Superconductivity in the two-dimensional Hubbard model?

A refined variational wave function for the two-dimensional repulsive Hubbard model is studied numerically, with the aim of approaching the difficult crossover regime of intermediate values of U. The issue of a superconducting ground state with d-wave symmetry is investigated for an average electron density n=0.8125 and for U=8t. Due to finite-size effects a clear-cut answer to this fundamental question has not yet been reached.Comment: 5 pages, 1 figure, Proc. 30th Int. Conf. of Theoretical Physics, Ustron, Poland, 2006, to be published in phys. stat. so

Combined burden and functional impact tests for cancer driver discovery using DriverPower

The discovery of driver mutations is one of the key motivations for cancer genome sequencing. Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, which aggregated whole genome sequencing data from 2658 cancers across 38 tumour types, we describe DriverPower, a software package that uses mutational burden and functional impact evidence to identify driver mutations in coding and non-coding sites within cancer whole genomes. Using a total of 1373 genomic features derived from public sources, DriverPower's background mutation model explains up to 93% of the regional variance in the mutation rate across multiple tumour types. By incorporating functional impact scores, we are able to further increase the accuracy of driver discovery. Testing across a collection of 2583 cancer genomes from the PCAWG project, DriverPower identifies 217 coding and 95 non-coding driver candidates. Comparing to six published methods used by the PCAWG Drivers and Functional Interpretation Working Group, DriverPower has the highest F1 score for both coding and non-coding driver discovery. This demonstrates that DriverPower is an effective framework for computational driver discovery

Use of recombinant activated factor VII for acute bleeding episodes in acquired hemophilia: final analysis from the Hemostasis and Thrombosis Research Society Registry acquired hemophilia study

The Hemostasis and Thrombosis Research Society Registry was used to monitor the postapproval use and safety of recombinant activated factor VII (rFVIIa). The objective of this article is to evaluate the data from the Hemostasis and Thrombosis Research Society Registry related to rFVIIa-treated bleeding episodes in patients with acquired hemophilia. For each rFVIIa-treated bleeding episode, the initial dose, total dose, average infused dose, number of doses, and treatment duration were calculated. Efficacy was assessed on a three-point scale. Out of the 166 registered patients with acquired hemophilia, 110 patients were treated for 237 bleeding episodes (139 rFVIIa treated); the majority (70%) were in patients older than 60 years. The most frequently reported bleeding locations were subcutaneous (40%) and mucosal (32%). Subcutaneous bleeding episodes were more commonly reported in women (55% vs. 40% men) and white patients (44 vs. 27% black). Of the 139 rFVIIa-treated bleeding episodes, rFVIIa was used as first-line treatment in 127 bleeding episodes. The median initial dose was 90 μg/kg; the median total dose per episode was 333.5 μg/kg. Physician-rated efficacy of rFVIIa for each bleeding episode was reported as ‘bleeding stopped’ in 85% of bleeding episodes, ‘bleeding slowed’ in 11% of bleeding episodes, ‘no improvement’ in 4% of bleeding episodes, and was not documented in 1 bleeding episode. One thromboembolic event was reported; transient neurologic symptoms were reported in a 31-year-old postpartum patient after 110 doses of rFVIIa. Adequate hemostasis was provided for most rFVIIa-treated bleeding episodes at doses largely conforming to the package insert. No major safety concerns were reported

Self-actualization of students personality in various areas of training in the HPE system

