Microstructural dependence of the fracture toughness of metallic thin films: A bulge test and atomistic simulation study on single-crystalline and polycrystalline silver films

The microstructure contribution to the very low fracture toughness of freestanding metallic thin films was investigated by bulge fracture tests on 200-nm-thick {100} single-crystalline and polycrystalline silver films. The single-crystalline films exhibited a significantly lower fracture toughness value (KIC= 0.88 MPa m1/2) than their polycrystalline counterparts (KIC= 1.45 MPa m1/2), which was rationalized by the observation of an unusual crack initiation behavior—characterized by twinning in front of the notch tip—during in situ testing in the atomic force microscope. Twinning was also observed as a dominant deformation mechanism in atomistic simulations. This twinning tendency is explained by comparing the resolved shear stresses acting on the leading partial dislocation and the full dislocation, which allows to develop a size- and orientation-dependent twinning criterion. The fracture toughness of polycrystalline samples was found to be higher because of the energy dissipation associated with full dislocation plasticity and because of crack meandering along grain boundaries

Rhamnolipids: diversity of structures, microbial origins and roles

Rhamnolipids are glycolipidic biosurfactants produced by various bacterial species. They were initially found as exoproducts of the opportunistic pathogen Pseudomonas aeruginosa and described as a mixture of four congeners: α-L-rhamnopyranosyl-α-L-rhamnopyranosyl-β-hydroxydecanoyl-β-hydroxydecanoate (Rha-Rha-C10-C10), α-L-rhamnopyranosyl-α-L-rhamnopyranosyl-β-hydroxydecanoate (Rha-Rha-C10), as well as their mono-rhamnolipid congeners Rha-C10-C10 and Rha-C10. The development of more sensitive analytical techniques has lead to the further discovery of a wide diversity of rhamnolipid congeners and homologues (about 60) that are produced at different concentrations by various Pseudomonas species and by bacteria belonging to other families, classes, or even phyla. For example, various Burkholderia species have been shown to produce rhamnolipids that have longer alkyl chains than those produced by P. aeruginosa. In P. aeruginosa, three genes, carried on two distinct operons, code for the enzymes responsible for the final steps of rhamnolipid synthesis: one operon carries the rhlAB genes and the other rhlC. Genes highly similar to rhlA, rhlB, and rhlC have also been found in various Burkholderia species but grouped within one putative operon, and they have been shown to be required for rhamnolipid production as well. The exact physiological function of these secondary metabolites is still unclear. Most identified activities are derived from the surface activity, wetting ability, detergency, and other amphipathic-related properties of these molecules. Indeed, rhamnolipids promote the uptake and biodegradation of poorly soluble substrates, act as immune modulators and virulence factors, have antimicrobial activities, and are involved in surface motility and in bacterial biofilm development

Response time variability and response inhibition predict affective problems in adolescent girls, not in boys: the TRAILS study

The present study examines the relationship between neurocognitive functioning and affective problems through adolescence, in a cross-sectional and longitudinal perspective. Baseline response speed, response speed variability, response inhibition, attentional flexibility and working memory were assessed in a cohort of 2,179 adolescents (age 10–12 years) from the TRacking Adolescents’ Individual Lives Survey (TRAILS). Affective problems were measured with the DSM-oriented Affective Problems scale of the Youth Self Report at wave 1 (baseline assessment), wave 2 (after 2.5 years) and wave 3 (after 5 years). Cross-sectionally, baseline response speed, response time variability, response inhibition and working memory were associated with baseline affective problems in girls, but not in boys. Longitudinally, enhanced response time variability predicted affective problems after 2.5 and 5 years in girls, but not in boys. Decreased response inhibition predicted affective problems after 5 years follow-up in girls, and again not in boys. The results are discussed in light of recent insights in gender differences in adolescence and state–trait issues in depression

Second asymptomatic carotid surgery trial (ACST-2): a randomised comparison of carotid artery stenting versus carotid endarterectomy

