Jets and large-scale vortices in rotating Rayleigh-Bénard convection

One of the most prominent dynamical features of turbulent, rapidly rotating convection is the formation of large-scale coherent structures, driven by Reynolds stresses resulting from the small-scale convective flows. In spherical geometry, such structures consist of intense zonal flows that are invariant along the rotation axis. In planar geometry, long-lived, depth-invariant structures also form at large scales, but, in the absence of horizontal anisotropy, they consist of vortices that grow to the domain size. In this work, through the introduction of horizontal anisotropy into a numerical model of planar rotating convection by the adoption of unequal horizontal box sizes (i.e., Lx≤Ly, where the xy plane is horizontal), we investigate whether unidirectional flows and large-scale vortices can coexist. We find that only a small degree of anisotropy is required to bring about a transition from dynamics dominated by persistent large-scale vortices to dynamics dominated by persistent unidirectional flows parallel to the shortest horizontal direction. When the anisotropy is sufficiently large, the unidirectional flow consists of multiple jets, generated on a time scale smaller than a global viscous time scale, thus signifying that the upscale energy transfer does not spontaneously feed the largest available mode in the system. That said, the multiple jets merge on much longer time scales. Large-scale vortices of size comparable with Lx systematically form in the flanks of the jets and can be persistent or intermittent. This indicates that large-scale vortices, either coexisting with jets or not, are a robust dynamical feature of planar rotating convection

Numerical Simulations of Dynamos Generated in Spherical Couette Flows

We numerically investigate the efficiency of a spherical Couette flow at generating a self-sustained magnetic field. No dynamo action occurs for axisymmetric flow while we always found a dynamo when non-axisymmetric hydrodynamical instabilities are excited. Without rotation of the outer sphere, typical critical magnetic Reynolds numbers $Rm_c$ are of the order of a few thousands. They increase as the mechanical forcing imposed by the inner core on the flow increases (Reynolds number $Re$). Namely, no dynamo is found if the magnetic Prandtl number $Pm=Rm/Re$ is less than a critical value $Pm_c\sim 1$. Oscillating quadrupolar dynamos are present in the vicinity of the dynamo onset. Saturated magnetic fields obtained in supercritical regimes (either $Re>2 Re_c$ or $Pm>2Pm_c$) correspond to the equipartition between magnetic and kinetic energies. A global rotation of the system (Ekman numbers $E=10^{-3}, 10^{-4}$) yields to a slight decrease (factor 2) of the critical magnetic Prandtl number, but we find a peculiar regime where dynamo action may be obtained for relatively low magnetic Reynolds numbers ($Rm_c\sim 300$). In this dynamical regime (Rossby number $Ro\sim -1$, spheres in opposite direction) at a moderate Ekman number ($E=10^{-3}$), a enhanced shear layer around the inner core might explain the decrease of the dynamo threshold. For lower $E$ ($E=10^{-4}$) this internal shear layer becomes unstable, leading to small scales fluctuations, and the favorable dynamo regime is lost. We also model the effect of ferromagnetic boundary conditions. Their presence have only a small impact on the dynamo onset but clearly enhance the saturated magnetic field in the ferromagnetic parts. Implications for experimental studies are discussed

Magnetoconvection in a rotating spherical shell in the presence of a uniform axial magnetic field

We report simulations of thermal convection and magnetic-field generation in a rapidly-rotating spherical shell, in the presence of a uniform axial magnetic field of variable strength. We consider the effect of the imposed field on the critical parameters (Rayleigh number, azimuthal wavenumber and propagation frequency) for the onset of convection, and on the relative importance of Coriolis, buoyancy and Lorentz forces in the resulting solutions. The imposed field strength must be of order one (corresponding to an Elsasser number of unity) to observe significant modifications of the flow; in this case, all the critical parameters are reduced, an effect that is more pronounced at small Ekman numbers. Beyond onset, we study the variations of the structure and properties of the magnetically-modified convective flows with increasing Rayleigh numbers. In particular, we note the weak relative kinetic helicity, the rapid breakdown of the columnarity, and the enhanced heat transport efficiency of the flows obtained for imposed field strengths of order one. Furthermore, magnetic and thermal winds drive a significant zonal flow in this case, which is not present with no imposed field or with stronger imposed fields. The mechanisms for magnetic field generation (particularly the lengthscales involved in the axisymmetric field production) vary with the strength of the imposed field, with three distinct regimes being observed for weak, order one, and stronger imposed fields. In the last two cases, the induced magnetic field reinforces the imposed field, even exceeding its strength for large Rayleigh numbers, which suggests that magnetically-modified flows might be able to produce large-scale self-sustained magnetic field. These magnetoconvection calculations are relevant to planets orbiting magnetically active hosts, and also help to elucidate the mechanisms for field generation in a strong-field regime

A spherical shell numerical dynamo benchmark with pseudo vacuum magnetic boundary conditions

