76 research outputs found
Autopercepción de maltrato y actitudes ante la victimización en las relaciones interpersonales de pareja
The purpose of this study is to analyse the connection between the perception of maltreatment and the experience of several abuse forms in romantic relationships held by young people. By the same token, the present research has the intention of ascertaining the ways in which some attitudes have an influence in the experience of maltreatment within intimate relationships. In order to do so, a survey has been conducted and addressed to a total of 450 secondary and tertiary-education students, from both sexes and aged between 18 and 28, a 30,2% and 69,8% of whom were men and women respectively. The evaluation tools were “Dating Violence Questionnarie-R”, focused on the study of violence within dating relationships and “Gender Role Attitudes Scale”, which is aimed at evaluating the manifestation of either sexist or equalitarian attitudes. The results show that maltreatment self-perception is significantly close to victimization experience while sexist attitudes increase the probability of experiencing different types of abuse present in young-people relationships. En este estudio, hemos querido analizar la relación entre la percepción de maltrato y la experimentación de las diferentes formas de abuso en las relaciones de noviazgo en parejas jóvenes. Igualmente, y según sea dicha percepción, evaluar la influencia que las actitudes ejercen en la experimentación de maltrato dentro de las relaciones de pareja. Para ello, han participado un total de 450 estudiantes de educación Secundaria y Universitarios, de ambos sexos y edades comprendas entre los 18 y 28 años, siendo el 30.2% varones, y el 69.8% mujeres. Los instrumentos de evaluación utilizados han sido el Cuestionario de Violencia de Novios Reducido, enfocado al estudio de la violencia dentro de las relaciones de noviazgo, y la Escala de Actitud de Rol de Género, que se encuentra destinada a la evaluación de la manifestación de actitudes sexistas o igualitarias. Los resultados muestran que la autopercepcion de maltrato se relaciona significativamente con la experiencia de victimización, al mismo tiempo que las actitudes de carácter sexista favorecerán la probabilidad de experimentar las diferentes formas de maltrato en las relaciones de pareja jove
Afrontamiento por duelo de separación familiar en estudiantes universitarios foráneos
En el proceso de adaptación a la vida universitaria los ámbitos social, cultural y académico se ven comprometidos, donde existen cambios afectivos, comportamentales y cognitivos; por lo tanto, factores como el apoyo social, los eventos vitales, la resolución exitosa de problemas prácticos en la nueva cultura y la interacción con ella, son elementos que entran en juego en los estudiantes para el afrontamiento a los problemas. Objetivo: Determinar las estrategias de afrontamiento y la adaptación social de los estudiantes de enfermería que emigraron de su lugar de origen para establecerse en otra región. Métodos: Estudio cuantitativo, no experimental, de tipo descriptivo-transversal con muestreo no probabilístico por conveniencia, con una muestra de 52 participantes. Se aplicó la Escala de Adaptación Social con 21 ítems, con cuatro niveles de respuesta (0 a 3) y Escala Estrategias de Coping- Modificada con 69 ítems agrupados con 12 estrategias de afrontamiento. Resultados: En cuanto a las estrategias de afrontamiento que perciben los estudiantes, se encontró que el 32.7% ocupan la solución de problemas con más frecuencia, 50% ocupa la reacción agresiva en moderada frecuencia. En el proceso de duelo por adaptación social se encontró que el 57.8% de la población total se encuentran adaptados normalmente y por otra parte el 42.2% presentan inadaptación moderada. Conclusiones: Las estrategias de afrontamiento son procesos adaptativos que enfrenta el ser humano ante una situación o problemática, que sirven para prevenir, controlar o empeorar el distrés emocional
Evolution of the corpus luteum volume determined ultrasonographically and its relation to the plasma progesterone concentration after artificial insemination in pregnant and non-pregnant dairy cows