Background: Among asymptomatic patients with severe carotid artery stenosis but no recent stroke or transient cerebral ischaemia, either carotid artery stenting (CAS) or carotid endarterectomy (CEA) can restore patency and reduce long-term stroke risks. However, from recent national registry data, each option causes about 1% procedural risk of disabling stroke or death. Comparison of their long-term protective effects requires large-scale randomised evidence. Methods: ACST-2 is an international multicentre randomised trial of CAS versus CEA among asymptomatic patients with severe stenosis thought to require intervention, interpreted with all other relevant trials. Patients were eligible if they had severe unilateral or bilateral carotid artery stenosis and both doctor and patient agreed that a carotid procedure should be undertaken, but they were substantially uncertain which one to choose. Patients were randomly allocated to CAS or CEA and followed up at 1 month and then annually, for a mean 5 years. Procedural events were those within 30 days of the intervention. Intention-to-treat analyses are provided. Analyses including procedural hazards use tabular methods. Analyses and meta-analyses of non-procedural strokes use Kaplan-Meier and log-rank methods. The trial is registered with the ISRCTN registry, ISRCTN21144362. Findings: Between Jan 15, 2008, and Dec 31, 2020, 3625 patients in 130 centres were randomly allocated, 1811 to CAS and 1814 to CEA, with good compliance, good medical therapy and a mean 5 years of follow-up. Overall, 1% had disabling stroke or death procedurally (15 allocated to CAS and 18 to CEA) and 2% had non-disabling procedural stroke (48 allocated to CAS and 29 to CEA). Kaplan-Meier estimates of 5-year non-procedural stroke were 2·5% in each group for fatal or disabling stroke, and 5·3% with CAS versus 4·5% with CEA for any stroke (rate ratio [RR] 1·16, 95% CI 0·86–1·57; p=0·33). Combining RRs for any non-procedural stroke in all CAS versus CEA trials, the RR was similar in symptomatic and asymptomatic patients (overall RR 1·11, 95% CI 0·91–1·32; p=0·21). Interpretation: Serious complications are similarly uncommon after competent CAS and CEA, and the long-term effects of these two carotid artery procedures on fatal or disabling stroke are comparable. Funding: UK Medical Research Council and Health Technology Assessment Programme

Test of lepton universality in beauty-quark decays

The standard model of particle physics currently provides our best description of fundamental particles and their interactions. The theory predicts that the different charged leptons, the electron, muon and tau, have identical electroweak interaction strengths. Previous measurements have shown that a wide range of particle decays are consistent with this principle of lepton universality. This article presents evidence for the breaking of lepton universality in beauty-quark decays, with a significance of 3.1 standard deviations, based on proton–proton collision data collected with the LHCb detector at CERN’s Large Hadron Collider. The measurements are of processes in which a beauty meson transforms into a strange meson with the emission of either an electron and a positron, or a muon and an antimuon. If confirmed by future measurements, this violation of lepton universality would imply physics beyond the standard model, such as a new fundamental interaction between quarks and leptons

First observation of the decay Lambda(0)(b) -> eta(c) (1S)pK(-)

The decay $\Lambda_b^0 \to \eta_c(1S) p K^-$ is observed for the first time using a data sample of proton-proton collisions, corresponding to an integrated luminosity of 5.5 $fb^{-1}$, collected with the LHCb experiment at a center-of-mass energy of 13 TeV. The branching fraction of the decay is measured, using the $\Lambda_b^0 \to J/\psi p K^-$ decay as a normalization mode, to be $\mathcal{B}(\Lambda_b^0 \to \eta_c(1S) p K^-)=(1.06\pm0.16\pm0.06^{+0.22}_{-0.19})\times10^{-4}$, where the quoted uncertainties are statistical, systematic and due to external inputs, respectively. A study of the $\eta_c(1S) p$ mass spectrum is performed to search for the $P_c(4312)^+$ pentaquark state. No evidence is observed and an upper limit of \begin{equation*} \frac{\mathcal{B}(\Lambda_b^0 \to P_c(4312)^+ K^-)\times \mathcal{B}(P_c(4312)^+ \to \eta_c(1S) p)}{\mathcal{B}(\Lambda_b^0 \to \eta_c(1S) p K^-)} < 0.24 \end{equation*} is obtained at the 95% confidence level.Comment: All figures and tables, along with any supplementary material and additional information, are available at https://cern.ch/lhcbproject/Publications/p/LHCb-PAPER-2020-012.html (LHCb public pages

