Risk profiles and one-year outcomes of patients with newly diagnosed atrial fibrillation in India: Insights from the GARFIELD-AF Registry.

BACKGROUND: The Global Anticoagulant Registry in the FIELD-Atrial Fibrillation (GARFIELD-AF) is an ongoing prospective noninterventional registry, which is providing important information on the baseline characteristics, treatment patterns, and 1-year outcomes in patients with newly diagnosed non-valvular atrial fibrillation (NVAF). This report describes data from Indian patients recruited in this registry. METHODS AND RESULTS: A total of 52,014 patients with newly diagnosed AF were enrolled globally; of these, 1388 patients were recruited from 26 sites within India (2012-2016). In India, the mean age was 65.8 years at diagnosis of NVAF. Hypertension was the most prevalent risk factor for AF, present in 68.5% of patients from India and in 76.3% of patients globally (P < 0.001). Diabetes and coronary artery disease (CAD) were prevalent in 36.2% and 28.1% of patients as compared with global prevalence of 22.2% and 21.6%, respectively (P < 0.001 for both). Antiplatelet therapy was the most common antithrombotic treatment in India. With increasing stroke risk, however, patients were more likely to receive oral anticoagulant therapy [mainly vitamin K antagonist (VKA)], but average international normalized ratio (INR) was lower among Indian patients [median INR value 1.6 (interquartile range {IQR}: 1.3-2.3) versus 2.3 (IQR 1.8-2.8) (P < 0.001)]. Compared with other countries, patients from India had markedly higher rates of all-cause mortality [7.68 per 100 person-years (95% confidence interval 6.32-9.35) vs 4.34 (4.16-4.53), P < 0.0001], while rates of stroke/systemic embolism and major bleeding were lower after 1 year of follow-up. CONCLUSION: Compared to previously published registries from India, the GARFIELD-AF registry describes clinical profiles and outcomes in Indian patients with AF of a different etiology. The registry data show that compared to the rest of the world, Indian AF patients are younger in age and have more diabetes and CAD. Patients with a higher stroke risk are more likely to receive anticoagulation therapy with VKA but are underdosed compared with the global average in the GARFIELD-AF. CLINICAL TRIAL REGISTRATION-URL: http://www.clinicaltrials.gov. Unique identifier: NCT01090362

Simulation of stresses and contact surfaces of disk rolling cutters with the rock when sinking in mixed soils

In this paper, we consider the crack propagation in the rocks during sinking depending on the distance between the cutters. Under the same conditions, the hard and soft rocks form various fracture networks that leads to uneven sinking and decrease in the efficiency of the tunneling machine. In order to study this issue, four ranges of distance between the contact surfaces and various incidence angles of the contact surface were selected. The study includes a system that is a mountain mass layout with a disk cutter the only parameter of which is the tip width or the contact width of the disk cutter with the end-type rock. Simulation of research conditions and finding a solution to the problem were performed using the Autodesk Inventor Nastran 3D simulation software

Hyoliths from the Bystraya Formation (Cambrian Series 2) of eastern Transbaikalia (Zabaykalsky Krai), Siberia

The hyolith fauna of the middle Bystraya Formation (Cambrian Series 2) of eastern Transbaikalia (Zabaykalsky Krai), Siberia, includes at least 17 described taxa distributed between the orders Hyolithida and Orthothecida. Species of Microcornus, Parkula, Conotheca, Neogloborilus and Cupitheca are widely reported from Cambrian strata elsewhere. Triplicatella uslonica sp. nov. is known only from Transbaikalia. Dauritheca is proposed as a replacement generic name for the junior homonym Pachytheca, originally described from Xinjiang, China, and its range is extended to Transbaikalia. A conch with prominent comarginal ribs is referred to Salanytheca daurica sp. nov., a genus otherwise known from the early Cambrian of Mongolia and northern Siberia

Diffusion Patterns of Social Network Posts

Social network posts as an efficient means of communication directly reflect users’ interests and engagements. Despite challenges there are strong interests in understanding how social network posts efficiently spread information. In this article some diffusion patterns of social network posts are explored. The information spreading via post chains based on partial data of popular social network is studied to gain insights of the problem of information diffusion. Mathematical models for information cascades are proposed and future research directions are discussed

Diffusion patterns of social network posts

Social network posts as an efficient means of communication directly reflect users’ interests and engagements. Despite challenges there are strong interests in understanding how social network posts efficiently spread information. In this article some diffusion patterns of social network posts are explored. The information spreading via post chains based on partial data of popular social network is studied to gain insights of the problem of information diffusion. Mathematical models for information cascades are proposed and future research directions are discussed

The results of evaluation of the collection of cocksfoot in the Central Chernozem zone

Cocksfoot is one of the earliest, highly nutritious valuable forage crops, which is widely used in agricultural production. It is relevant in developing varieties adapted to the environmental stress factors that have productive longevity, increased seed and fodder productivity. The paper presents the results of wild cocksfoot accessions conducted on Ekaterininskaya RS in 2017-2019. No accessions of cocksfoot were identified that consistently exceeded the standard grade for all three years of study. Accessions collected in the North Caucasus and Tajikistan and introduced from the Mediterranean region performed well in the first year of life, but by the third year of the life, they significantly reduced all characteristics. The accessions of cocksfoot from the Central Region of the European part of the RF and from the mountainous regions of the Southern Urals are of the greatest interest for breeding in the Central Chernozem zone

Preparation and properties of zirconium tungstate with anomalous thermal characteristics

The main aim of the study: The actuality of the discussed issue is caused by the lack of systematic studies of structural phase transformations of zirconium tungstate at temperature increase. The methods used in the study:High temperature in situ X-ray analysis, refinement of the structure by the Rietveld method using TOPAS v.4.2 (Bruker) software, thermogravimetric differential scanning calorimetry. The results: The morphology of the material was represented as rod-shaped particles having a block structure. The ZrW2O8 synthesized was kinetically stable from 25 to 540 °C. Temperature increase has initiated structural change which resulted decomposition of ZrW2O8 into ZrO2 and WO3. The ZrW2O8 synthesized demonstrated a negative thermal expansion behavior from 25 to 750 °C

E-expertise: modern collective intelligence

  This book focuses on organization and mechanisms of expert decision-making support using modern information and communication technologies, as well as information analysis and collective intelligence technologies (electronic expertise or simply e-expertise). Chapter 1 (E-Expertise) discusses the role of e-expertise in decision-making processes. The procedures of e-expertise are classified, their benefits and shortcomings are identified, and the efficiency conditions are considered. Chapter 2 (Expert Technologies and Principles) provides a comprehensive overview of modern expert technologies. A special emphasis is placed on the specifics of e-expertise. Moreover, the authors study the feasibility and reasonability of employing well-known methods and approaches in e-expertise. Chapter 3 (E-Expertise: Organization and Technologies) describes some examples of up-to-date technologies to perform e-expertise. Chapter 4 (Trust Networks and Competence Networks) deals with the problems of expert finding and grouping by information and communication technologies. Chapter 5 (Active Expertise) treats the problem of expertise stability against any strategic manipulation by experts or coordinators pursuing individual goals. The book addresses a wide range of readers interested in management, decision-making and expert activity in political, economic, social and industrial spheres