P. 183–188The aim of this study was to assess the relationship of the evolution of the corpus luteum (CL) volume that was determined ultrasonographically with the pregnancy status in lactating dairy cows during early pregnancy. Ultrasound examinations were carried out on 76 cows following artificial insemination (AI). Plasma concentrations of progesterone were determined from blood samples collected at each ultrasound examination. Conception was confirmed by ultrasonography on day 30 after AI. Around day 14 post-insemination (p.i.), the CL volume tended to decrease in pregnant and non-pregnant cows, and, after day 19 p.i., both groups differed significantly, indicating the luteal regression in non-pregnant cows. Reaching signification on day 20. The diminution in CL volume was also reflected in the plasma progesterone concentration. However, the patterns of CL volume, estimated by ultrasonography, differed more evidently and earlier between both groups (around 1 week p.i., at day 9 p.i. P < 0.05, whereas progesterone started to differ around 2 weeks p.i., at day 14 p.i, P < 0.05). These results indicate that the estimation of the CL volume by ultrasonography could be useful for assessing the presence of a functional CL.S
Applying the Modified Ten-Group Robson Classification in a Spanish Tertiary Hospital
[EN] Background: Caesarean section is necessary to save the lives of mothers and newborns at times, but it is important to perform it only when it is essential due to all the risks involved. This study aimed to examine the rate of caesarean sections performed at a tertiary hospital using the Robson classification to detect methods for the detection of and/or reduction in these caesarean section rates. Methods: A descriptive, cross-sectional study of a retrospective database was carried out. Results: A total of 10,317 births were assessed. The Robson classification was used to assess these interventions and verify whether the indication for performed caesarean sections was appropriate. In total, 2036 births by caesarean section were performed in the whole sample. The annual caesarean section rate varied between 18.67% and 21.18%. Conclusions: Caesarean sections increased by about 20% in 2021 compared to 2020 even though the trend over the years of study was decreasing. Vaginal delivery after caesarean section is a reasonable and safe option. Caesarean section rates could be improved, mostly in Robson’s Group 2. The Robson classification facilitated progress in the implementation of measures aimed at improving care and adjusting caesarean section rates.S
Intraventricular neurocysticercosis in a migrant from Honduras
We report in Madrid (Spain) a case of intraventricular neurocysticercosis in a migrant from Choluteca (Honduras) confirmed by epidemiological, radiological and microbiological criteria.S
LDR brachytherapy offers superior tumor control to single-fraction HDR prostate brachytherapy: A prospective study
[Purpose]: To compare the clinical outcomes of single-fraction high-dose-rate (HDR) brachytherapy and single-fraction low-dose-rate (LDR) brachytherapy as the sole treatment for primary prostate cancer.
[Material and Methods]: A quasi-randomized study that allocated, from March 2008 to February 2012, 129 low and intermediate risk prostate cancer patients to one single-fraction HDR of 19 Gy (61 patients) or to a 145 Gy 125I LDR permanent implant (68 patients. Biochemical relapse-free survival (bRFS) and overall survival (OS) were compared using the Kaplan–Meier method and Cox regression analysis.
[Results]: After a median follow-up of 72 months in the HDR group, 26 patients relapsed, and after a median follow-up of 84 months in the LDR group, 7 patients relapsed (p < 0.0001). The 5-year bRFS was significantly better for the LDR group than for the HDR group (93.7% and 61.1%, respectively) (p < 0.0001). The 5-year OS also was significantly better in the LDR group (95.5% vs. 89.9%) (p = 0.0436).
[Conclusions]: Permanent LDR prostate implant brachytherapy offers better clinical outcomes than single-fraction HDR for prostate cancer.Peer reviewe
Selenium and impaired physical function in US and Spanish older adults
Background: Selenium (Se) is a trace element with a narrow safety margin.
Objectives: To evaluate the cross-sectional and longitudinal dose-response association between Se exposure and
measures of impaired physical function and disability in older adults.
Design: NHANES 2011–2014 cross-sectional (US, n = 1733, age ≥60 years) and Seniors-ENRICA-2 2017–2019
cross-sectional and longitudinal (Spain, n = 2548 and 1741, respectively, age ≥65 years) data were analyzed.
