Coloured Identity in the Rainbow Nation: Historical Narratives of the Durban Coloured Community

South Africa is working to come to terms with the residual effects of institutionalized racist policies that governed all aspects of its citizens’ lives during Apartheid. One struggle individuals and communities must wage is to define how they see their own racial identity in a post-Apartheid South Africa. There are many questions to ask. Is race no longer pertinent, or does it have a past that must be earnestly engaged and challenged, or does it constitute eternally fixed boundaries embodying cultural norms and biological traits? I, as I show in this paper, see the concept of race itself as a historical construct, one that must be engaged and challenged in order to understand it in its present form. Looking at the coloured community of Durban, this paper seeks to study the historical formation of coloured identity and the manner in which coloured people in Durban understand, or not, the formation of that identity. The aims of this paper lie in the belief that any race is a product of a particular kind of knowledge production that suited particular interests; race thus is a man-made creation and as such it has the potential to continue evolving. As South Africa attempts to forge a new national narrative, one where the idea of a “rainbow nation” plays a central role, it is important that racial categories be given the space by individuals and the government to evolve and be contested. I will show how coloured identity has come to occupy some of the meaning it now assumes. I will also show that though recent scholarship has called for a change in the way coloured identity is viewed, suggesting a move from an essentialist perspective to one that sees the identity as dynamic and shaped by history but also by those who presently own it, this consensus is missing in the broader community for various reasons. In conclusion I suggest that in order for South Africa to become a true “rainbow nation” ordinary citizens need to create a space for one another other to construct their own identities. For this to be possible, the state must set the example and begin understanding its citizens as composed of a complicated, intertwined set of identities

'To the end of the world':Space, place and missing persons investigations

Police investigations of major crimes are typically conducted in contexts where there is contested or ambiguous knowledge about what occurred and such challenges are also routinely faced in the investigation of missing persons. This article examines ways in which attempts to ‘manufacture certainty’ in missing persons cases are strongly informed by geographical notions of space and place. The article is structured around the key phases of police investigations, each of which involves the mobilization of different forms of geographical knowledge. In the first stage of ‘identifying and acquiring’ information, the process of search is structured by knowledge about the possible spatial behaviours of missing people often generated using spatial profiling techniques. In the second phase of ‘interpreting and understanding’, more nuanced accounts of what may have happened to a missing person are constructed as the police attempt to ‘place’ a person’s disappearance within a particular narrative based on their reading of the intelligence picture that emerges during the investigation. In the concluding phase of ‘ordering and representing’, the case to internal (senior police management) and external (relatives of the missing person and wider public) audiences investigators will often invoke a notion of ‘the end of the world’ referring not just to how they have defined the geographical limits of the police search if the person is still unaccounted for but also the boundaries of reputational risk and the proportionality of the police response

Spectroscopic time series performance of the Mid-Infrared Instrument on the JWST

We present here the first ever mid-infrared spectroscopic time series observation of the transiting exoplanet \object{L 168-9 b} with the Mid-Infrared Instrument (MIRI) on the James Webb Space Telescope. The data were obtained as part of the MIRI commissioning activities, to characterize the performance of the Low Resolution Spectroscopy (LRS) mode for these challenging observations. To assess the MIRI LRS performance, we performed two independent analyses of the data. We find that with a single transit observation we reached a spectro-photometric precision of $\sim$50 ppm in the 7-8 \micron range at R=50, consistent with $\sim$25 ppm systematic noise. The derived band averaged transit depth is 524 $\pm$ 15 ppm and 547 $\pm$ 13 ppm for the two applied analysis methods, respectively, recovering the known transit depth to within 1 $\sigma$. The measured noise in the planet's transmission spectrum is approximately 15-20 \% higher than random noise simulations over wavelengths $6.8 \lesssim \lambda \lesssim 11$ $\mu$m. \added{We observed an larger excess noise at the shortest wavelengths of up to a factor of two, for which possible causes are discussed.} This performance was achieved with limited in-flight calibration data, demonstrating the future potential of MIRI for the characterization of exoplanet atmospheres.Comment: Accepted for publishing in PASP, 21 pages, 10 figure

Using research to influence sexual and reproductive health practice and implementation in Sub-Saharan Africa: a case-study analysis

Background Research institutions and donor organizations are giving growing attention to how research evidence is communicated to influence policy. In the area of sexual and reproductive health (SRH) and HIV there is less weight given to understanding how evidence is successfully translated into practice. Policy issues in SRH can be controversial, influenced by political factors and shaped by context such as religion, ethnicity, gender and sexuality. Methods The case-studies presented in this paper analyse findings from SRH/HIV research programmes in sub-Saharan Africa: 1) Maternal syphilis screening in Ghana, 2) Legislative change for sexual violence survivors In Ghana, 3) Male circumcision policy in South Africa, and 4) Male circumcision policy in Tanzania. Our analysis draws on two frameworks, Sumner et al’s synthesis approach and Nutley’s research use continuum. Results The analysis emphasises the relationships and communications involved in using research to influence policy and practice and recognises a distinction whereby practice is not necessarily influenced as a result of policy change – especially in SRH – where there are complex interactions between policy actors. Conclusion Both frameworks demonstrate how policy networks, partnership and advocacy are critical in shaping the extent to which research is used and the importance of on-going and continuous links between a range of actors to maximize research impact on policy uptake and implementation. The case-studies illustrate the importance of long-term engagement between researchers and policy makers and how to use evidence to develop policies which are sensitive to context: political, cultural and practical

