PLAN ESTRATEGICO PARA UNA MICROEMPRESA DEDICADA A LA PRODUCCIÓN Y DISTRIBUCIÓN DE LIBROS ESCOLARES, AREQUIPA 2014-2018

EL PLANEAMIENTO ESTRATÉGICO LA PLANEACIÓN ESTRATÉGICA CONCEPTOS DE PLANEACIÓN ESTRATÉGICA EL PROCESO DE PLANEACIÓN ESTRATÉGICA ETAPAS DEL PLAN ESTRATÉGICO LA MICROEMPRESA PARA LA QUE SE ELABORARA EL PLAN ESTRATÉGICO INDICADORES DE CALIDAD PARA LOS TEXTOS ESCOLARES PERUANO

Los Programas de Postitulación Docente: una apuesta universitaria para fortalecer la escuela pública

El trabajo recupera los orígenes y trayectoria de los Programas de Postitulación Docente en la Facultad de Filosofía y Humanidades, y particularmente, el Programa de Postitulación en Gestión Escolar, desde sus inicios en el año 1998. Repasa algunos de sus presupuestos y objetivos, inscribiendo esta iniciativa universitaria en su contexto político, social y educativo. Situado en plena vigencia de la Ley Federal de Educación y en el marco de fuertes avances de teorías gerencialistas sobre la cuestión directiva en las escuelas, el Programa de Postitulación Docente en Gestión de las Instituciones Educativas, buscó acercarse a las experiencias de las escuelas, de sus problemas y preocupaciones, atendiendo la especificidad de las instituciones y a las situaciones que enfrentaban, al tiempo que disputaba sentidos y orientaciones. Se revisan también los artículos incluidos en el libro, comentando sus contenidos centrales.Fil: Avila, Silvia. Universidad Nacional de Córdoba. Facultad de Filosofía y Humanidades. Escuela de Ciencias de la Educación; Argentina.Fil: Kravetz, Silvia. Universidad Nacional de Córdoba. Facultad de Filosofía y Humanidades. Escuela de Ciencias de la Educación; Argentina.Fil: Gutiérrez, Gonzalo. Universidad Nacional de Córdoba. Facultad de Filosofía y Humanidades. Escuela de Ciencias de la Educación; Argentina.Otras Ciencias de la Educació

Renal replacement therapy in Europe: a summary of the 2012 ERA-EDTA Registry Annual Report

BACKGROUND: This article summarizes the 2012 European Renal Association-European Dialysis and Transplant Association Registry Annual Report (available at www.era-edta-reg.org) with a specific focus on older patients (defined as ≥65 years). METHODS: Data provided by 45 national or regional renal registries in 30 countries in Europe and bordering the Mediterranean Sea were used. Individual patient level data were received from 31 renal registries, whereas 14 renal registries contributed data in an aggregated form. The incidence, prevalence and survival probabilities of patients with end-stage renal disease (ESRD) receiving renal replacement therapy (RRT) and renal transplantation rates for 2012 are presented. RESULTS: In 2012, the overall unadjusted incidence rate of patients with ESRD receiving RRT was 109.6 per million population (pmp) (n = 69 035), ranging from 219.9 pmp in Portugal to 24.2 pmp in Montenegro. The proportion of incident patients ≥75 years varied from 15 to 44% between countries. The overall unadjusted prevalence on 31 December 2012 was 716.7 pmp (n = 451 270), ranging from 1670.2 pmp in Portugal to 146.7 pmp in the Ukraine. The proportion of prevalent patients ≥75 years varied from 11 to 32% between countries. The overall renal transplantation rate in 2012 was 28.3 pmp (n = 15 673), with the highest rate seen in the Spanish region of Catalonia. The proportion of patients ≥65 years receiving a transplant ranged from 0 to 35%. Five-year adjusted survival for all RRT patients was 59.7% (95% confidence interval, CI: 59.3-60.0) which fell to 39.3% (95% CI: 38.7-39.9) in patients 65-74 years and 21.3% (95% CI: 20.8-21.9) in patients ≥75 years

Clonal chromosomal mosaicism and loss of chromosome Y in elderly men increase vulnerability for SARS-CoV-2

The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, COVID-19) had an estimated overall case fatality ratio of 1.38% (pre-vaccination), being 53% higher in males and increasing exponentially with age. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, we found 133 cases (1.42%) with detectable clonal mosaicism for chromosome alterations (mCA) and 226 males (5.08%) with acquired loss of chromosome Y (LOY). Individuals with clonal mosaic events (mCA and/or LOY) showed a 54% increase in the risk of COVID-19 lethality. LOY is associated with transcriptomic biomarkers of immune dysfunction, pro-coagulation activity and cardiovascular risk. Interferon-induced genes involved in the initial immune response to SARS-CoV-2 are also down-regulated in LOY. Thus, mCA and LOY underlie at least part of the sex-biased severity and mortality of COVID-19 in aging patients. Given its potential therapeutic and prognostic relevance, evaluation of clonal mosaicism should be implemented as biomarker of COVID-19 severity in elderly people. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, individuals with clonal mosaic events (clonal mosaicism for chromosome alterations and/or loss of chromosome Y) showed an increased risk of COVID-19 lethality

De novo assembly of maritime pine transcriptome: implications for forest breeding and biotechnology

Maritime pine (Pinus pinasterAit.) is a widely distributed conifer species in Southwestern Europe and one of the most advanced models for conifer research. In the current work, comprehensive characterization of the maritime pine transcriptome was performed using a combination of two different next-generation sequencing platforms, 454 and Illumina. De novo assembly of the transcriptome provided a catalogue of 26 020 unique transcripts in maritime pine trees and a collection of 9641 full-length cDNAs. Quality of the transcriptome assembly was validated by RT-PCR amplification of selected transcripts for structural and regulatory genes. Transcription factors and enzyme-encoding transcripts were annotated. Furthermore, the available sequencing data permitted the identification of polymorphisms and the establishment of robust single nucleotide polymorphism (SNP) and simple-sequence repeat (SSR) databases for genotyping applications and integration of translational genomics in maritime pine breeding programmes. All our data are freely available at SustainpineDB, the P. pinaster expressional database. Results reported here on the maritime pine transcriptome represent a valuable resource for future basic and applied studies on this ecological and economically important pine species