Whole blood and serum Se levels were measured using inductively coupled plasma-mass spectrometry. Lowerextremity
performance was assessed with the Short Physical Performance Battery, and muscle weakness with
a dynamometer. Incident mobility and agility limitations, and disability in instrumental activities of daily living
(IADL) were ascertained with standardized questionnaires. Analyses were adjusted for relevant confounders,
including physical activity. Results across studies were pooled using random-effects meta-analysis.
Results: Meta-analyzed odds ratios (95% confidence interval) per log2 increase in whole blood Se were 0.54
(0.32; 0.76) for weakness, 0.59 (0.34; 0.83) for impaired lower-extremity performance, 0.48 (0.31; 0.68) for
mobility limitations, 0.71 (0.45; 0.97) for agility limitations, and 0.34 (0.12; 0.56) for disability in at least one
IADL. Analyses for serum Se in NHANES showed similar results. Findings suggest the inverse association with
grip strength is progressive below 140 μg/L (p-value for non-linear trend in the Seniors-ENRICA-2 study = 0.13),
and above 140 μg/L (p-value for non-linear trend in NHANES = 0.11). In the Seniors-ENRICA-2 cohort, with a
2.2 year follow-up period, a doubling in baseline Se levels were associated with a lower incidence of weakness
[odds ratio (95% confidence interval): 0.45 (0.22; 0.91)], impaired lower-extremity performance [0.63 (0.32;
1.23)], mobility [0.43 (0.21; 0.91)] and agility [0.38 (0.18; 0.78)] limitations.
Discussion: In US and Spanish older adults, Se concentrations were inversely associated with physical function
limitations. Further studies are needed to elucidate underlying mechanisms.Instituto de Salud Carlos III
European Commission
PI18/287
16/609State Secretary of R + D + I
PID2019-108973RB-C21/C22European Social Fund (ESF)
European Commissio
A 3’-UTR polymorphism in soluble epoxide hydrolase gene Is associated with acute rejection in renal transplant recipients
Antecedentes y finalidad:
Los ácidos epoxyeicosatrienoic (EETs) son metabolitos del ácido araquidónico que desempeñan una función protectora contra procesos perjudiciales que pueden ocurrir después de re-oxigenación del injerto. Decidimos investigar si la presencia de polimorfismos funcionales en el gen que codifica el epóxido hidrolasa soluble (EPHX2), que metaboliza EETs a menos compuestos activos, pueden jugar un papel importante en el resultado del trasplante renal.
Métodos
En un grupo de 259 receptores caucásicos de trasplante renal y 183 donantes fallecidos, se determinó la presencia de tres EPHX2 común, a saber, los SNPs rs41507953 (K55R), rs751141 (R287Q) y rs1042032 A/G. Las asociaciones con los parámetros de la función del injerto y la incidencia de rechazo agudo fueron investigados retrospectivamente durante el primer año después del injerto mediante regresión logística, ajustándose a las variables clínicas y demográficas.
Resultados
Los portadores del genotipo rs1042032 GG muestran significativamente menor tasa de filtración glomerular estimada (eGFR) (38.15 ± 15.57 vs. 45.99 ± 16.05; p = 0,04) y mayores valores de creatinina sérica (1,57 ± 0,58 vs. 1,30 ± 0,47 g/dL; p=0.02) un año después del injerto, en comparación con los pacientes portadores del alelo A wildtype. El mismo genotipo GG también se asoció a un mayor riesgo de rechazo agudo. Curiosamente, esta asociación fue observada por el genotipo de ambos destinatarios [o =6.34 (1.35-29.90); p = 0,015] y donantes [OR = 5.53 (1.10 - 27.80); p=0,042]. Un modelo estadístico incluyendo ambos genotipos junto con otras variables demográficas y clínicas significativas se tradujo en un aumento de la importancia de la asociación con los receptores del genotipo [OR=8,28 (1.21-74.27); p=0,031].