Measurement of branching fraction ratios for B+ -> D*+D-K+, B+ -> D*-D+K+, and B-0 -> (D*-DK+)-K-0 decays

A measurement of four branching-fraction ratios for three-body decays of $B$ mesons involving two open-charm hadrons in the final state is presented. Run 1 and Run 2 $pp$ collision data are used, recorded by the LHCb experiment at centre-of-mass energies $7$, $8$, and $13$ TeV and corresponding to an integrated luminosity of $9$ fb$^{-1}$. The measured branching-fraction ratios are \begin{eqnarray} \frac{\mathcal{B} (B^+\to D^{*+}D^-K^+)}{\mathcal{B} (B^+\to \kern 0.2em\overline{\kern -0.2em D}{}^0 D^0 K^+)} &=& 0.517 \pm 0.015 \pm 0.013 \pm 0.011 , \\ \frac{\mathcal{B} (B^+\to D^{*-}D^+K^+)}{\mathcal{B} (B^+\to \kern 0.2em\overline{\kern -0.2em D}{}^0 D^0 K^+)} &=& 0.577 \pm 0.016 \pm 0.013 \pm 0.013 , \\ \frac{\mathcal{B} (B^0\to D^{*-}D^0K^+)}{\mathcal{B} (B^0\to D^- D^0 K^+)} &=& 1.754 \pm 0.028 \pm 0.016 \pm 0.035 , \\ \frac{\mathcal{B} (B^+\to D^{*+}D^-K^+)}{\mathcal{B} (B^+\to D^{*-}D^+K^+)} &=& 0.907 \pm 0.033 \pm 0.014 ,\end{eqnarray} where the first of the uncertainties is statistical, the second systematic, and the third is due to the uncertainties on the $D$-meson branching fractions. These are the most accurate measurements of these ratios to date

First observation of the decay Lambda(0)(b) -> eta(c) (1S)pK(-)

The decay $\Lambda_b^0 \to \eta_c(1S) p K^-$ is observed for the first time using a data sample of proton-proton collisions, corresponding to an integrated luminosity of 5.5 $fb^{-1}$, collected with the LHCb experiment at a center-of-mass energy of 13 TeV. The branching fraction of the decay is measured, using the $\Lambda_b^0 \to J/\psi p K^-$ decay as a normalization mode, to be $\mathcal{B}(\Lambda_b^0 \to \eta_c(1S) p K^-)=(1.06\pm0.16\pm0.06^{+0.22}_{-0.19})\times10^{-4}$, where the quoted uncertainties are statistical, systematic and due to external inputs, respectively. A study of the $\eta_c(1S) p$ mass spectrum is performed to search for the $P_c(4312)^+$ pentaquark state. No evidence is observed and an upper limit of \begin{equation*} \frac{\mathcal{B}(\Lambda_b^0 \to P_c(4312)^+ K^-)\times \mathcal{B}(P_c(4312)^+ \to \eta_c(1S) p)}{\mathcal{B}(\Lambda_b^0 \to \eta_c(1S) p K^-)} < 0.24 \end{equation*} is obtained at the 95% confidence level.Comment: All figures and tables, along with any supplementary material and additional information, are available at https://cern.ch/lhcbproject/Publications/p/LHCb-PAPER-2020-012.html (LHCb public pages