729 research outputs found
Information Gains from Cosmological Probes
In light of the growing number of cosmological observations, it is important
to develop versatile tools to quantify the constraining power and consistency
of cosmological probes. Originally motivated from information theory, we use
the relative entropy to compute the information gained by Bayesian updates in
units of bits. This measure quantifies both the improvement in precision and
the 'surprise', i.e. the tension arising from shifts in central values. Our
starting point is a WMAP9 prior which we update with observations of the
distance ladder, supernovae (SNe), baryon acoustic oscillations (BAO), and weak
lensing as well as the 2015 Planck release. We consider the parameters of the
flat CDM concordance model and some of its extensions which include
curvature and Dark Energy equation of state parameter . We find that,
relative to WMAP9 and within these model spaces, the probes that have provided
the greatest gains are Planck (10 bits), followed by BAO surveys (5.1 bits) and
SNe experiments (3.1 bits). The other cosmological probes, including weak
lensing (1.7 bits) and {} measures (1.7 bits), have contributed
information but at a lower level. Furthermore, we do not find any significant
surprise when updating the constraints of WMAP9 with any of the other
experiments, meaning that they are consistent with WMAP9. However, when we
choose Planck15 as the prior, we find that, accounting for the full
multi-dimensionality of the parameter space, the weak lensing measurements of
CFHTLenS produce a large surprise of 4.4 bits which is statistically
significant at the 8 level. We discuss how the relative entropy
provides a versatile and robust framework to compare cosmological probes in the
context of current and future surveys.Comment: 26 pages, 5 figure
Quantifying Tensions between CMB and Distance Datasets in Models with Free Curvature or Lensing Amplitude
Recent measurements of the Cosmic Microwave Background (CMB) by the Planck
Collaboration have produced arguably the most powerful observational evidence
in support of the standard model of cosmology, i.e. the spatially flat
CDM paradigm. In this work, we perform model selection tests to
examine whether the base CMB temperature and large scale polarization
anisotropy data from Planck 2015 (P15) prefer any of eight commonly used
one-parameter model extensions with respect to flat CDM. We find a
clear preference for models with free curvature, , or free
amplitude of the CMB lensing potential, . We also further develop
statistical tools to measure tension between datasets. We use a Gaussianization
scheme to compute tensions directly from the posterior samples using an
entropy-based method, the surprise, as well as a calibrated evidence ratio
presented here for the first time. We then proceed to investigate the
consistency between the base P15~CMB data and six other CMB and distance
datasets. In flat CDM we find a tension between the base
P15~CMB data and a distance ladder measurement, whereas the former are
consistent with the other datasets. In the curved CDM model we find
significant tensions in most of the cases, arising from the well-known low
power of the low- multipoles of the CMB data. In the flat CDM
model, however, all datasets are consistent with the base
P15~CMB observations except for the CMB lensing measurement, which remains in
significant tension. This tension is driven by the increased power of the CMB
lensing potential derived from the base P15~CMB constraints in both models,
pointing at either potentially unresolved systematic effects or the need for
new physics beyond the standard flat CDM model.Comment: 16 pages, 8 figures, 6 table
Biochemical Properties of a Decoy Oligodeoxynucleotide Inhibitor of STAT3 Transcription Factor.
Cyclic STAT3 decoy (CS3D) is a second-generation, double-stranded oligodeoxynucleotide (ODN) that mimics a genomic response element for signal transducer and activator of transcription 3 (STAT3), an oncogenic transcription factor. CS3D competitively inhibits STAT3 binding to target gene promoters, resulting in decreased expression of proteins that promote cellular proliferation and survival. Previous studies have demonstrated antitumor activity of CS3D in preclinical models of solid tumors. However, prior to entering human clinical trials, the efficiency of generating the CS3D molecule and its stability in biological fluids should be determined. CS3D is synthesized as a single-stranded ODN and must have its free ends ligated to generate the final cyclic form. In this study, we report a ligation efficiency of nearly 95 percent. The ligated CS3D demonstrated a half-life of 7.9 h in human serum, indicating adequate stability for intravenous delivery. These results provide requisite biochemical characterization of CS3D that will inform upcoming clinical trials
Liquid-liquid coexistence in the phase diagram of a fluid confined in fractal porous materials