Conclusiones
Nuestros resultados indican que la variabilidad genética en el gen metabolizante de EETs, EPHX2, pueden tener un impacto significativo en los resultados del trasplante renal de donante fallecido.Background and Purpose:
Epoxyeicosatrienoic acids (EETs) are arachidonic acid metabolites that play a protective
role against damaging processes that may occur after re-oxygenation of the graft. We
aimed to investigate whether the presence of functional polymorphisms in the gene encoding soluble epoxy hydrolase (EPHX2), which metabolizes EETs to less active compounds, may play a role in the outcome of renal transplantation.
Methods
In a group of 259 Caucasian renal transplant recipients and 183 deceased donors, we determined the presence of three common EPHX2 SNPs, namely rs41507953 (K55R), rs751141 (R287Q) and rs1042032 A/G. Associations with parameters of graft function and the incidence of acute rejection were retrospectively investigated throughout the first year after grafting by logistic regression adjusting for clinical and demographic variables.
Results
Carriers of the rs1042032 GG genotype displayed significantly lower estimated glomerular filtration rate (eGFR) (38.15 ± 15.57 vs. 45.99 ± 16.05; p = 0.04) and higher serum creatinine values (1.57 ± 0.58 vs. 1.30 ± 0.47 g/dL; p=0.02) one year after grafting, compared to patients carrying the wildtype A-allele. The same GG genotype was also associated to increased risk of acute rejection. Interestingly, this association was observed for the genotype of both recipients [OR =6.34 (1.35-29.90); p = 0.015] and donors [OR = 5.53 (1.10- 27.80); p=0.042]. A statistical model including both genotypes along with other meaningful demographic and clinical variables resulted in an increased significance for the association with the recipients’ genotype [OR=8.28 (1.21-74.27); p=0.031].
Conclusions
Our results suggest that genetic variability in the EETs-metabolizing gene, EPHX2, may
have a significant impact on the outcome of deceased-donor renal transplantation.• Asociación para el Estudio y la Prevención de las Enfermedades Renales (ASEPER), Badajoz
• Junta de Extremadura, Consejería de Economía, Comercio e Innovación: Proyecto GR10022
• Red de Investigación Renal - REDINREN (Instituto de Salud Carlos III – Fondo Europeo de Desarrollo Regional – FEDER) : Ayudas a Eliecer Coto García, Carmen Díaz Corte y Carlos López LarreapeerReviewe
Proyecto Orla 2.0. Curso 2019 La fotografía como herramienta para la innovación docente, la investigación etnográfica, la intervención social y la creación cultural
Memoria ID-072. Ayudas de la Universidad de Salamanca para la innovación docente, curso 2018-2019
Changes in Gut Microbiota Correlates with Response to Treatment with Probiotics in Patients with Atopic Dermatitis. A Post Hoc Analysis of a Clinical Trial.
Atopic dermatitis (AD) is a chronic recurrent inflammatory skin disease with a high impact on the comfort of those who are affected and long-term treated with corticosteroids with limited efficacy and a high prevalence of relapses. Because of the limited effectiveness of these treatments, new strategies for recovery from AD lesions are continually being explored. In this article, we describe the gut microbiome changes achieved in a recently published clinical trial with the probiotic formulation Bifidobacterium animalis subsp. lactis CECT 8145, Bifidobacterium longum CECT 7347, and Lacticaseibacillus casei CECT 9104 (formerly Lactobacillus casei CECT 9104), showing a significant improvement in SCORAD (scoring atopic dermatitis) index in children (4-17 years) with AD (Clinicaltrials.gov identifier: NCT02585986). The present gut microbiome post hoc study showed no significant changes in diversity (Shannon and Simpson indexes) after probiotic consumption. In the probiotic group, genera Bacteroides, Ruminococcus, and Bifidobacterium significantly increased their levels while Faecalibacterium decreased, compared to the placebo group. Faecalibacterium showed the highest presence and significant positive correlation with AD severity (SCORAD index), whereas Abyssivirga, Bifidobacterium, and Lactococcus were inversely correlated. The results suggest that the consumption of the probiotic formulation here assayed modulates the gut microbiome with significant changes in genera Bacteroides and Faecalibacterium. In turn, the improvement in SCORAD correlates with a decrease in Faecalibacterium and an increase in Bifidobacterium, among others
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