intensive care units

Background To evaluate the prevalence, risk factors and treatment of retinopathy of prematurity (ROP) in Turkey and to establish screening criteria for this condition. Methods A prospective cohort study (TR-ROP) was performed between 1 April 2016 and 30 April 2017 in 69 neonatal intensive care units (NICUs). Infants with a birth weight (BW)=1500 g or gestational age (GA) 1500 g or GA> 32 weeks with an unstable clinical course were included in the study. Predictors for the development of ROP were determined by logistic regression analyses. Results The TR-ROP study included 6115 infants: 4964 (81%) with a GA 32 weeks. Overall, 27% had any stage of ROP and 6.7% had severe ROP. A lower BW, smaller GA, total days on oxygen, late-onset sepsis, frequency of red blood cell transfusions and relative weight gain were identified as independent risk factors for severe ROP in infants with a BW=1500 g. Of all infants, 414 needed treatment and 395 (95.4%) of the treated infants had a BW <= 1500 g. Sixty-six (16%) of the treated infants did not fulfil the Early Treatment for Retinopathy of Prematurity requirements for treatment. Conclusions Screening of infants with a GA <= 34 weeks or a BW<1700 g appears to be appropriate in Turkey. Monitoring standards of neonatal care and conducting quality improvement projects across the country are recommended to improve neonatal outcomes in Turkish NICUs