Multicanonical ensemble sampling simulations have been performed to calculate
the phase diagram of a Lennard-Jones fluid embedded in a fractal random matrix
generated through diffusion limited cluster aggregation. The study of the
system at increasing size and constant porosity shows that the results are
independent from the matrix realization but not from the size effects. A
gas-liquid transition shifted with respect to bulk is found. On growing the
size of the system on the high density side of the gas-liquid coexistence curve
it appears a second coexistence region between two liquid phases. These two
phases are characterized by a different behaviour of the local density inside
the interconnected porous structure at the same temperature and chemical
potential.Comment: 5 pages, 4 figures. To be published in Europhys. Letter
The comparison of latero-medial versus dorso-palmar/plantar drilling for cartilage removal in the proximal interphalangeal joint
The aims of the present study were to compare the percentages of articular cartilage removed using a lateral drilling approach of the proximal interphalangeal joint (PIPJ) and a dorsal drilling approach, and to assess the usefulness of digital fluoroscopy when performing a lateral drilling approach. Sixty cadaveric PIPJs were drilled using a surgical drill bit to remove the articular cartilage. The limbs were divided into three groups containing 10 forelimbs and 10 hindlimbs each. One group received the dorsal drilling approach, the second one received the lateral drilling approach and the last one received the lateral drilling approach under digital fluoroscopy guidance. The percentage of articular cartilage removed from each articular surface was assessed using Adobe PhotoshopÂź software. The percentages of removed cartilage turned out to be significantly higher with lateral approach, especially under fluoroscopic guidance, both in the forelimbs (p = 0.00712) and hindlimbs (p = 0.00962). In conclusion, the lateral drilling approach seems to be a minimally invasive technique with which to perform PIPJ arthrodesis, even more efficient than the previously reported dorsal approach
Mass calibration of the CODEX cluster sample using SPIDERS spectroscopy - II. The X-ray luminosity-mass relation
We perform the calibration of the X-ray luminosity-mass scaling relation on a sample of 344 CODEX clusters with z <0.66 using the dynamics of their member galaxies. Spectroscopic follow-up measurements have been obtained from the SPIDERS survey, leading to a sample of 6658 red member galaxies. We use the Jeans equation to calculate halo masses, assuming an NFW mass profile and analysing a broad range of anisotropy profiles. With a scaling relation of the form L-X proportional to A(X)M(200c)(BX) E(z)(2)(1 + z)(gamma x), we find best-fitting parameters A(X) = 0.62(-0.06)(+0.05) (+/- 0.06) x 10(44) erg s(-)(1), B-X = 2.35(-0.18)(+0.21)(+/- 0.09), gamma(X) = -2.77(-1.05)(+1.06)(+/- 0.79), where we include systematic uncertainties in parentheses and for a pivot mass and redshift of 3 x 10(14) M-circle dot and 0.16, respectively. We compare our constraints with previous results, and we combine our sample with the SPT SZE-selected cluster subsample observed with XMM-Newton extending the validity of our results to a wider range of redshifts and cluster masses.Peer reviewe
The laminar organization of the motor cortex in monodactylous mammals: a comparative assessment based on horse, chimpanzee, and macaque
The architecture of the neocortex classically consists of six layers, based on cytological criteria and on the layout of intra/interlaminar connections. Yet, the comparison of cortical cytoarchitectonic features across different species proves overwhelmingly difficult, due to the lack of a reliable model to analyze the connection patterns of neuronal ensembles forming the different layers. We first defined a set of suitable morphometric cell features, obtained in digitized Nissl-stained sections of the motor cortex of the horse, chimpanzee, and crab-eating macaque. We then modeled them using a quite general non-parametric data representation model, showing that the assessment of neuronal cell complexity (i.e., how a given cell differs from its neighbors) can be performed using a suitable measure of statistical dispersion such as the mean absolute deviation\u2014mean absolute deviation (MAD). Along with the non-parametric combination and permutation methodology, application of MAD allowed not only to estimate, but also to compare and rank the motor cortical complexity across different species. As to the instances presented in this paper, we show that the pyramidal layers of the motor cortex of the horse are far more irregular than those of primates. This feature could be related to the different organizations of the motor system in monodactylous mammals
Brainstem neurodegeneration correlates with clinical dysfunction in SCA1 but not in SCA2. A quantitative volumetric, diffusion and proton spectroscopy MR study.