BRCA2 polymorphic stop codon K3326X and the risk of breast, prostate, and ovarian cancers

Background: The K3326X variant in BRCA2 (BRCA2*c.9976A>T; p.Lys3326*; rs11571833) has been found to be associated with small increased risks of breast cancer. However, it is not clear to what extent linkage disequilibrium with fully pathogenic mutations might account for this association. There is scant information about the effect of K3326X in other hormone-related cancers. Methods: Using weighted logistic regression, we analyzed data from the large iCOGS study including 76 637 cancer case patients and 83 796 control patients to estimate odds ratios (ORw) and 95% confidence intervals (CIs) for K3326X variant carriers in relation to breast, ovarian, and prostate cancer risks, with weights defined as probability of not having a pathogenic BRCA2 variant. Using Cox proportional hazards modeling, we also examined the associations of K3326X with breast and ovarian cancer risks among 7183 BRCA1 variant carriers. All statistical tests were two-sided. Results: The K3326X variant was associated with breast (ORw = 1.28, 95% CI = 1.17 to 1.40, P = 5.9x10- 6) and invasive ovarian cancer (ORw = 1.26, 95% CI = 1.10 to 1.43, P = 3.8x10-3). These associations were stronger for serous ovarian cancer and for estrogen receptor–negative breast cancer (ORw = 1.46, 95% CI = 1.2 to 1.70, P = 3.4x10-5 and ORw = 1.50, 95% CI = 1.28 to 1.76, P = 4.1x10-5, respectively). For BRCA1 mutation carriers, there was a statistically significant inverse association of the K3326X variant with risk of ovarian cancer (HR = 0.43, 95% CI = 0.22 to 0.84, P = .013) but no association with breast cancer. No association with prostate cancer was observed. Conclusions: Our study provides evidence that the K3326X variant is associated with risk of developing breast and ovarian cancers independent of other pathogenic variants in BRCA2. Further studies are needed to determine the biological mechanism of action responsible for these associations

A chemical survey of exoplanets with ARIEL

Thousands of exoplanets have now been discovered with a huge range of masses, sizes and orbits: from rocky Earth-like planets to large gas giants grazing the surface of their host star. However, the essential nature of these exoplanets remains largely mysterious: there is no known, discernible pattern linking the presence, size, or orbital parameters of a planet to the nature of its parent star. We have little idea whether the chemistry of a planet is linked to its formation environment, or whether the type of host star drives the physics and chemistry of the planet’s birth, and evolution. ARIEL was conceived to observe a large number (~1000) of transiting planets for statistical understanding, including gas giants, Neptunes, super-Earths and Earth-size planets around a range of host star types using transit spectroscopy in the 1.25–7.8 μm spectral range and multiple narrow-band photometry in the optical. ARIEL will focus on warm and hot planets to take advantage of their well-mixed atmospheres which should show minimal condensation and sequestration of high-Z materials compared to their colder Solar System siblings. Said warm and hot atmospheres are expected to be more representative of the planetary bulk composition. Observations of these warm/hot exoplanets, and in particular of their elemental composition (especially C, O, N, S, Si), will allow the understanding of the early stages of planetary and atmospheric formation during the nebular phase and the following few million years. ARIEL will thus provide a representative picture of the chemical nature of the exoplanets and relate this directly to the type and chemical environment of the host star. ARIEL is designed as a dedicated survey mission for combined-light spectroscopy, capable of observing a large and well-defined planet sample within its 4-year mission lifetime. Transit, eclipse and phase-curve spectroscopy methods, whereby the signal from the star and planet are differentiated using knowledge of the planetary ephemerides, allow us to measure atmospheric signals from the planet at levels of 10–100 part per million (ppm) relative to the star and, given the bright nature of targets, also allows more sophisticated techniques, such as eclipse mapping, to give a deeper insight into the nature of the atmosphere. These types of observations require a stable payload and satellite platform with broad, instantaneous wavelength coverage to detect many molecular species, probe the thermal structure, identify clouds and monitor the stellar activity. The wavelength range proposed covers all the expected major atmospheric gases from e.g. H2O, CO2, CH4 NH3, HCN, H2S through to the more exotic metallic compounds, such as TiO, VO, and condensed species. Simulations of ARIEL performance in conducting exoplanet surveys have been performed – using conservative estimates of mission performance and a full model of all significant noise sources in the measurement – using a list of potential ARIEL targets that incorporates the latest available exoplanet statistics. The conclusion at the end of the Phase A study, is that ARIEL – in line with the stated mission objectives – will be able to observe about 1000 exoplanets depending on the details of the adopted survey strategy, thus confirming the feasibility of the main science objectives.Peer reviewedFinal Published versio

Force-Velocity Measurements of a Few Growing Actin Filaments

The authors propose a new mechanism for actin-based force generation based on results using chains of actin-grafted magnetic colloids