The modern development of society and the market relations that are formed in it, requires from a specialist of any profile and direction of training not only a high level of formation of General cultural and professional competencies, development of personal qualities and features that will contribute to success in professional activities, but also the desire to realize their potential, constantly improving themselves at the same time. In this regard, the system of higher professional education has fundamentally new goals and tasks related to the training and education of a specialist of the so-called “new format”. And it is the educational organization that today should create such conditions for each student that will promote their self-knowledge and disclosure, as well as a constant desire for self-learning, self-development and self-actualization. The purpose of the work is to study the self-actualization of the personality of students studying in the Humanities and technical areas during the entire period of study in the HPE system. In the theoretical aspect, various approaches to the study of self-actualization of the individual, including the student, are analyzed. During the research, we used theoretical and empirical methods. In order to identify the features of students’ self-actualization, we used the method of measuring the level of personal self-actualization (CAT), developed by L. Y. Gozman and M. V. Kroz. The analysis of the results shows that by the end of training in the HPE system, students of the Humanities and technical areas of training demonstrate indicators of self-actualization of the individual at different levels. Moreover, the level of self-actualization among students of the faculty of psychology is higher. In our opinion, significant positive changes in the self-actualizing personality of students of the faculty of psychology are the result of a well-organized learning process, as well as the search and finding of an individual approach to each of them. The practical significance of the work is that the results obtained can be used both in the practice of psychological services, and in the educational organization as a whole in the construction of the educational process.Современное развитие общества и рыночные отношения, которые складываются в нем, требуют от специалиста любого профиля и направления подготовки не только высокого уровня сформированности общекультурных и профессиональных компетенций, развитости личностных качеств и особенностей, которые будут способствовать успеху в профессиональной деятельности, но и стремления реализовывать свои потенциальные возможности, постоянно самосовершенствуясь при этом. В связи с этим, перед системой высшего профессионального образования возникают принципиально новые цели и задачи, связанные с подготовкой и воспитанием специалиста так называемого «нового формата». И именно образовательная организация сегодня должна создать для каждого студента такие условия, которые будут способствовать его самопознанию и раскрытию, а также постоянному стремлению к самообучению, саморазвитию и самоактуализации. Целью работы является изучение самоактуализации личности студентов, обучающихся на гуманитарных и технических направлениях, в течение всего периода обучения в системе ВПО. В теоретическом аспекте проанализированы различные подходы к изучению самоактуализации личности, в том числе студента. В ходе исследования нами были использованы теоретические и эмпирические методы. С целью выявления особенностей самоактуализации студентов нами была использована методика измерения уровня самоактуализации личности (CAT), разработанная Л. Я. Гозманом и М. В. Крозом. Анализ результатов свидетельствует о том, что к концу обучения в системе ВПО студенты гуманитарных и технических направлений подготовки демонстрируют показатели самоактуализации личности на разном уровне. Причем, уровень самоактуализации у студентов факультета психологии выше. По нашему мнению, существенные положительные изменения в самоактуализирующейся личности студентов факультета психологии являются следствием грамотно организованного процесса обучения, а также поиска и нахождения индивидуального подхода к каждому из них. Практическая значимость работы заключается в том, что полученные результаты могут использоваться как в практике психологической службы, так и в образовательной организации в целом при построении учебно-воспитательного процесса

Surface Quality Augmentation for Metalworking Industry with Pix2Pix

Image augmentation has become an important part of the data preprocessing pipeline, helping to acquire more samples by altering existing samples by cutting, shifting, etc.. For some domains, augmenting existing images is not sufficient, due to missing samples in the domains (e.g., faulty work pieces or events that occur infrequently). In such a case, new samples must be generated, since images with surface quality defects are often rare occurrence in metalworking and the amount of samples even with standard augmentation techniques does not meet requirements to train a Convolutional Neural Network (CNN) for fault detection. This paper utilizes Pix2Pix for image augmentation to generate new images with surface quality defects. The approach allows specifying the kind of defect, location, and size and transforms images by adding new defects. Furthermore, metrics to evaluate the augmented images are discussed and a recommendation of the best performing metric within the domain of metalworking is given

Searching for planar signatures in WMAP

We search for planar deviations of statistical isotropy in the Wilkinson Microwave Anisotropy Probe (WMAP) data by applying a recently introduced angular-planar statistics both to full-sky and to masked temperature maps, including in our analysis the effect of the residual foreground contamination and systematics in the foreground removing process as sources of error. We confirm earlier findings that full-sky maps exhibit anomalies at the planar ($l$) and angular ($\ell$) scales $(l,\ell)=(2,5),(4,7),$ and $(6,8)$, which seem to be due to unremoved foregrounds since this features are present in the full-sky map but not in the masked maps. On the other hand, our test detects slightly anomalous results at the scales $(l,\ell)=(10,8)$ and $(2,9)$ in the masked maps but not in the full-sky one, indicating that the foreground cleaning procedure (used to generate the full-sky map) could not only be creating false anomalies but also hiding existing ones. We also find a significant trace of an anomaly in the full-sky map at the scale $(l,\ell)=(10,5)$, which is still present when we consider galactic cuts of 18.3% and 28.4%. As regards the quadrupole ($\ell=2$), we find a coherent over-modulation over the whole celestial sphere, for all full-sky and cut-sky maps. Overall, our results seem to indicate that current CMB maps derived from WMAP data do not show significant signs of anisotropies, as measured by our angular-planar estimator. However, we have detected a curious coherence of planar modulations at angular scales of the order of the galaxy's plane, which may be an indication of residual contaminations in the full- and cut-sky maps.Comment: 15 pages with pdf figure

DNA sequencing by MALDI-TOF MS using alkali cleavage of RNA/DNA chimeras

Approaches developed for sequencing DNA with detection by mass spectrometry use strategies that deviate from the Sanger-type methods. Procedures demonstrated so far used the sequence specificity of RNA endonucleases, as unfortunately equivalent enzymes for DNA do not exist and therefore require transcription of DNA into RNA prior to fragmentation