It is frequently considered that many planetary magnetic fields originate as a result of convection within planetary cores. Buoyancy forces responsible for driving the convection generate a fluid flow that is able to induce magnetic fields; numerous sophisticated computer codes are able to simulate the dynamic behaviour of such systems. This paper reports the results of a community activity aimed at comparing numerical results of several different types of computer codes that are capable of solving the equations of momentum transfer, magnetic field generation and heat transfer in the setting of a spherical shell, namely a sphere containing an inner core. The electrically conducting fluid is incompressible and rapidly rotating and the forcing of the flow is thermal convection under the Boussinesq approximation. We follow the original specifications and results reported in Harder & Hansen to construct a specific benchmark in which the boundaries of the fluid are taken to be impenetrable, non-slip and isothermal, with the added boundary condition for the magnetic field <b>B</b> that the field must be entirely radial there; this type of boundary condition for <b>B</b> is frequently referred to as ‘pseudo-vacuum’. This latter condition should be compared with the more frequently used insulating boundary condition. This benchmark is so-defined in order that computer codes based on local methods, such as finite element, finite volume or finite differences, can handle the boundary condition with ease. The defined benchmark, governed by specific choices of the Roberts, magnetic Rossby, Rayleigh and Ekman numbers, possesses a simple solution that is steady in an azimuthally drifting frame of reference, thus allowing easy comparison among results. Results from a variety of types of code are reported, including codes that are fully spectral (based on spherical harmonic expansions in angular coordinates and polynomial expansions in radius), mixed spectral and finite difference, finite volume, finite element and also a mixed Fourier-finite element code. There is good agreement among codes

Extracorporeal Membrane Oxygenation for Severe Acute Respiratory Distress Syndrome

BACKGROUND: The efficacy of venovenous extracorporeal membrane oxygenation (ECMO) in patients with severe acute respiratory distress syndrome (ARDS) remains controversial. METHODS: In an international clinical trial, we randomly assigned patients with very severe ARDS, as indicated by one of three criteria - a ratio of partial pressure of arterial oxygen (Pao) to the fraction of inspired oxygen (Fio) of less than 50 mm Hg for more than 3 hours; a Pao:Fio of less than 80 mm Hg for more than 6 hours; or an arterial blood pH of less than 7.25 with a partial pressure of arterial carbon dioxide of at least 60 mm Hg for more than 6 hours - to receive immediate venovenous ECMO (ECMO group) or continued conventional treatment (control group). Crossover to ECMO was possible for patients in the control group who had refractory hypoxemia. The primary end point was mortality at 60 days. RESULTS: At 60 days, 44 of 124 patients (35%) in the ECMO group and 57 of 125 (46%) in the control group had died (relative risk, 0.76; 95% confidence interval [CI], 0.55 to 1.04; P=0.09). Crossover to ECMO occurred a mean (±SD) of 6.5±9.7 days after randomization in 35 patients (28%) in the control group, with 20 of these patients (57%) dying. The frequency of complications did not differ significantly between groups, except that there were more bleeding events leading to transfusion in the ECMO group than in the control group (in 46% vs. 28% of patients; absolute risk difference, 18 percentage points; 95% CI, 6 to 30) as well as more cases of severe thrombocytopenia (in 27% vs. 16%; absolute risk difference, 11 percentage points; 95% CI, 0 to 21) and fewer cases of ischemic stroke (in no patients vs. 5%; absolute risk difference, -5 percentage points; 95% CI, -10 to -2). CONCLUSIONS: Among patients with very severe ARDS, 60-day mortality was not significantly lower with ECMO than with a strategy of conventional mechanical ventilation that included ECMO as rescue therapy. (Funded by the Direction de la Recherche Clinique et du Développement and the French Ministry of Health; EOLIA ClinicalTrials.gov number, NCT01470703 .)

c-Myc Regulates Self-Renewal in Bronchoalveolar Stem Cells

BACKGROUND: Bronchoalveolar stem cells (BASCs) located in the bronchoalveolar duct junction are thought to regenerate both bronchiolar and alveolar epithelium during homeostatic turnover and in response to injury. The mechanisms directing self-renewal in BASCs are poorly understood. METHODS: BASCs (Sca-1(+), CD34(+), CD31(-) and, CD45(-)) were isolated from adult mouse lung using FACS, and their capacity for self-renewal and differentiation were demonstrated by immunostaining. A transcription factor network of 53 genes required for pluripotency in embryonic stem cells was assessed in BASCs, Kras-initiated lung tumor tissue, and lung organogenesis by real-time PCR. c-Myc was knocked down in BASCs by infection with c-Myc shRNA lentivirus. Comprehensive miRNA and mRNA profiling for BASCs was performed, and significant miRNAs and mRNAs potentially regulated by c-Myc were identified. We explored a c-Myc regulatory network in BASCs using a number of statistical and computational approaches through two different strategies; 1) c-Myc/Max binding sites within individual gene promoters, and 2) miRNA-regulated target genes. RESULTS: c-Myc expression was upregulated in BASCs and downregulated over the time course of lung organogenesis in vivo. The depletion of c-Myc in BASCs resulted in decreased proliferation and cell death. Multiple mRNAs and miRNAs were dynamically regulated in c-Myc depleted BASCs. Among a total of 250 dynamically regulated genes in c-Myc depleted BASCs, 57 genes were identified as potential targets of miRNAs through miRBase and TargetScan-based computational mapping. A further 88 genes were identified as potential downstream targets through their c-Myc binding motif. CONCLUSION: c-Myc plays a critical role in maintaining the self-renewal capacity of lung bronchoalveolar stem cells through a combination of miRNA and transcription factor regulatory networks