The X-ray invisible Universe. A look into the halos undetected by eROSITA
The paper presents the analysis of GAMA spectroscopic groups and clusters
detected and undetected in the SRG/eROSITA X-ray map of the eFEDS (eROSITA
Final Equatorial Depth Survey) area, in the halo mass range
and at . We compare the X-ray surface brightness profiles
of the eROSITA detected groups with the mean stacked profile of the undetected
low-mass halos. Overall, we find that the undetected groups exhibit less
concentrated X-ray surface brightness, dark matter, and galaxy distributions
with respect to the X-ray detected halos. Consistently with the low mass
concentration, the magnitude gap indicates that these are younger systems. The
later assembly time is confirmed by the bluer average color of the BCG and of
the galaxy population with respect to the detected systems. They reside with a
higher probability in filaments while X-ray detected low-mass halos favor the
nodes of the Cosmic Web. Because of the suppressed X-ray central emission, the
undetected systems tend to be X-ray under-luminous at fixed halo mass, and to
lie below the relation. Interestingly, the X-ray detected
systems inhabiting the nodes scatter the less around the relation, while those
in filaments tend to lie below it. We do not observe any strong relation
between the properties of detected and undetected systems with the AGN
activity. The fraction of optically selected AGN in the galaxy population is
consistent in the two samples. More interestingly, the probability that the BCG
hosts a radio AGN is lower in the undetected groups. We, thus, argue that the
observed differences between X-ray detected and undetected groups are
ascribable to the Cosmic Web, and its role in the halo assembly bias. Our
results suggest that the X-ray selection is biased to favor the most
concentrated and old systems located in the nodes of the Cosmic Web.Comment: 15 pages, 13 figures, Submitted to MNRA
Frequent mutation of receptor protein tyrosine phosphatases provides a mechanism for STAT3 hyperactivation in head and neck cancer
The underpinnings of STAT3 hyperphosphorylation resulting in enhanced signaling and cancer progression are incompletely understood. Loss-of-function mutations of enzymes that dephosphorylate STAT3, such as receptor protein tyrosine phosphatases, which are encoded by the PTPR gene family, represent a plausible mechanism of STAT3 hyperactivation. We analyzed whole exome sequencing (n = 374) and reverse-phase protein array data (n = 212) from head and neck squamous cell carcinomas (HNSCCs). PTPR mutations are most common and are associated with significantly increased phospho-STAT3 expression in HNSCC tumors. Expression of receptor-like protein tyrosine phosphatase T (PTPRT) mutant proteins induces STAT3 phosphorylation and cell survival, consistent with a âdriverâ phenotype. Computational modeling reveals functional consequences of PTPRT mutations on phospho-tyrosineâsubstrate interactions. A high mutation rate (30%) of PTPRs was found in HNSCC and 14 other solid tumors, suggesting that PTPR alterations, in particular PTPRT mutations, may define a subset of patients where STAT3 pathway inhibitors hold particular promise as effective therapeutic agents.Fil: Lui, Vivian Wai Yan. University of Pittsburgh; Estados UnidosFil: Peyser, Noah D.. University of Pittsburgh; Estados UnidosFil: Ng, Patrick Kwok-Shing. University Of Texas Md Anderson Cancer Center;Fil: Hritz, Jozef. University of Pittsburgh at Johnstown; Estados Unidos. University of Pittsburgh; Estados Unidos. Masaryk University; RepĂșblica ChecaFil: Zeng, Yan. University of Pittsburgh at Johnstown; Estados Unidos. University of Pittsburgh; Estados UnidosFil: Lu, Yiling. University Of Texas Md Anderson Cancer Center;Fil: Li, Hua. University of Pittsburgh; Estados Unidos. University of Pittsburgh at Johnstown; Estados UnidosFil: Wang, Lin. University of Pittsburgh; Estados Unidos. University of Pittsburgh at Johnstown; Estados UnidosFil: Gilbert, Breean R.. University of Pittsburgh; Estados Unidos. University of Pittsburgh at Johnstown; Estados UnidosFil: General, Ignacio. University of Pittsburgh; Estados Unidos. University of Pittsburgh at Johnstown; Estados UnidosFil: Bahar, Ivet. University of Pittsburgh at Johnstown; Estados Unidos. University of Pittsburgh; Estados UnidosFil: Ju, Zhenlin. University Of Texas Md Anderson Cancer Center;Fil: Wang, Zhenghe. Case Western Reserve University; Estados UnidosFil: Pendleton, Kelsey P.. University of Pittsburgh; Estados Unidos. University of Pittsburgh at Johnstown; Estados UnidosFil: Xiao, Xiao. University of Pittsburgh at Johnstown; Estados Unidos. University of Pittsburgh; Estados UnidosFil: Du, Yu. University of Pittsburgh at Johnstown; Estados Unidos. University of Pittsburgh; Estados UnidosFil: Vries, John K.. University of Pittsburgh; Estados Unidos. University of Pittsburgh at Johnstown; Estados UnidosFil: Hammerman, Peter S.. Harvard Medical School; Estados UnidosFil: Garraway, Levi A.. Harvard Medical School; Estados UnidosFil: Mills, Gordon B.. University Of Texas Md Anderson Cancer Center;Fil: Johnson, Daniel E.. University of Pittsburgh at Johnstown; Estados Unidos. University of Pittsburgh; Estados UnidosFil: Grandis, Jennifer R.. University of Pittsburgh; Estados Unidos. University of Pittsburgh at Johnstown; Estados Unido
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